A novel cationic Pt(Ⅱ)complex 2 with 2-(2,4-difluorophenyl)pyridine as the cyclometalating ligand and 1,10-phenanthroline as the auxiliary ligand has been synthesized and fully characterized.This complex exhibits muc...A novel cationic Pt(Ⅱ)complex 2 with 2-(2,4-difluorophenyl)pyridine as the cyclometalating ligand and 1,10-phenanthroline as the auxiliary ligand has been synthesized and fully characterized.This complex exhibits much higher aggregation-induced phosphorescent emission activity than that of a nonfluorinated complex 1 in CH_(3)CN/H_(2)O.The complex 2 demonstrates efficient detection on picric acid(PA)in CH_(3)CN/H_(2)O,providing a high quenching constant(K_(SV)=2.3×10^(4) L/mol)and a low limit of detection(LOD=0.26μmol/L).In addition,complex 2 shows high selectivity for detection of PA in real water samples.Density functional theory calculations and proton nuclear magnetic resonance spectra suggest that the detection mechanism is attributed to the photo-induced electron transfer.展开更多
许多生物标志物被国内外学者发现并应用于临床,而选择一种简单且容易测定的生物标志物用来评估并预测疾病的风险则显得尤为重要。血浆动脉粥样硬化指数(Atherogenic Index of Plasma,AIP)是一种创新性新型生物标志物,其值是由甘油三酯...许多生物标志物被国内外学者发现并应用于临床,而选择一种简单且容易测定的生物标志物用来评估并预测疾病的风险则显得尤为重要。血浆动脉粥样硬化指数(Atherogenic Index of Plasma,AIP)是一种创新性新型生物标志物,其值是由甘油三酯与高密度脂蛋白-胆固醇的摩尔浓度对数转换比率组成。本综述通过对AIP作基本概括及其脂代谢的相关机制,了解到AIP作为一种新型综合生物标志物,对2型糖尿病及其并发症以及对相关疾病比如动脉粥样硬化性心血管疾病、非酒精性脂肪性肝病、代谢综合征等疾病具有很好的预测及风险评估能力。本文重点分析AIP与2型糖尿病、2型糖尿病大血管病变以及肾脏病变之间的关联,探索AIP作为新型生物标志物的研究潜力,以期为上述疾病的预防和治疗提供一种诊疗思路和研究方向。展开更多
基金financial support from the National Natural Science Foundation of China(No.21978042)the Fundamental Research Funds for the Central Universities(No.DUT22LAB610).
文摘A novel cationic Pt(Ⅱ)complex 2 with 2-(2,4-difluorophenyl)pyridine as the cyclometalating ligand and 1,10-phenanthroline as the auxiliary ligand has been synthesized and fully characterized.This complex exhibits much higher aggregation-induced phosphorescent emission activity than that of a nonfluorinated complex 1 in CH_(3)CN/H_(2)O.The complex 2 demonstrates efficient detection on picric acid(PA)in CH_(3)CN/H_(2)O,providing a high quenching constant(K_(SV)=2.3×10^(4) L/mol)and a low limit of detection(LOD=0.26μmol/L).In addition,complex 2 shows high selectivity for detection of PA in real water samples.Density functional theory calculations and proton nuclear magnetic resonance spectra suggest that the detection mechanism is attributed to the photo-induced electron transfer.
文摘许多生物标志物被国内外学者发现并应用于临床,而选择一种简单且容易测定的生物标志物用来评估并预测疾病的风险则显得尤为重要。血浆动脉粥样硬化指数(Atherogenic Index of Plasma,AIP)是一种创新性新型生物标志物,其值是由甘油三酯与高密度脂蛋白-胆固醇的摩尔浓度对数转换比率组成。本综述通过对AIP作基本概括及其脂代谢的相关机制,了解到AIP作为一种新型综合生物标志物,对2型糖尿病及其并发症以及对相关疾病比如动脉粥样硬化性心血管疾病、非酒精性脂肪性肝病、代谢综合征等疾病具有很好的预测及风险评估能力。本文重点分析AIP与2型糖尿病、2型糖尿病大血管病变以及肾脏病变之间的关联,探索AIP作为新型生物标志物的研究潜力,以期为上述疾病的预防和治疗提供一种诊疗思路和研究方向。
