Pan-sharpening is a process of obtaining a high spatial and spectral multispectral image(HMS)by combining a low-resolution multispectral image(LMS)with a high-resolution panchromatic image(PAN).In this paper,a pan-sha...Pan-sharpening is a process of obtaining a high spatial and spectral multispectral image(HMS)by combining a low-resolution multispectral image(LMS)with a high-resolution panchromatic image(PAN).In this paper,a pan-sharpening method called PAIHS is proposed,which is based on adaptive intensity-hue-saturation(AIHS)transformation,variational pan-sharpening framework and the two fidelity hypotheses.The suitable objective function is established and optimized by adopting particle swarm optimization(PSO)to obtain the optimal control parameters and minimum value.This value corresponds to the best pan-sharpening quality.The experimental results show that the proposed method has high efficiency and reliability,and the obtained performance index is superior to the four mainstream pan-sharpening methods.展开更多
Objective:To explore the molecular mechanism and action pathways of Wumei Pill in the treatment of autoimmune hepatitis(AIH)using network pharmacology and molecular docking methods.Methods:The active components and ta...Objective:To explore the molecular mechanism and action pathways of Wumei Pill in the treatment of autoimmune hepatitis(AIH)using network pharmacology and molecular docking methods.Methods:The active components and targets of Wumei Pill,as well as AIH-related disease targets,were screened through the TCMSP,GeneCards,OMIM,and Disgenet databases.Cytoscape 3.9.1 was used to construct a series of topological networks,followed by Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis and Gene Ontology(GO)enrichment analysis.Molecular docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.4.0.Results:A total of 124 active components of Wumei Pill,877 drug targets,1130 disease targets,and 64 overlapping targets were obtained.GO enrichment analysis yielded 82 biological processes,4 cellular components,and 19 molecular functions.KEGG pathway enrichment analysis identified 21 signaling pathways.Conclusion:Wumei Pill can act on targets such as Tumor Necrosis Factor(TNF),Caspase 3(CASP3),C-X-C Motif Chemokine Ligand 8(CXCL8),Nuclear Factor Kappa B Subunit 1(NFKB1),and Transforming Growth Factor Beta 1(TGFB1)through active components including girinimbine and(R)-tetrahydroberberine.It further regulates inflammation and apoptosis-related pathways such as tumorrelated signaling pathways and Th17 cell differentiation pathway to treat AIH.This study provides a theoretical basis for in-depth research on the mechanism of Wumei Pill in the treatment of AIH and the development of therapeutic drugs.展开更多
基金National Natural Science Foundation of China(No.61703278)。
文摘Pan-sharpening is a process of obtaining a high spatial and spectral multispectral image(HMS)by combining a low-resolution multispectral image(LMS)with a high-resolution panchromatic image(PAN).In this paper,a pan-sharpening method called PAIHS is proposed,which is based on adaptive intensity-hue-saturation(AIHS)transformation,variational pan-sharpening framework and the two fidelity hypotheses.The suitable objective function is established and optimized by adopting particle swarm optimization(PSO)to obtain the optimal control parameters and minimum value.This value corresponds to the best pan-sharpening quality.The experimental results show that the proposed method has high efficiency and reliability,and the obtained performance index is superior to the four mainstream pan-sharpening methods.
基金University-Level College Student Innovation and Entrepreneurship Training Program of Qiqihar Medical UniversityExploring the Mechanism of Ganjiang Huangqin Huanglian Renshen Decoction on AIH Mice Based on Network Pharmacology and In Vivo Experiments(Project No.:X202311230039)。
文摘Objective:To explore the molecular mechanism and action pathways of Wumei Pill in the treatment of autoimmune hepatitis(AIH)using network pharmacology and molecular docking methods.Methods:The active components and targets of Wumei Pill,as well as AIH-related disease targets,were screened through the TCMSP,GeneCards,OMIM,and Disgenet databases.Cytoscape 3.9.1 was used to construct a series of topological networks,followed by Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis and Gene Ontology(GO)enrichment analysis.Molecular docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.4.0.Results:A total of 124 active components of Wumei Pill,877 drug targets,1130 disease targets,and 64 overlapping targets were obtained.GO enrichment analysis yielded 82 biological processes,4 cellular components,and 19 molecular functions.KEGG pathway enrichment analysis identified 21 signaling pathways.Conclusion:Wumei Pill can act on targets such as Tumor Necrosis Factor(TNF),Caspase 3(CASP3),C-X-C Motif Chemokine Ligand 8(CXCL8),Nuclear Factor Kappa B Subunit 1(NFKB1),and Transforming Growth Factor Beta 1(TGFB1)through active components including girinimbine and(R)-tetrahydroberberine.It further regulates inflammation and apoptosis-related pathways such as tumorrelated signaling pathways and Th17 cell differentiation pathway to treat AIH.This study provides a theoretical basis for in-depth research on the mechanism of Wumei Pill in the treatment of AIH and the development of therapeutic drugs.
