Background We aimed to investigate the relationships between metabolic syndrome(MetS)and its severity score(Metsss)with asymptomatic intracranial arterial stenosis(aICAS)while also assessing the additional effect of h...Background We aimed to investigate the relationships between metabolic syndrome(MetS)and its severity score(Metsss)with asymptomatic intracranial arterial stenosis(aICAS)while also assessing the additional effect of high-sensitivity C reactive protein(hsCRP).Methods This cross-sectional study included 2390 individuals who underwent health examinations at our centre from June 2019 to August 2023.Participants received physical examinations,laboratory tests and magnetic resonance angiography evaluations.MetS was defined by the modified acknowledged criteria and quantified by Metsss.Logistic regression,interaction analysis and mediation analysis were employed.Results Among the 2390 participants,135(5.65%)had aICAS,and 726(30.40%)had MetS.After adjusting for confounders,MetS was significantly associated with aICAS(OR:1.68,95%CI:1.16 to 2.43,p=0.006).The prevalence of aICAS increased significantly from 3.6%to 8.6%as the number of MetS components increased.Higher quartiles of Metsss also significantly increased aICAS risk(P for trend<0.001).After multivariable adjustment,MetS(p=0.001)and elevated Metsss(p<0.001)were only associated with posterior circulation aICAS(vs anterior).Furthermore,participants with both MetS and elevated hsCRP levels had a greater risk for aICAS(OR:2.32,95%CI:1.36 to 3.96,p=0.002).hsCRP mediated the association between MetS and alCAS in participants≤65 years old.Conclusions MetS and Metsss were independently associated with the risk of aICAS.The mediating effect of hsCRP on the relationship between MetS and aICAS appears to be age-dependent.These findings offer valuable insights into clinical decision making of aICAS and further improve the primary stroke prevention.展开更多
By using a three-level atmospheric general circulation model (AGCM),we have completed several numerical experiments to study the impacts of sea surface temperature anomaly (SSTA) and antarctic ice cover anomaly (AICA)...By using a three-level atmospheric general circulation model (AGCM),we have completed several numerical experiments to study the impacts of sea surface temperature anomaly (SSTA) and antarctic ice cover anomaly (AICA) during 1981—1983 on climate variability.The results show that during the El Nino period of 1982—1983 the impact of SSTA overrides that of AICA.SSTA mainly affects equatorial zonal circulation and produces PNA wave train,and SE-NW wave train in East Asia to influence the weather of China.AICA produces west-east anomalous vortex streets in the middle latitudes of both hemispheres and affects the intensity of the polar vortex of Southern Hemisphere.展开更多
基金supported by National Key Research and Development Program of China(2018YFC1311203).
文摘Background We aimed to investigate the relationships between metabolic syndrome(MetS)and its severity score(Metsss)with asymptomatic intracranial arterial stenosis(aICAS)while also assessing the additional effect of high-sensitivity C reactive protein(hsCRP).Methods This cross-sectional study included 2390 individuals who underwent health examinations at our centre from June 2019 to August 2023.Participants received physical examinations,laboratory tests and magnetic resonance angiography evaluations.MetS was defined by the modified acknowledged criteria and quantified by Metsss.Logistic regression,interaction analysis and mediation analysis were employed.Results Among the 2390 participants,135(5.65%)had aICAS,and 726(30.40%)had MetS.After adjusting for confounders,MetS was significantly associated with aICAS(OR:1.68,95%CI:1.16 to 2.43,p=0.006).The prevalence of aICAS increased significantly from 3.6%to 8.6%as the number of MetS components increased.Higher quartiles of Metsss also significantly increased aICAS risk(P for trend<0.001).After multivariable adjustment,MetS(p=0.001)and elevated Metsss(p<0.001)were only associated with posterior circulation aICAS(vs anterior).Furthermore,participants with both MetS and elevated hsCRP levels had a greater risk for aICAS(OR:2.32,95%CI:1.36 to 3.96,p=0.002).hsCRP mediated the association between MetS and alCAS in participants≤65 years old.Conclusions MetS and Metsss were independently associated with the risk of aICAS.The mediating effect of hsCRP on the relationship between MetS and aICAS appears to be age-dependent.These findings offer valuable insights into clinical decision making of aICAS and further improve the primary stroke prevention.
基金This work is supported by the 8th 5-year scientific key program"the interaction and influence of Antarctic and global climate"(85-905-02)of State Science and Technology Commission.
文摘By using a three-level atmospheric general circulation model (AGCM),we have completed several numerical experiments to study the impacts of sea surface temperature anomaly (SSTA) and antarctic ice cover anomaly (AICA) during 1981—1983 on climate variability.The results show that during the El Nino period of 1982—1983 the impact of SSTA overrides that of AICA.SSTA mainly affects equatorial zonal circulation and produces PNA wave train,and SE-NW wave train in East Asia to influence the weather of China.AICA produces west-east anomalous vortex streets in the middle latitudes of both hemispheres and affects the intensity of the polar vortex of Southern Hemisphere.
