The configuration of a spoiler plays a crucial role in the aerodynamics of a vehicle.In particular,investigating the impact of spoiler design on aerodynamic performance is essential for effectively reducing drag and o...The configuration of a spoiler plays a crucial role in the aerodynamics of a vehicle.In particular,investigating the impact of spoiler design on aerodynamic performance is essential for effectively reducing drag and optimizing efficiency.This study focuses on the 35°Ahmed body as the test model and examines six different spoiler types mounted on its slant surface.Using the Lattice Boltzmann Method(LBM)in XFlow and the Large Eddy Simulation(LES)technique,the aerodynamic effects of these spoilers were analyzed.The numerical approach was validated against published experimental data.Results indicate that aerodynamic drag is strongly influenced by the spoiler’s opening area,with certain configurations achieving a drag reduction as high as 6.5%.This configuration effectively suppresses airflow separation in the wake of the Ahmed body,reducing the formation of separation bubbles on the slant surface and enhancing pressure recovery on both the slant and base regions.The observed pressure recovery is attributed to the reduction in vortex loop breadth and length.展开更多
AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glauc...AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glaucoma eyes undergoing ACP implantation,as a standalone procedure or in combination with cataract phacoemulsification.Intraocular pressure(IOP)was evaluated prior to surgery and 1wk,1,3,6mo and 1y postoperatively.In addition,the number of antiglaucoma drugs and intra and postoperative complications were assessed.RESULTS:A total of 30 eyes of 28 patients were included in the study.The patients were on average 72.8(13.4)years old and 53.6%were male.Totally 40%of the eyes had primary open angle glaucoma,16.7%had neovascular glaucoma,16.7%had pseudoexfoliative glaucoma,10%had glaucoma secondary to pars plana vitrectomy with silicone oil tamponade,6.7%had aphakic glaucoma,6.7%had primary congenital glaucoma and 3.3%had pigmentary glaucoma.Before surgery mean IOP was 26.1(10.8)mm Hg and mean glaucoma medication use was 3.7(0.5).At 1,3,6 and 12mo mean IOP was 16.1,11.7,11.8 and 11.5 mm Hg,respectively.Mean glaucoma medication use was 1.9,1.5,1.2 and 1.2,respectively.At 1y,complete surgical success was found in 46.7%patients(n=14)and qualified success in 53.3%(n=16).There were no intraoperative complications.Postoperative complications include choroidal effusion(n=5),transient hyphema(n=2),early hypotony with shallow anterior chamber(n=2)and late hemorrhagic choroidal detachment(n=1).CONCLUSION:The ACP appears to be an efficient surgical option for treating refractory glaucoma,achieving good IOP control and decreasing medication burden.The results obtained at 6mo are an important prognostic factor for long-term outcomes.展开更多
目的:通过构建药物利用评价(drug use evaluation,DUE)标准并应用,提高甘草酸二铵注射液使用合理性。方法:以甘草酸二铵注射液说明书、肝功能不全相关指南、专家共识为依据建立DUE标准评价指标,采用属性层次模型(attribute hierarchy mo...目的:通过构建药物利用评价(drug use evaluation,DUE)标准并应用,提高甘草酸二铵注射液使用合理性。方法:以甘草酸二铵注射液说明书、肝功能不全相关指南、专家共识为依据建立DUE标准评价指标,采用属性层次模型(attribute hierarchy model,AHM)确定各指标的综合权重。临床药师按照甘草酸二铵注射液DUE标准具体内容对临床进行一系列合理应用干预,调取使用甘草酸二铵注射液的病历,将2022年1—12月共118例为干预前,2023年1—12月共171例为干预后,采用加权优劣解距离法(technique for order preference by similarity to an ideal solution,TOPSIS)分别统计干预前后两组病历与最优解的相对接近度(Ci)。结果:干预后在特殊人群、联合用药、给药后监护、不良反应处理合理性方面差异有统计学意义(P<0.05);干预后90%≤Ci≤100%为合理的病历占比从12.71%提高至40.94%;60%≤Ci<90%为基本合理的病历占比从78.81%下降至54.97%,差异均有统计学意义(P<0.01)。结论:加权TOPSIS联合AHM构建甘草酸二铵注射液药物利用评价标准并于真实世界的应用,切实提高了其使用合理性,并为其他药品临床使用评价及管理提供参考。展开更多
基金funding from the National Natural Science Foundation of China(No.52272366,No.52072156)the Postdoctoral Foundation of China(2020M682269)。
文摘The configuration of a spoiler plays a crucial role in the aerodynamics of a vehicle.In particular,investigating the impact of spoiler design on aerodynamic performance is essential for effectively reducing drag and optimizing efficiency.This study focuses on the 35°Ahmed body as the test model and examines six different spoiler types mounted on its slant surface.Using the Lattice Boltzmann Method(LBM)in XFlow and the Large Eddy Simulation(LES)technique,the aerodynamic effects of these spoilers were analyzed.The numerical approach was validated against published experimental data.Results indicate that aerodynamic drag is strongly influenced by the spoiler’s opening area,with certain configurations achieving a drag reduction as high as 6.5%.This configuration effectively suppresses airflow separation in the wake of the Ahmed body,reducing the formation of separation bubbles on the slant surface and enhancing pressure recovery on both the slant and base regions.The observed pressure recovery is attributed to the reduction in vortex loop breadth and length.
文摘AIM:To present the clinical outcomes in efficacy and safety of the Ahmed ClearPath®(ACP)250 mm2 model as well as our surgical technique.METHODS:Single-center prospective interventional study of uncontrolled glaucoma eyes undergoing ACP implantation,as a standalone procedure or in combination with cataract phacoemulsification.Intraocular pressure(IOP)was evaluated prior to surgery and 1wk,1,3,6mo and 1y postoperatively.In addition,the number of antiglaucoma drugs and intra and postoperative complications were assessed.RESULTS:A total of 30 eyes of 28 patients were included in the study.The patients were on average 72.8(13.4)years old and 53.6%were male.Totally 40%of the eyes had primary open angle glaucoma,16.7%had neovascular glaucoma,16.7%had pseudoexfoliative glaucoma,10%had glaucoma secondary to pars plana vitrectomy with silicone oil tamponade,6.7%had aphakic glaucoma,6.7%had primary congenital glaucoma and 3.3%had pigmentary glaucoma.Before surgery mean IOP was 26.1(10.8)mm Hg and mean glaucoma medication use was 3.7(0.5).At 1,3,6 and 12mo mean IOP was 16.1,11.7,11.8 and 11.5 mm Hg,respectively.Mean glaucoma medication use was 1.9,1.5,1.2 and 1.2,respectively.At 1y,complete surgical success was found in 46.7%patients(n=14)and qualified success in 53.3%(n=16).There were no intraoperative complications.Postoperative complications include choroidal effusion(n=5),transient hyphema(n=2),early hypotony with shallow anterior chamber(n=2)and late hemorrhagic choroidal detachment(n=1).CONCLUSION:The ACP appears to be an efficient surgical option for treating refractory glaucoma,achieving good IOP control and decreasing medication burden.The results obtained at 6mo are an important prognostic factor for long-term outcomes.
文摘目的:通过构建药物利用评价(drug use evaluation,DUE)标准并应用,提高甘草酸二铵注射液使用合理性。方法:以甘草酸二铵注射液说明书、肝功能不全相关指南、专家共识为依据建立DUE标准评价指标,采用属性层次模型(attribute hierarchy model,AHM)确定各指标的综合权重。临床药师按照甘草酸二铵注射液DUE标准具体内容对临床进行一系列合理应用干预,调取使用甘草酸二铵注射液的病历,将2022年1—12月共118例为干预前,2023年1—12月共171例为干预后,采用加权优劣解距离法(technique for order preference by similarity to an ideal solution,TOPSIS)分别统计干预前后两组病历与最优解的相对接近度(Ci)。结果:干预后在特殊人群、联合用药、给药后监护、不良反应处理合理性方面差异有统计学意义(P<0.05);干预后90%≤Ci≤100%为合理的病历占比从12.71%提高至40.94%;60%≤Ci<90%为基本合理的病历占比从78.81%下降至54.97%,差异均有统计学意义(P<0.01)。结论:加权TOPSIS联合AHM构建甘草酸二铵注射液药物利用评价标准并于真实世界的应用,切实提高了其使用合理性,并为其他药品临床使用评价及管理提供参考。
