目的:建立ICU中成人使用右美托咪定注射液的药物利用评价(drug use evaluation,DUE)标准,评价药学服务前后右美托咪定注射液使用合理性。方法:参照药品说明书和指南共识建立右美托咪定注射液DUE标准,对2022年1月至12月成人在ICU中使用...目的:建立ICU中成人使用右美托咪定注射液的药物利用评价(drug use evaluation,DUE)标准,评价药学服务前后右美托咪定注射液使用合理性。方法:参照药品说明书和指南共识建立右美托咪定注射液DUE标准,对2022年1月至12月成人在ICU中使用右美托咪定注射液的病例采用层次分析模型(analytic hierarchical model,AHM)和加权优劣解距离法(technique for order of preference by similarity to idcal solution,TOPSIS)评价其合理性,实施针对性药学服务后抽取2023年1月至12月病例通过相同的方法再评价,比较干预前后右美托咪定注射液合理性。结果:干预后,病历合理率提高,评价为合理(0.8≤C_(i)<1)的病例占比由32.94%提高至50%,评价为基本合理(0.6≤C_(i)<0.8)的病例占比由52.69%下降至46.88%,评价为不合理(C_(i)<0.6)的病例占比由14.37%降低至3.13%;干预后,在配置浓度、给药剂量、特殊人群、镇静深度监测及药学监护等方面,差异均有统计学意义(P<0.05)。结论:构建ICU中成人使用右美托咪定注射液DUE标准,并对AHM-TOPSIS法点评出来的不合理用药问题实施针对性药学服务可提高其合理性,并为其他药品评价及管理提供参考。展开更多
A semi-analytical finite element method(SAFEM),based on the two-scale asymptotic homogenization method(AHM)and the finite element method(FEM),is implemented to obtain the effective properties of two-phase fiber-reinfo...A semi-analytical finite element method(SAFEM),based on the two-scale asymptotic homogenization method(AHM)and the finite element method(FEM),is implemented to obtain the effective properties of two-phase fiber-reinforced composites(FRCs).The fibers are periodically distributed and unidirectionally aligned in a homogeneous matrix.This framework addresses the static linear elastic micropolar problem through partial differential equations,subject to boundary conditions and perfect interface contact conditions.The mathematical formulation of the local problems and the effective coefficients are presented by the AHM.The local problems obtained from the AHM are solved by the FEM,which is denoted as the SAFEM.The numerical results are provided,and the accuracy of the solutions is analyzed,indicating that the formulas and results obtained with the SAFEM may serve as the reference points for validating the outcomes of experimental and numerical computations.展开更多
文摘目的:建立ICU中成人使用右美托咪定注射液的药物利用评价(drug use evaluation,DUE)标准,评价药学服务前后右美托咪定注射液使用合理性。方法:参照药品说明书和指南共识建立右美托咪定注射液DUE标准,对2022年1月至12月成人在ICU中使用右美托咪定注射液的病例采用层次分析模型(analytic hierarchical model,AHM)和加权优劣解距离法(technique for order of preference by similarity to idcal solution,TOPSIS)评价其合理性,实施针对性药学服务后抽取2023年1月至12月病例通过相同的方法再评价,比较干预前后右美托咪定注射液合理性。结果:干预后,病历合理率提高,评价为合理(0.8≤C_(i)<1)的病例占比由32.94%提高至50%,评价为基本合理(0.6≤C_(i)<0.8)的病例占比由52.69%下降至46.88%,评价为不合理(C_(i)<0.6)的病例占比由14.37%降低至3.13%;干预后,在配置浓度、给药剂量、特殊人群、镇静深度监测及药学监护等方面,差异均有统计学意义(P<0.05)。结论:构建ICU中成人使用右美托咪定注射液DUE标准,并对AHM-TOPSIS法点评出来的不合理用药问题实施针对性药学服务可提高其合理性,并为其他药品评价及管理提供参考。
基金Project supported by the National Council of Humanities,Sciences,and Technologies of Mexico(Nos.CF-2023-G-792 and CF-2023-G-1458)the National Council for Scientific and Technological Development of Brazil(No.09/2023)the Research on Productivity of Brazil(No.307188/2023-0)。
文摘A semi-analytical finite element method(SAFEM),based on the two-scale asymptotic homogenization method(AHM)and the finite element method(FEM),is implemented to obtain the effective properties of two-phase fiber-reinforced composites(FRCs).The fibers are periodically distributed and unidirectionally aligned in a homogeneous matrix.This framework addresses the static linear elastic micropolar problem through partial differential equations,subject to boundary conditions and perfect interface contact conditions.The mathematical formulation of the local problems and the effective coefficients are presented by the AHM.The local problems obtained from the AHM are solved by the FEM,which is denoted as the SAFEM.The numerical results are provided,and the accuracy of the solutions is analyzed,indicating that the formulas and results obtained with the SAFEM may serve as the reference points for validating the outcomes of experimental and numerical computations.
