目的:探讨术前血浆白蛋白与纤维蛋白原比值(albumin to fibrinogen ratio,AFR)及纤维蛋白原与前白蛋白比值(fibrinogen to prealbumin ratio,FPR)对结直肠癌患者生存的预后评价。方法:回顾性分析2012年6月至2014年6月徐州医科大学附属...目的:探讨术前血浆白蛋白与纤维蛋白原比值(albumin to fibrinogen ratio,AFR)及纤维蛋白原与前白蛋白比值(fibrinogen to prealbumin ratio,FPR)对结直肠癌患者生存的预后评价。方法:回顾性分析2012年6月至2014年6月徐州医科大学附属医院行根治性手术切除的286例结直肠癌患者的临床病例资料。通过受试者工作特征(receiver operating characteristic,ROC)曲线确定AFR和FPR的最佳分界值,并通过卡方检验分析AFR和FPR与患者临床病理特征的关系,Kaplan-Meier法进行生存分析,运用log-rank法进行差异性检验,Cox比例风险模型进行多因素回归分析。结果:根据ROC曲线下面积,AFR,FPR对结直肠癌患者预后的预测价值均较好(P<0.05)。术前AFR和FPR均与年龄、大体类型、临床分期、浸润深度、淋巴结转移有密切关系(P<0.05),与性别、肿瘤部位、肿瘤大小、组织学分级、神经侵犯无明显关联(P>0.05)。低FPR水平患者的总生存期(overall survival,OS)明显高于高FPR水平患者(P<0.05);高AFR水平患者的OS明显高于低AFR水平患者(P<0.05)。单因素分析显示:临床分期、浸润深度、淋巴结转移、术后放化疗、AFR、FPR、纤维蛋白原浓度、血浆白蛋白、前白蛋白水平是影响结直肠癌患者OS的危险因素(P<0.05);多因素分析结果表明:临床分期、浸润深度、淋巴结转移、术后放化疗、pAlb、FPR是影响结直肠癌患者术后OS的独立危险因素。结论:术前FPR对结直肠癌患者预后有较好的预测能力,有望成为评估结直肠癌患者预后的必要指标之一。展开更多
Under the influence of the upper coal pillars and dynamic pressure of coal mining,the roadway of the lower coal seam is prone to large deformation failure.In this paper,a novel control method and key technologies of a...Under the influence of the upper coal pillars and dynamic pressure of coal mining,the roadway of the lower coal seam is prone to large deformation failure.In this paper,a novel control method and key technologies of automatically formed roadway(AFR)by roof cutting and confined concrete column in extremely close-distance coal seam are proposed.Furthermore,a numerical model is established to analyze the structure characteristics of overlying roof strata.Based on numerical results,the roof structure model of“voussoir beam of upper layer+short cantilever beam of lower layer”of this method is proposed.What’s more,the calculation equation of the roof bending moment and evaluation indexes is established,and the influence of different factors on roof stability control of AFR is studied.Finally,a field test is conducted to verify the effectiveness of this novel method.Field results were as follows:1)The maximum and average support stress of working face obviously decreased;2)The confined concrete column can provide high-strength support in dynamic influence zone;3)The maximum deformation of AFR safety requirement can be met.This study can provide effective guidance for the application of this method in extremely close-distance coal seam.展开更多
文摘目的:探讨术前血浆白蛋白与纤维蛋白原比值(albumin to fibrinogen ratio,AFR)及纤维蛋白原与前白蛋白比值(fibrinogen to prealbumin ratio,FPR)对结直肠癌患者生存的预后评价。方法:回顾性分析2012年6月至2014年6月徐州医科大学附属医院行根治性手术切除的286例结直肠癌患者的临床病例资料。通过受试者工作特征(receiver operating characteristic,ROC)曲线确定AFR和FPR的最佳分界值,并通过卡方检验分析AFR和FPR与患者临床病理特征的关系,Kaplan-Meier法进行生存分析,运用log-rank法进行差异性检验,Cox比例风险模型进行多因素回归分析。结果:根据ROC曲线下面积,AFR,FPR对结直肠癌患者预后的预测价值均较好(P<0.05)。术前AFR和FPR均与年龄、大体类型、临床分期、浸润深度、淋巴结转移有密切关系(P<0.05),与性别、肿瘤部位、肿瘤大小、组织学分级、神经侵犯无明显关联(P>0.05)。低FPR水平患者的总生存期(overall survival,OS)明显高于高FPR水平患者(P<0.05);高AFR水平患者的OS明显高于低AFR水平患者(P<0.05)。单因素分析显示:临床分期、浸润深度、淋巴结转移、术后放化疗、AFR、FPR、纤维蛋白原浓度、血浆白蛋白、前白蛋白水平是影响结直肠癌患者OS的危险因素(P<0.05);多因素分析结果表明:临床分期、浸润深度、淋巴结转移、术后放化疗、pAlb、FPR是影响结直肠癌患者术后OS的独立危险因素。结论:术前FPR对结直肠癌患者预后有较好的预测能力,有望成为评估结直肠癌患者预后的必要指标之一。
基金Projects(52074164,42077267)supported by the National Natural Science Foundation of ChinaProject(2023M742073)supported by the China Postdoctoral Science FoundationProject(SDCX-ZG-202303010)supported by the Shandong Postdoctora1 Science Foundation,China。
文摘Under the influence of the upper coal pillars and dynamic pressure of coal mining,the roadway of the lower coal seam is prone to large deformation failure.In this paper,a novel control method and key technologies of automatically formed roadway(AFR)by roof cutting and confined concrete column in extremely close-distance coal seam are proposed.Furthermore,a numerical model is established to analyze the structure characteristics of overlying roof strata.Based on numerical results,the roof structure model of“voussoir beam of upper layer+short cantilever beam of lower layer”of this method is proposed.What’s more,the calculation equation of the roof bending moment and evaluation indexes is established,and the influence of different factors on roof stability control of AFR is studied.Finally,a field test is conducted to verify the effectiveness of this novel method.Field results were as follows:1)The maximum and average support stress of working face obviously decreased;2)The confined concrete column can provide high-strength support in dynamic influence zone;3)The maximum deformation of AFR safety requirement can be met.This study can provide effective guidance for the application of this method in extremely close-distance coal seam.
