We are pleased to present this special issue for the“Asian Federation for Pharmaceutical Sciences(AFPS)2015 Conference”of the Asian Journal of Pharmaceutical Sciences.The abstracts included in this issue are from th...We are pleased to present this special issue for the“Asian Federation for Pharmaceutical Sciences(AFPS)2015 Conference”of the Asian Journal of Pharmaceutical Sciences.The abstracts included in this issue are from those presented as lectures and posters at the Asian Federation for Pharmaceutical Sciences(AFPS)2015 Conference held in Bangkok,Thailand,during 25–27 November 2015.This was the latest in the well-established AFPS series of international conferences,which are organized in alternate years in different Asian countries to provide a forum for the presentation and discussion of recent progress in the field of pharmaceutical sciences.展开更多
《亚洲药物制剂科学》杂志,即Asian Journal of Pharmaceutical Sciences(AJPS,ISSN1818-0876,CN21-1608/R)创刊于2006年,为亚洲药学联盟(AFPS)的官方杂志,是由沈阳药科大学主办,Elsevier出版的全英文双月刊,是中国第一个被SCIE收录的...《亚洲药物制剂科学》杂志,即Asian Journal of Pharmaceutical Sciences(AJPS,ISSN1818-0876,CN21-1608/R)创刊于2006年,为亚洲药学联盟(AFPS)的官方杂志,是由沈阳药科大学主办,Elsevier出版的全英文双月刊,是中国第一个被SCIE收录的药剂学学术期刊。展开更多
目的:探讨评估临床指标和多期动态增强CT (Contrast-enhanced computed tomography, CECT)的影像学特征,并构建回归模型预测术前肝细胞癌(Hepatocellular carcinoma, HCC)微血管侵犯(Microvascular invasion, MVI)状态。方法:回顾性研究...目的:探讨评估临床指标和多期动态增强CT (Contrast-enhanced computed tomography, CECT)的影像学特征,并构建回归模型预测术前肝细胞癌(Hepatocellular carcinoma, HCC)微血管侵犯(Microvascular invasion, MVI)状态。方法:回顾性研究141例HCC患者的临床、影像学和病理资料。根据是否存在微血管侵犯,分为MVI阳性组77例,MVI阴性组64例。用单因素和多因素Logistic回归分析筛选MVI的独立危险因素,构建回归模型预测MVI,使用Area under the curve (AUC值)、特异度和灵敏度评估模型的预测效能。结果:最终筛选出MVI的临床和影像学独立危险因素为甲胎蛋白(Alpha-fetoprotein, AFP) ≥ 400 ng/ml、瘤周低密度环和肝外生长。结合这三个因素构建的模型ROC曲线下面积(Area under the curve, AUC)值为0.730,特异度为0.625,灵敏度为0.727。结论:由AFP联合影像学特征(瘤周低密度环和生长方式)建立的回归模型可以在一定程度上预测术前MVI状态,有助于临床优化治疗策略。Objective: To investigate the role of clinical indicators and imaging characteristics from multiphase contrast-enhanced computed tomography (CECT) in predicting preoperative microvascular invasion (MVI) in hepatocellular carcinoma (HCC), and to construct a predictive regression model for microvascular invasion (MVI) status. Methods: Clinical, imaging, and pathological data of 141 patients with HCC were studied retrospectively. Based on the presence or absence of microvascular invasion, patients were divided into MVI-positive group (n = 77) and MVI-negative group (n = 64). Independent risk factors for MVI were screened using univariate and multivariate Logistic regression analyses, and a regression model was constructed to predict MVI, and the predictive efficacy of the model was assessed using the Area under the curve (AUC value), specificity and sensitivity. Results: Independent risk factors for MVI identified from both clinical and imaging data included AFP ≥ 400 ng/ml, peritumoral hypodense halo, and extrahepatic growth. The area under the ROC curve (AUC) value of the model combining these three factors was 0.730, the specificity was 0.625 and the sensitivity was 0.727. Conclusion: The regression model incorporating AFP levels and key imaging features (peritumoral hypodense halo and extrahepatic growth) demonstrates moderate predictive value for preoperative MVI status, which may assist in optimizing clinical treatment strategies for patients with HCC.展开更多
Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi Arabia.Our study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child...Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi Arabia.Our study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020.All patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1.All patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to HCV.Cirrhosis was diagnosed in 79%of cases.Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the patients.There was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest survival.BSC was the most common treatment provided to HCC patients followed by sorafenib therapy.There was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor size.Being having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.展开更多
文摘We are pleased to present this special issue for the“Asian Federation for Pharmaceutical Sciences(AFPS)2015 Conference”of the Asian Journal of Pharmaceutical Sciences.The abstracts included in this issue are from those presented as lectures and posters at the Asian Federation for Pharmaceutical Sciences(AFPS)2015 Conference held in Bangkok,Thailand,during 25–27 November 2015.This was the latest in the well-established AFPS series of international conferences,which are organized in alternate years in different Asian countries to provide a forum for the presentation and discussion of recent progress in the field of pharmaceutical sciences.
文摘《亚洲药物制剂科学》杂志,即Asian Journal of Pharmaceutical Sciences(AJPS,ISSN1818-0876,CN21-1608/R)创刊于2006年,为亚洲药学联盟(AFPS)的官方杂志,是由沈阳药科大学主办,Elsevier出版的全英文双月刊,是中国第一个被SCIE收录的药剂学学术期刊。
文摘目的:探讨评估临床指标和多期动态增强CT (Contrast-enhanced computed tomography, CECT)的影像学特征,并构建回归模型预测术前肝细胞癌(Hepatocellular carcinoma, HCC)微血管侵犯(Microvascular invasion, MVI)状态。方法:回顾性研究141例HCC患者的临床、影像学和病理资料。根据是否存在微血管侵犯,分为MVI阳性组77例,MVI阴性组64例。用单因素和多因素Logistic回归分析筛选MVI的独立危险因素,构建回归模型预测MVI,使用Area under the curve (AUC值)、特异度和灵敏度评估模型的预测效能。结果:最终筛选出MVI的临床和影像学独立危险因素为甲胎蛋白(Alpha-fetoprotein, AFP) ≥ 400 ng/ml、瘤周低密度环和肝外生长。结合这三个因素构建的模型ROC曲线下面积(Area under the curve, AUC)值为0.730,特异度为0.625,灵敏度为0.727。结论:由AFP联合影像学特征(瘤周低密度环和生长方式)建立的回归模型可以在一定程度上预测术前MVI状态,有助于临床优化治疗策略。Objective: To investigate the role of clinical indicators and imaging characteristics from multiphase contrast-enhanced computed tomography (CECT) in predicting preoperative microvascular invasion (MVI) in hepatocellular carcinoma (HCC), and to construct a predictive regression model for microvascular invasion (MVI) status. Methods: Clinical, imaging, and pathological data of 141 patients with HCC were studied retrospectively. Based on the presence or absence of microvascular invasion, patients were divided into MVI-positive group (n = 77) and MVI-negative group (n = 64). Independent risk factors for MVI were screened using univariate and multivariate Logistic regression analyses, and a regression model was constructed to predict MVI, and the predictive efficacy of the model was assessed using the Area under the curve (AUC value), specificity and sensitivity. Results: Independent risk factors for MVI identified from both clinical and imaging data included AFP ≥ 400 ng/ml, peritumoral hypodense halo, and extrahepatic growth. The area under the ROC curve (AUC) value of the model combining these three factors was 0.730, the specificity was 0.625 and the sensitivity was 0.727. Conclusion: The regression model incorporating AFP levels and key imaging features (peritumoral hypodense halo and extrahepatic growth) demonstrates moderate predictive value for preoperative MVI status, which may assist in optimizing clinical treatment strategies for patients with HCC.
文摘Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi Arabia.Our study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020.All patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1.All patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to HCV.Cirrhosis was diagnosed in 79%of cases.Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the patients.There was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest survival.BSC was the most common treatment provided to HCC patients followed by sorafenib therapy.There was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor size.Being having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.
