Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"ove...Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"overcoming rigidity by flexibility",the prevention and control method with"rigid-flexible coupling(R-F-C)"was put forward.Through numerical simulation calculation,the impact damage process,acoustic emission(AE)evolution characteristics,and element stress/displacement evolution characteristics of unsupported surrounding rock structure model,rigid supporting surrounding rock structure model,and"R-F-C"supporting surrounding rock structure model under horizontal bidirectional impact loading were compared and analyzed.Based on the theory of stress wave propagation,the dynamic instability catastrophe mechanism of three kinds of supporting structure models induced by horizontal bidirectional impact loading was revealed.Based on the Mohr-Coulomb strength theory,the stress discrimination methods of dynamic catastrophe of surrounding rock induced by horizontal bidirectional impact loading under three kinds of supporting structures were proposed.Combined with the above numerical simulation study,the explosion impact physical and mechanical test of"R-F-C"surrounding rock supporting plate structure was further designed and carried out.Finally,combined with the"conceptual model of ball-cliff potential energy instability",the energy driving theory and energy transformation mechanism of impact-induced rockburst under three kinds of supporting structures were discussed deeply.The research results provided a scientific basis for further promoting the effective application of"R-F-C"supporting structure in the prevention and control of dynamic instability of deep tunnel/roadway surrounding rock.展开更多
Structure stability analysis of rock masses is essential for forecasting catastrophic structure failure in coal seam mining. Steeply dipping thick coal seams （SDTCS） are common in the Urumqi coalfield, and some dyna...Structure stability analysis of rock masses is essential for forecasting catastrophic structure failure in coal seam mining. Steeply dipping thick coal seams （SDTCS） are common in the Urumqi coalfield, and some dynamical hazards such as roof collapse and mining-induced seismicity occur frequently in the coal mines. The cause of these events is mainly structure instability in giant rock pillars sand- wiched between SDTCS. Developing methods to predict these events is important for safe mining in such a complex environment. This study focuses on understanding the structural mechanics model of a giant rock pillar and presents a viewpoint of the stability of a trend sphenoid fractured beam （TSFB）. Some stability index parameters such as failure surface dips were measured, and most dips were observed to be between 46° and 51°. We used a digital panoramic borehole monitoring system to measure the TSFB＇s height （△H）, which varied from 56.37 to 60.50 m. Next, FLAC^3D was used to model the distribution and evolution of vertical displacement in the giant rock pillars; the results confirmed the existence of a TSFB structure. Finally, we investigated the acoustic emission （AE） energy accumulation rate and observed that the rate commonly ranged from 20 to 40 kJ/min. The AE energy accumulation rate could be used to anticipate impeding seismic events related to structure failure. The results presented provide a useful approach for forecasting catastrophic events related to structure instability and for developing hazard prevention technology for mining in SDTCS.展开更多
The microstructure in vacuum-assisted high-pressure die casting(HPDC) Mg-4Al-4RE(AE44) alloy was studied. Special attention was paid to the characteristics of defect bands and their formation mechanisms. Since double ...The microstructure in vacuum-assisted high-pressure die casting(HPDC) Mg-4Al-4RE(AE44) alloy was studied. Special attention was paid to the characteristics of defect bands and their formation mechanisms. Since double defect bands are commonly observed, the cross section of die cast samples is divided into five parts with different grain morphologies and size distributions. The inner defect band is much wider than the outer one. Both the defect bands are solute segregation bands, resulting in a higher area fraction of Al;RE;phase than that in the adjacent regions. No obvious aggregation of porosities is observed in the defect bands of AE44 alloy. This may be due to a narrow solidification temperature range of AE44 alloy and a large amount of latent heat released during the precipitation of intermetallic phases. The formation of the defect bands is related to the shear stress acting upon the partially solidified alloy, which can lead to collapse of the grain network. However, the generation mechanisms of shear stress in the outer and inner defect bands are quite different.展开更多
The characteristics of defect bands in the microstructure of high pressure die casting(HPDC)AE44 magnesium alloy were investigated.Special attention was paid to the effects of process parameters during the HPDC proces...The characteristics of defect bands in the microstructure of high pressure die casting(HPDC)AE44 magnesium alloy were investigated.Special attention was paid to the effects of process parameters during the HPDC process and casting structure on the distribution of defect bands.Results show that the defect bands are solute segregation bands with the enrichment of Al,Ce and La elements,which are basically in the form of Al_(11)RE_(3) phase.There is no obvious aggregation of porosities in the defect bands.The width of the inner defect band is 4-8 times larger than that of the outer one.The variation trends of the distribution of the inner and outer defect bands are not consistent under different process parameters and at different locations of castings.This is due to the discrepancy between the formation mechanisms of double defect bands.The filling and solidification behavior of the melt near the chilling layer is very complicated,which finally leads to a fluctuation of the width and location of the outer defect band.By affecting the content and aggregation degree of externally solidified crystals(ESCs)in the cross section of die castings,the process parameters and casting structure have a great influence on the distribution of the inner defect band.展开更多
The interaction between a molten magnesium alloy AE44 and a SiC?Al2O3?SiO2 ceramics and the resulting reaction products were studied. The samples were investigated using optical and electron microscopy, energy dispers...The interaction between a molten magnesium alloy AE44 and a SiC?Al2O3?SiO2 ceramics and the resulting reaction products were studied. The samples were investigated using optical and electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction. SiO2was predominantly reduced by Mg during the contact of the magnesium-rich melt with the ceramics. The main reaction product was MgO, whilst Si dissolved in the melt. Two novel tetragonal phases formed at the interface: AlSiRE and AlMgSiRE, having a specific mutual crystallographic orientation relationship. The interactions resulted in strongly connected interfaces between the metal and ceramics after short interaction time; however, interactions lead to disintegration of the ceramics after longer contact time.展开更多
The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor therapy.Dual-targeted therapy combining tumor cell targeting and organelle targeting is a...The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor therapy.Dual-targeted therapy combining tumor cell targeting and organelle targeting is an effective solution.Here,an anticancer nanoformulation accurate delivery system was prepared using hyaluronic acid (HA) targeting CD44 receptors on the surface of tumor cells and IR780iodine (IR780) targeting mitochondrial for delivery.The system is based on an ultra-small Janus structured inorganic sensitizer TiO_(2-x)@NaGdF_(4) nanoparticles (TN NPs) prepared by one-step pyrolysis,further loaded with organic small molecule acoustic sensitizer IR780 and mitochondrial hexokinase Ⅱ inhibitor lonidamine (LND),followed by encapsulation of HA.Ultra-small size nanoparticles exhibit strong tissue penetration,tumor inhibition and in vivo metabolism.Under ultrasound radiation,TN NPs and IR780could produce a synergistic effect,effectively increased the efficiency of reactive oxygen species (ROS)production.Meanwhile,the released IR780 could smoothly target the mitochondria,and the ROS produced by IR780 can destroy the mitochondrial structure and disrupt the mitochondrial respiration.LND could inhibit the energy metabolism of tumor cells by reducing the activity of hexokinase Ⅱ (HK Ⅱ),which further accelerates the process of apoptosis.Furthermore,since the Janus structure allows the integration of multifunctional components into a single system,TN NPs can not only serve as an acoustic sensitizer to generate ROS,but the Gd element contained can also act as the nuclear magnetic resonance (MR)imaging contrast agent,suggesting that the nanoformulation can enable imaging-guided diagnosis and therapy.In conclusion,a new scheme to enhance sonodynamic therapy (SDT) and chemotherapy synergistically is proposed here based on ultra-small dual-targeted nanoformulation with Janus structure in the ultrasound radiation environment.展开更多
基金Project(2023AH051167)supported by the Natural Science Research Project of Anhui Educational Committee,ChinaProject(AHBP2024B-04)supported by the Foundation of Anhui Engineering Research Center of New Explosive Materials and Blasting Technology,China+1 种基金Project(GXZDSYS2023103)supported by the Open Fund for Anhui Key Laboratory of Mining Construction Engineering,ChinaProjects(52274071,52404155)supported by the National Natural Science Foundation of China。
文摘Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"overcoming rigidity by flexibility",the prevention and control method with"rigid-flexible coupling(R-F-C)"was put forward.Through numerical simulation calculation,the impact damage process,acoustic emission(AE)evolution characteristics,and element stress/displacement evolution characteristics of unsupported surrounding rock structure model,rigid supporting surrounding rock structure model,and"R-F-C"supporting surrounding rock structure model under horizontal bidirectional impact loading were compared and analyzed.Based on the theory of stress wave propagation,the dynamic instability catastrophe mechanism of three kinds of supporting structure models induced by horizontal bidirectional impact loading was revealed.Based on the Mohr-Coulomb strength theory,the stress discrimination methods of dynamic catastrophe of surrounding rock induced by horizontal bidirectional impact loading under three kinds of supporting structures were proposed.Combined with the above numerical simulation study,the explosion impact physical and mechanical test of"R-F-C"surrounding rock supporting plate structure was further designed and carried out.Finally,combined with the"conceptual model of ball-cliff potential energy instability",the energy driving theory and energy transformation mechanism of impact-induced rockburst under three kinds of supporting structures were discussed deeply.The research results provided a scientific basis for further promoting the effective application of"R-F-C"supporting structure in the prevention and control of dynamic instability of deep tunnel/roadway surrounding rock.
基金financially supported by the Key National Basic Research Program of China (Nos.2014CB260404 and 2015CB251602)the Key National Natural Science Foundation of China (No.U13612030)+1 种基金Shaanxi Innovation Team Program (No.2013KCT-16)the High Technology Development Program of Xin Jiang Municipality (No.201432102)
文摘Structure stability analysis of rock masses is essential for forecasting catastrophic structure failure in coal seam mining. Steeply dipping thick coal seams （SDTCS） are common in the Urumqi coalfield, and some dynamical hazards such as roof collapse and mining-induced seismicity occur frequently in the coal mines. The cause of these events is mainly structure instability in giant rock pillars sand- wiched between SDTCS. Developing methods to predict these events is important for safe mining in such a complex environment. This study focuses on understanding the structural mechanics model of a giant rock pillar and presents a viewpoint of the stability of a trend sphenoid fractured beam （TSFB）. Some stability index parameters such as failure surface dips were measured, and most dips were observed to be between 46° and 51°. We used a digital panoramic borehole monitoring system to measure the TSFB＇s height （△H）, which varied from 56.37 to 60.50 m. Next, FLAC^3D was used to model the distribution and evolution of vertical displacement in the giant rock pillars; the results confirmed the existence of a TSFB structure. Finally, we investigated the acoustic emission （AE） energy accumulation rate and observed that the rate commonly ranged from 20 to 40 kJ/min. The AE energy accumulation rate could be used to anticipate impeding seismic events related to structure failure. The results presented provide a useful approach for forecasting catastrophic events related to structure instability and for developing hazard prevention technology for mining in SDTCS.
基金the financial supports from the the National Natural Science Foundation of China (No. 51805389)the Natural Science Foundation of Hubei Province, China (No. 2018CFB210)the “111” Project, China (No. B17034)
文摘The microstructure in vacuum-assisted high-pressure die casting(HPDC) Mg-4Al-4RE(AE44) alloy was studied. Special attention was paid to the characteristics of defect bands and their formation mechanisms. Since double defect bands are commonly observed, the cross section of die cast samples is divided into five parts with different grain morphologies and size distributions. The inner defect band is much wider than the outer one. Both the defect bands are solute segregation bands, resulting in a higher area fraction of Al;RE;phase than that in the adjacent regions. No obvious aggregation of porosities is observed in the defect bands of AE44 alloy. This may be due to a narrow solidification temperature range of AE44 alloy and a large amount of latent heat released during the precipitation of intermetallic phases. The formation of the defect bands is related to the shear stress acting upon the partially solidified alloy, which can lead to collapse of the grain network. However, the generation mechanisms of shear stress in the outer and inner defect bands are quite different.
基金the National Natural Science Foundation of China(No.51805389)the Key R&D Program of Hubei Province,China(No.2021BAA048)+1 种基金the 111 Project(No.B17034)the fund of the Hubei Key Laboratory of Advanced Technology for Automotive Components,Wuhan University of Technology(No.XDQCKF2021011).
文摘The characteristics of defect bands in the microstructure of high pressure die casting(HPDC)AE44 magnesium alloy were investigated.Special attention was paid to the effects of process parameters during the HPDC process and casting structure on the distribution of defect bands.Results show that the defect bands are solute segregation bands with the enrichment of Al,Ce and La elements,which are basically in the form of Al_(11)RE_(3) phase.There is no obvious aggregation of porosities in the defect bands.The width of the inner defect band is 4-8 times larger than that of the outer one.The variation trends of the distribution of the inner and outer defect bands are not consistent under different process parameters and at different locations of castings.This is due to the discrepancy between the formation mechanisms of double defect bands.The filling and solidification behavior of the melt near the chilling layer is very complicated,which finally leads to a fluctuation of the width and location of the outer defect band.By affecting the content and aggregation degree of externally solidified crystals(ESCs)in the cross section of die castings,the process parameters and casting structure have a great influence on the distribution of the inner defect band.
基金financed by the Slovenian Research Agency (ARRS), projects 1000-09-310152 and L2-2269
文摘The interaction between a molten magnesium alloy AE44 and a SiC?Al2O3?SiO2 ceramics and the resulting reaction products were studied. The samples were investigated using optical and electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction. SiO2was predominantly reduced by Mg during the contact of the magnesium-rich melt with the ceramics. The main reaction product was MgO, whilst Si dissolved in the melt. Two novel tetragonal phases formed at the interface: AlSiRE and AlMgSiRE, having a specific mutual crystallographic orientation relationship. The interactions resulted in strongly connected interfaces between the metal and ceramics after short interaction time; however, interactions lead to disintegration of the ceramics after longer contact time.
基金financially supported by the National Natural Science Foundation of China (Nos. 52250077, 52272156, 51872263 and 52202175)Taishan Scholars Project (No. ts20190911)+1 种基金Shandong Natural Science Foundation (No. ZR2020ZD36)Guangdong Basic and Applied Basic Research Foundation (No. 2022A1515010461)。
文摘The accurate delivery of nanoparticles and organic small molecule drugs remains a serious challenge in nanoparticle-based tumor therapy.Dual-targeted therapy combining tumor cell targeting and organelle targeting is an effective solution.Here,an anticancer nanoformulation accurate delivery system was prepared using hyaluronic acid (HA) targeting CD44 receptors on the surface of tumor cells and IR780iodine (IR780) targeting mitochondrial for delivery.The system is based on an ultra-small Janus structured inorganic sensitizer TiO_(2-x)@NaGdF_(4) nanoparticles (TN NPs) prepared by one-step pyrolysis,further loaded with organic small molecule acoustic sensitizer IR780 and mitochondrial hexokinase Ⅱ inhibitor lonidamine (LND),followed by encapsulation of HA.Ultra-small size nanoparticles exhibit strong tissue penetration,tumor inhibition and in vivo metabolism.Under ultrasound radiation,TN NPs and IR780could produce a synergistic effect,effectively increased the efficiency of reactive oxygen species (ROS)production.Meanwhile,the released IR780 could smoothly target the mitochondria,and the ROS produced by IR780 can destroy the mitochondrial structure and disrupt the mitochondrial respiration.LND could inhibit the energy metabolism of tumor cells by reducing the activity of hexokinase Ⅱ (HK Ⅱ),which further accelerates the process of apoptosis.Furthermore,since the Janus structure allows the integration of multifunctional components into a single system,TN NPs can not only serve as an acoustic sensitizer to generate ROS,but the Gd element contained can also act as the nuclear magnetic resonance (MR)imaging contrast agent,suggesting that the nanoformulation can enable imaging-guided diagnosis and therapy.In conclusion,a new scheme to enhance sonodynamic therapy (SDT) and chemotherapy synergistically is proposed here based on ultra-small dual-targeted nanoformulation with Janus structure in the ultrasound radiation environment.
