Duplications of the alimentary tract (ATD) are rare congenital anomalies often found early in life. They may occur anywhere in the intestinal tract but the ileum is the most frequently affected site. Clinical presenta...Duplications of the alimentary tract (ATD) are rare congenital anomalies often found early in life. They may occur anywhere in the intestinal tract but the ileum is the most frequently affected site. Clinical presentation of ATD in adults is variable and because these lesions occur so infrequently they are rarely suspected. In the present report we describe a case of ileal duplication in a 61-year-old patient with Crohn’s disease. Despite various radiological investigations and medical consultations, the diagnosis was only made on the surgical specimen.展开更多
Emerging adulthood(EA)is a critical stage of life to develop and sustain a healthy lifestyle,which is also a time of vulnerability to poor physical and mental health outcomes.In this study,we conducted a path analysis...Emerging adulthood(EA)is a critical stage of life to develop and sustain a healthy lifestyle,which is also a time of vulnerability to poor physical and mental health outcomes.In this study,we conducted a path analysis(N=1326)to examine associations among four dimensions of EA,levels of regular physical activity(PA),self-control,MPA tendency and irrational procrastination.Results found:1)higher levels of PA predicted both MPA tendency(β=−0.08,95%CI:−0.11 to−0.06,p<0.001)and irrational procrastination(β=−0.01,95%CI:−0.17 to−0.008,p<0.01)indirectly via self-control;2)Instability(β=0.13,95%CI:0.08 to 0.18,p<0.01)and Responsibility(β=−0.06,95%CI:−0.10 to−0.08,p=0.03)exerted direct effects on irrational procrastination and Instability also indirectly predicted irrational procrastination via MPA tendency(β=0.03,95%CI:0.02 to 0.05,p<0.01).These findings proved that perceived features of EA are linked to behavioral problems and supported that regular PA plays a crucial role to protect mental health.展开更多
BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, infl...BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, inflammatory bowel diseaseand loss of interlobular bile ducts.CASE SUMMARY This case presents a 27-year-old woman with elevation of transaminases andalkaline phosphatase without clinical symptoms. Five years ago, the patient hadabnormal transaminases but no cholestasis. Three months before admission,physical examination revealed an increase in transaminases. Oralhepatoprotective drugs did not show any significant improvement, and she wasadmitted to hospital for further diagnosis and treatment. Liver biopsy confirmedIAD. After about 2 wk of ursodeoxycholic acid treatment, serological andhistological examination showed a significant response.CONCLUSION IAD is a manifestation of cholestasis, but also may be an abnormal increase intransaminase in the early stage.展开更多
A significant portion of emerging adults do not achieve recommended levels of physical activity (PA). Previous studies observedassociations between features of emerging adulthood and PA levels, while the potential psy...A significant portion of emerging adults do not achieve recommended levels of physical activity (PA). Previous studies observedassociations between features of emerging adulthood and PA levels, while the potential psychological mechanisms that mightexplain this phenomenon are not fully understood. In this context, there is some evidence that situated decisions towardphysical activity (SDPA) and exercise-intensity tolerance might influence PA level. To provide empirical support for thisassumption, the current study investigated whether (i) features of emerging adulthood are linked to SDPA, which, in turn,might affect PA engagement;(ii) exercise-intensity tolerance moderate the relationship between SDPA and PA level;and (iii)SDPA is a mediator of the relationship between features of emerging adulthood and PA levels under the prerequisite thatexercise-intensity tolerance moderates the link between SDPA and PA engagement. In this study a group of 1,706 Chinesecollege students was recruited and asked to complete a set of questionnaires assessing their SDPA, PA levels, exercise-intensitytolerance, and features associated with emerging adulthood, namely Self-exploration, Instability, and Possibility. Our resultsindicated that SDPA positively predicted PA levels and this relationship became stronger when exercise-intensity tolerance wasused as a moderator. Furthermore, it was observed that individuals with a higher level of Instability and a lower level ofPossibility during emerging adulthood exhibited a lower level of SDPA. Taken together, the results of our study providefurther insights on a potential psychological mechanism linking features of emerging adulthood and physical activity.展开更多
Background Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-y...Background Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to hypercholesterolemia in early adulthood and future coronary heart disease （CHD） risk.展开更多
This study explored psychological, biomedical, and social factors in childhood and adulthood associated with the occurrence of self-reported hearing problems in adulthood. In total, 4828 participants with complete dat...This study explored psychological, biomedical, and social factors in childhood and adulthood associated with the occurrence of self-reported hearing problems in adulthood. In total, 4828 participants with complete data on parental social class at birth, childhood hearing impairment measured at age 7 years and cognitive ability accessed at age 11 years, educational qualifications obtained at age 33 years, the Big-Five-Factor personality traits measured at age 50 years, current occupational levels and self-reported hearing problems at age 54 years were included in the study. Logistic regression analysis showed that among all the factors examined childhood hearing impairment and trait neuroticism as well as gender were the significant and independent predictors of hearing problems in adulthood.展开更多
BACKGROUND Most studies have defined economic well-being as socioeconomic status,with little attention given to whether other indicators influence self-esteem.Little is known about racial/ethnic disparities in the rel...BACKGROUND Most studies have defined economic well-being as socioeconomic status,with little attention given to whether other indicators influence self-esteem.Little is known about racial/ethnic disparities in the relationship between economic wellbeing and self-esteem during adulthood.AIM To explore the impact of economic well-being on self-esteem in adulthood and differences in the association across race/ethnicity.METHODS The current study used data from the National Longitudinal Survey of Youth 1979.The final sample consisted of 2267 African Americans,1425 Hispanics,and 3678 non-Hispanic Whites.Ordinary linear regression analyses and logistic regression analyses were conducted.RESULTS African Americans and Hispanics were more likely to be in poverty in comparison with non-Hispanic Whites.More African Americans were unemployed than Whites.Those who received fringe benefits,were more satisfied with jobs,and were employed were more likely to have higher levels of self-esteem.Poverty was negatively associated with self-esteem.Interaction effects were found between African Americans and job satisfaction predicting self-esteem.CONCLUSION The role of employers is important in cultivating employees’self-esteem.Satisfactory outcomes or feelings of happiness from the workplace may be more important to non-Hispanic Whites compared to African Americans and Hispanics.展开更多
Introduction: Primary hyperoxaluria type 1 (HP1) is a rare lithiasis with systemic involvement, due to the accumulation of calcium oxalate crystals. In the absence of therapeutic management, it progresses to end-stage...Introduction: Primary hyperoxaluria type 1 (HP1) is a rare lithiasis with systemic involvement, due to the accumulation of calcium oxalate crystals. In the absence of therapeutic management, it progresses to end-stage chronic renal failure. The aim of this study is to describe and analyse the observations of our patients with HP1. Patients and methods: This is a retrospective study carried out between 2014 and 2023 in the Nephrology-Dialysis Transplant Department of the Ibn Sina University Hospital in Rabat. The clinical, paraclinical and evolutionary elements were taken from the patients’ medical records. Results: We collected 11 cases, with a mean age of 27 ± 8.5 years and a M/F sex ratio of 1.7. The diagnosis of HP1 was made on the basis of genetic analysis in 8 patients, morphological and spectro-photometric analysis of the calculus in one patient, biopsy of the graft in one patient and crystalluria and a family history of PH1 in one patient. Two patients died, and 8 patients were on chronic haemdialysis with systemic damage. Only one patient maintained a stable GFR at 60 ml/min. Conclusion: Early diagnosis combined with conservative treatment is the only way to limit the rapid progression of this disease. This requires awareness and collaboration between nephrologists, urologists and biologists within a specialised team.展开更多
In a few decades, transition to adulthood has undergone significant changes in the manner and timing of attaining adulthood. The objective of the paper is to focus on the most significant transformations： the transit...In a few decades, transition to adulthood has undergone significant changes in the manner and timing of attaining adulthood. The objective of the paper is to focus on the most significant transformations： the transition to adulthood process has undergone in different European contexts, through the use of the findings of research performed in 2004 in Denmark, Germany and Italy. For the purpose of the comparison, in-depth analysis was performed of the interviews conducted on young people aged between 19 and 35, who had completed their education and were preparing to enter into the workplace. By means of the analysis of the interviews, the paper evaluates how youths perceive the passage from education to the workplace, taking into consideration the opportunities and resources provided by individual national contexts （social benefits, training and work opportunities） to facilitate the process of attainment of adult roles. The role played by family support to achieve transition is also analyzed. In particular, the type of support （financial, emotional and affective） provided by parents to their offspring during the various transition phases, with the aim of highlighting the existence of different parent-child relationships in the three countries examined.展开更多
Although mental health symptoms in children and adolescents are shown to predict young adult mental health outcomes, long-term prospective studies of childhood cohorts are few. The aim of the present study was to anal...Although mental health symptoms in children and adolescents are shown to predict young adult mental health outcomes, long-term prospective studies of childhood cohorts are few. The aim of the present study was to analyze the prospective importance of internalized mental health symptoms in adolescence for internalized symptoms in adulthood. Methods: A community-based prospective longitudinal cohort provided information by questionnaire about psychological status at age 16 and 43 (n=1010, representing 94.3% of those still alive). Socio-demographic variables which were indicative of possible childhood adversity (parental class, absence, illness, unemployment, relationship, crowding, number of moves) were treated as confounders and controlled for in ordinal regression. Results: For both women and men, internalizing mental health symptoms reported at 16 significantly predicted the same outcome at 43 years, after controlling for previous adverse environmental conditions (OR =1.2 for women, 1.3 for men). Conclusion: In this representative cohort studied over 27 years with excellent retention rates, the occurrence of self-reported worry, panic and sadness in mid-adolescence significantly increased the likelihood of similar states in middle adulthood.展开更多
Objective: to study the close relationship between social and economic changes from childhood to adulthood and senile depression, so as to explore the main inducement of senile depression. Methods: one hundred patient...Objective: to study the close relationship between social and economic changes from childhood to adulthood and senile depression, so as to explore the main inducement of senile depression. Methods: one hundred patients who entered our hospital from November 2020 to November 2021 for treatment of depression and corresponding research work were selected. Then, 100 elderly patients with depression were randomly divided into control group and observation group by means of statistical random drawing of lots. All patients in the control group were male, and all patients in the observation group were female. The fixed number of patients in each group was 50. In the control group and the observation group, different research forms of senile depression will be adopted to judge the stage of senile depression and the disease situation through visiting investigation, psychological test and other forms. Results: compared with men, women are more likely to suffer from psychological diseases and even depression due to their economic status and social status. If patients have major changes in adulthood due to many problems such as work and physical diseases, they are more likely to suffer from depression in old age. Conclusion: the social status, living conditions, physical health and psychological pressure in childhood are related to depression in old age.展开更多
The rite of passage into adulthood is one of the most important rites of passage for the Mosuo people.The rite of passage into adulthood ceremony is held in the Spring Festival at the age of thirteen to declare that t...The rite of passage into adulthood is one of the most important rites of passage for the Mosuo people.The rite of passage into adulthood ceremony is held in the Spring Festival at the age of thirteen to declare that they have a complete life and have become adults with responsibilities from now on.Changing clothes is the core of the ceremony,in which the Daba and the Daba Scriptures play an important role in the ceremony.The rite of passage into adulthood has the unique functions of strengthening self-knowledge,family education,and transmission of Mosuo culture.The exploration of the origin,process,cultural significance and cultural connotation of rite of passage into adulthood can deeply reflect the value of Mosuo culture with“harmony”as the main connotation,which is of great significance to the inheritance and promotion of the excellent traditional culture of the Chinese nation.展开更多
In critical areas,the transition of pediatric patients to adult care focuses on developing structures and supportive systems to ensure smooth and successful transitions for young people to adult healthcare[1].Transiti...In critical areas,the transition of pediatric patients to adult care focuses on developing structures and supportive systems to ensure smooth and successful transitions for young people to adult healthcare[1].Transition medicine,a new field of medicine,helps with the safe transition of medical care from pediatric to adult settings and is an ongoing challenge[2].展开更多
The advances in research and treatment of autism spectrum disorders(ASD) over the past three decades have focused largely on early childhood and school-age years. Although ASD is a lifelong condition, there has been r...The advances in research and treatment of autism spectrum disorders(ASD) over the past three decades have focused largely on early childhood and school-age years. Although ASD is a lifelong condition, there has been relatively little attention paid to ASD during the adolescent and adulthood periods. As the population of those with ASD continues to rise and age, the need to provide research and treatment for this group has become increasingly evident. This paper reviews the current literature available on symptoms, functioning, and treatment of adolescents and adults with ASD, as well as the unique issues that arise for individuals with ASD after childhood. Adulthood outcomes for ASD are generally poor, even for those with average to above average cognitive ability. Further research and additional clinical resources are needed for this rapidly increasing group.展开更多
Mild idiopathic adulthood ductopenia(IAD)is a rare cholestatic disease of unknown cause and characterized by interlobular bile duct loss in less than 50%of the portal tracts.We describe the case of a middLe-aged male ...Mild idiopathic adulthood ductopenia(IAD)is a rare cholestatic disease of unknown cause and characterized by interlobular bile duct loss in less than 50%of the portal tracts.We describe the case of a middLe-aged male who presented with persistent elevation of transaminases and alkaline phosphatase.He had a normal biliary tree on endoscopic retrograde cholangiopathy and negative anti-mitochondrial antibody.His liver biopsy specimen showed chronic biliary disease,duct loss in 4 out of 15 portal tracts and prominent cholestasis.Based on the work-up,he likely had mild IAD.Liver transplantation would be necessary if his disease becomes progressive.展开更多
文摘Duplications of the alimentary tract (ATD) are rare congenital anomalies often found early in life. They may occur anywhere in the intestinal tract but the ileum is the most frequently affected site. Clinical presentation of ATD in adults is variable and because these lesions occur so infrequently they are rarely suspected. In the present report we describe a case of ileal duplication in a 61-year-old patient with Crohn’s disease. Despite various radiological investigations and medical consultations, the diagnosis was only made on the surgical specimen.
基金the Start-Up Research Grant of Shenzhen University[20200807163056003]the Start-Up Research Grant[Peacock Plan:20191105534C].
文摘Emerging adulthood(EA)is a critical stage of life to develop and sustain a healthy lifestyle,which is also a time of vulnerability to poor physical and mental health outcomes.In this study,we conducted a path analysis(N=1326)to examine associations among four dimensions of EA,levels of regular physical activity(PA),self-control,MPA tendency and irrational procrastination.Results found:1)higher levels of PA predicted both MPA tendency(β=−0.08,95%CI:−0.11 to−0.06,p<0.001)and irrational procrastination(β=−0.01,95%CI:−0.17 to−0.008,p<0.01)indirectly via self-control;2)Instability(β=0.13,95%CI:0.08 to 0.18,p<0.01)and Responsibility(β=−0.06,95%CI:−0.10 to−0.08,p=0.03)exerted direct effects on irrational procrastination and Instability also indirectly predicted irrational procrastination via MPA tendency(β=0.03,95%CI:0.02 to 0.05,p<0.01).These findings proved that perceived features of EA are linked to behavioral problems and supported that regular PA plays a crucial role to protect mental health.
文摘BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, inflammatory bowel diseaseand loss of interlobular bile ducts.CASE SUMMARY This case presents a 27-year-old woman with elevation of transaminases andalkaline phosphatase without clinical symptoms. Five years ago, the patient hadabnormal transaminases but no cholestasis. Three months before admission,physical examination revealed an increase in transaminases. Oralhepatoprotective drugs did not show any significant improvement, and she wasadmitted to hospital for further diagnosis and treatment. Liver biopsy confirmedIAD. After about 2 wk of ursodeoxycholic acid treatment, serological andhistological examination showed a significant response.CONCLUSION IAD is a manifestation of cholestasis, but also may be an abnormal increase intransaminase in the early stage.
基金supported by the University Malaya Community Campus Grant-RUU2022-LL016Private Grant PV086-2022(University Poly-Tech MARA-UPTM),Kuala LumpurUniversitas Negeri Malang,Indonesia.
文摘A significant portion of emerging adults do not achieve recommended levels of physical activity (PA). Previous studies observedassociations between features of emerging adulthood and PA levels, while the potential psychological mechanisms that mightexplain this phenomenon are not fully understood. In this context, there is some evidence that situated decisions towardphysical activity (SDPA) and exercise-intensity tolerance might influence PA level. To provide empirical support for thisassumption, the current study investigated whether (i) features of emerging adulthood are linked to SDPA, which, in turn,might affect PA engagement;(ii) exercise-intensity tolerance moderate the relationship between SDPA and PA level;and (iii)SDPA is a mediator of the relationship between features of emerging adulthood and PA levels under the prerequisite thatexercise-intensity tolerance moderates the link between SDPA and PA engagement. In this study a group of 1,706 Chinesecollege students was recruited and asked to complete a set of questionnaires assessing their SDPA, PA levels, exercise-intensitytolerance, and features associated with emerging adulthood, namely Self-exploration, Instability, and Possibility. Our resultsindicated that SDPA positively predicted PA levels and this relationship became stronger when exercise-intensity tolerance wasused as a moderator. Furthermore, it was observed that individuals with a higher level of Instability and a lower level ofPossibility during emerging adulthood exhibited a lower level of SDPA. Taken together, the results of our study providefurther insights on a potential psychological mechanism linking features of emerging adulthood and physical activity.
文摘Background Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to hypercholesterolemia in early adulthood and future coronary heart disease （CHD） risk.
文摘This study explored psychological, biomedical, and social factors in childhood and adulthood associated with the occurrence of self-reported hearing problems in adulthood. In total, 4828 participants with complete data on parental social class at birth, childhood hearing impairment measured at age 7 years and cognitive ability accessed at age 11 years, educational qualifications obtained at age 33 years, the Big-Five-Factor personality traits measured at age 50 years, current occupational levels and self-reported hearing problems at age 54 years were included in the study. Logistic regression analysis showed that among all the factors examined childhood hearing impairment and trait neuroticism as well as gender were the significant and independent predictors of hearing problems in adulthood.
文摘BACKGROUND Most studies have defined economic well-being as socioeconomic status,with little attention given to whether other indicators influence self-esteem.Little is known about racial/ethnic disparities in the relationship between economic wellbeing and self-esteem during adulthood.AIM To explore the impact of economic well-being on self-esteem in adulthood and differences in the association across race/ethnicity.METHODS The current study used data from the National Longitudinal Survey of Youth 1979.The final sample consisted of 2267 African Americans,1425 Hispanics,and 3678 non-Hispanic Whites.Ordinary linear regression analyses and logistic regression analyses were conducted.RESULTS African Americans and Hispanics were more likely to be in poverty in comparison with non-Hispanic Whites.More African Americans were unemployed than Whites.Those who received fringe benefits,were more satisfied with jobs,and were employed were more likely to have higher levels of self-esteem.Poverty was negatively associated with self-esteem.Interaction effects were found between African Americans and job satisfaction predicting self-esteem.CONCLUSION The role of employers is important in cultivating employees’self-esteem.Satisfactory outcomes or feelings of happiness from the workplace may be more important to non-Hispanic Whites compared to African Americans and Hispanics.
文摘Introduction: Primary hyperoxaluria type 1 (HP1) is a rare lithiasis with systemic involvement, due to the accumulation of calcium oxalate crystals. In the absence of therapeutic management, it progresses to end-stage chronic renal failure. The aim of this study is to describe and analyse the observations of our patients with HP1. Patients and methods: This is a retrospective study carried out between 2014 and 2023 in the Nephrology-Dialysis Transplant Department of the Ibn Sina University Hospital in Rabat. The clinical, paraclinical and evolutionary elements were taken from the patients’ medical records. Results: We collected 11 cases, with a mean age of 27 ± 8.5 years and a M/F sex ratio of 1.7. The diagnosis of HP1 was made on the basis of genetic analysis in 8 patients, morphological and spectro-photometric analysis of the calculus in one patient, biopsy of the graft in one patient and crystalluria and a family history of PH1 in one patient. Two patients died, and 8 patients were on chronic haemdialysis with systemic damage. Only one patient maintained a stable GFR at 60 ml/min. Conclusion: Early diagnosis combined with conservative treatment is the only way to limit the rapid progression of this disease. This requires awareness and collaboration between nephrologists, urologists and biologists within a specialised team.
文摘In a few decades, transition to adulthood has undergone significant changes in the manner and timing of attaining adulthood. The objective of the paper is to focus on the most significant transformations： the transition to adulthood process has undergone in different European contexts, through the use of the findings of research performed in 2004 in Denmark, Germany and Italy. For the purpose of the comparison, in-depth analysis was performed of the interviews conducted on young people aged between 19 and 35, who had completed their education and were preparing to enter into the workplace. By means of the analysis of the interviews, the paper evaluates how youths perceive the passage from education to the workplace, taking into consideration the opportunities and resources provided by individual national contexts （social benefits, training and work opportunities） to facilitate the process of attainment of adult roles. The role played by family support to achieve transition is also analyzed. In particular, the type of support （financial, emotional and affective） provided by parents to their offspring during the various transition phases, with the aim of highlighting the existence of different parent-child relationships in the three countries examined.
文摘Although mental health symptoms in children and adolescents are shown to predict young adult mental health outcomes, long-term prospective studies of childhood cohorts are few. The aim of the present study was to analyze the prospective importance of internalized mental health symptoms in adolescence for internalized symptoms in adulthood. Methods: A community-based prospective longitudinal cohort provided information by questionnaire about psychological status at age 16 and 43 (n=1010, representing 94.3% of those still alive). Socio-demographic variables which were indicative of possible childhood adversity (parental class, absence, illness, unemployment, relationship, crowding, number of moves) were treated as confounders and controlled for in ordinal regression. Results: For both women and men, internalizing mental health symptoms reported at 16 significantly predicted the same outcome at 43 years, after controlling for previous adverse environmental conditions (OR =1.2 for women, 1.3 for men). Conclusion: In this representative cohort studied over 27 years with excellent retention rates, the occurrence of self-reported worry, panic and sadness in mid-adolescence significantly increased the likelihood of similar states in middle adulthood.
文摘Objective: to study the close relationship between social and economic changes from childhood to adulthood and senile depression, so as to explore the main inducement of senile depression. Methods: one hundred patients who entered our hospital from November 2020 to November 2021 for treatment of depression and corresponding research work were selected. Then, 100 elderly patients with depression were randomly divided into control group and observation group by means of statistical random drawing of lots. All patients in the control group were male, and all patients in the observation group were female. The fixed number of patients in each group was 50. In the control group and the observation group, different research forms of senile depression will be adopted to judge the stage of senile depression and the disease situation through visiting investigation, psychological test and other forms. Results: compared with men, women are more likely to suffer from psychological diseases and even depression due to their economic status and social status. If patients have major changes in adulthood due to many problems such as work and physical diseases, they are more likely to suffer from depression in old age. Conclusion: the social status, living conditions, physical health and psychological pressure in childhood are related to depression in old age.
文摘The rite of passage into adulthood is one of the most important rites of passage for the Mosuo people.The rite of passage into adulthood ceremony is held in the Spring Festival at the age of thirteen to declare that they have a complete life and have become adults with responsibilities from now on.Changing clothes is the core of the ceremony,in which the Daba and the Daba Scriptures play an important role in the ceremony.The rite of passage into adulthood has the unique functions of strengthening self-knowledge,family education,and transmission of Mosuo culture.The exploration of the origin,process,cultural significance and cultural connotation of rite of passage into adulthood can deeply reflect the value of Mosuo culture with“harmony”as the main connotation,which is of great significance to the inheritance and promotion of the excellent traditional culture of the Chinese nation.
文摘In critical areas,the transition of pediatric patients to adult care focuses on developing structures and supportive systems to ensure smooth and successful transitions for young people to adult healthcare[1].Transition medicine,a new field of medicine,helps with the safe transition of medical care from pediatric to adult settings and is an ongoing challenge[2].
文摘The advances in research and treatment of autism spectrum disorders(ASD) over the past three decades have focused largely on early childhood and school-age years. Although ASD is a lifelong condition, there has been relatively little attention paid to ASD during the adolescent and adulthood periods. As the population of those with ASD continues to rise and age, the need to provide research and treatment for this group has become increasingly evident. This paper reviews the current literature available on symptoms, functioning, and treatment of adolescents and adults with ASD, as well as the unique issues that arise for individuals with ASD after childhood. Adulthood outcomes for ASD are generally poor, even for those with average to above average cognitive ability. Further research and additional clinical resources are needed for this rapidly increasing group.
文摘Mild idiopathic adulthood ductopenia(IAD)is a rare cholestatic disease of unknown cause and characterized by interlobular bile duct loss in less than 50%of the portal tracts.We describe the case of a middLe-aged male who presented with persistent elevation of transaminases and alkaline phosphatase.He had a normal biliary tree on endoscopic retrograde cholangiopathy and negative anti-mitochondrial antibody.His liver biopsy specimen showed chronic biliary disease,duct loss in 4 out of 15 portal tracts and prominent cholestasis.Based on the work-up,he likely had mild IAD.Liver transplantation would be necessary if his disease becomes progressive.
