Neuroinflammation is a crucial factor in the progression of various diseases,ranging from immune-related conditions such as sepsis to neurodegenerative disorders such as Alzheimer’s disease(AD)(Ravichandran and Henek...Neuroinflammation is a crucial factor in the progression of various diseases,ranging from immune-related conditions such as sepsis to neurodegenerative disorders such as Alzheimer’s disease(AD)(Ravichandran and Heneka,2024).This perspective article,which draws on insights from diverse fields including neuroscience,immunology,and pathology,p rovides a critical analysis of ongoing research efforts in inflammasome biology,with specific emphasis on Nod-like receptor(NLR)and pyrin domain-containing protein 3(NLRP3).展开更多
The Accelerator Driven Sub-critical(ADS)system is a strategic plan to solve the nuclear waste problem for nuclear power plants in China.High-energy particle accelerators and colliders contain long strings of supercond...The Accelerator Driven Sub-critical(ADS)system is a strategic plan to solve the nuclear waste problem for nuclear power plants in China.High-energy particle accelerators and colliders contain long strings of superconducting devices,superconducting radio frequency cavities,and magnets,which may require cooling by 2 K superfluid helium(HeliumⅡ).2 K superfluid helium cryogenic system has become a research hot spot in the field of superconducting accelerators.In this study,the ADS Injector-I 2 K cryogenic system is examined in detail.The cryogenic system scheme design,key equipment,and technology design,such as the 2 K Joule–Thomson(J–T)heat exchanger and cryomodules CM1+CM2 design,are examined,in addition to the commissioning and operation of the cryogenic system.The ADS Injector-I 2 K cryogenic system is the first 100 W superfluid helium system designed and built independently in China.The ADS proton beam reached 10 Me V at 10 m A in July 2016 and 10 Me V at 2 m A in continuous mode in January 2017 and has been operated reliably for over 15,000 h,proving that the design of ADS Injector-I 2 K cryogenic system,the key equipment,and technology research are reasonable,reliable,and meet the requirements.The research into key technologies provides valuable engineering experience that can be helpful for future projects such as CI-ADS(China Initiative Accelerator-Driven System),SHINE(Shanghai High Repetition Rate XFEL and Extreme Light Facility),PAPS(Platform of Advanced Photon Source Technology),and CEPC(Circular Electron-Positron Collider),thereby developing national expertise in the field of superfluid helium cryogenic systems.展开更多
The tuner system of ADS 25 MeV Linac(Fig.1)built in CM1,CM2 and CM3 consists of 17 tuners and every tuner consists of two parts-linear drive unit and tuning implement unit.Linear drive unit is mainly composed of step ...The tuner system of ADS 25 MeV Linac(Fig.1)built in CM1,CM2 and CM3 consists of 17 tuners and every tuner consists of two parts-linear drive unit and tuning implement unit.Linear drive unit is mainly composed of step motor,reduction box,screw-nut and coupler(Fig.2).To learn about the working conditions and structure characteristics,17 tuners were tested and the CM1-2,CM2-3 and CM3-1 were chosen as representatives to give a brief introduction of test procedure and results.展开更多
Copper metal is widely electroplated for microelectronic interconnections such as redistribution layers(RDL),pillar bumps,through silicon vias,etc.With advances of multilayered RDL,via-on-via structures have been deve...Copper metal is widely electroplated for microelectronic interconnections such as redistribution layers(RDL),pillar bumps,through silicon vias,etc.With advances of multilayered RDL,via-on-via structures have been developed for ultrahigh-density any-layer interconnection,which expects superconformal filling of interlayer low aspect-ratio vias jointly with coplanar lines and pads.However,it poses a great challenge to electrodeposition,because current via fill mechanisms are stemming from middle to high aspect-ratio(>0.8)vias and lacking applicability in low aspect-ratio(<0.3)RDL-vias,where via geometry related electric-flow fields coupling must be reconsidered.In the present work,a four-additive strategy has been developed for RDL-vias fill and thoroughly investigated from additive electrochemistry,in situ Raman spectroelectrochemistry,and quantum chemistry perspectives.A novel adsorbate configuration controlled(ACC)electrodeposition mechanism is established that at weak-convection bilateral edges and lower corners,the adsorbate displays a weakly-adsorbing configuration to assist accelerator-governed deposition,whereas at strong-convection center,the adsorbate exhibits a mildlyadsorbing configuration to promote leveler-determined inhibition.Deposit profiles can be tailored from dished,flat to domed,depending on predominance of leveler over accelerator.This study should lay theoretical and practical foundations in design and application of copper electroplating additives of multiple adsorbate configurations to cope with complicated interconnect scenarios.展开更多
Active damping(AD)strategy is an economical and efficient method to solve the resonant problem of the permanent magnet synchronous motor(PMSM)drive system with inductor-capacitor(LC)sine wave filter.In this article,th...Active damping(AD)strategy is an economical and efficient method to solve the resonant problem of the permanent magnet synchronous motor(PMSM)drive system with inductor-capacitor(LC)sine wave filter.In this article,the AD methods used in PMSM drive system are classified as inherent damping(ID),state variable feedback,and digital filter.Based on this,the purpose of this article is to provide an overview and analysis of the AD methods on PMSM drive system in recent years,and to comprehensively review,compare,and summarize the stability,dynamic performance,robustness,and algorithm complexity.Furthermore,a new expansion of AD method based on capacitor current feedback with high-pass filter(HPF-CCF)is studied to ensure the effectiveness when the resonant frequency is around sixth of the sampling frequency.The simulation and experimental results validate the effectiveness of theoretical analysis.展开更多
基金supported by Texas Alzheimer’s Research and Care Consortium-TARCC 2022-26,The National Football League Players Association-NFLPA,NIH/NIA Grant 1R01 AG072491 to TB and FDP.
文摘Neuroinflammation is a crucial factor in the progression of various diseases,ranging from immune-related conditions such as sepsis to neurodegenerative disorders such as Alzheimer’s disease(AD)(Ravichandran and Heneka,2024).This perspective article,which draws on insights from diverse fields including neuroscience,immunology,and pathology,p rovides a critical analysis of ongoing research efforts in inflammasome biology,with specific emphasis on Nod-like receptor(NLR)and pyrin domain-containing protein 3(NLRP3).
文摘The Accelerator Driven Sub-critical(ADS)system is a strategic plan to solve the nuclear waste problem for nuclear power plants in China.High-energy particle accelerators and colliders contain long strings of superconducting devices,superconducting radio frequency cavities,and magnets,which may require cooling by 2 K superfluid helium(HeliumⅡ).2 K superfluid helium cryogenic system has become a research hot spot in the field of superconducting accelerators.In this study,the ADS Injector-I 2 K cryogenic system is examined in detail.The cryogenic system scheme design,key equipment,and technology design,such as the 2 K Joule–Thomson(J–T)heat exchanger and cryomodules CM1+CM2 design,are examined,in addition to the commissioning and operation of the cryogenic system.The ADS Injector-I 2 K cryogenic system is the first 100 W superfluid helium system designed and built independently in China.The ADS proton beam reached 10 Me V at 10 m A in July 2016 and 10 Me V at 2 m A in continuous mode in January 2017 and has been operated reliably for over 15,000 h,proving that the design of ADS Injector-I 2 K cryogenic system,the key equipment,and technology research are reasonable,reliable,and meet the requirements.The research into key technologies provides valuable engineering experience that can be helpful for future projects such as CI-ADS(China Initiative Accelerator-Driven System),SHINE(Shanghai High Repetition Rate XFEL and Extreme Light Facility),PAPS(Platform of Advanced Photon Source Technology),and CEPC(Circular Electron-Positron Collider),thereby developing national expertise in the field of superfluid helium cryogenic systems.
文摘The tuner system of ADS 25 MeV Linac(Fig.1)built in CM1,CM2 and CM3 consists of 17 tuners and every tuner consists of two parts-linear drive unit and tuning implement unit.Linear drive unit is mainly composed of step motor,reduction box,screw-nut and coupler(Fig.2).To learn about the working conditions and structure characteristics,17 tuners were tested and the CM1-2,CM2-3 and CM3-1 were chosen as representatives to give a brief introduction of test procedure and results.
基金supported by Key-Area Research and Development Program of Guangdong Province(No.2023B0101040002)National Natural Science Foundation of China(Nos.62304143,52303092 and 62274172)Guangdong Basic and Applied Basic Research Fund(No.2022B1515120037).
文摘Copper metal is widely electroplated for microelectronic interconnections such as redistribution layers(RDL),pillar bumps,through silicon vias,etc.With advances of multilayered RDL,via-on-via structures have been developed for ultrahigh-density any-layer interconnection,which expects superconformal filling of interlayer low aspect-ratio vias jointly with coplanar lines and pads.However,it poses a great challenge to electrodeposition,because current via fill mechanisms are stemming from middle to high aspect-ratio(>0.8)vias and lacking applicability in low aspect-ratio(<0.3)RDL-vias,where via geometry related electric-flow fields coupling must be reconsidered.In the present work,a four-additive strategy has been developed for RDL-vias fill and thoroughly investigated from additive electrochemistry,in situ Raman spectroelectrochemistry,and quantum chemistry perspectives.A novel adsorbate configuration controlled(ACC)electrodeposition mechanism is established that at weak-convection bilateral edges and lower corners,the adsorbate displays a weakly-adsorbing configuration to assist accelerator-governed deposition,whereas at strong-convection center,the adsorbate exhibits a mildlyadsorbing configuration to promote leveler-determined inhibition.Deposit profiles can be tailored from dished,flat to domed,depending on predominance of leveler over accelerator.This study should lay theoretical and practical foundations in design and application of copper electroplating additives of multiple adsorbate configurations to cope with complicated interconnect scenarios.
基金supported in part by the National Natural Science Foundational of China under Grants 62373363 and 52007190
文摘Active damping(AD)strategy is an economical and efficient method to solve the resonant problem of the permanent magnet synchronous motor(PMSM)drive system with inductor-capacitor(LC)sine wave filter.In this article,the AD methods used in PMSM drive system are classified as inherent damping(ID),state variable feedback,and digital filter.Based on this,the purpose of this article is to provide an overview and analysis of the AD methods on PMSM drive system in recent years,and to comprehensively review,compare,and summarize the stability,dynamic performance,robustness,and algorithm complexity.Furthermore,a new expansion of AD method based on capacitor current feedback with high-pass filter(HPF-CCF)is studied to ensure the effectiveness when the resonant frequency is around sixth of the sampling frequency.The simulation and experimental results validate the effectiveness of theoretical analysis.
