We aimed to characterize, and analyze the presence of factors such as polypharmacy and personal medical history that predispose to Adverse Drug Reactions （ADRs） and potential preventability of these. The Civil Hospi...We aimed to characterize, and analyze the presence of factors such as polypharmacy and personal medical history that predispose to Adverse Drug Reactions （ADRs） and potential preventability of these. The Civil Hospital of Culiacan （HCC）, in Sinaloa, where the study was conducted has 80 beds in total, in which the Department of Internal Medicine with 24 beds： 12 lbr men and 12 for women, we found the part of the share to contribute to the 200,000 cases of ADRs that according with the WHO each of the countries members report ever）, year to the Uppsala Monitoring Centre. We have not only but also ordered frequency of drugs, pathologies, and analytical tests of the hospitalized patients.展开更多
目的:为解决传统药品不良反应(adverse drug reaction,ADR)监测方式存在的问题,设计药品不良反应智能监测平台。方法:药品不良反应智能监测平台基于人工智能、大数据等技术设计,采用浏览器/服务器(Browser/Server,B/S)架构,使用C#语言...目的:为解决传统药品不良反应(adverse drug reaction,ADR)监测方式存在的问题,设计药品不良反应智能监测平台。方法:药品不良反应智能监测平台基于人工智能、大数据等技术设计,采用浏览器/服务器(Browser/Server,B/S)架构,使用C#语言、基于.NET平台开发。整个平台包括ADR知识库、监测规则设置、智能监测、报告管理、统计分析5个功能模块。结果:该平台实现了ADR智能监测、上报、审核、统计分析全流程管理,有效提高了ADR报告的数量、质量和时效性。结论:该平台有利于提高ADR监测能力,提升患者的用药安全监管水平。展开更多
Background:Toxic Epidermal Necrolysis(TEN)is a potentially fatal dermatological condition primarily triggered by adverse drug reactions.It is characterized by extensive epidermal necrosis and separation,affecting more...Background:Toxic Epidermal Necrolysis(TEN)is a potentially fatal dermatological condition primarily triggered by adverse drug reactions.It is characterized by extensive epidermal necrosis and separation,affecting more than 30%of the body surface area,and leading to severe complications such as sepsis and multi-organ failure.Common causative agents include antibiotics,anticonvulsants,and NSAIDs.The pathophysiology of TEN in-volves an immune-mediated response,where cytotoxic T lymphocytes(CTLs)and natural killer(NK)cells release cytotoxic proteins such as perforin,granzyme B,and granulysin,leading to widespread keratinocyte apoptosis.This immune response results in massive skin detachment and mucosal damage.Despite its rarity,TEN has a high mortality rate,necessitating early diagnosis and intervention.Case presentation:This paper provides a comprehensive review of TEN,discussing its history,pathophysiology,clinical features,and current understanding of treatment strategies.A case series of 11 patients who developed TEN after exposure to various drugs,including Lamotrigine,Phenytoin,Diclofenac,Ibuprofen,Aceclofenac,Amoxicillin,Sulfadoxine-Pyrimethamine,Amoxiclav,and Gabapentin,is presented.The cases highlight the importance of early drug discontinuation,supportive care,and adjunctive therapies such as intravenous immunoglobulin(IVIG)and corticosteroids.Prognostic factors,such as the extent of skin detachment and sys-temic complications,significantly influenced patient outcomes.All patients recovered with timely intervention and intensive care,except for a few who succumbed to the severity of the condition.Conclusion:This study underscores the need for early intervention,multidisciplinary care,and robust pharma-covigilance systems to reduce the incidence and severity of TEN.Increased awareness of risk factors and early recognition of symptoms associated with high-risk medications are crucial in improving patient outcomes and reducing mortality.展开更多
文摘We aimed to characterize, and analyze the presence of factors such as polypharmacy and personal medical history that predispose to Adverse Drug Reactions （ADRs） and potential preventability of these. The Civil Hospital of Culiacan （HCC）, in Sinaloa, where the study was conducted has 80 beds in total, in which the Department of Internal Medicine with 24 beds： 12 lbr men and 12 for women, we found the part of the share to contribute to the 200,000 cases of ADRs that according with the WHO each of the countries members report ever）, year to the Uppsala Monitoring Centre. We have not only but also ordered frequency of drugs, pathologies, and analytical tests of the hospitalized patients.
文摘目的:为解决传统药品不良反应(adverse drug reaction,ADR)监测方式存在的问题,设计药品不良反应智能监测平台。方法:药品不良反应智能监测平台基于人工智能、大数据等技术设计,采用浏览器/服务器(Browser/Server,B/S)架构,使用C#语言、基于.NET平台开发。整个平台包括ADR知识库、监测规则设置、智能监测、报告管理、统计分析5个功能模块。结果:该平台实现了ADR智能监测、上报、审核、统计分析全流程管理,有效提高了ADR报告的数量、质量和时效性。结论:该平台有利于提高ADR监测能力,提升患者的用药安全监管水平。
文摘Background:Toxic Epidermal Necrolysis(TEN)is a potentially fatal dermatological condition primarily triggered by adverse drug reactions.It is characterized by extensive epidermal necrosis and separation,affecting more than 30%of the body surface area,and leading to severe complications such as sepsis and multi-organ failure.Common causative agents include antibiotics,anticonvulsants,and NSAIDs.The pathophysiology of TEN in-volves an immune-mediated response,where cytotoxic T lymphocytes(CTLs)and natural killer(NK)cells release cytotoxic proteins such as perforin,granzyme B,and granulysin,leading to widespread keratinocyte apoptosis.This immune response results in massive skin detachment and mucosal damage.Despite its rarity,TEN has a high mortality rate,necessitating early diagnosis and intervention.Case presentation:This paper provides a comprehensive review of TEN,discussing its history,pathophysiology,clinical features,and current understanding of treatment strategies.A case series of 11 patients who developed TEN after exposure to various drugs,including Lamotrigine,Phenytoin,Diclofenac,Ibuprofen,Aceclofenac,Amoxicillin,Sulfadoxine-Pyrimethamine,Amoxiclav,and Gabapentin,is presented.The cases highlight the importance of early drug discontinuation,supportive care,and adjunctive therapies such as intravenous immunoglobulin(IVIG)and corticosteroids.Prognostic factors,such as the extent of skin detachment and sys-temic complications,significantly influenced patient outcomes.All patients recovered with timely intervention and intensive care,except for a few who succumbed to the severity of the condition.Conclusion:This study underscores the need for early intervention,multidisciplinary care,and robust pharma-covigilance systems to reduce the incidence and severity of TEN.Increased awareness of risk factors and early recognition of symptoms associated with high-risk medications are crucial in improving patient outcomes and reducing mortality.
