The main goal of this paper is to employ longitudinal trajectories in a significant number of sub-regional brain volumetric MRI data as statistical predictors for Alzheimer's disease(AD)clas-sification.We use logi...The main goal of this paper is to employ longitudinal trajectories in a significant number of sub-regional brain volumetric MRI data as statistical predictors for Alzheimer's disease(AD)clas-sification.We use logistic regression in a Bayesian framework that includes many functional predictors.The direct sampling of regression Coefficients from the Bayesian logistic model is dif-ficult due to its complicated likelihood function.In high-dimensional scenarios,the selection of predictors is paramount with the introduction of either spike-and-slab priors,non-local priors,or Horseshoe priors.We seek to avoid the complicated Metropolis-Hastings approach and to develop an easily implementable Gibbs sampler.In addition,the Bayesian estimation provides proper estimates of the model parameters,which are also useful for building inference.Another advantage of working with logistic regression is that it calculates the log of odds of relative risk for AD compared to normal control based on the selected longitudinal predictors,rather than simply classifying patients based on cross-sectional estimates.Ultimately,however,we com-bine approaches and use a probability threshold to classify individual patients.We employ 49 functional predictors consisting of volumetric estimates of brain sub-regions,chosen for their established clinical significance.Moreover,the use of spike and slab priors ensures that many redundant predictors are dropped from the model.展开更多
Alzheimer’s disease(AD)is a very complex disease that causes brain failure,then eventually,dementia ensues.It is a global health problem.99%of clinical trials have failed to limit the progression of this disease.The ...Alzheimer’s disease(AD)is a very complex disease that causes brain failure,then eventually,dementia ensues.It is a global health problem.99%of clinical trials have failed to limit the progression of this disease.The risks and barriers to detecting AD are huge as pathological events begin decades before appearing clinical symptoms.Therapies for AD are likely to be more helpful if the diagnosis is determined early before the final stage of neurological dysfunction.In this regard,the need becomes more urgent for biomarker-based detection.A key issue in understanding AD is the need to solve complex and high-dimensional datasets and heterogeneous biomarkers,such as genetics,magnetic resonance imaging(MRI),cerebrospinal fluid(CSF),and cognitive scores.Establishing an interpretable reasoning system and performing interoperability that achieves in terms of a semantic model is potentially very useful.Thus,our aim in this work is to propose an interpretable approach to detect AD based on Alzheimer’s disease diagnosis ontology(ADDO)and the expression of semantic web rule language(SWRL).This work implements an ontology-based application that exploits three different machine learning models.These models are random forest(RF),JRip,and J48,which have been used along with the voting ensemble.ADNI dataset was used for this study.The proposed classifier’s result with the voting ensemble achieves a higher accuracy of 94.1%and precision of 94.3%.Our approach provides effective inference rules.Besides,it contributes to a real,accurate,and interpretable classifier model based on various AD biomarkers for inferring whether the subject is a normal cognitive(NC),significant memory concern(SMC),early mild cognitive impairment(EMCI),late mild cognitive impairment(LMCI),or AD.展开更多
The prediction of mild cognitive impairment or Alzheimer’s disease(AD)has gained the attention of huge researchers as the disease occurrence is increasing,and there is a need for earlier prediction.Regrettably,due to...The prediction of mild cognitive impairment or Alzheimer’s disease(AD)has gained the attention of huge researchers as the disease occurrence is increasing,and there is a need for earlier prediction.Regrettably,due to the highdimensionality nature of neural data and the least available samples,modelling an efficient computer diagnostic system is highly solicited.Learning approaches,specifically deep learning approaches,are essential in disease prediction.Deep Learning(DL)approaches are successfully demonstrated for their higher-level performance in various fields like medical imaging.A novel 3D-Convolutional Neural Network(3D-CNN)architecture is proposed to predict AD with Magnetic resonance imaging(MRI)data.The proposed model predicts the AD occurrence while the existing approaches lack prediction accuracy and perform binary classification.The proposed prediction model is validated using the Alzheimer’s disease Neuro-Imaging Initiative(ADNI)data.The outcomes demonstrate that the anticipated model attains superior prediction accuracy and works better than the brain-image dataset’s general approaches.The predicted model reduces the human effort during the prediction process and makes it easier to diagnose it intelligently as the feature learning is adaptive.Keras’experimentation is carried out,and the model’s superiority is compared with various advanced approaches for multi-level classification.The proposed model gives better prediction accuracy,precision,recall,and F-measure than other systems like Long Short Term Memory-Recurrent Neural Networks(LSTM-RNN),Stacked Autoencoder with Deep Neural Networks(SAE-DNN),Deep Convolutional Neural Networks(D-CNN),Two Dimensional Convolutional Neural Networks(2D-CNN),Inception-V4,ResNet,and Two Dimensional Convolutional Neural Networks(3D-CNN).展开更多
基金This work was supported by Directorate for Mathematical and Physical Sciences[1924724].
文摘The main goal of this paper is to employ longitudinal trajectories in a significant number of sub-regional brain volumetric MRI data as statistical predictors for Alzheimer's disease(AD)clas-sification.We use logistic regression in a Bayesian framework that includes many functional predictors.The direct sampling of regression Coefficients from the Bayesian logistic model is dif-ficult due to its complicated likelihood function.In high-dimensional scenarios,the selection of predictors is paramount with the introduction of either spike-and-slab priors,non-local priors,or Horseshoe priors.We seek to avoid the complicated Metropolis-Hastings approach and to develop an easily implementable Gibbs sampler.In addition,the Bayesian estimation provides proper estimates of the model parameters,which are also useful for building inference.Another advantage of working with logistic regression is that it calculates the log of odds of relative risk for AD compared to normal control based on the selected longitudinal predictors,rather than simply classifying patients based on cross-sectional estimates.Ultimately,however,we com-bine approaches and use a probability threshold to classify individual patients.We employ 49 functional predictors consisting of volumetric estimates of brain sub-regions,chosen for their established clinical significance.Moreover,the use of spike and slab priors ensures that many redundant predictors are dropped from the model.
基金This work was supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2021R1A2C1011198).
文摘Alzheimer’s disease(AD)is a very complex disease that causes brain failure,then eventually,dementia ensues.It is a global health problem.99%of clinical trials have failed to limit the progression of this disease.The risks and barriers to detecting AD are huge as pathological events begin decades before appearing clinical symptoms.Therapies for AD are likely to be more helpful if the diagnosis is determined early before the final stage of neurological dysfunction.In this regard,the need becomes more urgent for biomarker-based detection.A key issue in understanding AD is the need to solve complex and high-dimensional datasets and heterogeneous biomarkers,such as genetics,magnetic resonance imaging(MRI),cerebrospinal fluid(CSF),and cognitive scores.Establishing an interpretable reasoning system and performing interoperability that achieves in terms of a semantic model is potentially very useful.Thus,our aim in this work is to propose an interpretable approach to detect AD based on Alzheimer’s disease diagnosis ontology(ADDO)and the expression of semantic web rule language(SWRL).This work implements an ontology-based application that exploits three different machine learning models.These models are random forest(RF),JRip,and J48,which have been used along with the voting ensemble.ADNI dataset was used for this study.The proposed classifier’s result with the voting ensemble achieves a higher accuracy of 94.1%and precision of 94.3%.Our approach provides effective inference rules.Besides,it contributes to a real,accurate,and interpretable classifier model based on various AD biomarkers for inferring whether the subject is a normal cognitive(NC),significant memory concern(SMC),early mild cognitive impairment(EMCI),late mild cognitive impairment(LMCI),or AD.
文摘The prediction of mild cognitive impairment or Alzheimer’s disease(AD)has gained the attention of huge researchers as the disease occurrence is increasing,and there is a need for earlier prediction.Regrettably,due to the highdimensionality nature of neural data and the least available samples,modelling an efficient computer diagnostic system is highly solicited.Learning approaches,specifically deep learning approaches,are essential in disease prediction.Deep Learning(DL)approaches are successfully demonstrated for their higher-level performance in various fields like medical imaging.A novel 3D-Convolutional Neural Network(3D-CNN)architecture is proposed to predict AD with Magnetic resonance imaging(MRI)data.The proposed model predicts the AD occurrence while the existing approaches lack prediction accuracy and perform binary classification.The proposed prediction model is validated using the Alzheimer’s disease Neuro-Imaging Initiative(ADNI)data.The outcomes demonstrate that the anticipated model attains superior prediction accuracy and works better than the brain-image dataset’s general approaches.The predicted model reduces the human effort during the prediction process and makes it easier to diagnose it intelligently as the feature learning is adaptive.Keras’experimentation is carried out,and the model’s superiority is compared with various advanced approaches for multi-level classification.The proposed model gives better prediction accuracy,precision,recall,and F-measure than other systems like Long Short Term Memory-Recurrent Neural Networks(LSTM-RNN),Stacked Autoencoder with Deep Neural Networks(SAE-DNN),Deep Convolutional Neural Networks(D-CNN),Two Dimensional Convolutional Neural Networks(2D-CNN),Inception-V4,ResNet,and Two Dimensional Convolutional Neural Networks(3D-CNN).
