Background: There is much interest regarding metal-on-metal implants in medical and general media. Much of this has been regarding failure of specific implant systems and metal ion toxicity. We present our early mid-t...Background: There is much interest regarding metal-on-metal implants in medical and general media. Much of this has been regarding failure of specific implant systems and metal ion toxicity. We present our early mid-term experience of the ADEPT metal-on-metal system which has both modular and non-modular hip options. Methods: Functional assessment, blood metal ion quantification, and radiographic analysis were performed for the modular and non-modular ADEPT variants. Fifty implants were implanted with a mean follow up time of 28 months. Unpaired t-tests were used to compare modular and resurfacing groups, standardised hip scores were used to compare function to conventional total hip arthroplasty. Results: Metal ion levels were significantly higher in modular prostheses compared to resurfacing implants, but not at “harmful” levels (as determined by a previous metal-on-metal implant recall). Functional outcomes were excellent and revision rates were lower than expected. Conclusions: At our institution we have good outcomes with the ADEPT hip prosthesis. Though patient selection and implant position are crucial, poor performance of metal-on-metal hip replacements is implant specific.展开更多
案例客户:ADEPT案例相关行业:航空航天案例相关产品:Autodesk Inventor项目挑战位于南飞的ADEPT Air motive(ADEPT)成立四年后就明确了自己的目标:开发通用航空引擎,获得绝对竞争力。为了实现这一目标,ADEPT决定采用业内最先进的技...案例客户:ADEPT案例相关行业:航空航天案例相关产品:Autodesk Inventor项目挑战位于南飞的ADEPT Air motive(ADEPT)成立四年后就明确了自己的目标:开发通用航空引擎,获得绝对竞争力。为了实现这一目标,ADEPT决定采用业内最先进的技术和流程。但是在南非,航空和工程业规模不大,能获得的补助也非常有限。因此,ADEPT的运营预算颇为紧张。展开更多
The prognostic values of tissue Doppler imaging and color M-mode diastolic indexes were studied in 225 patients who had symptomatic systolic heart failure in the ADEPT study. The primary end point of death, transplant...The prognostic values of tissue Doppler imaging and color M-mode diastolic indexes were studied in 225 patients who had symptomatic systolic heart failure in the ADEPT study. The primary end point of death, transplantation, or hospitalization due to heart failure occurred in 65 patients and was independently predicted by shorter deceleration time, lower ratio of pulmonary vein systolic to diastolic velocity, and increasing levels of the ratios of early transmitral velocity to early annular velocity or velocity of propagation. For the ratio of early transmitral velocity to early annular velocity, this prediction was additive to deceleration time. Newer diastolic indexes provide an independent prediction of clinical outcomes.展开更多
A novel Hybrid Clustering Algonthm (HCA) that incorporates the K-means into the canonical immune programming algorithm is proposed after analyzing the advantages and disadvantages of the classical k-means clustering a...A novel Hybrid Clustering Algonthm (HCA) that incorporates the K-means into the canonical immune programming algorithm is proposed after analyzing the advantages and disadvantages of the classical k-means clustering algorithm in the paper. The theory analyse and experimental results show, the algorithm not only avoids the local optima and is robust to imtialization, but also increases the convergent speed, meanwhile evidently restrains the degenerating phenomenon during the evolutionary process.展开更多
Antibody-directed enzyme prodrug therapy（ADEPT） is a new strategy for the treatment of cancer that has arisen in recent twenty years, the main merits of which are that it can improve the selectivity of anticancer dr...Antibody-directed enzyme prodrug therapy（ADEPT） is a new strategy for the treatment of cancer that has arisen in recent twenty years, the main merits of which are that it can improve the selectivity of anticancer drugs and reduce the side effects in remote tissue. In the present study, two prodrugs-glycosylated aromatic nitrogen mustard derivatives were synthesized. Glucose and lactose were converted into glycosyl donors-trichloroacetimidate; the obtained glycosyl donors were glycosylated with p-nitrophenol （ glycosyl donors） to form β-glucosyl p-nitrobenzene and β-lactosyl p-nitrobenzene that were protected by acetyl in a stereoselective manner; the two products were reduced by zinc dust and then treated with ethylene oxide, afforded two glycosylated nitrogen mustard derivatives that were protected by acetyl; the last step was to deacetylate and then afforded the two target compounds that could be used as prodrugs of ADEPT for further Anti-tumor research.展开更多
文摘Background: There is much interest regarding metal-on-metal implants in medical and general media. Much of this has been regarding failure of specific implant systems and metal ion toxicity. We present our early mid-term experience of the ADEPT metal-on-metal system which has both modular and non-modular hip options. Methods: Functional assessment, blood metal ion quantification, and radiographic analysis were performed for the modular and non-modular ADEPT variants. Fifty implants were implanted with a mean follow up time of 28 months. Unpaired t-tests were used to compare modular and resurfacing groups, standardised hip scores were used to compare function to conventional total hip arthroplasty. Results: Metal ion levels were significantly higher in modular prostheses compared to resurfacing implants, but not at “harmful” levels (as determined by a previous metal-on-metal implant recall). Functional outcomes were excellent and revision rates were lower than expected. Conclusions: At our institution we have good outcomes with the ADEPT hip prosthesis. Though patient selection and implant position are crucial, poor performance of metal-on-metal hip replacements is implant specific.
文摘案例客户:ADEPT案例相关行业:航空航天案例相关产品:Autodesk Inventor项目挑战位于南飞的ADEPT Air motive(ADEPT)成立四年后就明确了自己的目标:开发通用航空引擎,获得绝对竞争力。为了实现这一目标,ADEPT决定采用业内最先进的技术和流程。但是在南非,航空和工程业规模不大,能获得的补助也非常有限。因此,ADEPT的运营预算颇为紧张。
文摘The prognostic values of tissue Doppler imaging and color M-mode diastolic indexes were studied in 225 patients who had symptomatic systolic heart failure in the ADEPT study. The primary end point of death, transplantation, or hospitalization due to heart failure occurred in 65 patients and was independently predicted by shorter deceleration time, lower ratio of pulmonary vein systolic to diastolic velocity, and increasing levels of the ratios of early transmitral velocity to early annular velocity or velocity of propagation. For the ratio of early transmitral velocity to early annular velocity, this prediction was additive to deceleration time. Newer diastolic indexes provide an independent prediction of clinical outcomes.
文摘A novel Hybrid Clustering Algonthm (HCA) that incorporates the K-means into the canonical immune programming algorithm is proposed after analyzing the advantages and disadvantages of the classical k-means clustering algorithm in the paper. The theory analyse and experimental results show, the algorithm not only avoids the local optima and is robust to imtialization, but also increases the convergent speed, meanwhile evidently restrains the degenerating phenomenon during the evolutionary process.
基金Supported by the National Natural Science Foundation of China(No20030708)the Natural Science Foundation of JinlinProrince, P R China(No20050702-4)
文摘Antibody-directed enzyme prodrug therapy（ADEPT） is a new strategy for the treatment of cancer that has arisen in recent twenty years, the main merits of which are that it can improve the selectivity of anticancer drugs and reduce the side effects in remote tissue. In the present study, two prodrugs-glycosylated aromatic nitrogen mustard derivatives were synthesized. Glucose and lactose were converted into glycosyl donors-trichloroacetimidate; the obtained glycosyl donors were glycosylated with p-nitrophenol （ glycosyl donors） to form β-glucosyl p-nitrobenzene and β-lactosyl p-nitrobenzene that were protected by acetyl in a stereoselective manner; the two products were reduced by zinc dust and then treated with ethylene oxide, afforded two glycosylated nitrogen mustard derivatives that were protected by acetyl; the last step was to deacetylate and then afforded the two target compounds that could be used as prodrugs of ADEPT for further Anti-tumor research.
