As a typical in-memory computing hardware design, nonvolatile ternary content-addressable memories(TCAMs) enable the logic operation and data storage for high throughout in parallel big data processing. However,TCAM c...As a typical in-memory computing hardware design, nonvolatile ternary content-addressable memories(TCAMs) enable the logic operation and data storage for high throughout in parallel big data processing. However,TCAM cells based on conventional silicon-based devices suffer from structural complexity and large footprintlimitations. Here, we demonstrate an ultrafast nonvolatile TCAM cell based on the MoTe2/hBN/multilayergraphene (MLG) van der Waals heterostructure using a top-gated partial floating-gate field-effect transistor(PFGFET) architecture. Based on its ambipolar transport properties, the carrier type in the source/drain andcentral channel regions of the MoTe2 channel can be efficiently tuned by the control gate and top gate, respectively,enabling the reconfigurable operation of the device in either memory or FET mode. When working inthe memory mode, it achieves an ultrafast 60 ns programming/erase speed with a current on-off ratio of ∼105,excellent retention capability, and robust endurance. When serving as a reconfigurable transistor, unipolar p-typeand n-type FETs are obtained by adopting ultrafast 60 ns control-gate voltage pulses with different polarities.The monolithic integration of memory and logic within a single device enables the content-addressable memory(CAM) functionality. Finally, by integrating two PFGFETs in parallel, a TCAM cell with a high current ratioof ∼10^(5) between the match and mismatch states is achieved without requiring additional peripheral circuitry.These results provide a promising route for the design of high-performance TCAM devices for future in-memorycomputing applications.展开更多
This paper proposes a content addres sable storage optimization method, VDeskCAS, for desktop virtualization storage based disaster backup storage system. The method implements a blocklevel storage optimization, by em...This paper proposes a content addres sable storage optimization method, VDeskCAS, for desktop virtualization storage based disaster backup storage system. The method implements a blocklevel storage optimization, by employing the algorithms of chunking image file into blocks, the blockffmger calculation and the block dedup li cation. A File system in Use Space （FUSE） based storage process for VDeskCAS is also introduced which optimizes current direct storage to suit our content addressable storage. An interface level modification makes our system easy to extend. Experiments on virtual desktop image files and normal files verify the effectiveness of our method and above 60% storage volume decrease is a chieved for Red Hat Enterprise Linux image files. Key words： disaster backup; desktop virtualization; storage optimization; content addressable storage展开更多
Titanium dioxide (TiO2) thin film was deposited on the surface of the light addressable potentiometric sensor (LAPS) to modify the sensor surface for the non-labeled detection of DNA molecules. To evaluate the effect ...Titanium dioxide (TiO2) thin film was deposited on the surface of the light addressable potentiometric sensor (LAPS) to modify the sensor surface for the non-labeled detection of DNA molecules. To evaluate the effect of ultraviolet (UV) treatment on the silanization level of TiO2 thin film by 3-aminopropyltriethoxysilane (APTS),fluorescein isothiocyanate (FITC) was used to label the amine group on the end of APTS immobilized onto the TiO2 thin film. We found that,with UV irradiation,the silanization level of the irradiated area of the TiO2 film was improved compared with the non-irradiated area under well-controlled conditions. This result indicates that TiO2 can act as a coating material on the biosensor surface to improve the effect and efficiency of the covalent immobilization of biomolecules on the sensor surface. The artificially synthesized probe DNA molecules were covalently linked onto the surface of TiO2 film. The hybridization of probe DNA and target DNA was monitored by the recording of I-V curves that shift along the voltage axis during the process of reaction. A significant LAPS signal can be detected at 10 μmol/L of target DNA sample.展开更多
This paper presents a novel biosensor for bitter substance detection on the basis of light addressable potentiometric sensor(LAPS).Taste receptor cells(TRCs)were used as sensitive elements,which can respond to differe...This paper presents a novel biosensor for bitter substance detection on the basis of light addressable potentiometric sensor(LAPS).Taste receptor cells(TRCs)were used as sensitive elements,which can respond to different bitter stimuli with extreme high sensitivity and speci-ficity.TRCs were isolated from the taste buds of rats and cultured on the surface of LAPS chip.Due to the unique advantages such as single-cell recording,light addressable capability,and noninvasiveness,LAPS chip was used as secondary transducer to monitor the responses of TRCs by recording extracelluar potential changes.The results indicate LAPS chip can effectively record the responses of TRCs to different bitter substances used in this study in a real-time manner for a long-term.In addition,by performing principal component analysis on the LAPS recording data,different bitter substances tested can be successfully discriminated.It is suggested this TRCsLAPS hybrid biosensor could be a valuable tool for bitter substance detection.With further improvement and novel design,it has great potentials to be applied in both basic research and practical applications related to bitter taste detection.展开更多
Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to acc...Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to access the shared cache simultaneously.The main problem in improving memory performance is the shared cache architecture and cache replacement.This paper documents the implementation of a Dual-Port Content Addressable Memory(DPCAM)and a modified Near-Far Access Replacement Algorithm(NFRA),which was previously proposed as a shared L2 cache layer in a multi-core processor.Standard Performance Evaluation Corporation(SPEC)Central Processing Unit(CPU)2006 benchmark workloads are used to evaluate the benefit of the shared L2 cache layer.Results show improved performance of the multicore processor’s DPCAM and NFRA algorithms,corresponding to a higher number of concurrent accesses to shared memory.The new architecture significantly increases system throughput and records performance improvements of up to 8.7%on various types of SPEC 2006 benchmarks.The miss rate is also improved by about 13%,with some exceptions in the sphinx3 and bzip2 benchmarks.These results could open a new window for solving the long-standing problems with shared cache in multi-core processors.展开更多
Multicore systems oftentimes use multiple levels of cache to bridge the gap between processor and memory speed.This paper presents a new design of a dedicated pipeline cache memory for multicore processors called dual...Multicore systems oftentimes use multiple levels of cache to bridge the gap between processor and memory speed.This paper presents a new design of a dedicated pipeline cache memory for multicore processors called dual port content addressable memory(DPCAM).In addition,it proposes a new replacement algorithm based on hardware which is called a near-far access replacement algorithm(NFRA)to reduce the cost overhead of the cache controller and improve the cache access latency.The experimental results indicated that the latency for write and read operations are significantly less in comparison with a set-associative cache memory.Moreover,it was shown that a latency of a read operation is nearly constant regardless of the size of DPCAM.However,an estimation of the power dissipation showed that DPCAM consumes about 7%greater than a set-associative cache memory of the same size.These results encourage for embedding DPCAM within the multicore processors as a small shared cache memory.展开更多
The article mainly studies the application strategy of automatic addressable single-lamp control technology in tunnel lighting.It encompasses an introduction to this technology,an analysis of the tunnel lighting syste...The article mainly studies the application strategy of automatic addressable single-lamp control technology in tunnel lighting.It encompasses an introduction to this technology,an analysis of the tunnel lighting system using automatic addressable single-lamp control technology,and outlines the main development direction for this technology in modern tunnel lighting.The aim is to offer insights that can inform the rational deployment of this technology,thereby enhancing the lighting control effectiveness in modern tunnels and meeting their specific lighting requirements more effectively.展开更多
Content Addressable Memory (CAM) is a type of memory used for high-speed search applications. Due to parallel comparison feature, the CAM memory leads to large power consumption which is caused by frequent pre-charge ...Content Addressable Memory (CAM) is a type of memory used for high-speed search applications. Due to parallel comparison feature, the CAM memory leads to large power consumption which is caused by frequent pre-charge or discharge of match line. In this paper, CAM for automatic charge balancing with self-control mechanism is proposed to control the voltage swing of ML for reducing the power consumption of CAM. Another technique to reduce the power dissipation is to use MSML, it combines the master-slave architecture with charge minimization technique. Unlike the conventional design, only one match line (ML) is used, whereas in Master-Slave Match Line (MSML) one master ML and several slave MLs are used to reduce the power dissipation in CAM caused by match lines (MLs). Theoretically, the match line (ML) reduces the power consumption up to 50% which is independent of search and match case. The simulation results using Cadence tool of MSML show the reduced power consumption in CAM and modified CAM cell.展开更多
We first study the impacts of soft errors on various types of CAM for different feature sizes.After presenting a soft error immune CAM cell,SSB-RCAM,we propose two kinds of reliable CAM,DCF-RCAM and DCK-RCAM. In addit...We first study the impacts of soft errors on various types of CAM for different feature sizes.After presenting a soft error immune CAM cell,SSB-RCAM,we propose two kinds of reliable CAM,DCF-RCAM and DCK-RCAM. In addition,we present an ignore mechanism to protect dual cell redundancy CAMs against soft errors.Experimental results indicate that the 11T-NOR CAM cell has an advantage in soft error immunity.Based on 11T-NOR,the proposed reliable CAMs reduce the SER by about 81%on average with acceptable overheads.The SER of dual cell redundancy CAMs can also be decreased using the ignore mechanism in specific applications.展开更多
For many biomedical and catalytic applications, such as encapsulation of proteins/enzymes in nanopartides （NPs）, it is preferable to have well-dispersed small NPs that are stable in solution and behave quasi-homogen...For many biomedical and catalytic applications, such as encapsulation of proteins/enzymes in nanopartides （NPs）, it is preferable to have well-dispersed small NPs that are stable in solution and behave quasi-homogeneously. However, conventional liquid phase methods for small-NP synthesis and functionalization usually face great difficulties in separation/purification and recycling. In addition, controlling the orientation of proteins inside NPs is also a crucial issue to maximize the activity of the encapsulated proteins. Herein, we report a solid phase method to solve these problems. Using His-tagged proteins as cores, well-dispersed core-sheU silica NPs are facilely synthesized and functionalized in a column. The core His-tagged proteins are kept bound on the surface of the resIn beads in the column during the entire process, making the separation/purification of NPs and their precursors during the multiple-step process as simple as a few-minutes procedure of draining and washing the column. Each obtained silica NP has an adjustable eccentric core-shell structure with only one His-tag sticking out of the particle. This single His-tag on the surface of each NP not only makes it easy for addressable and stoichiometric functionalization of the NP but also provides an easy way to reversibly assemble NPs into dimers or be oriented on the surface of large particles. Notably, this solid phase approach also provides a versatile means to control the orientation of proteins inside NPs, and the His-tag makes it easy to recycle those well-dispersed small NPs.展开更多
Content addressable memory （CAM） is widely used and its tests mostly use functional fault models. However, functional fault models cannot describe some physical faults exactly. This paper introduces physical fault m...Content addressable memory （CAM） is widely used and its tests mostly use functional fault models. However, functional fault models cannot describe some physical faults exactly. This paper introduces physical fault models for write-only CAM. Two test algorithms which can cover 100% targeted physical faults are also proposed. The algorithm for a CAM module with N-bit match output signal needs only 2N＋2L＋4 comparison operations and 5N writing operations, where N is the number of words and L is the word length. The algorithm for a HIT-signal-only CAM module uses 2N＋2L＋5 comparison operations and 8N writing operations. Compared to previous work, the proposed algorithms can test more physical faults with a few more operations. An experiment on a test chip shows the effectiveness and efficiency of the proposed physical fault models and algorithms.展开更多
1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconn...1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.展开更多
The year 2025 marks both the 25th anniversary of the Forum on China-Africa Cooperation(FOCAC)and the first year of implementation of the outcomes of the 2024 FOCAC Beijing Summit.Throughout the year,China has supporte...The year 2025 marks both the 25th anniversary of the Forum on China-Africa Cooperation(FOCAC)and the first year of implementation of the outcomes of the 2024 FOCAC Beijing Summit.Throughout the year,China has supported Africa in addressing historical injustices at diplomatic and political levels and firmly backed South Africa in hosting the G20 Leaders’Summit,further deepening China-Africa strategic mutual trust.展开更多
On the occasion of the New Year,I would like to extend my sincere gratitude and New Year greetings to the experts,scholars,author teams,and readers who have long supported the development of Animal Models and Experime...On the occasion of the New Year,I would like to extend my sincere gratitude and New Year greetings to the experts,scholars,author teams,and readers who have long supported the development of Animal Models and Experimental Medicine(AMEM).Over the past year,we have faced challenges together and achieved breakthroughs in academic influence,internationalization,and fulfilling social respon-sibilities.Looking ahead,we are filled with confidence as we strive to build an important bridge connecting laboratory animal science and technology with academic research.展开更多
在分析现有P2P(peer to peer)路由算法的基础上,提出了一种基于二阶矩定位、支持多维资源数据描述的高效资源路由算法——FAN(flabellate addressable network)路由算法.FAN算法将节点映射到统一的多维笛卡尔空间,并以节点相对空间原点...在分析现有P2P(peer to peer)路由算法的基础上,提出了一种基于二阶矩定位、支持多维资源数据描述的高效资源路由算法——FAN(flabellate addressable network)路由算法.FAN算法将节点映射到统一的多维笛卡尔空间,并以节点相对空间原点的二阶矩作为子空间管理和资源搜索的依据.FAN路由算法具有O(log(N/k))的高路由效率,在节点加入和退出FAN网络时,更新路由信息的代价为O(klog(N/k)).实验结果表明,FAN路由算法具有路由效率高、维护代价小的优点,是一种P2P环境中支持多维资源数据描述的高效结构化资源路由算法.而且,目前部分基于CAN(content-addressable network)网络的改进算法也可以在FAN网络中适用,并获得更好的路由效率和更低的维护代价.展开更多
This study explores the variations in address forms within the Tinghu dialect of Yancheng city.The findings reveal that the ways individuals address one another in this region deviate from the established principles o...This study explores the variations in address forms within the Tinghu dialect of Yancheng city.The findings reveal that the ways individuals address one another in this region deviate from the established principles of tone sandhi theory.In Chinese phonology,it is generally assumed that individual characters serve as fundamental forms based on their standard pronunciations,with real-time pronunciations adapting to phonetic conditions.However,the study of address forms has not traditionally been integrated into this framework.Observations indicate that a wide range of addressing methods is employed in social interactions,reflecting the complexity of regional cultural traits and social dynamics.This research highlights the distinctive features of address forms in the Tinghu dialect,particularly in terms of tone sandhi,vocative expressions,and indirect address.By examining these unique characteristics,the study enhances our understanding of the principles governing tonal changes in Chinese.Furthermore,it offers valuable insights into the preservation and inheritance of regional dialects.展开更多
High-performance, large-area optical gratings for applications like chirped pulse amplification, gravitational wave astronomy, and X-ray optics require sub-nanometer line placement control over several cm^(2). Electro...High-performance, large-area optical gratings for applications like chirped pulse amplification, gravitational wave astronomy, and X-ray optics require sub-nanometer line placement control over several cm^(2). Electron beam lithography with a variable shaped beam(VSB) is well suited but limited by tool-dependent address grid discretization. We adapted address grid interpolation to the VSB method, reducing the effective placement grid to 25 pm, as confirmed by stray light measurements.展开更多
Archroma,a global leader in specialty chemicals fo-cused on sustainable solutions,has supported the Institute of ChemicalTechnology(ICT),Mumbai,lndia in the renova-tion and development of a sustainable laboratory faci...Archroma,a global leader in specialty chemicals fo-cused on sustainable solutions,has supported the Institute of ChemicalTechnology(ICT),Mumbai,lndia in the renova-tion and development of a sustainable laboratory facility as part of its Corporate Social Responsibility(CSR)program.The upgraded facility will strengthen the department's capacity to conduct fundamental research and develop future-oriented technologies in textile processing,manufac-turing,and effluent treatment.It is designed to help address current industrial challenges while encouraging innovation in sustainable and resource-efficient textile technologies.展开更多
基金supported by the National Key Research&Development Projects of China(Grant No.2022YFA1204100)National Natural Science Foundation of China(Grant No.62488201)+1 种基金CAS Project for Young Scientists in Basic Research(YSBR-003)the Innovation Program of Quantum Science and Technology(2021ZD0302700)。
文摘As a typical in-memory computing hardware design, nonvolatile ternary content-addressable memories(TCAMs) enable the logic operation and data storage for high throughout in parallel big data processing. However,TCAM cells based on conventional silicon-based devices suffer from structural complexity and large footprintlimitations. Here, we demonstrate an ultrafast nonvolatile TCAM cell based on the MoTe2/hBN/multilayergraphene (MLG) van der Waals heterostructure using a top-gated partial floating-gate field-effect transistor(PFGFET) architecture. Based on its ambipolar transport properties, the carrier type in the source/drain andcentral channel regions of the MoTe2 channel can be efficiently tuned by the control gate and top gate, respectively,enabling the reconfigurable operation of the device in either memory or FET mode. When working inthe memory mode, it achieves an ultrafast 60 ns programming/erase speed with a current on-off ratio of ∼105,excellent retention capability, and robust endurance. When serving as a reconfigurable transistor, unipolar p-typeand n-type FETs are obtained by adopting ultrafast 60 ns control-gate voltage pulses with different polarities.The monolithic integration of memory and logic within a single device enables the content-addressable memory(CAM) functionality. Finally, by integrating two PFGFETs in parallel, a TCAM cell with a high current ratioof ∼10^(5) between the match and mismatch states is achieved without requiring additional peripheral circuitry.These results provide a promising route for the design of high-performance TCAM devices for future in-memorycomputing applications.
基金the Hi-tech Research and Development Program of China，the National Natural Science Foundation of China，the Beijing Natural Science Foundation，the Fundamental Research Funds for the Central Universities，the Fund of the State Key Laboratory of Software Development Environment
文摘This paper proposes a content addres sable storage optimization method, VDeskCAS, for desktop virtualization storage based disaster backup storage system. The method implements a blocklevel storage optimization, by employing the algorithms of chunking image file into blocks, the blockffmger calculation and the block dedup li cation. A File system in Use Space （FUSE） based storage process for VDeskCAS is also introduced which optimizes current direct storage to suit our content addressable storage. An interface level modification makes our system easy to extend. Experiments on virtual desktop image files and normal files verify the effectiveness of our method and above 60% storage volume decrease is a chieved for Red Hat Enterprise Linux image files. Key words： disaster backup; desktop virtualization; storage optimization; content addressable storage
基金Project supported by the National Natural Science Foundation of China (Nos. 30627002 and 60725102)the Interdisciplinary Research Foundation of Zhejiang University (No. 2009-15), China
文摘Titanium dioxide (TiO2) thin film was deposited on the surface of the light addressable potentiometric sensor (LAPS) to modify the sensor surface for the non-labeled detection of DNA molecules. To evaluate the effect of ultraviolet (UV) treatment on the silanization level of TiO2 thin film by 3-aminopropyltriethoxysilane (APTS),fluorescein isothiocyanate (FITC) was used to label the amine group on the end of APTS immobilized onto the TiO2 thin film. We found that,with UV irradiation,the silanization level of the irradiated area of the TiO2 film was improved compared with the non-irradiated area under well-controlled conditions. This result indicates that TiO2 can act as a coating material on the biosensor surface to improve the effect and efficiency of the covalent immobilization of biomolecules on the sensor surface. The artificially synthesized probe DNA molecules were covalently linked onto the surface of TiO2 film. The hybridization of probe DNA and target DNA was monitored by the recording of I-V curves that shift along the voltage axis during the process of reaction. A significant LAPS signal can be detected at 10 μmol/L of target DNA sample.
基金This work was supported by the grants from the National Natural Science Foundation of China(Grant Nos.60725102,31000448)the China Postdoctoral Science Foundation(Grant Nos.20100471737,201104734)the Key Project of Zhejiang Province(Grant No.2010C14006).
文摘This paper presents a novel biosensor for bitter substance detection on the basis of light addressable potentiometric sensor(LAPS).Taste receptor cells(TRCs)were used as sensitive elements,which can respond to different bitter stimuli with extreme high sensitivity and speci-ficity.TRCs were isolated from the taste buds of rats and cultured on the surface of LAPS chip.Due to the unique advantages such as single-cell recording,light addressable capability,and noninvasiveness,LAPS chip was used as secondary transducer to monitor the responses of TRCs by recording extracelluar potential changes.The results indicate LAPS chip can effectively record the responses of TRCs to different bitter substances used in this study in a real-time manner for a long-term.In addition,by performing principal component analysis on the LAPS recording data,different bitter substances tested can be successfully discriminated.It is suggested this TRCsLAPS hybrid biosensor could be a valuable tool for bitter substance detection.With further improvement and novel design,it has great potentials to be applied in both basic research and practical applications related to bitter taste detection.
文摘Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to access the shared cache simultaneously.The main problem in improving memory performance is the shared cache architecture and cache replacement.This paper documents the implementation of a Dual-Port Content Addressable Memory(DPCAM)and a modified Near-Far Access Replacement Algorithm(NFRA),which was previously proposed as a shared L2 cache layer in a multi-core processor.Standard Performance Evaluation Corporation(SPEC)Central Processing Unit(CPU)2006 benchmark workloads are used to evaluate the benefit of the shared L2 cache layer.Results show improved performance of the multicore processor’s DPCAM and NFRA algorithms,corresponding to a higher number of concurrent accesses to shared memory.The new architecture significantly increases system throughput and records performance improvements of up to 8.7%on various types of SPEC 2006 benchmarks.The miss rate is also improved by about 13%,with some exceptions in the sphinx3 and bzip2 benchmarks.These results could open a new window for solving the long-standing problems with shared cache in multi-core processors.
文摘Multicore systems oftentimes use multiple levels of cache to bridge the gap between processor and memory speed.This paper presents a new design of a dedicated pipeline cache memory for multicore processors called dual port content addressable memory(DPCAM).In addition,it proposes a new replacement algorithm based on hardware which is called a near-far access replacement algorithm(NFRA)to reduce the cost overhead of the cache controller and improve the cache access latency.The experimental results indicated that the latency for write and read operations are significantly less in comparison with a set-associative cache memory.Moreover,it was shown that a latency of a read operation is nearly constant regardless of the size of DPCAM.However,an estimation of the power dissipation showed that DPCAM consumes about 7%greater than a set-associative cache memory of the same size.These results encourage for embedding DPCAM within the multicore processors as a small shared cache memory.
文摘The article mainly studies the application strategy of automatic addressable single-lamp control technology in tunnel lighting.It encompasses an introduction to this technology,an analysis of the tunnel lighting system using automatic addressable single-lamp control technology,and outlines the main development direction for this technology in modern tunnel lighting.The aim is to offer insights that can inform the rational deployment of this technology,thereby enhancing the lighting control effectiveness in modern tunnels and meeting their specific lighting requirements more effectively.
文摘Content Addressable Memory (CAM) is a type of memory used for high-speed search applications. Due to parallel comparison feature, the CAM memory leads to large power consumption which is caused by frequent pre-charge or discharge of match line. In this paper, CAM for automatic charge balancing with self-control mechanism is proposed to control the voltage swing of ML for reducing the power consumption of CAM. Another technique to reduce the power dissipation is to use MSML, it combines the master-slave architecture with charge minimization technique. Unlike the conventional design, only one match line (ML) is used, whereas in Master-Slave Match Line (MSML) one master ML and several slave MLs are used to reduce the power dissipation in CAM caused by match lines (MLs). Theoretically, the match line (ML) reduces the power consumption up to 50% which is independent of search and match case. The simulation results using Cadence tool of MSML show the reduced power consumption in CAM and modified CAM cell.
基金supported by the National Natural Science Foundation of China(No.60703074)the National High-Tech Research and Development Program of China(No.2009AA01Z124)
文摘We first study the impacts of soft errors on various types of CAM for different feature sizes.After presenting a soft error immune CAM cell,SSB-RCAM,we propose two kinds of reliable CAM,DCF-RCAM and DCK-RCAM. In addition,we present an ignore mechanism to protect dual cell redundancy CAMs against soft errors.Experimental results indicate that the 11T-NOR CAM cell has an advantage in soft error immunity.Based on 11T-NOR,the proposed reliable CAMs reduce the SER by about 81%on average with acceptable overheads.The SER of dual cell redundancy CAMs can also be decreased using the ignore mechanism in specific applications.
基金This work was supported by the National Natural Science Foundation of China （NSFC） （Nos. 21371117 and 31571024） and the National Basic Research Program of China （No. 2016YFA0201602）.
文摘For many biomedical and catalytic applications, such as encapsulation of proteins/enzymes in nanopartides （NPs）, it is preferable to have well-dispersed small NPs that are stable in solution and behave quasi-homogeneously. However, conventional liquid phase methods for small-NP synthesis and functionalization usually face great difficulties in separation/purification and recycling. In addition, controlling the orientation of proteins inside NPs is also a crucial issue to maximize the activity of the encapsulated proteins. Herein, we report a solid phase method to solve these problems. Using His-tagged proteins as cores, well-dispersed core-sheU silica NPs are facilely synthesized and functionalized in a column. The core His-tagged proteins are kept bound on the surface of the resIn beads in the column during the entire process, making the separation/purification of NPs and their precursors during the multiple-step process as simple as a few-minutes procedure of draining and washing the column. Each obtained silica NP has an adjustable eccentric core-shell structure with only one His-tag sticking out of the particle. This single His-tag on the surface of each NP not only makes it easy for addressable and stoichiometric functionalization of the NP but also provides an easy way to reversibly assemble NPs into dimers or be oriented on the surface of large particles. Notably, this solid phase approach also provides a versatile means to control the orientation of proteins inside NPs, and the His-tag makes it easy to recycle those well-dispersed small NPs.
基金supported by the National Natural Science Foundation of China (No.60603049)the National High Technology Research and Development Program of China (Nos.2008AA110901,2007AA01Z112,2009AA01Z125)+1 种基金the State Key Development Program for Basic Research of China (No.2005CB321600)the Beijing Natural Science Foundation (No.4072024)
文摘Content addressable memory （CAM） is widely used and its tests mostly use functional fault models. However, functional fault models cannot describe some physical faults exactly. This paper introduces physical fault models for write-only CAM. Two test algorithms which can cover 100% targeted physical faults are also proposed. The algorithm for a CAM module with N-bit match output signal needs only 2N＋2L＋4 comparison operations and 5N writing operations, where N is the number of words and L is the word length. The algorithm for a HIT-signal-only CAM module uses 2N＋2L＋5 comparison operations and 8N writing operations. Compared to previous work, the proposed algorithms can test more physical faults with a few more operations. An experiment on a test chip shows the effectiveness and efficiency of the proposed physical fault models and algorithms.
文摘1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.
文摘The year 2025 marks both the 25th anniversary of the Forum on China-Africa Cooperation(FOCAC)and the first year of implementation of the outcomes of the 2024 FOCAC Beijing Summit.Throughout the year,China has supported Africa in addressing historical injustices at diplomatic and political levels and firmly backed South Africa in hosting the G20 Leaders’Summit,further deepening China-Africa strategic mutual trust.
文摘On the occasion of the New Year,I would like to extend my sincere gratitude and New Year greetings to the experts,scholars,author teams,and readers who have long supported the development of Animal Models and Experimental Medicine(AMEM).Over the past year,we have faced challenges together and achieved breakthroughs in academic influence,internationalization,and fulfilling social respon-sibilities.Looking ahead,we are filled with confidence as we strive to build an important bridge connecting laboratory animal science and technology with academic research.
文摘This study explores the variations in address forms within the Tinghu dialect of Yancheng city.The findings reveal that the ways individuals address one another in this region deviate from the established principles of tone sandhi theory.In Chinese phonology,it is generally assumed that individual characters serve as fundamental forms based on their standard pronunciations,with real-time pronunciations adapting to phonetic conditions.However,the study of address forms has not traditionally been integrated into this framework.Observations indicate that a wide range of addressing methods is employed in social interactions,reflecting the complexity of regional cultural traits and social dynamics.This research highlights the distinctive features of address forms in the Tinghu dialect,particularly in terms of tone sandhi,vocative expressions,and indirect address.By examining these unique characteristics,the study enhances our understanding of the principles governing tonal changes in Chinese.Furthermore,it offers valuable insights into the preservation and inheritance of regional dialects.
基金Bundesministerium für Bildung und Forschung(03Z1H534, 13N16028)Deutsche Forschungsgemeinschaft(448663633, 455425131)。
文摘High-performance, large-area optical gratings for applications like chirped pulse amplification, gravitational wave astronomy, and X-ray optics require sub-nanometer line placement control over several cm^(2). Electron beam lithography with a variable shaped beam(VSB) is well suited but limited by tool-dependent address grid discretization. We adapted address grid interpolation to the VSB method, reducing the effective placement grid to 25 pm, as confirmed by stray light measurements.
文摘Archroma,a global leader in specialty chemicals fo-cused on sustainable solutions,has supported the Institute of ChemicalTechnology(ICT),Mumbai,lndia in the renova-tion and development of a sustainable laboratory facility as part of its Corporate Social Responsibility(CSR)program.The upgraded facility will strengthen the department's capacity to conduct fundamental research and develop future-oriented technologies in textile processing,manufac-turing,and effluent treatment.It is designed to help address current industrial challenges while encouraging innovation in sustainable and resource-efficient textile technologies.
