Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.展开更多
Tel Ad办公空间坐落于以色列卡法萨巴一栋翻新建筑内。因自然采光条件有限,设计团队引入中央人工照明中庭,重塑空间流线,并通过材料运用,明确空间界定与功能分区。该中庭既是空间锚点,亦是氛围焦点。鉴于建筑进深较大,难以持续获取自然...Tel Ad办公空间坐落于以色列卡法萨巴一栋翻新建筑内。因自然采光条件有限,设计团队引入中央人工照明中庭,重塑空间流线,并通过材料运用,明确空间界定与功能分区。该中庭既是空间锚点,亦是氛围焦点。鉴于建筑进深较大,难以持续获取自然光线,中庭采用全光谱农业照明系统,以确保绿植全年茂盛生长。同时,空间流线也经重新设计,形成环绕绿色核心的环形路径,既确保了与绿植的持续视觉联系,又使各工作区域间的流线直观且流畅。除满足空间功能需求外,中庭在提升员工福祉与工作效率方面亦扮演关键角色:研究显示,相较于传统无窗办公环境,接触绿植及动态照明等自然元素,可有效降低压力、增强专注力并缓解视疲劳。室内统一采用水磨石地面、不锈钢装饰及天然木饰面,实现了整体空间的连贯性。展开更多
文摘Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.
