This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors inf...This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors influencing return to work,and current research problems and development trends,to provide scientific evidence for psychological rehabilitation and social function recovery of young and middle-aged ACS patients.展开更多
Most research on carbon storage in forests has focused on qualitative studies of carbon storage and influ-encing factors rather than on quantifying the effect of the spatial distribution of carbon storage and of its i...Most research on carbon storage in forests has focused on qualitative studies of carbon storage and influ-encing factors rather than on quantifying the effect of the spatial distribution of carbon storage and of its influencing factors at different scales.Here we described the spatial dis-tribution of aboveground carbon storage(ACS)in a 20-ha plot in a subtropical evergreen broad-leaved forest to evalu-ate and quantify the relative effects of biotic factors(species diversity and structural diversity)and abiotic factors(soil and topographic factors)on ACS at different scales.Scale effects of the spatial distribution of ACS were significant,with higher variability at smaller scales,but less at larger scales.The distribution was also spatially heterogeneous,with more carbon storage on north-and east-facing slopes than on south-and west-facing slopes.At a smaller scale,species diversity and structural diversity each had a direct positive impact on ACS,but soil factors had no significant direct impact.At increasing scales,topographic and soil fac-tors gradually had a greater direct influence,whereas the influence of species diversity gradually decreased.Structural diversity had the greatest impact,followed by topographic factors and soil factors,while species diversity had a rela-tively smaller impact.These findings suggest studies on ACS in subtropical evergreen broadleaf forests in southern China should consider scale effects,specifically on the heterogene-ity of ACS distribution at small scales.Studies and conser-vation efforts need to focus on smaller habitat types with particular emphasis on habitat factors such as aspect and soil conditions,which have significant influences on community species diversity,structural diversity,and ACS distribution.展开更多
Recent clinical trials have demonstrated a protective effect in using traditional Chinese medicine Tongxinluo(TXL)capsule to treat atherosclerosis.However,clinical evidence of the effects of TXL treatment on coronary ...Recent clinical trials have demonstrated a protective effect in using traditional Chinese medicine Tongxinluo(TXL)capsule to treat atherosclerosis.However,clinical evidence of the effects of TXL treatment on coronary plaque vulnerability is unavailable.In response,we developed this study to investigate the hypothesis that on the basis of statin therapy,treatment with TXL capsule may stabilize coronary lesions in patients with acute coronary syndrome(ACS).The TXL-CAP study was an investigator-initiated,randomized,double-blind clinical trial conducted across 18 medical centers in China.Patients with ACS aging from 18 to 80 years old who had a non-intervened coronary target lesion with a fibrous cap thickness(FCT)<100μm and lipid arc>90°as defined by optical coherence tomography(OCT)were recruited.A total of 220 patients who met the selection criteria but did not meet the exclusion criteria will be finally recruited and randomized to receive treatment with TXL(n=110)or placebo(n=110)for a duration of 12 months.The primary endpoint was the difference in the minimum FCT of the coronary target lesion between TXL and placebo groups at the end of the 12-month follow-up.Secondary endpoints included:(1)changes of the maximum lipid arc and length of the target plaque,and the percentage of lipid,fibrous,and calcified plaques at the end of the12-month period;(2)the incidence of composite cardiovascular events and coronary revascularization within the 12 months;(3)changes in the grade and scores of the angina pectoris as assessed using the Canadian Cardiovascular Society(CCS)grading system and Seattle angina questionnaire(SAQ)score,respectively;and(4)changes in hs-CRP serum levels.The results of the TXLCAP trial will provide additional clinical data for revealing whether TXL capsules stabilizes coronary vulnerable plaques in Chinese ACS patients.展开更多
基金Supported by Humanities and Social Sciences Project of Hubei Provincial Department of Education(22Q149&19Y090).
文摘This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors influencing return to work,and current research problems and development trends,to provide scientific evidence for psychological rehabilitation and social function recovery of young and middle-aged ACS patients.
基金supported by the Guangxi Natural Science Foundation Program(2022GXNSFAA035583,2021GXNSFBA196052)the National Natural Science Foundation of China(32060305,32460270).
文摘Most research on carbon storage in forests has focused on qualitative studies of carbon storage and influ-encing factors rather than on quantifying the effect of the spatial distribution of carbon storage and of its influencing factors at different scales.Here we described the spatial dis-tribution of aboveground carbon storage(ACS)in a 20-ha plot in a subtropical evergreen broad-leaved forest to evalu-ate and quantify the relative effects of biotic factors(species diversity and structural diversity)and abiotic factors(soil and topographic factors)on ACS at different scales.Scale effects of the spatial distribution of ACS were significant,with higher variability at smaller scales,but less at larger scales.The distribution was also spatially heterogeneous,with more carbon storage on north-and east-facing slopes than on south-and west-facing slopes.At a smaller scale,species diversity and structural diversity each had a direct positive impact on ACS,but soil factors had no significant direct impact.At increasing scales,topographic and soil fac-tors gradually had a greater direct influence,whereas the influence of species diversity gradually decreased.Structural diversity had the greatest impact,followed by topographic factors and soil factors,while species diversity had a rela-tively smaller impact.These findings suggest studies on ACS in subtropical evergreen broadleaf forests in southern China should consider scale effects,specifically on the heterogene-ity of ACS distribution at small scales.Studies and conser-vation efforts need to focus on smaller habitat types with particular emphasis on habitat factors such as aspect and soil conditions,which have significant influences on community species diversity,structural diversity,and ACS distribution.
基金National Key Research and Development Program of China(2017YFC1700502)Ministry of Science and Technology of China。
文摘Recent clinical trials have demonstrated a protective effect in using traditional Chinese medicine Tongxinluo(TXL)capsule to treat atherosclerosis.However,clinical evidence of the effects of TXL treatment on coronary plaque vulnerability is unavailable.In response,we developed this study to investigate the hypothesis that on the basis of statin therapy,treatment with TXL capsule may stabilize coronary lesions in patients with acute coronary syndrome(ACS).The TXL-CAP study was an investigator-initiated,randomized,double-blind clinical trial conducted across 18 medical centers in China.Patients with ACS aging from 18 to 80 years old who had a non-intervened coronary target lesion with a fibrous cap thickness(FCT)<100μm and lipid arc>90°as defined by optical coherence tomography(OCT)were recruited.A total of 220 patients who met the selection criteria but did not meet the exclusion criteria will be finally recruited and randomized to receive treatment with TXL(n=110)or placebo(n=110)for a duration of 12 months.The primary endpoint was the difference in the minimum FCT of the coronary target lesion between TXL and placebo groups at the end of the 12-month follow-up.Secondary endpoints included:(1)changes of the maximum lipid arc and length of the target plaque,and the percentage of lipid,fibrous,and calcified plaques at the end of the12-month period;(2)the incidence of composite cardiovascular events and coronary revascularization within the 12 months;(3)changes in the grade and scores of the angina pectoris as assessed using the Canadian Cardiovascular Society(CCS)grading system and Seattle angina questionnaire(SAQ)score,respectively;and(4)changes in hs-CRP serum levels.The results of the TXLCAP trial will provide additional clinical data for revealing whether TXL capsules stabilizes coronary vulnerable plaques in Chinese ACS patients.
