在信息网络高速发展的今天，网络安全无疑成为信息化的热点。然而，在构建信息网络安全堡垒的众多产品、方案背后，是更多的高校、科研机构和企业实验室的基础研究工作。因而，信息安全领域理论层面的国际化交流随之变得越发重要。由国...在信息网络高速发展的今天，网络安全无疑成为信息化的热点。然而，在构建信息网络安全堡垒的众多产品、方案背后，是更多的高校、科研机构和企业实验室的基础研究工作。因而，信息安全领域理论层面的国际化交流随之变得越发重要。由国际密码和信息安全协会(International Cryptograph and Information展开更多
[Objectives]This study was conducted to investigate the antibacterial effect of a self-designed acne-relieving Chinese herbal formula and prepare a kind of acne-removing soap according to the antibacterial effect.[Met...[Objectives]This study was conducted to investigate the antibacterial effect of a self-designed acne-relieving Chinese herbal formula and prepare a kind of acne-removing soap according to the antibacterial effect.[Methods]Chinese herbs Lonicera japonica,Taraxacum mongolicum,Scutellaria baicalensis,Angelica dahurica,Centella asiatica and Aloe vera,were decocted with water,and the antibacterial effects on Staphylococcus aureus,Staphylococcus albus,Candida albicans and Propionibacterium acnei were tested by inhibition zone experiments.The soap base was prepared by saponification of coconut oil,palm oil,hazelnut oil and sodium hydroxide,and then the herbal liquid was added into the soap.[Results]The liquid had bacteriostatic effect on S.aureus,S.albus and P.acnes,but no inhibitory effect on C.albicans.The best bacteriostatic effect on S.aureus and S.albus was achieved at 330 mg/ml,and the best bacteriostatic effect on P.acnes was at 160 mg/ml.[Conclusions]The Chinese herbal formula has antibacterial effect.The handmade soap made from the Chinese herbal formula has the characteristics of smooth surface,moderate hardness,fine texture,rich foam and fresh smell.展开更多
Acne vulgaris is one of the most common skin disorders affecting millions of patients worldwide,its long-lasting inflammation greatly reduces life quality and causes negative psychosocial impacts.Conventional treatmen...Acne vulgaris is one of the most common skin disorders affecting millions of patients worldwide,its long-lasting inflammation greatly reduces life quality and causes negative psychosocial impacts.Conventional treatments often along with side effects and issues of patient compliance,and ineffective in treating severe conditions.In recent years,microneedle(MN)has emerged as a versatile therapeutic technology,owing to its minimally invasive,effective,and reduced side effects.However,there are few review articles that systematically summarize the progress of microneedles for the treatment of acne.Here conclude the material,function,and application of microneedle technology in the treatment of acne,with a particular focus on two types of anti-acne microneedle:drug-loaded microneedle(DMN)and radio-frequency microneedle(RMN).DMN facilitates targeted drug delivery to the skin's deeper layers,while RMN utilizes radio-frequency currents to stimulate collagen regeneration,thus addressing acne scarring.Additionally,future directions for advanced acne-treating microneedle technology are envisioned,such as diversified drug loading,multi-functionality,production process optimization,and personalized treatment.These different directions are expected to further enhance the safety,efficacy,and patient satisfaction of microneedle acne treatments.展开更多
To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm format...To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining,and then 60 effective volunteers were selected for the efficacy measurement of topical acne elimination combinations+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers’facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the combination can inhibit the formation of P.acnes biofilm and will not completely kill P.acnes and will not disrupt the micro-ecological balance of the skin;3%and 5%acne combinations can reduce the biofilm of P.acnes by 61.3%and 61.6%respectively;after 4 weeks of continuous use,the area of acne lesions of the samples with 5%acne combinations decreased by 54.61%and the colour of acne lesions decreased by 54.61%compared with the area of acne lesions before the use of the combination.54.61%,acne lesion colour a^(*)decreased by 13.74%,and the subjects’self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The acne combination can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.展开更多
Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide ...Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide a comprehensive analysis of truncal acne,identifying its characteristics and exploring assessment methods and management of truncal acne.Methods:The study examines the causes and contributing factors of truncal acne by analyzing the skin characteristics and acne phenotypes of the trunk area.It also evaluates the existing methods for assessing the severity of truncal acne.Results:Trunk sebum secretion and pH levels are lower than those of the face,while the degree of microbial imbalance is greater.Variability in androgen levels and gender differences also influence truncal acne.Additionally,contact with certain materials exacerbates acne outbreaks on the trunk.The study highlights the advantages,disadvantages,mechanisms of action,and specific targets of each product.Conclusion:This paper provides insights for future research and practical approaches to truncal acne management,assisting in selecting effective products for managing truncal acne.展开更多
Cutibacterium acnes were used to induce lipase production,and to establish ex-vivo skin model of inflammatory response and post-inflammatory hyperpigmentation,in purpose of exploring the mechanism of chamomilla recuti...Cutibacterium acnes were used to induce lipase production,and to establish ex-vivo skin model of inflammatory response and post-inflammatory hyperpigmentation,in purpose of exploring the mechanism of chamomilla recutita extract.Clinical study was designed to investigate the effects of chamomilla recutita extract on Chinese volunteers with sequelae of adult acne,by evaluating the severity of acne,post-acne erythema and pigmentation,skin basic physiological conditions.The results showed that chamomilla recutita extract inhibited lipase activity,cellular inflammatory response,and melanin production.In the clinical study,the acnes were relieved 173%,with a 78%lower post-acne erythema index and 202%less hyperpigmentation as compared to placebo,after applying samples containing 1%chamomilla recutita extract for 28 days.Meanwhile,chamomilla recutita extract showed instant oil control effect.The extract significantly reduced sebum secretion by 293%,increased skin moisture content by 102%,and strengthened the skin barrier by 193%after 28 days application,which provided favorable skin physiological basis for the prevention and improvement of acne vulgaris and sequelae.展开更多
Background:Acne vulgaris is a common skin disorder that impacts quality of life.Both acne and menstrual symptoms share a hormonal pathogenesis,often linked to hormonal imbalances in women.This suggests a relationship ...Background:Acne vulgaris is a common skin disorder that impacts quality of life.Both acne and menstrual symptoms share a hormonal pathogenesis,often linked to hormonal imbalances in women.This suggests a relationship between acne counts and the various phases of the menstrual cycle.Objective:In this study,we aimed to assess the relationship between acne counts and the menstrual cycle in healthy young Indian women suffering from mild to moderate acne.The objective was to further understand the role of the various phases of the menstrual cycle in acne flares.Methods:This study explores the data from two(2)previously conducted clinical trials.The studies originally aimed to evaluate the efficacy of topical creams in the reduction of acne lesion count on the face.The data from these studies were retrieved and compiled.The number of days between the last menstrual period(LMP)and the actual day of the visit was calculated and regrouped as follows:1–7 days(early to mid-follicular phase),8–15 days(mid-to late follicular phase),16–24 days(post-ovulation to early luteal phase)and>24 days(mid-to late luteal phase).Subsequently,the global acne count—recorded by the dermatologist as part of the study procedures—was cross-tabulated with these menstrual phases using measures of central tendency and dispersion,followed by inferential analyses to evaluate differences between groups.Results:On average,the female subjects visiting the centre during the end of their luteal phase or bleeding days had higher acne counts(p=0.032).This effect was statistically significant only at the baseline visit,which followed a 14-day washout period involving the use of a neutral cleanser and adoption of a general skincare routine.During the product use phase,the effect of the menstrual cycle diminished.Conclusion:The study demonstrates an association between acne flares and the menstrual cycle:acne counts are likely to be higher by an average of 5–6 units during the late luteal and early follicular phases.Such differences may impact the outcome of clinical trials if not carefully monitored and accounted for in study designs and data analysis.展开更多
BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome,a rare inflammatory disease,was described in 1987 by Chamot et al,who identified its common characteristics and transitional forms through ...BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome,a rare inflammatory disease,was described in 1987 by Chamot et al,who identified its common characteristics and transitional forms through case reports.The inci-dence rate is now 1 in 10000 among Caucasians and 0.00144 in 10000 among Japanese.Pneumothorax occurs when gas enters the pleural cavity,typically due to lung disease or chest trauma,and is characterized as either spontaneous or traumatic.Spontaneous pneumothorax is commonly linked to congenital lung tissue abnormalities or lung conditions,such as ruptured pulmonary bullae,emphysema,and bronchial asthma.Respiratory involvement in SAPHO syn-drome has historically been noted.CASE SUMMARY We present the case of a 44-year-old male patient who had previously been diagnosed with SAPHO syndrome.Following a two-year cessation of methotrexate therapy,he experienced recurrent anterior chest wall and joint pain accompanied by dyspnea.We conducted a comprehensive examination for the patient,which included physical examination,laboratory tests,and imaging studies.The clinical presentation and treatment outcomes suggest that his pneumothorax was related to an episode of SAPHO syndrome.We performed closed thoracic drainage surgery for the patient and treated his symptoms with etoricoxib(60 mg daily).Upon discharge,methotrexate was prescribed again.In subsequent follow-ups,there was no recurrence of joint and respiratory symptoms observed in the patient.CONCLUSION SAPHO syndrome has been proposed as a transitional stage between ankylosing spondylitis and psoriatic arthritis.One study reported a 0.29%incidence of spontaneous pneumothorax in patients with ankylosing spondylitis,higher than in the general population.Additionally,30%of patients with SAPHO syndrome test positive for HLA-B27,an antigen linked to ankylosing spondylitis.Symptomatically,some patients with SAPHO syndrome meet diagnostic criteria for ankylosing spondylitis,with sternoclavicular joint involvement and paravertebral ossific-ations resembling syndesmophytes in ankylosing spondylitis.These features suggest a possible linked between SAPHO syndrome and ankylosing spondylitis.展开更多
Objective To evaluate the efficacy of fire-needle therapy for acne to provide an objective basis for clinical decisions.Method Pub Med,Chinese Biomedical Medicine disc（CBM）,Chinese National knowledge infrastructure...Objective To evaluate the efficacy of fire-needle therapy for acne to provide an objective basis for clinical decisions.Method Pub Med,Chinese Biomedical Medicine disc（CBM）,Chinese National knowledge infrastructure（CNKI）,and Wanfang database were searched to include eligible randomized controlled trails.Bias risk was assessed and data were extracted.Meta-analysis was performed and as was subgroup analysis.Results Thirty-three RCTs involving 3362 patients were included.Most of them had a high risk or unclear risk of bias regarding allocation concealment,incomplete outcome data and selective reporting.Compared with control groups,meta-analysis revealed that fireneedle therapy had an overall higher total effectiveness rate（RR=1.19,95% CI：1.16–1.22,P0.000 01）.Subgroup analysis showed fire-needle therapy was associated with an increased total effective rate（RR=1.20,95%CI：1.14–1.28,P0.000 01）,when compared against drug therapy.Fire-Needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.12–1.24,P0.000 01）,when fire-needle plus other TCM therapy was compared against other therapy.fire-needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.13–1.24,P0.000 01）,when fire-needle plus Chinese herb therapy was compared against Chinese herb therapy alone.fireneedle therapy was associated with an increased total effective rate（RR=1.28,95%CI：1.18–1.39,P0.000 01）,when compared fire-needle plus Western drug therapy against western drug therapy alone.Adverse events were not reported in most articles.Conclusion Our study showed that fire-needle appears to be an effective therapy for treating acne,but the evidence is currently insufficient due to the poor quality of the studies.The safety of fire-needle therapy is also uncertain due to the small sample size and the lack of reporting in included articles.Larger sample,higher quality studies are needed.展开更多
文摘在信息网络高速发展的今天，网络安全无疑成为信息化的热点。然而，在构建信息网络安全堡垒的众多产品、方案背后，是更多的高校、科研机构和企业实验室的基础研究工作。因而，信息安全领域理论层面的国际化交流随之变得越发重要。由国际密码和信息安全协会(International Cryptograph and Information
基金Supported by National Undergraduate Innovation and Entrepreneurship Training Program of Guangxi University of Chinese Medicine in 2022(202210600026).
文摘[Objectives]This study was conducted to investigate the antibacterial effect of a self-designed acne-relieving Chinese herbal formula and prepare a kind of acne-removing soap according to the antibacterial effect.[Methods]Chinese herbs Lonicera japonica,Taraxacum mongolicum,Scutellaria baicalensis,Angelica dahurica,Centella asiatica and Aloe vera,were decocted with water,and the antibacterial effects on Staphylococcus aureus,Staphylococcus albus,Candida albicans and Propionibacterium acnei were tested by inhibition zone experiments.The soap base was prepared by saponification of coconut oil,palm oil,hazelnut oil and sodium hydroxide,and then the herbal liquid was added into the soap.[Results]The liquid had bacteriostatic effect on S.aureus,S.albus and P.acnes,but no inhibitory effect on C.albicans.The best bacteriostatic effect on S.aureus and S.albus was achieved at 330 mg/ml,and the best bacteriostatic effect on P.acnes was at 160 mg/ml.[Conclusions]The Chinese herbal formula has antibacterial effect.The handmade soap made from the Chinese herbal formula has the characteristics of smooth surface,moderate hardness,fine texture,rich foam and fresh smell.
基金support from the College Students’Innovative Entrepreneurial Training Plan Program(Northwestern Polytechnical University),the National Natural Science Foundation of China(No.52473265)the Shaanxi Provincial Science Fund for Distinguished Young Scholars(No.2023-JC-JQ-32).
文摘Acne vulgaris is one of the most common skin disorders affecting millions of patients worldwide,its long-lasting inflammation greatly reduces life quality and causes negative psychosocial impacts.Conventional treatments often along with side effects and issues of patient compliance,and ineffective in treating severe conditions.In recent years,microneedle(MN)has emerged as a versatile therapeutic technology,owing to its minimally invasive,effective,and reduced side effects.However,there are few review articles that systematically summarize the progress of microneedles for the treatment of acne.Here conclude the material,function,and application of microneedle technology in the treatment of acne,with a particular focus on two types of anti-acne microneedle:drug-loaded microneedle(DMN)and radio-frequency microneedle(RMN).DMN facilitates targeted drug delivery to the skin's deeper layers,while RMN utilizes radio-frequency currents to stimulate collagen regeneration,thus addressing acne scarring.Additionally,future directions for advanced acne-treating microneedle technology are envisioned,such as diversified drug loading,multi-functionality,production process optimization,and personalized treatment.These different directions are expected to further enhance the safety,efficacy,and patient satisfaction of microneedle acne treatments.
文摘To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining,and then 60 effective volunteers were selected for the efficacy measurement of topical acne elimination combinations+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers’facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the combination can inhibit the formation of P.acnes biofilm and will not completely kill P.acnes and will not disrupt the micro-ecological balance of the skin;3%and 5%acne combinations can reduce the biofilm of P.acnes by 61.3%and 61.6%respectively;after 4 weeks of continuous use,the area of acne lesions of the samples with 5%acne combinations decreased by 54.61%and the colour of acne lesions decreased by 54.61%compared with the area of acne lesions before the use of the combination.54.61%,acne lesion colour a^(*)decreased by 13.74%,and the subjects’self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The acne combination can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.
文摘Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide a comprehensive analysis of truncal acne,identifying its characteristics and exploring assessment methods and management of truncal acne.Methods:The study examines the causes and contributing factors of truncal acne by analyzing the skin characteristics and acne phenotypes of the trunk area.It also evaluates the existing methods for assessing the severity of truncal acne.Results:Trunk sebum secretion and pH levels are lower than those of the face,while the degree of microbial imbalance is greater.Variability in androgen levels and gender differences also influence truncal acne.Additionally,contact with certain materials exacerbates acne outbreaks on the trunk.The study highlights the advantages,disadvantages,mechanisms of action,and specific targets of each product.Conclusion:This paper provides insights for future research and practical approaches to truncal acne management,assisting in selecting effective products for managing truncal acne.
文摘Cutibacterium acnes were used to induce lipase production,and to establish ex-vivo skin model of inflammatory response and post-inflammatory hyperpigmentation,in purpose of exploring the mechanism of chamomilla recutita extract.Clinical study was designed to investigate the effects of chamomilla recutita extract on Chinese volunteers with sequelae of adult acne,by evaluating the severity of acne,post-acne erythema and pigmentation,skin basic physiological conditions.The results showed that chamomilla recutita extract inhibited lipase activity,cellular inflammatory response,and melanin production.In the clinical study,the acnes were relieved 173%,with a 78%lower post-acne erythema index and 202%less hyperpigmentation as compared to placebo,after applying samples containing 1%chamomilla recutita extract for 28 days.Meanwhile,chamomilla recutita extract showed instant oil control effect.The extract significantly reduced sebum secretion by 293%,increased skin moisture content by 102%,and strengthened the skin barrier by 193%after 28 days application,which provided favorable skin physiological basis for the prevention and improvement of acne vulgaris and sequelae.
文摘Background:Acne vulgaris is a common skin disorder that impacts quality of life.Both acne and menstrual symptoms share a hormonal pathogenesis,often linked to hormonal imbalances in women.This suggests a relationship between acne counts and the various phases of the menstrual cycle.Objective:In this study,we aimed to assess the relationship between acne counts and the menstrual cycle in healthy young Indian women suffering from mild to moderate acne.The objective was to further understand the role of the various phases of the menstrual cycle in acne flares.Methods:This study explores the data from two(2)previously conducted clinical trials.The studies originally aimed to evaluate the efficacy of topical creams in the reduction of acne lesion count on the face.The data from these studies were retrieved and compiled.The number of days between the last menstrual period(LMP)and the actual day of the visit was calculated and regrouped as follows:1–7 days(early to mid-follicular phase),8–15 days(mid-to late follicular phase),16–24 days(post-ovulation to early luteal phase)and>24 days(mid-to late luteal phase).Subsequently,the global acne count—recorded by the dermatologist as part of the study procedures—was cross-tabulated with these menstrual phases using measures of central tendency and dispersion,followed by inferential analyses to evaluate differences between groups.Results:On average,the female subjects visiting the centre during the end of their luteal phase or bleeding days had higher acne counts(p=0.032).This effect was statistically significant only at the baseline visit,which followed a 14-day washout period involving the use of a neutral cleanser and adoption of a general skincare routine.During the product use phase,the effect of the menstrual cycle diminished.Conclusion:The study demonstrates an association between acne flares and the menstrual cycle:acne counts are likely to be higher by an average of 5–6 units during the late luteal and early follicular phases.Such differences may impact the outcome of clinical trials if not carefully monitored and accounted for in study designs and data analysis.
基金Supported by The National Natural Science Foundation of China,No.82074246.
文摘BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome,a rare inflammatory disease,was described in 1987 by Chamot et al,who identified its common characteristics and transitional forms through case reports.The inci-dence rate is now 1 in 10000 among Caucasians and 0.00144 in 10000 among Japanese.Pneumothorax occurs when gas enters the pleural cavity,typically due to lung disease or chest trauma,and is characterized as either spontaneous or traumatic.Spontaneous pneumothorax is commonly linked to congenital lung tissue abnormalities or lung conditions,such as ruptured pulmonary bullae,emphysema,and bronchial asthma.Respiratory involvement in SAPHO syn-drome has historically been noted.CASE SUMMARY We present the case of a 44-year-old male patient who had previously been diagnosed with SAPHO syndrome.Following a two-year cessation of methotrexate therapy,he experienced recurrent anterior chest wall and joint pain accompanied by dyspnea.We conducted a comprehensive examination for the patient,which included physical examination,laboratory tests,and imaging studies.The clinical presentation and treatment outcomes suggest that his pneumothorax was related to an episode of SAPHO syndrome.We performed closed thoracic drainage surgery for the patient and treated his symptoms with etoricoxib(60 mg daily).Upon discharge,methotrexate was prescribed again.In subsequent follow-ups,there was no recurrence of joint and respiratory symptoms observed in the patient.CONCLUSION SAPHO syndrome has been proposed as a transitional stage between ankylosing spondylitis and psoriatic arthritis.One study reported a 0.29%incidence of spontaneous pneumothorax in patients with ankylosing spondylitis,higher than in the general population.Additionally,30%of patients with SAPHO syndrome test positive for HLA-B27,an antigen linked to ankylosing spondylitis.Symptomatically,some patients with SAPHO syndrome meet diagnostic criteria for ankylosing spondylitis,with sternoclavicular joint involvement and paravertebral ossific-ations resembling syndesmophytes in ankylosing spondylitis.These features suggest a possible linked between SAPHO syndrome and ankylosing spondylitis.
基金Supported by National Basic Research Program of China(973 program):2012CB518504Guangdong Administration of TCM Research Foundation:20151233
文摘Objective To evaluate the efficacy of fire-needle therapy for acne to provide an objective basis for clinical decisions.Method Pub Med,Chinese Biomedical Medicine disc（CBM）,Chinese National knowledge infrastructure（CNKI）,and Wanfang database were searched to include eligible randomized controlled trails.Bias risk was assessed and data were extracted.Meta-analysis was performed and as was subgroup analysis.Results Thirty-three RCTs involving 3362 patients were included.Most of them had a high risk or unclear risk of bias regarding allocation concealment,incomplete outcome data and selective reporting.Compared with control groups,meta-analysis revealed that fireneedle therapy had an overall higher total effectiveness rate（RR=1.19,95% CI：1.16–1.22,P0.000 01）.Subgroup analysis showed fire-needle therapy was associated with an increased total effective rate（RR=1.20,95%CI：1.14–1.28,P0.000 01）,when compared against drug therapy.Fire-Needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.12–1.24,P0.000 01）,when fire-needle plus other TCM therapy was compared against other therapy.fire-needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.13–1.24,P0.000 01）,when fire-needle plus Chinese herb therapy was compared against Chinese herb therapy alone.fireneedle therapy was associated with an increased total effective rate（RR=1.28,95%CI：1.18–1.39,P0.000 01）,when compared fire-needle plus Western drug therapy against western drug therapy alone.Adverse events were not reported in most articles.Conclusion Our study showed that fire-needle appears to be an effective therapy for treating acne,but the evidence is currently insufficient due to the poor quality of the studies.The safety of fire-needle therapy is also uncertain due to the small sample size and the lack of reporting in included articles.Larger sample,higher quality studies are needed.
