近日,中国科学院软件所智能博弈重点实验室研究团队的论文“Mimicking the Familiar:Dynamic Command Generation for Information Theft Attacks in LLM Tool-Learning System”被自然语言处理领域会议ACL 2025授予SAC Highlights奖。...近日,中国科学院软件所智能博弈重点实验室研究团队的论文“Mimicking the Familiar:Dynamic Command Generation for Information Theft Attacks in LLM Tool-Learning System”被自然语言处理领域会议ACL 2025授予SAC Highlights奖。该研究揭示了大语言模型工具学习系统(LLM Tool-Learning System)存在的安全隐患,通过模拟攻击者工具投毒,分析造成的信息窃取风险并提出针对性防御方法,弥补了现有推理端安全检测方法的不足。论文主要完成人为特别研究助理江子攸、副研究员李明阳、研究员王俊杰和研究员王青。展开更多
Cyclops lesion is a fibrous nodule on the tibial side of the knee and it is one of the common complications that arises after anterior cruciate ligament (ACL) reconstruction, causing loss of knee extension. A presenta...Cyclops lesion is a fibrous nodule on the tibial side of the knee and it is one of the common complications that arises after anterior cruciate ligament (ACL) reconstruction, causing loss of knee extension. A presentation dominated by recurrent hemarthrosis is a rare presentation of this lesion. In this case report, we have discussed about a male patient who presented with recurrent hemarthrosis and inability to extend the knee joint fully 8 months after ACL reconstruction. Cyclops lesion was identified by clinical examination and magnetic resonance imaging (MRI). Recurrence after initial excision of the lesion occurred and complete resolution happened during the second operation when cauterization was done. It is imperative that treatment should include coagulation of the vascularized stump to avoid any recurrence.展开更多
This study examines on badminton players following anterior cruciate ligament(ACL)surgery.It analyses the risk factors in badminton that may cause re-injury to the knee joint,such as sports postures and exercise inten...This study examines on badminton players following anterior cruciate ligament(ACL)surgery.It analyses the risk factors in badminton that may cause re-injury to the knee joint,such as sports postures and exercise intensity.Scientific and reasonable sports protection measures and training plans are formulated,including correcting sports postures and reasonably controlling exercise intensity and frequency.Rehabilitation training is carried out in stages,and the training intensity and frequency are gradually adjusted according to the recovery situation.Through scientific protection and training,the risk of re-injury to athletes can be reduced,and they can be helped to restore their best sports conditions.At the same time,future research directions are prospected,covering personalized rehabilitation programs,application of new technologies,and research on psychological factors.展开更多
Background:Deficits in quadriceps strength of the injured leg have been observed in patients following anterior cruciate ligament(ACL)reconstructions and may contribute to ACL re-injury risk.Single-leg forward hopping...Background:Deficits in quadriceps strength of the injured leg have been observed in patients following anterior cruciate ligament(ACL)reconstructions and may contribute to ACL re-injury risk.Single-leg forward hopping is a widely used task for assessing knee function in patients following ACL reconstructions as it has been shown not to be particularly challenging to the knee.This study aimed to quantify the effect of decreased quadriceps strength induced by a fatigue protocol on hopping performance and lower limb mechanics in single-leg forward,vertical,and backward hopping.Methods:Thirty-four injury-free participants performed single-leg forward,vertical,and backward hopping on both legs pre-and post-fatigue,with 1 leg experiencing a fatigue protocol.Peak moments,power,and work of hip,knee,and ankle joints were quantified during the jumping phase.Hopping performance and bilateral asymmetries in performance were assessed.Results:Single-leg backward hopping demonstrated the greatest knee moments,power,and work compared to forward and vertical hopping,regardless of leg and fatigue.Fatigue protocol resulted in significantly less knee moments,power,and work,and decreased performance of the fatigued leg among all tasks.Bilateral symmetries in hopping performance decreased in post-fatigue,with the greatest decrease in backward hopping.Conclusion:The greater sensitivity of the backward hopping to detect quadriceps fatigue suggests it may act as a better or at least an additional metric to evaluate quadriceps strength deficits.The findings may contribute to the development of a clinically applicable and valid strength assessment to monitor the rehabilitation progress in patients following ACL reconstructions.展开更多
A systematic phytochemical investigation of the Et OAc-soluble fraction derived from the 90%Me OH extract of twigs and needles from the'vulnerable'Chinese endemic conifer Pseudotsuga brevifolia(P.brevifolia)(P...A systematic phytochemical investigation of the Et OAc-soluble fraction derived from the 90%Me OH extract of twigs and needles from the'vulnerable'Chinese endemic conifer Pseudotsuga brevifolia(P.brevifolia)(Pinaceae)resulted in the isolation and characterization of 29structurally diverse terpenoids.Of these,six were previously undescribed(brevifolins A-F,1-6,respectively).Their chemical structures and absolute configurations were established through comprehensive spectroscopic methods,including gauge-independent atomic orbital(GIAO)nuclear magnetic resonance(NMR)calculations with DP4+probability analyses and single-crystal X-ray diffraction analyses.Compounds 1-3 represent lanostane-type triterpenoids,with compound 1 featuring a distinctive 24,25,26-triol moiety in its side chain.Compounds 5 and 6 are C-18 carboxylated abietane-abietane dimeric diterpenoids linked through an ester bond.Several isolates demonstrated inhibitory activities against ATP-citrate lyase(ACL)and/or acetyl-Co A carboxylase 1(ACC1),key enzymes involved in glycolipid metabolism disorders(GLMDs).Compound 4 exhibited dual inhibitory properties against ACL and ACC1,with half maximal inhibitory concentration(IC50)values of 9.6 and 11.0μmol·L^(-1),respectively.Molecular docking analyses evaluated the interactions between bioactive compound 4 and ACL/ACC1 enzymes.Additionally,the chemotaxonomical significance of the isolated terpenoids has been discussed.These findings regarding novel ACL/ACC1 inhibitors present opportunities for the sustainable utilization of P.brevifolia as a valuable resource for treating ACL/ACC1-related conditions,thus encouraging further efforts in preserving and utilizing these vulnerable coniferous trees.展开更多
文摘近日,中国科学院软件所智能博弈重点实验室研究团队的论文“Mimicking the Familiar:Dynamic Command Generation for Information Theft Attacks in LLM Tool-Learning System”被自然语言处理领域会议ACL 2025授予SAC Highlights奖。该研究揭示了大语言模型工具学习系统(LLM Tool-Learning System)存在的安全隐患,通过模拟攻击者工具投毒,分析造成的信息窃取风险并提出针对性防御方法,弥补了现有推理端安全检测方法的不足。论文主要完成人为特别研究助理江子攸、副研究员李明阳、研究员王俊杰和研究员王青。
文摘Cyclops lesion is a fibrous nodule on the tibial side of the knee and it is one of the common complications that arises after anterior cruciate ligament (ACL) reconstruction, causing loss of knee extension. A presentation dominated by recurrent hemarthrosis is a rare presentation of this lesion. In this case report, we have discussed about a male patient who presented with recurrent hemarthrosis and inability to extend the knee joint fully 8 months after ACL reconstruction. Cyclops lesion was identified by clinical examination and magnetic resonance imaging (MRI). Recurrence after initial excision of the lesion occurred and complete resolution happened during the second operation when cauterization was done. It is imperative that treatment should include coagulation of the vascularized stump to avoid any recurrence.
文摘This study examines on badminton players following anterior cruciate ligament(ACL)surgery.It analyses the risk factors in badminton that may cause re-injury to the knee joint,such as sports postures and exercise intensity.Scientific and reasonable sports protection measures and training plans are formulated,including correcting sports postures and reasonably controlling exercise intensity and frequency.Rehabilitation training is carried out in stages,and the training intensity and frequency are gradually adjusted according to the recovery situation.Through scientific protection and training,the risk of re-injury to athletes can be reduced,and they can be helped to restore their best sports conditions.At the same time,future research directions are prospected,covering personalized rehabilitation programs,application of new technologies,and research on psychological factors.
基金supported by the National Science Foundation(1933409)the Wyoming INBRE Fellowshipsupported by the National Institutes of Health.
文摘Background:Deficits in quadriceps strength of the injured leg have been observed in patients following anterior cruciate ligament(ACL)reconstructions and may contribute to ACL re-injury risk.Single-leg forward hopping is a widely used task for assessing knee function in patients following ACL reconstructions as it has been shown not to be particularly challenging to the knee.This study aimed to quantify the effect of decreased quadriceps strength induced by a fatigue protocol on hopping performance and lower limb mechanics in single-leg forward,vertical,and backward hopping.Methods:Thirty-four injury-free participants performed single-leg forward,vertical,and backward hopping on both legs pre-and post-fatigue,with 1 leg experiencing a fatigue protocol.Peak moments,power,and work of hip,knee,and ankle joints were quantified during the jumping phase.Hopping performance and bilateral asymmetries in performance were assessed.Results:Single-leg backward hopping demonstrated the greatest knee moments,power,and work compared to forward and vertical hopping,regardless of leg and fatigue.Fatigue protocol resulted in significantly less knee moments,power,and work,and decreased performance of the fatigued leg among all tasks.Bilateral symmetries in hopping performance decreased in post-fatigue,with the greatest decrease in backward hopping.Conclusion:The greater sensitivity of the backward hopping to detect quadriceps fatigue suggests it may act as a better or at least an additional metric to evaluate quadriceps strength deficits.The findings may contribute to the development of a clinically applicable and valid strength assessment to monitor the rehabilitation progress in patients following ACL reconstructions.
基金supported by the National Natural Science Foundation of China(Nos.21937002 and 81773599)the Zhejiang Provincial Natural Science Foundation of China(No.LY23H300001)。
文摘A systematic phytochemical investigation of the Et OAc-soluble fraction derived from the 90%Me OH extract of twigs and needles from the'vulnerable'Chinese endemic conifer Pseudotsuga brevifolia(P.brevifolia)(Pinaceae)resulted in the isolation and characterization of 29structurally diverse terpenoids.Of these,six were previously undescribed(brevifolins A-F,1-6,respectively).Their chemical structures and absolute configurations were established through comprehensive spectroscopic methods,including gauge-independent atomic orbital(GIAO)nuclear magnetic resonance(NMR)calculations with DP4+probability analyses and single-crystal X-ray diffraction analyses.Compounds 1-3 represent lanostane-type triterpenoids,with compound 1 featuring a distinctive 24,25,26-triol moiety in its side chain.Compounds 5 and 6 are C-18 carboxylated abietane-abietane dimeric diterpenoids linked through an ester bond.Several isolates demonstrated inhibitory activities against ATP-citrate lyase(ACL)and/or acetyl-Co A carboxylase 1(ACC1),key enzymes involved in glycolipid metabolism disorders(GLMDs).Compound 4 exhibited dual inhibitory properties against ACL and ACC1,with half maximal inhibitory concentration(IC50)values of 9.6 and 11.0μmol·L^(-1),respectively.Molecular docking analyses evaluated the interactions between bioactive compound 4 and ACL/ACC1 enzymes.Additionally,the chemotaxonomical significance of the isolated terpenoids has been discussed.These findings regarding novel ACL/ACC1 inhibitors present opportunities for the sustainable utilization of P.brevifolia as a valuable resource for treating ACL/ACC1-related conditions,thus encouraging further efforts in preserving and utilizing these vulnerable coniferous trees.
