Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is sig...Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is significant controversy regarding its concurrent use with ACS owing to concerns of increased risk of intra-abdominal pressure(IAP).[1]We present a case of successful PPV application without adverse eff ects.展开更多
To elucidate the effect of calcite-regulated activated carbon(AC)structure on low-temperature denitrification performance of SCR catalysts,this work prepared a series of Mn-Ce/De-AC-xCaCO_(3)(x is the calcite content ...To elucidate the effect of calcite-regulated activated carbon(AC)structure on low-temperature denitrification performance of SCR catalysts,this work prepared a series of Mn-Ce/De-AC-xCaCO_(3)(x is the calcite content in coal)catalysts were prepared by the incipient wetness impregnation method,followed by acid washing to remove calcium-containing minerals.Comprehensive characterization and low-temperature denitrification tests revealed that calcite-induced structural modulation of coal-derived AC significantly enhances catalytic activity.Specifically,NO conversion increased from 88.3%of Mn-Ce/De-AC to 91.7%of Mn-Ce/De-AC-1CaCO_(3)(210℃).The improved SCR denitrification activity results from the enhancement of physicochemical properties including higher Mn^(4+)content and Ce^(4+)/Ce^(3+)ratio,an abundance of chemisorbed oxygen and acidic sites,which could strengthen the SCR reaction pathways(richer NH_(3)activated species and bidentate nitrate active species).Therefore,NO removal is enhanced.展开更多
Background Endometrial receptivity(ERE)is a transient uterine state that determines the success of blastocyst implantation;however,the epigenomic regulation underlying ERE establishment in goats remains unclear.Here,w...Background Endometrial receptivity(ERE)is a transient uterine state that determines the success of blastocyst implantation;however,the epigenomic regulation underlying ERE establishment in goats remains unclear.Here,we profiled transcriptional and epigenomic features of endometrial tissues from pregnant goats during the peri-implantation window and nonpregnant control goats in the regressed luteal phase to uncover the transcriptional regulatory networks responsible for ERE establishment in goats,utilizing RNA-seq,ATAC-seq,and H3 K27 ac CUT&Tag.Results A total of 3,143 differentially expressed genes(DEGs)were identified,accompanied by significant alterations in chromatin accessibility and H3 K27 ac modifications between receptive and non-receptive endometria.The targeted genes associated with these epigenetic changes were significantly enriched in pathways related to cell adhesion,immune tolerance,and embryo attachment.Motif enrichment and transcription factor(TF)footprinting analyses identified members of the FOS/JUN,SOX,HNF1,CEBP,and BATF families as candidate regulators,implicating downstream genes involved in ERE establishment,including SPP1,FOXO1,KLF4/6,STAT1,IFI6,ITGB8,PLAC8,DUSP4,NR1D1,ISG15,RUFY4,and PIK3R3.In addition,numerous super-enhancers were identified,indicating regions of high regulatory activity and potential long-range gene-enhancers interactions in the endometrium.Integration of multi-omics datasets revealed a strong correlation(r>0.7)among chromatin accessibility,H3 K27 ac activation,and the expression of 172 DEGs.Furthermore,a set of hub genes(KLF6,IFI6,MCL1,SDC4,SUSD6,MAFF,and IL6R)that appear to coordinate TF binding and distal super-enhancers activity associated with ERE establishment.Conclusions Our data provided an integrated epigenomic atlas of endometrial receptivity establishment in goats and identify candidate regulatory elements and transcription factors that may orchestrate uterine preparation for implantation.These findings offer valuable insights and testable targets for improving fertility in ruminant livestock.展开更多
文摘Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is significant controversy regarding its concurrent use with ACS owing to concerns of increased risk of intra-abdominal pressure(IAP).[1]We present a case of successful PPV application without adverse eff ects.
基金Supported by the Science and Technology Cooperation and Exchange special project of Cooperation of Shanxi Province(202404041101014)the Fundamental Research Program of Shanxi Province(202403021212333)+3 种基金the Joint Funds of the National Natural Science Foundation of China(U24A20555)the Lvliang Key R&D of University-Local Cooperation(2023XDHZ10)the Initiation Fund for Doctoral Research of Taiyuan University of Science and Technology(20242026)the Outstanding Doctor Funding Award of Shanxi Province(20242080).
文摘To elucidate the effect of calcite-regulated activated carbon(AC)structure on low-temperature denitrification performance of SCR catalysts,this work prepared a series of Mn-Ce/De-AC-xCaCO_(3)(x is the calcite content in coal)catalysts were prepared by the incipient wetness impregnation method,followed by acid washing to remove calcium-containing minerals.Comprehensive characterization and low-temperature denitrification tests revealed that calcite-induced structural modulation of coal-derived AC significantly enhances catalytic activity.Specifically,NO conversion increased from 88.3%of Mn-Ce/De-AC to 91.7%of Mn-Ce/De-AC-1CaCO_(3)(210℃).The improved SCR denitrification activity results from the enhancement of physicochemical properties including higher Mn^(4+)content and Ce^(4+)/Ce^(3+)ratio,an abundance of chemisorbed oxygen and acidic sites,which could strengthen the SCR reaction pathways(richer NH_(3)activated species and bidentate nitrate active species).Therefore,NO removal is enhanced.
基金financially supported by the National Natural Science Foundation of China(No.32502862)the Collection,Utilization and Innovation of Animal Resources by Research Institutes and Enterprises of Chongqing(No.Cqnyncwkqlhtxm)+1 种基金the Chongqing Modern Agricultural Industry Technology System(CQMAITS202513)the Key Project of Chongqing Technology Innovation and Application Development Special Program(CTSB2025TIAD-KPX0079)。
文摘Background Endometrial receptivity(ERE)is a transient uterine state that determines the success of blastocyst implantation;however,the epigenomic regulation underlying ERE establishment in goats remains unclear.Here,we profiled transcriptional and epigenomic features of endometrial tissues from pregnant goats during the peri-implantation window and nonpregnant control goats in the regressed luteal phase to uncover the transcriptional regulatory networks responsible for ERE establishment in goats,utilizing RNA-seq,ATAC-seq,and H3 K27 ac CUT&Tag.Results A total of 3,143 differentially expressed genes(DEGs)were identified,accompanied by significant alterations in chromatin accessibility and H3 K27 ac modifications between receptive and non-receptive endometria.The targeted genes associated with these epigenetic changes were significantly enriched in pathways related to cell adhesion,immune tolerance,and embryo attachment.Motif enrichment and transcription factor(TF)footprinting analyses identified members of the FOS/JUN,SOX,HNF1,CEBP,and BATF families as candidate regulators,implicating downstream genes involved in ERE establishment,including SPP1,FOXO1,KLF4/6,STAT1,IFI6,ITGB8,PLAC8,DUSP4,NR1D1,ISG15,RUFY4,and PIK3R3.In addition,numerous super-enhancers were identified,indicating regions of high regulatory activity and potential long-range gene-enhancers interactions in the endometrium.Integration of multi-omics datasets revealed a strong correlation(r>0.7)among chromatin accessibility,H3 K27 ac activation,and the expression of 172 DEGs.Furthermore,a set of hub genes(KLF6,IFI6,MCL1,SDC4,SUSD6,MAFF,and IL6R)that appear to coordinate TF binding and distal super-enhancers activity associated with ERE establishment.Conclusions Our data provided an integrated epigenomic atlas of endometrial receptivity establishment in goats and identify candidate regulatory elements and transcription factors that may orchestrate uterine preparation for implantation.These findings offer valuable insights and testable targets for improving fertility in ruminant livestock.
