研究了聚磷酸铵APP、三聚氰胺氰尿酸盐MCA、乙酰丙酮锌以及ABS高胶粉对磷-氮复配无卤阻燃ABS材料的阻燃性能、力学性能及热学特性的影响。实验表明单独使用聚磷酸铵APP阻燃剂对ABS材料进行阻燃改性效果一般,阻燃等级无法达到V-0级别。将...研究了聚磷酸铵APP、三聚氰胺氰尿酸盐MCA、乙酰丙酮锌以及ABS高胶粉对磷-氮复配无卤阻燃ABS材料的阻燃性能、力学性能及热学特性的影响。实验表明单独使用聚磷酸铵APP阻燃剂对ABS材料进行阻燃改性效果一般,阻燃等级无法达到V-0级别。将APP与MCA复配使用后材料阻燃效果良好,能够达到1.6 mm V-0级别。在无卤阻燃ABS体系中添加部分ABS高胶粉能够改善阻燃ABS抗冲击性能不足的缺点,但会降低阻燃效果,添加部分乙酰丙酮锌能够将该影响消除,同时能提高阻燃ABS的抗冲击性能。展开更多
Sulfuretin is a flavonoid that protects cell from damage induced by reactive oxygen species and inflammation.In this study,we investigated the role of sulfuretin in the processing of amyloid precursor protein(APP),in ...Sulfuretin is a flavonoid that protects cell from damage induced by reactive oxygen species and inflammation.In this study,we investigated the role of sulfuretin in the processing of amyloid precursor protein(APP),in association with the two catalytic enzymes the a-secretase a disintegrin and metalloproteinase(ADAM10),and the beta-site APP cleaving enzyme 1(BACE1)that play important roles in the generation of β amyloid protein(Aβ)in Alzheimer’s disease(AD).We found that sulfuretin increased the levels of the immature but not the mature form of ADAM10 protein.The enhanced ADAM10 transcription by sulfuretin was mediated by the nucleotides444 to300 in the promoter region,and was attenuated by silencing or mutation of transcription factor retinoid X receptor(RXR)and by GW6471,a specific inhibitor of peroxisome proliferator-activated receptor α(PPAR-α).We further found that sulfuretin preferentially increased protein levels of the immature form of APP(im-APP)but significantly reduced those of BACE1,sAPPβ and β-CTF,whereas Ab1-42 levels were slightly increased.Finally,the effect of sulfuretin on BACE1 and im-APP was selectively attenuated by the translation inhibitor cycloheximide and by lysosomal inhibitor chloroquine,respectively.Taken together,(1)RXR/PPAR-α signaling was involved in sulfuretin-mediated ADAM10 transcription.(2)Alteration of Aβ protein level by sulfuretin was not consistent with that of ADAM10 and BACE1 protein levels,but was consistent with the elevated level of im-APP protein,suggesting that im-APP,an isoform mainly localized to trans-Golgi network,plays an important role in Ab generation.展开更多
文摘研究了聚磷酸铵APP、三聚氰胺氰尿酸盐MCA、乙酰丙酮锌以及ABS高胶粉对磷-氮复配无卤阻燃ABS材料的阻燃性能、力学性能及热学特性的影响。实验表明单独使用聚磷酸铵APP阻燃剂对ABS材料进行阻燃改性效果一般,阻燃等级无法达到V-0级别。将APP与MCA复配使用后材料阻燃效果良好,能够达到1.6 mm V-0级别。在无卤阻燃ABS体系中添加部分ABS高胶粉能够改善阻燃ABS抗冲击性能不足的缺点,但会降低阻燃效果,添加部分乙酰丙酮锌能够将该影响消除,同时能提高阻燃ABS的抗冲击性能。
基金This work was supported by National Key R&D Program of China(2018YFC1314700)to L-J Jinby NSFC(81971030)+3 种基金Chongqing Science and Technology Commission grant(cstc2018jcyjAX0067)to G-J.Chenby The strategic science&technology cooperation Project of North Sichuan Medical College and Nanchong Municipal Government(18SXHZ0184)Scientific Research Development Project of North Sichuan Medical College(CBY17-A-ZD03)Sichuan Provincial Health and Family Planning Commission(18PJ335)to Li-Tian Hu.
文摘Sulfuretin is a flavonoid that protects cell from damage induced by reactive oxygen species and inflammation.In this study,we investigated the role of sulfuretin in the processing of amyloid precursor protein(APP),in association with the two catalytic enzymes the a-secretase a disintegrin and metalloproteinase(ADAM10),and the beta-site APP cleaving enzyme 1(BACE1)that play important roles in the generation of β amyloid protein(Aβ)in Alzheimer’s disease(AD).We found that sulfuretin increased the levels of the immature but not the mature form of ADAM10 protein.The enhanced ADAM10 transcription by sulfuretin was mediated by the nucleotides444 to300 in the promoter region,and was attenuated by silencing or mutation of transcription factor retinoid X receptor(RXR)and by GW6471,a specific inhibitor of peroxisome proliferator-activated receptor α(PPAR-α).We further found that sulfuretin preferentially increased protein levels of the immature form of APP(im-APP)but significantly reduced those of BACE1,sAPPβ and β-CTF,whereas Ab1-42 levels were slightly increased.Finally,the effect of sulfuretin on BACE1 and im-APP was selectively attenuated by the translation inhibitor cycloheximide and by lysosomal inhibitor chloroquine,respectively.Taken together,(1)RXR/PPAR-α signaling was involved in sulfuretin-mediated ADAM10 transcription.(2)Alteration of Aβ protein level by sulfuretin was not consistent with that of ADAM10 and BACE1 protein levels,but was consistent with the elevated level of im-APP protein,suggesting that im-APP,an isoform mainly localized to trans-Golgi network,plays an important role in Ab generation.
