Marginal seas,as transitional zones,are closely connected to the open ocean and adjacent coastal systems.Their circulations often exhibit strong oscillatory behavior that shapes heat and salt transport,nutrient cyclin...Marginal seas,as transitional zones,are closely connected to the open ocean and adjacent coastal systems.Their circulations often exhibit strong oscillatory behavior that shapes heat and salt transport,nutrient cycling,and regional ocean-atmosphere interactions.However,the characteristics and underlying dynamics of these oscillations remain insufficiently understood.Using the unique three-layer alternating circulation in the South China Sea as an example,we show that the system undergoes a pronounced regime transition from 1993-2008 to 2009-2018.This transition is closely linked to the phase change of the Pacific Decadal Oscillation.Specifically,upper-layer cyclonic circulation intensifies during the pre-2009 but weakens during the post-2009 period,while the middle-layer anticyclonic circulation exhibits the opposite pattern.In contrast,the deep-layer circulation strengthens substantially during the post-20o9 period.These regime transitions arise from the interplay of surface wind forcing,the external exchanging current with the Pacific,and topographically modulated internal vertical coupling.The decadal trend of the upper-layer circulation is primarily wind-driven.The weakening of middle-layer circulation during pre-2oo9 is governed by pressure torque influenced by the upperlayer,whereas its post-2009 strengthening is attributed to vortex stretching associated with enhanced deep intrusion from the Pacific and a stronger deep-layer circulation.The findings clarify the oscillatory nature of South China Sea layered circulation under climate variability and highlight its role in regulating regional mass transport and ocean-atmosphere interaction.展开更多
Based on the comprehensive analysis of data from petrology and mineralogy,well logging,seismic surveys,paleontology,and geochemistry,a detailed research was conducted on paleoenvironmental and paleoclimatic conditions...Based on the comprehensive analysis of data from petrology and mineralogy,well logging,seismic surveys,paleontology,and geochemistry,a detailed research was conducted on paleoenvironmental and paleoclimatic conditions,and modeling of the source rocks in the second member of the Eocene Wenchang Formation(Wen 2 Member)in the Northern Shunde Subsag at the southwestern margin of the Pearl River Mouth Basin.The Wen 2 Member hosts excellent,thick lacustrine source rocks with strong longitudinal heterogeneity and an average total organic carbon(TOC)content of over 4.9%.The Wen 2 Member can be divided into three units(I,II,III)from bottom to top.Unit I features excellent source rocks with Type I organic matters(average TOC of 5.9%)primarily sourced from lake organisms;Unit II hosts source rocks dominated by Type II2 organic matters(average TOC of 2.2%),which are originated from mixed sources dominated by terrestrial input.Unit III contains good to excellent source rocks dominated by Type II1 organic matters(average TOC of 4.9%),which are mainly contributed by lake organisms and partially by terrestrial input.Under the background of rapid subsidence and limited source supply during intense rifting period in the Eocene,excellent source rocks were developed in Wen 2 Member in the Northern Shunde Subsag under the coordinated control of warm and humid climate,volcanic activity,and deep-water reducing conditions.During the deposition of Unit I,the warm and humid climate and volcanic activity promoted the proliferation of lake algaes,primarily Granodiscus,resulting in high initial productivity,and deep-water reducing conditions enabled satisfactory preservation of organic matters.These factors jointly controlled the development and occurrence of excellent source rocks.During the deposition of Unit II,a transition from warm to cool and semi-arid paleoclimatic conditions led to a decrease in lake algaes and initial productivity.Additionally,enhanced terrestrial input and shallow-water,weakly oxidizing water conditions caused a significant dilution and decomposition of organic matters,degrading the quality of source rocks.During the deposition of Unit III,when the paleoclimatic conditions are cool and humid,Pediastrum and Botryococcus began to thrive,leading to an increase in productivity.Meanwhile,the reducing environment of semi-deep water facilitated the preservation of excellent source rocks,albeit slightly inferior to those in Unit I.The study results clarify the differential origins and development models of various source rocks in the Shunde Sag,offering valuable guidance for evaluating source rocks and selecting petroleum exploration targets in similar marginal sags.展开更多
The trace element selenium(Se)occurs naturally throughout the earth.Se deficiency has been linked to impaired breast health and other diseases in human and animals.Compared to severe Se deficiency,marginal dietary Se ...The trace element selenium(Se)occurs naturally throughout the earth.Se deficiency has been linked to impaired breast health and other diseases in human and animals.Compared to severe Se deficiency,marginal dietary Se deficiency accusers more frequently in low-Se regions.Therefore,to investigate the Se status and inflammatory response of the mammary gland under marginal dietary Se levels,an lipopolysaccharide(LPS)induced mouse mastitis model was established.Mice were fed with moderate Se diet(0.087 mg•kg^(-1) Se),adequate Se diet(0.15 mg•kg^(-1) Se)or excessive Se diet(1.5 mg•kg^(-1) Se)for 60 days.Se status and inflammatory factors were investigated.Results showed that the Se status of mammary gland correlated with dietary Se levels.Marginal Se deficiency exacerbated mammary tissue histopathology;increased the mRNA level of inflammatory genes tumor necrosis factor alpha(TNF-α),interleukin-1β(IL-1β)and cyclooxygenase-2(COX-2);and enhanced the phosphorylation of NF-κB p65 in mammary gland tissues.Supplementation of Se in diet higher than recommended levels reduced the inflammatory reaction of mammary glands in LPS-induced mastitis model and provided a protective effect.展开更多
BACKGROUND Postpancreatectomy hemorrhage is one of the most severe and life-threatening complications after pancreaticoduodenectomy.We present four cases of gastrointestinal bleeding patients to clarify its appropriat...BACKGROUND Postpancreatectomy hemorrhage is one of the most severe and life-threatening complications after pancreaticoduodenectomy.We present four cases of gastrointestinal bleeding patients to clarify its appropriate treatment and prevention.CASE SUMMARY The main symptoms included black stool,hematochezia,haematemesis,blood in the nasogastric tube,and hemorrhagic shock.The mean age was 66.25 years old and the median onset time was 340 d after the surgery.The bleeding location comprised gastrointestinal anastomosis,bile duct-jejunum anastomosis,and extraluminal bleeding.The possible causes included marginal ulcer,jejunal varix,and abdominal infection.Endoscopic hemostatic clips,as well as a covered stent using angiography,were utilized to stop the bleeding and three patients survived.Only one patient died of gastrointestinal bleeding,abdominal bleeding,abdominal infection,hypovolemic shock,and disseminated intravascular coagulation.CONCLUSION Early and effective endoscopic intervention is the key to successful hemostasis in patients with gastrointestinal bleeding after pancreatoduodenectomy.展开更多
Marginal Fisher analysis(MFA)stands out as a prominent dimensionality reduction algorithm,striving to minimize within-class scatter while maximizing the separability between marginal data points.However,MFA and its va...Marginal Fisher analysis(MFA)stands out as a prominent dimensionality reduction algorithm,striving to minimize within-class scatter while maximizing the separability between marginal data points.However,MFA and its variants require substantial computational resources when dealing with large-scale data.To address this,we propose quantum algorithms for MFA(called QMFA).QMFA is composed of two core processes:the first is the efficient construction of the weight matrices for the intrinsic and penalty graphs,and the second is solving the generalized eigenvalue problem(GEP)using the block-encoding technique.Compared to classical MFA,the proposed QMFA achieves a polynomial acceleration in the number of samples and exponential acceleration in the dimensionality.Additionally,we investigate quantum algorithms for different variants of MFA.Specifically,for enhanced MFA and multiple MFA,we address the construction of the related weight matrix,which differs from that in standard MFA.For kernel MFA,we solve the GEP associated with the corresponding kernel matrix.The proposed quantum algorithms achieve a speedup equivalent to that of QMFA.展开更多
BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma is a subtype of extranodal marginal zone lymphoma,typically occurring in mucosal sites such as the stomach,salivary glands,and lungs.This study aims to analyz...BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma is a subtype of extranodal marginal zone lymphoma,typically occurring in mucosal sites such as the stomach,salivary glands,and lungs.This study aims to analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.AIM To analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.METHODS A retrospective cohort study was conducted using the Surveillance,Epidemiology,and End Results(SEER)database,which included 2453 patients diagnosed with MALT lymphoma from 2010 to 2021.Data were analyzed for demographic factors,tumor characteristics,treatment modalities,and survival outcomes.A Cox proportional hazards regression model was used to identify predictors of overall mortality and cancer-specific mortality.RESULTS The study predominantly included Non-Hispanic White patients(62.78%),with nearly equal gender distribution(50.31%females,49.69%males),and most diagnoses occurring in individuals aged 60-79 years.The majority of tumors were localized(80.07%).Multivariate analysis identified older age,male gender,advanced tumor stage,and socioeconomic factors—such as annual income and marital status—as independent predictors of mortality.No significant interaction between age and gender on mortality outcomes was observed.CONCLUSION Sociodemographic factors,including advanced age,male gender,annual income,and marital status,as well as advanced tumor stage,significantly impacted survival outcomes in patients with MALT lymphoma.Radiotherapy was associated with a reduction in overall mortality.Early detection is crucial for optimizing outcomes,as localized disease responds well to available treatment modalities.展开更多
As PEGylated liposomes have witnessed remarkable advancements in drug delivery,their immunogenicity has emerged as a notable challenge.In this study,we discovered that a simple pre-injection of folic acid(FA)effective...As PEGylated liposomes have witnessed remarkable advancements in drug delivery,their immunogenicity has emerged as a notable challenge.In this study,we discovered that a simple pre-injection of folic acid(FA)effectively mitigated the immunogenicity of PEGylated liposomes and enhanced their in vivo performance by tolerating splenic marginal zone B cells.FA specifically inhibited the internalization of PEGylated liposomes by splenic marginal zone B cells,thereby reducing splenic lymphocyte proliferation and specific IgM secretion.This modulation alleviated Ig M-mediated accelerated blood clearance and adverse accumulation of the PEGylated liposomes in the skin.These findings provide new insights into the immunomodulatory effects of FA and promising avenues to enhance the efficacy and safety of PEGylated liposomal nanomedicines.展开更多
Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysi...Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysis of the main source rocks,reservoirs,and vertical migration pathways within the Rovuma(RB)and Tanzania(TB)basins in East Africa utilizing drilling,logging,seismic,and geochemical data.The results indicate that the enhanced preservation conditions of the Lower Jurassic source rocks in the southwest could lead to the discovery of large natural gas fields in the southern TB and RB.The primary reservoir is a deep-water turbidite sandstone.Due to topographic differences,the expanse of the turbidite sandstones in the RB is significantly larger than those in Tanzania.The main vertical migration pathways are the western boundary fault zone of the Kerimbas Graben(WBFZ)and the Seagap fault zone(SFZ).In the RB,natural gas migrates vertically along the WBFZ and preferentially accumulates in the deep-water turbidite sandstones of the footwall under the control of the fluid potential.Conversely,in the southern TB,the deep natural gas first migrates upward along the SFZ,then moves along the shallow branch faults in the sandstones on both sides of the SFZ.展开更多
In this paper,we propose STPLF,which stands for the short-term forecasting of locational marginal price components,including the forecasting of non-conforming hourly net loads.The volatility of transmission-level hour...In this paper,we propose STPLF,which stands for the short-term forecasting of locational marginal price components,including the forecasting of non-conforming hourly net loads.The volatility of transmission-level hourly locational marginal prices(LMPs)is caused by several factors,including weather data,hourly gas prices,historical hourly loads,and market prices.In addition,variations of non-conforming net loads,which are affected by behind-the-meter distributed energy resources(DERs)and retail customer loads,could have a major impact on the volatility of hourly LMPs,as bulk grid operators have limited visibility of such retail-level resources.We propose a fusion forecasting model for the STPLF,which uses machine learning and deep learning methods to forecast non-conforming loads and respective hourly prices.Additionally,data preprocessing and feature extraction are used to increase the accuracy of the STPLF.The proposed STPLF model also includes a post-processing stage for calculating the probability of hourly LMP spikes.We use a practical set of data to analyze the STPLF results and validate the proposed probabilistic method for calculating the LMP spikes.展开更多
This study documents pioneering results in marginal wells in Texas,where the application of RDV-00■restored production through delayed protonic activation catalyzed by reservoir energy.The product,based on RDV■(Vaso...This study documents pioneering results in marginal wells in Texas,where the application of RDV-00■restored production through delayed protonic activation catalyzed by reservoir energy.The product,based on RDV■(Vasoactive Dynamic Reactor)technology,operates via:Controlled protonation of molecular structures;Release of energetic carbocations;Autonomous transformation without external inputs.(a)Case 1(Well#E2-Starr County):Certified as“dry”by RRC(2022)after 48 months at 0 BPD;8 months post-injection of 5 gal RDV-00■(Fluid column:37 bbl;Wellhead pressure:80 psi(vs.0 psi initially)).(b)Case 2(Well#P1-Luling Field):Historical stripper well(0.25-0.5 BPD);23 months of immobilization with 15 gal RDV-00■;Critical results:(1)Initial production:42 BPD(8,400%above baseline);(2)Shut-in wellhead pressure:40 psi(neighboring wells=0-3 psi);(3)Current behavior:Continuous recharge from reservoir(well shut-in due to lack of storage).(c)Technically Significant Observations:(1)First case of self-sustaining reactivation in depleted wells;(2)Mechanism validated by Autonomous pressure generation(0→40-80 psi),and Continuous flow without additional stimulation;(3)No documented precedents in SPE/OnePetro literature to our knowledge.展开更多
AIM:To analyze the clinical and pathological features of 89 patients presenting as lacrimal gland prolapse(LGP).METHODS:This retrospective study included 89 patients presenting as LGP.Magnetic resonance imaging(MRI)sc...AIM:To analyze the clinical and pathological features of 89 patients presenting as lacrimal gland prolapse(LGP).METHODS:This retrospective study included 89 patients presenting as LGP.Magnetic resonance imaging(MRI)scan was performed for all patients.Pathology and immunohistochemical staining of prolapsed tissue were performed during the surgery.The histopathological subtype was obtained,and the related clinical manifestations of different subtype were marked.RESULTS:Among the 89 patients involved,the histopathological subtype includes dacryoadenitis(43%;n=38),focal lymphocytes infiltration(20%;n=18),immunoglobulin G4(IgG4)-related lacrimal gland inflammatory disease(15%;n=13),lacrimal gland(13%;n=12),and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue(9%;n=8).As for manifestations of different subtypes,eyelid swelling was found the most frequent of lymphocytes infiltration(44%,n=8),and palpable lacrimal gland mass of dacryoadenitis(55%,n=21).All the IgG4-related lacrimal gland inflammatory disease(100%,n=13)and most dacryoadenitis(97%,n=37)presented as bilateral.CONCLUSION:LGP has the histopathological subtype most commonly as inflammation,followed by structural and lymphoproliferative changes.Most of patients present as eyelid swelling.Clinical manifestations can be significant to differentiate the diagnosis.展开更多
The woodland-steppe ecotone in the. southern Nei Mongol Plateau is located at the northern edge of the east Asian monsoon influences. A marked southeastern - northwestern (SE - NW) precipitation gradient exists in thi...The woodland-steppe ecotone in the. southern Nei Mongol Plateau is located at the northern edge of the east Asian monsoon influences. A marked southeastern - northwestern (SE - NW) precipitation gradient exists in this region. Quantitative reconstruction of palaeo-precipitation of this region is helpful to reveal the development of monsoon climate and to predict die future desertification. Based on modern vegetation and surface pollen studies, a pollen-precipitation transfer function in the study region was established. Pollen data from three sediment sequences within the ecotone were used to reconstruct palaeo-precipitation during the Holocene. The processes of precipitation changes in the three sequences were quite different. There was a tendency of precipitation declined from the onset of the Holocene to 1 100 a BP in Haoluku. But, in Liuzhouwan and Xiaoniuchang, both located south of Haoluku, the annual precipitation reached highest values during 7 800 - 6 200 a BP and 7 200 - 5 000 a BP, respectively. The influences of southwestern (SW) monsoon and the variances of topographical conditions have possibly caused these temporal-spatial variances.展开更多
基金supported by the National Natural Science Foundation of China(42376024and 42450181)the Science and Technology Development Fund,Macao SAR(File/Project no.001/2024/SKL)+2 种基金supported by the Centre for Regional Oceans in the University of Macao(SP2025-00005-CRO)CORE,which is a joint research center for ocean research between Laoshan Laboratory and HKUSTsubstantially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region,China(AoE/P-601/23-N and GRF 16310724).
文摘Marginal seas,as transitional zones,are closely connected to the open ocean and adjacent coastal systems.Their circulations often exhibit strong oscillatory behavior that shapes heat and salt transport,nutrient cycling,and regional ocean-atmosphere interactions.However,the characteristics and underlying dynamics of these oscillations remain insufficiently understood.Using the unique three-layer alternating circulation in the South China Sea as an example,we show that the system undergoes a pronounced regime transition from 1993-2008 to 2009-2018.This transition is closely linked to the phase change of the Pacific Decadal Oscillation.Specifically,upper-layer cyclonic circulation intensifies during the pre-2009 but weakens during the post-2009 period,while the middle-layer anticyclonic circulation exhibits the opposite pattern.In contrast,the deep-layer circulation strengthens substantially during the post-20o9 period.These regime transitions arise from the interplay of surface wind forcing,the external exchanging current with the Pacific,and topographically modulated internal vertical coupling.The decadal trend of the upper-layer circulation is primarily wind-driven.The weakening of middle-layer circulation during pre-2oo9 is governed by pressure torque influenced by the upperlayer,whereas its post-2009 strengthening is attributed to vortex stretching associated with enhanced deep intrusion from the Pacific and a stronger deep-layer circulation.The findings clarify the oscillatory nature of South China Sea layered circulation under climate variability and highlight its role in regulating regional mass transport and ocean-atmosphere interaction.
基金Supported by the Research Project of China National Offshore Oil Corporation(SCKY-2023-HN-3)。
文摘Based on the comprehensive analysis of data from petrology and mineralogy,well logging,seismic surveys,paleontology,and geochemistry,a detailed research was conducted on paleoenvironmental and paleoclimatic conditions,and modeling of the source rocks in the second member of the Eocene Wenchang Formation(Wen 2 Member)in the Northern Shunde Subsag at the southwestern margin of the Pearl River Mouth Basin.The Wen 2 Member hosts excellent,thick lacustrine source rocks with strong longitudinal heterogeneity and an average total organic carbon(TOC)content of over 4.9%.The Wen 2 Member can be divided into three units(I,II,III)from bottom to top.Unit I features excellent source rocks with Type I organic matters(average TOC of 5.9%)primarily sourced from lake organisms;Unit II hosts source rocks dominated by Type II2 organic matters(average TOC of 2.2%),which are originated from mixed sources dominated by terrestrial input.Unit III contains good to excellent source rocks dominated by Type II1 organic matters(average TOC of 4.9%),which are mainly contributed by lake organisms and partially by terrestrial input.Under the background of rapid subsidence and limited source supply during intense rifting period in the Eocene,excellent source rocks were developed in Wen 2 Member in the Northern Shunde Subsag under the coordinated control of warm and humid climate,volcanic activity,and deep-water reducing conditions.During the deposition of Unit I,the warm and humid climate and volcanic activity promoted the proliferation of lake algaes,primarily Granodiscus,resulting in high initial productivity,and deep-water reducing conditions enabled satisfactory preservation of organic matters.These factors jointly controlled the development and occurrence of excellent source rocks.During the deposition of Unit II,a transition from warm to cool and semi-arid paleoclimatic conditions led to a decrease in lake algaes and initial productivity.Additionally,enhanced terrestrial input and shallow-water,weakly oxidizing water conditions caused a significant dilution and decomposition of organic matters,degrading the quality of source rocks.During the deposition of Unit III,when the paleoclimatic conditions are cool and humid,Pediastrum and Botryococcus began to thrive,leading to an increase in productivity.Meanwhile,the reducing environment of semi-deep water facilitated the preservation of excellent source rocks,albeit slightly inferior to those in Unit I.The study results clarify the differential origins and development models of various source rocks in the Shunde Sag,offering valuable guidance for evaluating source rocks and selecting petroleum exploration targets in similar marginal sags.
基金Supported by the Natural Science Foundation of the Heilongjiang Province of China(C2016003)China Postdoctoral Science Foundation(2015M581415)Heilongjiang Postdoctoral Fund(LBH-Z15005)。
文摘The trace element selenium(Se)occurs naturally throughout the earth.Se deficiency has been linked to impaired breast health and other diseases in human and animals.Compared to severe Se deficiency,marginal dietary Se deficiency accusers more frequently in low-Se regions.Therefore,to investigate the Se status and inflammatory response of the mammary gland under marginal dietary Se levels,an lipopolysaccharide(LPS)induced mouse mastitis model was established.Mice were fed with moderate Se diet(0.087 mg•kg^(-1) Se),adequate Se diet(0.15 mg•kg^(-1) Se)or excessive Se diet(1.5 mg•kg^(-1) Se)for 60 days.Se status and inflammatory factors were investigated.Results showed that the Se status of mammary gland correlated with dietary Se levels.Marginal Se deficiency exacerbated mammary tissue histopathology;increased the mRNA level of inflammatory genes tumor necrosis factor alpha(TNF-α),interleukin-1β(IL-1β)and cyclooxygenase-2(COX-2);and enhanced the phosphorylation of NF-κB p65 in mammary gland tissues.Supplementation of Se in diet higher than recommended levels reduced the inflammatory reaction of mammary glands in LPS-induced mastitis model and provided a protective effect.
文摘BACKGROUND Postpancreatectomy hemorrhage is one of the most severe and life-threatening complications after pancreaticoduodenectomy.We present four cases of gastrointestinal bleeding patients to clarify its appropriate treatment and prevention.CASE SUMMARY The main symptoms included black stool,hematochezia,haematemesis,blood in the nasogastric tube,and hemorrhagic shock.The mean age was 66.25 years old and the median onset time was 340 d after the surgery.The bleeding location comprised gastrointestinal anastomosis,bile duct-jejunum anastomosis,and extraluminal bleeding.The possible causes included marginal ulcer,jejunal varix,and abdominal infection.Endoscopic hemostatic clips,as well as a covered stent using angiography,were utilized to stop the bleeding and three patients survived.Only one patient died of gastrointestinal bleeding,abdominal bleeding,abdominal infection,hypovolemic shock,and disseminated intravascular coagulation.CONCLUSION Early and effective endoscopic intervention is the key to successful hemostasis in patients with gastrointestinal bleeding after pancreatoduodenectomy.
基金supported by the National Natural Science Foundation of China(Grant Nos.62372048,62371069,62272056,and U25B2014)。
文摘Marginal Fisher analysis(MFA)stands out as a prominent dimensionality reduction algorithm,striving to minimize within-class scatter while maximizing the separability between marginal data points.However,MFA and its variants require substantial computational resources when dealing with large-scale data.To address this,we propose quantum algorithms for MFA(called QMFA).QMFA is composed of two core processes:the first is the efficient construction of the weight matrices for the intrinsic and penalty graphs,and the second is solving the generalized eigenvalue problem(GEP)using the block-encoding technique.Compared to classical MFA,the proposed QMFA achieves a polynomial acceleration in the number of samples and exponential acceleration in the dimensionality.Additionally,we investigate quantum algorithms for different variants of MFA.Specifically,for enhanced MFA and multiple MFA,we address the construction of the related weight matrix,which differs from that in standard MFA.For kernel MFA,we solve the GEP associated with the corresponding kernel matrix.The proposed quantum algorithms achieve a speedup equivalent to that of QMFA.
文摘BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma is a subtype of extranodal marginal zone lymphoma,typically occurring in mucosal sites such as the stomach,salivary glands,and lungs.This study aims to analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.AIM To analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.METHODS A retrospective cohort study was conducted using the Surveillance,Epidemiology,and End Results(SEER)database,which included 2453 patients diagnosed with MALT lymphoma from 2010 to 2021.Data were analyzed for demographic factors,tumor characteristics,treatment modalities,and survival outcomes.A Cox proportional hazards regression model was used to identify predictors of overall mortality and cancer-specific mortality.RESULTS The study predominantly included Non-Hispanic White patients(62.78%),with nearly equal gender distribution(50.31%females,49.69%males),and most diagnoses occurring in individuals aged 60-79 years.The majority of tumors were localized(80.07%).Multivariate analysis identified older age,male gender,advanced tumor stage,and socioeconomic factors—such as annual income and marital status—as independent predictors of mortality.No significant interaction between age and gender on mortality outcomes was observed.CONCLUSION Sociodemographic factors,including advanced age,male gender,annual income,and marital status,as well as advanced tumor stage,significantly impacted survival outcomes in patients with MALT lymphoma.Radiotherapy was associated with a reduction in overall mortality.Early detection is crucial for optimizing outcomes,as localized disease responds well to available treatment modalities.
基金supported by the National Natural Science Foundation of China(Nos.82373817 and 82003659)Shanghai Natural Science Foundation(No.23ZR1477500)Pudong Health Bureau of Shanghai(No.YC-2023-0401)。
文摘As PEGylated liposomes have witnessed remarkable advancements in drug delivery,their immunogenicity has emerged as a notable challenge.In this study,we discovered that a simple pre-injection of folic acid(FA)effectively mitigated the immunogenicity of PEGylated liposomes and enhanced their in vivo performance by tolerating splenic marginal zone B cells.FA specifically inhibited the internalization of PEGylated liposomes by splenic marginal zone B cells,thereby reducing splenic lymphocyte proliferation and specific IgM secretion.This modulation alleviated Ig M-mediated accelerated blood clearance and adverse accumulation of the PEGylated liposomes in the skin.These findings provide new insights into the immunomodulatory effects of FA and promising avenues to enhance the efficacy and safety of PEGylated liposomal nanomedicines.
基金financially supported by the National Natural Science Foundation of China(Grant No.42002150)the Open Foundation of Cooperative Innovation Center of Unconventional Oil and Gas,Yangtze University(Ministry of Education&Hubei Province,Grant No.UOG2024-12)+1 种基金the Open Foundation Project of the Key Laboratory of Polar Geology and Marine Mineral Resources(China University of Geosciences,Beijing,China),Ministry of Education(Grant No.PGMR-2023-201)the National Key Research Program of China(Grant No.2017ZX05032-002)。
文摘Compared to discrete continental marginal basins,the mechanisms of hydrocarbon migration and enrichment in transform continental marginal basins are poorly understood.In this study,we conducted a comprehensive analysis of the main source rocks,reservoirs,and vertical migration pathways within the Rovuma(RB)and Tanzania(TB)basins in East Africa utilizing drilling,logging,seismic,and geochemical data.The results indicate that the enhanced preservation conditions of the Lower Jurassic source rocks in the southwest could lead to the discovery of large natural gas fields in the southern TB and RB.The primary reservoir is a deep-water turbidite sandstone.Due to topographic differences,the expanse of the turbidite sandstones in the RB is significantly larger than those in Tanzania.The main vertical migration pathways are the western boundary fault zone of the Kerimbas Graben(WBFZ)and the Seagap fault zone(SFZ).In the RB,natural gas migrates vertically along the WBFZ and preferentially accumulates in the deep-water turbidite sandstones of the footwall under the control of the fluid potential.Conversely,in the southern TB,the deep natural gas first migrates upward along the SFZ,then moves along the shallow branch faults in the sandstones on both sides of the SFZ.
基金funded in part by Grant No.DF-091-135-1441 from the Deanship of Scientific Research(DSR)at King Abdulaziz University in Saudi Arabia.
文摘In this paper,we propose STPLF,which stands for the short-term forecasting of locational marginal price components,including the forecasting of non-conforming hourly net loads.The volatility of transmission-level hourly locational marginal prices(LMPs)is caused by several factors,including weather data,hourly gas prices,historical hourly loads,and market prices.In addition,variations of non-conforming net loads,which are affected by behind-the-meter distributed energy resources(DERs)and retail customer loads,could have a major impact on the volatility of hourly LMPs,as bulk grid operators have limited visibility of such retail-level resources.We propose a fusion forecasting model for the STPLF,which uses machine learning and deep learning methods to forecast non-conforming loads and respective hourly prices.Additionally,data preprocessing and feature extraction are used to increase the accuracy of the STPLF.The proposed STPLF model also includes a post-processing stage for calculating the probability of hourly LMP spikes.We use a practical set of data to analyze the STPLF results and validate the proposed probabilistic method for calculating the LMP spikes.
文摘This study documents pioneering results in marginal wells in Texas,where the application of RDV-00■restored production through delayed protonic activation catalyzed by reservoir energy.The product,based on RDV■(Vasoactive Dynamic Reactor)technology,operates via:Controlled protonation of molecular structures;Release of energetic carbocations;Autonomous transformation without external inputs.(a)Case 1(Well#E2-Starr County):Certified as“dry”by RRC(2022)after 48 months at 0 BPD;8 months post-injection of 5 gal RDV-00■(Fluid column:37 bbl;Wellhead pressure:80 psi(vs.0 psi initially)).(b)Case 2(Well#P1-Luling Field):Historical stripper well(0.25-0.5 BPD);23 months of immobilization with 15 gal RDV-00■;Critical results:(1)Initial production:42 BPD(8,400%above baseline);(2)Shut-in wellhead pressure:40 psi(neighboring wells=0-3 psi);(3)Current behavior:Continuous recharge from reservoir(well shut-in due to lack of storage).(c)Technically Significant Observations:(1)First case of self-sustaining reactivation in depleted wells;(2)Mechanism validated by Autonomous pressure generation(0→40-80 psi),and Continuous flow without additional stimulation;(3)No documented precedents in SPE/OnePetro literature to our knowledge.
基金Supported by National Natural Science Foundation of China(No.82201214,No.82201221)Ophthalmic New Technology Incubation Fund Project of China Primary Health Care Foundation(No.2022 No.005)Shaanxi Key Research and Development Program(No.2021SF-156).
文摘AIM:To analyze the clinical and pathological features of 89 patients presenting as lacrimal gland prolapse(LGP).METHODS:This retrospective study included 89 patients presenting as LGP.Magnetic resonance imaging(MRI)scan was performed for all patients.Pathology and immunohistochemical staining of prolapsed tissue were performed during the surgery.The histopathological subtype was obtained,and the related clinical manifestations of different subtype were marked.RESULTS:Among the 89 patients involved,the histopathological subtype includes dacryoadenitis(43%;n=38),focal lymphocytes infiltration(20%;n=18),immunoglobulin G4(IgG4)-related lacrimal gland inflammatory disease(15%;n=13),lacrimal gland(13%;n=12),and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue(9%;n=8).As for manifestations of different subtypes,eyelid swelling was found the most frequent of lymphocytes infiltration(44%,n=8),and palpable lacrimal gland mass of dacryoadenitis(55%,n=21).All the IgG4-related lacrimal gland inflammatory disease(100%,n=13)and most dacryoadenitis(97%,n=37)presented as bilateral.CONCLUSION:LGP has the histopathological subtype most commonly as inflammation,followed by structural and lymphoproliferative changes.Most of patients present as eyelid swelling.Clinical manifestations can be significant to differentiate the diagnosis.
文摘The woodland-steppe ecotone in the. southern Nei Mongol Plateau is located at the northern edge of the east Asian monsoon influences. A marked southeastern - northwestern (SE - NW) precipitation gradient exists in this region. Quantitative reconstruction of palaeo-precipitation of this region is helpful to reveal the development of monsoon climate and to predict die future desertification. Based on modern vegetation and surface pollen studies, a pollen-precipitation transfer function in the study region was established. Pollen data from three sediment sequences within the ecotone were used to reconstruct palaeo-precipitation during the Holocene. The processes of precipitation changes in the three sequences were quite different. There was a tendency of precipitation declined from the onset of the Holocene to 1 100 a BP in Haoluku. But, in Liuzhouwan and Xiaoniuchang, both located south of Haoluku, the annual precipitation reached highest values during 7 800 - 6 200 a BP and 7 200 - 5 000 a BP, respectively. The influences of southwestern (SW) monsoon and the variances of topographical conditions have possibly caused these temporal-spatial variances.
