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Transplantation of human neural stem cells repairs neural circuits and restores neurological function in the stroke-injured brain
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作者 Peipei Wang Peng Liu +7 位作者 Yingying Ding Guirong Zhang Nan Wang Xiaodong Sun Mingyue Li Mo Li Xinjie Bao Xiaowei Chen 《Neural Regeneration Research》 2026年第3期1162-1171,共10页
Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju... Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients. 展开更多
关键词 behavioral recovery circuit repair electrophysiological properties functional integration human neural stem cell transplantation infarction volume STROKE synaptic tracing
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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits
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作者 Yuehua Cui Xiaokuang Ma +7 位作者 Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu 《Neural Regeneration Research》 SCIE CAS 2025年第5期1431-1444,共14页
Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse functi... Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions. 展开更多
关键词 aging circuit connectivity cortical circuits molecular mechanisms neural regeneration NEURODEGENERATION synapses
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Preface to Special Topic on Integrated Circuits, Technologies and Applications 2024
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作者 Zheng Wang Yan Lu 《Journal of Semiconductors》 2025年第6期6-7,共2页
This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which w... This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which was held in Hangzhou,Zhejiang,China,from October 25 to 27,2024. 展开更多
关键词 TECHNOLOGIES IEEE International Conference Integrated circuits Technologies Applications integrated circuits technologies integrated circuits ZHEJIANG expanded versions key articles journal semiconductors APPLICATIONS
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CRISPR-Cas systems in DNA functional circuits:Strategies,challenges,prospects
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作者 Xiaolong Li Changjiang Li +4 位作者 Chaopeng Shi Jiarun Wang Bei Yan Xianjin Xiao Tongbo Wu 《Chinese Chemical Letters》 2025年第7期49-57,共9页
Strand displacement-based DNA circuits have emerged as highly effective tools for molecular computation,serving purposes of amplification or decision-making.They are favored for their inherent occurrence and sensitivi... Strand displacement-based DNA circuits have emerged as highly effective tools for molecular computation,serving purposes of amplification or decision-making.They are favored for their inherent occurrence and sensitivity to external conditions.However,achieving enhanced amplification or decision-making necessitates the incorporation of multiple strands,thereby increasing the risk of contamination.Recent advancements have led to the development of CRISPR-Cas-based DNA circuits.These systems aim to simplify the complexity associated with conventional circuits,mitigate contamination risks,and enable more substantial amplification or decision-making capabilities.Here,the review article centers on current strategies of CRISPR-Cas(Cas9,Cas12a,Cas13a)system-assisted circuits in amplification and decisionmaking,and assesses their tendencies and limitations in amplification circuits and decision-making circuits.Furthermore,we discuss the challenges of CRISPR-Cas in circuits and propose prospects that will contribute to constructing more efficient and diverse CRISPR-Cas-based DNA functional circuits. 展开更多
关键词 CRISPR-Cas DNA circuit AMPLIFICATION DECISION-MAKING
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Investigation and Research on Students'Learning Ability in Vocational Undergraduate Education:A Case Study of the Integrated Circuits Major at Shenzhen Polytechnic University
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作者 CHENG Bowen 《Philosophy Study》 2025年第5期269-276,共8页
Vocational undergraduate education has entered a new stage of high-quality development,making the cultivation of students'learning ability a core issue in enhancing talent cultivation quality.This study conducted ... Vocational undergraduate education has entered a new stage of high-quality development,making the cultivation of students'learning ability a core issue in enhancing talent cultivation quality.This study conducted a questionnaire survey with 177 students majoring in integrated circuits at Shenzhen Polytechnic University(SZPU),focusing on six dimensions:self-learning proficiency,academic competence,goal planning,self-discipline,learning initiative,and learning environment.The results indicate that while students possess a solid learning foundation and clear career planning,significant deficiencies exist in the execution of academic plans,self-discipline,and learning initiative.In response to these issues,this study proposes four systematic improvement pathways from the institutional perspective:establishing a closed-loop academic navigation system incorporating“goal-process-feedback”,creating an immersive“virtual-physical integrated”learning environment,implementing a multi-dimensional“cognitive-affective-practical”initiative activation plan,and building a synergistic cultivation mechanism for“self-discipline and core competencies”.The findings aim to provide references for talent cultivation and teaching reform in vocational undergraduate integrated circuit programs. 展开更多
关键词 vocational undergraduate education students'learning ability integrated circuit major
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Simulation of the non-Hermitian Kitaev chain by electrical circuits
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作者 Jiali Xu Hao Geng +3 位作者 Abdul Wahab Xiaosen Yang Yuee Xie Yuanping Chen 《Chinese Physics B》 2025年第6期588-595,共8页
We investigate the topological properties of the non-Hermitian Kitaev chain by exploiting the versatility of the circuit.We implement non-reciprocal coupling through a negative impedance converter with current inversi... We investigate the topological properties of the non-Hermitian Kitaev chain by exploiting the versatility of the circuit.We implement non-reciprocal coupling through a negative impedance converter with current inversion(INIC). By conducting impedance measurements between neighboring nodes, we identify both topologically non-trivial and trivial phases within the circuit's admittance band dispersion under open boundary conditions(OBC). Our analysis of complex admittance spectra reveals differences when comparing circuits with periodic boundary conditions(PBC) to those with OBC.Furthermore, we observe Z_(2) skin effects and Majorana zero modes in the topologically non-trivial phases, which are robust against disorders. Notably, the admittance spectra exhibit remarkable sensitivity to the attenuation of the boundary coupling strength. This AC circuit system serves as a promising platform for investigating topological phenomena, opening avenues for the development of functional devices across various application scenarios. 展开更多
关键词 non-Hermitian Kitaev chain non-Hermitian skin effect CIRCUIT
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维生素C缓解缙云麻鸭上笼应激引起的肝肠氧化损伤
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作者 任晋东 田勇 +5 位作者 刘香杉 陈黎 曾涛 顾天天 许文武 卢立志 《中国家禽》 北大核心 2026年第3期36-45,共10页
研究旨在探讨维生素C对蛋鸭上笼应激引起的肝肠氧化损伤的缓解作用。试验选取82日龄缙云麻鸭120只,随机分成对照组和维生素C组,每组3个重复,每个重复20只鸭。两组蛋鸭在适宜温度下进行常规平养7 d后进行上笼饲养10 d。试验期间,对照组... 研究旨在探讨维生素C对蛋鸭上笼应激引起的肝肠氧化损伤的缓解作用。试验选取82日龄缙云麻鸭120只,随机分成对照组和维生素C组,每组3个重复,每个重复20只鸭。两组蛋鸭在适宜温度下进行常规平养7 d后进行上笼饲养10 d。试验期间,对照组饲喂基础饲粮(维生素C实测水平为37 mg/kg),维生素C组在基础饲粮中添加500 mg/kg维生素C。结果显示:饲粮中补充维生素C能够显著改善蛋鸭上笼后的应激行为,并提高其血清和组织中的抗氧化能力。具体表现为:(1)与对照组相比,维生素C组蛋鸭血清中过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶活性显著升高(P<0.05)。(2)与对照组相比,维生素C组蛋鸭上笼应激第7天肝脏组织中过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶活性和总抗氧化能力显著提升(P<0.05),同时丙二醛含量显著降低(P<0.05);上笼应激第2天和第7天十二指肠中谷胱甘肽过氧化物酶活性和超氧化物歧化酶分别显著提升(P<0.05)。(3)与对照组相比,维生素C组蛋鸭肝脏和十二指肠的病理损伤明显减轻;上笼应激第2天肝脏组织中应激和炎症关键基因COX2、GRP78和iNOS的基因表达水平显著降低(P<0.05);上笼应激第7天十二指肠中GRP78的基因表达水平显著降低(P<0.05),而iNOS的基因表达水平显著增加(P<0.05)。研究表明,蛋鸭饲粮总维生素C含量为537 mg/kg时能显著提升上笼应激蛋鸭的血液、肝脏、十二指肠抗氧化能力,减轻上笼应激造成肝肠病理损伤,提高蛋鸭的健康水平和生产性能。 展开更多
关键词 维生素C 蛋鸭 上笼应激 氧化损伤
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Fault-Tolerant Control of Current Measurement Circuits for Three-Phase Grid-Connected Inverters
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作者 Fatma Ben Youssef Ahlem Ben Youssef +1 位作者 Mohamed Naoui Lassaad Sbita 《Journal of Dynamics, Monitoring and Diagnostics》 2025年第4期308-317,共10页
Three-phase grid-connected inverters(GCIs)are essential components in distributed generation systems,where the accuracy of current measurement circuits is fundamental for reliable closed-loop operation.Nevertheless,th... Three-phase grid-connected inverters(GCIs)are essential components in distributed generation systems,where the accuracy of current measurement circuits is fundamental for reliable closed-loop operation.Nevertheless,the presence of a DC offset in the measured current can disrupt the regulation of grid currents and significantly degrade system performance.In this work,a fault-tolerant control approach is introduced to counteract the impact of such offset faults through a dedicated current compensation mechanism.The proposed solution is built around two main stages:(i)detecting and isolating DC offset faults that may appear in one or multiple phases of the measured grid currents,and(ii)estimating the fault magnitude and reconstructing the corrected current signal.The offset magnitude is obtained analytically by examining the grid current projected onto the synchronous d-axis at the grid angular frequency,eliminating the need for any additional sensing hardware.Simulation and experimental investigations conducted under several fault scenarios confirm the robustness of the proposed strategy and highlight significant improvements in detection speed and diagnostic accuracy. 展开更多
关键词 fault detection grid-connected inverter fault isolation fault-tolerant control sensing circuit
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A low-noise and high-stability DC source for superconducting quantum circuits
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作者 Daxiong Sun Jiawei Zhang +16 位作者 Peisheng Huang Yubin Zhang Zechen Guo Tingjin Chen Rui Wang Xuandong Sun Jiajian Zhang Wenhui Huang Jiawei Qiu Ji Chu Ziyu Tao Weijie Guo Xiayu Linpeng Ji Jiang Jingjing Niu Youpeng Zhong Dapeng Yu 《Chinese Physics B》 2025年第9期48-55,共8页
With the rapid scaling of superconducting quantum processors,electronic control systems relying on commercial off-the-shelf instruments face critical bottlenecks in signal density,power consumption,and crosstalk mitig... With the rapid scaling of superconducting quantum processors,electronic control systems relying on commercial off-the-shelf instruments face critical bottlenecks in signal density,power consumption,and crosstalk mitigation.Here we present a custom dual-channel direct current(DC)source module(QPower)dedicated to large-scale superconducting quantum processors.The module delivers a voltage range of±7 V with 200 m A maximum current per channel,while achieving the following key performance benchmarks:noise spectral density of√Hz at 10 k Hz,output ripple<500μV_(pp)within 20 MHz bandwidth,and long-term voltage drift<5μVpp over 12 hours.Integrated into the control electronics of a 66-qubit quantum processor,QPower enables qubit coherence time of T_(1)=87.6μs and Ramsey dephasing time of T_(2)=5.1μs,with qubit resonance frequency drift constrained to±40 k Hz during 12-hour operation.This modular design is compact in size and efficient in energy consumption,providing a scalable DC source solution for intermediate-scale quantum processors with stringent noise and stability requirements,with potential extensions to other quantum hardware platforms and precision measurement systems. 展开更多
关键词 superconducting quantum circuits superconducting qubit low noise DC source
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Research on Optimization Strategies for Signal Integrity of High-Speed Digital Circuits in Electronic Information Engineering
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作者 Yiming Li 《Journal of Electronic Research and Application》 2025年第5期304-309,共6页
With the rapid development of electronic information engineering,high-speed digital circuits have been increasingly widely applied in various fields.In high-speed digital circuits,signal integrity is prone to interfer... With the rapid development of electronic information engineering,high-speed digital circuits have been increasingly widely applied in various fields.In high-speed digital circuits,signal integrity is prone to interference from various external factors,leading to issues such as signal distortion or degradation of system performance.Based on this,this paper conducts research on the optimization strategies for signal integrity of high-speed digital circuits in electronic information engineering.It deeply analyzes the importance of high-speed digital circuits,elaborates on the challenges they face and the specific manifestations of signal integrity issues,and proposes a series of optimization strategies in electronic information engineering.The aim is to improve the signal integrity of highspeed digital circuits and provide theoretical support and practical guidance for the development of related fields. 展开更多
关键词 High-speed digital circuits Signal integrity Electronic information engineering Optimization strategies
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Single-Molecule Detection by Silicon-based Photonic Integrated Circuits Chip
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作者 Dong Li Chengda Pan +7 位作者 Qiannan Huang Xiao Li Yan Zou Pengxiao Lv Xiujun Zheng Sarp Kerman Chunrui Hu Chang Chen 《Chinese Journal of Chemical Physics》 2025年第2期149-155,I0001,I0039,共9页
The single-molecule detection tech-nique plays a pivotal role in elucidat-ing the fundamental mechanisms of various scientific processes at the molecular level,and holds essential im-portance in multiple fields includ... The single-molecule detection tech-nique plays a pivotal role in elucidat-ing the fundamental mechanisms of various scientific processes at the molecular level,and holds essential im-portance in multiple fields including physics,biology,and chemistry.Re-cently,single-molecule detection has garnered increasing attention owing to its practical utility in medical diagno-sis,primarily due to its exceptional sensitivity and the minimal sample volume required for analysis.However,the conventional single-molecule technique,represented by total internal reflection microscopy,faces challenges such as sophisticated operation procedures and limited detection throughput,thereby impeding its broader application.To address these limitations,we have demonstrated single-molecule detection using an integrated silicon photonic chip,of-fering a cost-effective and user-friendly alternative.By employing basic optics,we efficiently introduce the excitation source for single-molecule fluorescence by harnessing the strong evanescent field of high refractive-index waveguides.Subsequently,fluorescence signals are collected using basic optics comprising a water-immersion objective,relay optics,and a digi-tal camera.Our results highlight a low-cost,high-throughput single-molecule technique achieved through the integrated silicon photonic chip.This innovative approach is promised to facilitate the widespread adoption of single-molecule fluorescence in medical diagnosis. 展开更多
关键词 Single-molecule fluorescence Silicon photonics Photonic integrated circuit To-tal internal reflection fluorescence microscopy
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Two-Dimensional Materials,the Ultimate Solution for Future Electronics and Very-Large-Scale Integrated Circuits
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作者 Laixiang Qin Li Wang 《Nano-Micro Letters》 2025年第10期600-652,共53页
The relentless down-scaling of electronics grands the modern integrated circuits(ICs)with the high speed,low power dissipation and low cost,fulfilling diverse demands of modern life.Whereas,with the semiconductor indu... The relentless down-scaling of electronics grands the modern integrated circuits(ICs)with the high speed,low power dissipation and low cost,fulfilling diverse demands of modern life.Whereas,with the semiconductor industry entering into sub-10 nm technology nodes,degrading device performance and increasing power consumption give rise to insurmountable roadblocks confronted by modern ICs that need to be conquered to sustain the Moore law's life.Bulk semiconductors like prevalent Si are plagued by seriously degraded carrier mobility as thickness thinning down to sub-5 nm,which is imperative to maintain sufficient gate electrostatic controllability to combat the increasingly degraded short channel effects.Nowadays,the emergence of two-dimensional(2D)materials opens up new gateway to eschew the hurdles laid in front of the scaling trend of modern IC,mainly ascribed to their ultimately atomic thickness,capability to maintain carrier mobility with thickness thinning down,dangling-bonds free surface,wide bandgaps tunability and feasibility to constitute diverse heterostructures.Blossoming breakthroughs in discrete electronic device,such as contact engineering,dielectric integration and vigorous channel-length scaling,or large circuits arrays,as boosted yields,improved variations and full-functioned processor fabrication,based on 2D materials have been achieved nowadays,facilitating 2D materials to step under the spotlight of IC industry to be treated as the most potential future successor or complementary counterpart of incumbent Si to further sustain the down-scaling of modern IC. 展开更多
关键词 2D materials Short channel effects Integrated circuits Degraded carrier mobility Moore's law
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镍/可见光协同催化的溴代芳烃与醇的C—O键偶联反应
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作者 高山 解鑫 刘元红 《有机化学》 北大核心 2026年第1期266-278,共13页
研究了镍/可见光协同催化的溴代芳烃/杂芳烃与醇的C—O键偶联反应.在456 nm蓝光的照射下,以有机光敏剂2,4,5,6-四(9-咔唑基)间苯二腈(4CzIPN)或者2,4,5,6-四(二苯胺基)间苯二腈(4DPAIPN)为光催化剂,以乙二醇二甲醚溴化镍(NiBr2•DME)、... 研究了镍/可见光协同催化的溴代芳烃/杂芳烃与醇的C—O键偶联反应.在456 nm蓝光的照射下,以有机光敏剂2,4,5,6-四(9-咔唑基)间苯二腈(4CzIPN)或者2,4,5,6-四(二苯胺基)间苯二腈(4DPAIPN)为光催化剂,以乙二醇二甲醚溴化镍(NiBr2•DME)、配体和碱为协同催化体系,高效地实现了烷基芳基醚类化合物的合成.该反应的可能历程为:Ni(0)中间体先与溴代芳烃发生氧化加成,再与醇进行配体交换;生成的Ni(II)中间体被激发态光催化剂氧化为Ni(III)中间体,继而发生还原消除反应.该反应具有良好的底物适用性,可以用于苄醇、一级醇与二级醇的转化,且官能团兼容性较好. 展开更多
关键词 镍催化 可见光 C—O键偶联 烷基芳基醚
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知识图谱驱动的C++课程BOPPPS+ADCD教学模式探索 被引量:2
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作者 王云艳 《计算机教育》 2026年第1期233-239,共7页
针对传统教学中自主学习和迁移学习不足、高阶计算思维培养不足、评价体系动态反馈不足等问题,提出知识图谱驱动的BOPPPS+ADCD线上线下混合教学模式,以C++程序设计课程为例,阐述如何通过知识图谱引领学生自主学习,并在BOPPPS参与式教学... 针对传统教学中自主学习和迁移学习不足、高阶计算思维培养不足、评价体系动态反馈不足等问题,提出知识图谱驱动的BOPPPS+ADCD线上线下混合教学模式,以C++程序设计课程为例,阐述如何通过知识图谱引领学生自主学习,并在BOPPPS参与式教学环节融入ADCD四阶段强化高阶计算思维训练,构建“教学—评价—改进”智慧评价的动态教学闭环以实现教学动态优化,最后说明教学实践效果。 展开更多
关键词 C++程序设计 知识图谱 BOPPPS+ADCD教学模式 智慧评价
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亚洲罕见伴VCP基因变异的肌病1例并文献复习
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作者 朱琳 赵珺 +2 位作者 王爽 邱峰 陈娟 《解放军医学杂志》 北大核心 2026年第1期65-69,共5页
目的总结含缬酪肽蛋白(VCP)基因c.464G>A变异的临床特征并进行文献复习,以提高对该突变相关疾病的认识。方法回顾性分析1例随访7年仅表现为肌病的VCP基因c.464G>A变异病例的临床资料;检索PubMed、万方数据和中国知网数据库截至202... 目的总结含缬酪肽蛋白(VCP)基因c.464G>A变异的临床特征并进行文献复习,以提高对该突变相关疾病的认识。方法回顾性分析1例随访7年仅表现为肌病的VCP基因c.464G>A变异病例的临床资料;检索PubMed、万方数据和中国知网数据库截至2025年4月发表的病例文献,总结同类型基因突变病例的临床特征。结果患者女,43岁,病程7年,无家族史和发育畸形,隐袭缓慢进展四肢近端肌无力,由腰部至双下肢、双上肢,后期出现肉跳,肌酸肌酶正常。MRI见双侧臀部及大腿肌肉脂肪浸润,伴肌肉萎缩。组织病理学检查显示骨骼肌出现肌纤维内镶边空泡、肌纤维坏死、再生和肥大,部分肌纤维可见胞浆体,核内包涵体形成,符合空泡肌病样病理改变。头颅MRI、认知功能筛查和骨密度未见异常。依据基因检测结果确诊为VCP基因c.464G>A(p.Arg155His)突变所致包涵体肌病。通过文献检索,共收集8例携带VCP 155位点突变(R155H)的患者,早期多表现为肌肉疾病或额颞叶痴呆。结论VCP基因c.464G>A变异临床表现具有高度异质性。VCP基因表型对相关包涵体肌病诊断起关键作用;临床缺少特效治疗,需长期随访观察。 展开更多
关键词 肌肉病 R155H突变 含缬酪肽蛋白 c.464G>A 包涵体肌病
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基于WOA-BP-LSTM自编码器的CFRP薄壁C柱轴压响应预测
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作者 牟浩蕾 张贾 +1 位作者 冯振宇 白春玉 《航空学报》 北大核心 2026年第4期112-124,共13页
针对航空器货舱下部碳纤维增强复合材料(CFRP)薄壁C柱在准静态轴压下的力-位移响应预测问题,提出了一种融合鲸鱼优化算法(WOA)、反向传播(BP)神经网络和长短期记忆(LSTM)自编码器的智能预测模型(WOA-BPLSTM自编码器模型)。通过CFRP薄壁... 针对航空器货舱下部碳纤维增强复合材料(CFRP)薄壁C柱在准静态轴压下的力-位移响应预测问题,提出了一种融合鲸鱼优化算法(WOA)、反向传播(BP)神经网络和长短期记忆(LSTM)自编码器的智能预测模型(WOA-BPLSTM自编码器模型)。通过CFRP薄壁C柱准静态轴压试验验证了有限元模型可靠性,其轴压响应评价指标误差均小于10%,基于该模型构建了包含700组变截面几何参数的力-位移响应数据集。采用LSTM自编码器实现力-位移响应特征降维与重建,随后采用BP神经网络对力-位移响应进行预测,并采用WOA进行神经网络参数优化。结果表明,LSTM自编码器实现了力-位移响应的高精度重建,测试集初始峰值压溃力和能量吸收的重建误差均小于3%,80%样本误差小于1%;优化后预测模型的力-位移响应预测精度显著提升,测试集平均绝对误差(MAE)降低17.55%,均方误差(MSE)降低31.77%,均方根误差(RMSE)降低17.47%,初始峰值压溃力和能量吸收的预测误差均小于8%,80%样本误差小于5%。该智能预测模型实现了变截面CFRP薄壁C柱轴压响应的快速精准预测并降低了计算成本,为其轴压响应研究提供了一种高效的参数-性能映射工具。 展开更多
关键词 CFRP薄壁C柱 轴压响应 LSTM自编码器 鲸鱼优化算法 BP神经网络
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C反应蛋白/白蛋白比值与D-二聚体联合检测对妊娠合并急性胰腺炎病情严重程度的预测价值
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作者 刘英男 严丽梅 《中国医科大学学报》 北大核心 2026年第1期75-79,共5页
目的探讨血清C反应蛋白/白蛋白比值(CAR)、D-二聚体及二者联合检测预测妊娠合并急性胰腺炎(APIP)病情严重程度的价值。方法收集2021年1月至2023年12月间我院APIP患者及同期分娩的正常妊娠者(健康对照组)的临床资料。根据APIP病情严重程... 目的探讨血清C反应蛋白/白蛋白比值(CAR)、D-二聚体及二者联合检测预测妊娠合并急性胰腺炎(APIP)病情严重程度的价值。方法收集2021年1月至2023年12月间我院APIP患者及同期分娩的正常妊娠者(健康对照组)的临床资料。根据APIP病情严重程度将患者分为非重症组、重症组;根据病因分为胆源型组、高脂血症型组、特发型组。用logistic回归分析影响APIP病情严重程度的危险因素及其诊断效能。结果CAR、D-二聚体是影响APIP病情严重程度的独立危险因素。CAR和D-二聚体联合检测受试者操作特征曲线下面积最大,且灵敏度、特异度等诊断效能均优于单独检测。结论CAR及D-二聚体是APIP病情严重程度的独立危险因素,且二者联合检测可作为APIP病情严重程度的良好预测指标。 展开更多
关键词 妊娠合并急性胰腺炎 C反应蛋白/白蛋白比值 D-二聚体 联合预测
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Enhancing Safety in Electric Vehicles:Multi-Tiered Fault Detection for Micro Short Circuits and Aging in Battery Modules
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作者 Yi-Feng Luo Jyuan-FongYen Wen-Cheng Su 《Computer Modeling in Engineering & Sciences》 2025年第3期3069-3087,共19页
This article proposes a multi-tiered fault detection system for series-connected lithium-ion battery modules.Improper use of batteries can lead to electrolyte decomposition,resulting in the formation of lithium dendri... This article proposes a multi-tiered fault detection system for series-connected lithium-ion battery modules.Improper use of batteries can lead to electrolyte decomposition,resulting in the formation of lithium dendrites.These dendrites may pierce the separator,leading to the failure of the insulation layer between electrodes and causing micro short circuits.When a micro short circuit occurs,the electrolyte typically undergoes exothermic reactions,leading to thermal runaway and posing a safety risk to users.Relying solely on temperature-based judgment mechanisms within the battery management system often results in delayed intervention.To address this issue,the article develops a multi-tiered fault detection algorithm for series-connected lithium-ion batteries.This algorithm can effectively diagnose micro short circuits,aging,and normal batteries using minimal battery data,thereby improving diagnostic accuracy and enhancing the flexibility of fault detection.Simulations and experiments conducted under various levels of micro short circuits validate the effectiveness of the algorithm,demonstrating its ability to distinguish between short-circuited,aged,and normal batteries under different conditions.This technology can be applied to electric vehicles and energy storage systems,enabling early warnings to ensure safety and prevent thermal runaway. 展开更多
关键词 Multi-tiered fault detection micro short circuits(MSC) battery management system(BMS) lithiumion batteries electric vehicles(EV) energy storage systems(ESS)
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C++11库在操作系统教学中的应用探讨
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作者 张治国 李运娣 《信息与电脑》 2026年第5期242-244,共3页
文章探讨了操作系统原理教学中存在的问题。针对多数院校缺少操作系统实践环节或实践学习深度不足的情况,提出了使用C++标准库辅助操作系统原理教学的思路及具体方法,并针对操作系统原理相关章节的内容,给出了运用C++标准库开展教学的... 文章探讨了操作系统原理教学中存在的问题。针对多数院校缺少操作系统实践环节或实践学习深度不足的情况,提出了使用C++标准库辅助操作系统原理教学的思路及具体方法,并针对操作系统原理相关章节的内容,给出了运用C++标准库开展教学的案例。 展开更多
关键词 操作系统教学 实践 C++11 C++标准库
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碱玉米芯-硫磺复合填料反硝化协同脱氮性能研究
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作者 刘艳芳 邢琳琼 +2 位作者 刘柏利 李雨轩 高湘 《应用化工》 北大核心 2026年第2期388-394,共7页
以玉米芯为碳源,通过静态试验,探究预处理方式对释碳性能影响,并构建连续流硫自养-异养混合营养反硝化反应器,通过调整水力停留时间(HRT),考察其脱氮性能。结果表明,碱处理是提升玉米芯释碳性能的最佳预处理方式,能够有效去除木质素组分... 以玉米芯为碳源,通过静态试验,探究预处理方式对释碳性能影响,并构建连续流硫自养-异养混合营养反硝化反应器,通过调整水力停留时间(HRT),考察其脱氮性能。结果表明,碱处理是提升玉米芯释碳性能的最佳预处理方式,能够有效去除木质素组分,提升其生物利用率。在进水浓度50 mg/L,HRT为4 h条件下,碱玉米芯-硫磺混合营养反硝化体系对硝态氮(NO_(3)^(-)-N)的去除率达到了98.58%,且亚硝态氮(NO_(2)^(-)-N)积累量较少,出水COD稳定维持在50.64 mg/L,pH值保持在中性范围内。微生物群落分析结果表明,混合营养反硝化系统中的主要优势菌属为Thiobacillus(24.13%)、Thauera(14.95%)和Thermomonas(15.54%)。自养菌和异养菌的协同作用,对于反硝化的高效运行至关重要。 展开更多
关键词 碱处理 玉米芯 混合营养反硝化 微生物群落结构 低C/N比废水
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