Background: Due to extensive use of antibiotics, multidrug resistance of Acinetobacter baumannii (A.b) infection has become one of the major challenges in clinic, which is difficult to treat and have a high mortality ...Background: Due to extensive use of antibiotics, multidrug resistance of Acinetobacter baumannii (A.b) infection has become one of the major challenges in clinic, which is difficult to treat and have a high mortality rate. Based on this, we must take pro active measures against antimicrobial resistance by improving the efficacy. To provide a high-quality clinical evidence, a meta-analysis was conducted to compare the efficacy and safety of three anti-infection therapeutic regimens for the treatment of multidrug resistance of Acinetobacter baumannii(MRAB) infection. Methods: A meta-analysis of 36 randomized controlled trials, comprising approximately 3014 patients, was conducted to compare the efficacy and safety of three anti-infection therapeutic regimens for the treatment of MRAB infection. The clinical response rate and microbiological response rate between cefbperazone-sulbactam group and tigecycline plus cefbperazone-sulbactam group were RR=1.33, 95% CI= 1.27-1.39 and RR=1.72, 95% CI=1.55-1.90, respectively;Cefoperazone-sulbactam group and tigecycline plus isepamicin group were RR=1.29, 95% CI=1.19-1.39 and RR=1.59, 95% CI=1.37-1.84, respectively. Results: There was no significant difference between tigecycline plus cefbperazone-sulbactam group and tigecycline plus isepamicin group in the clinical response rate or microbiological response rate. Neither was there any adverse events (AEs) among the three regimens. Conclusion: Our finding suggested that tigecycline combined with cefbperazone-sulbactam or isepamicin may be performed with more efficacy than cefoperazone-sulbactam monotherapy in MRAB infections treatment.展开更多
Based on an investigation on the current situation of SPM in some enterprises, this paper presents the common probletns and poor fields existing in SPM in enterprise; analyzes the reasons which resulted in the situati...Based on an investigation on the current situation of SPM in some enterprises, this paper presents the common probletns and poor fields existing in SPM in enterprise; analyzes the reasons which resulted in the situation, and then puts forward some feasible measures to improve it. Lastly, some fields that should be paid more attention in SPM are provided.展开更多
A fractional[a,b]-factor of a graph G is a function h from E(G)to[0,1]satisfying a≤d^(h)_(G)(v)≤b for every vertex v of G,where d^(h)_(G)(v)=∑e∈E(v)h(e)and E(v)={e=uv:u∈V(G)}.A graph G is called fractional[a,b]-c...A fractional[a,b]-factor of a graph G is a function h from E(G)to[0,1]satisfying a≤d^(h)_(G)(v)≤b for every vertex v of G,where d^(h)_(G)(v)=∑e∈E(v)h(e)and E(v)={e=uv:u∈V(G)}.A graph G is called fractional[a,b]-covered if G contains a fractional[a,b]-factor h with h(e)=1 for any edge e of G.A graph G is called fractional(a,b,k)-critical covered if G—Q is fractional[a,b]-covered for any Q⊆V(G)with∣Q∣=k.In this article,we demonstrate a neighborhood condition for a graph to be fractional(a,b,k)-critical covered.Furthermore,we claim that the result is sharp.展开更多
Recently, the intensive investigations of chemical constituents of Taxaceac, especially the antitumor diterpenes related to taxane, have already been stimulated by the significant discovery of antitumor activity of ta...Recently, the intensive investigations of chemical constituents of Taxaceac, especially the antitumor diterpenes related to taxane, have already been stimulated by the significant discovery of antitumor activity of taxol. Such studies will eventually result in the development of a new type of chemotherapeutic antitumor agents.展开更多
基金shandong Medical and Health science and technology Development Program(Project no.2017Ws201 and no.2047Ws029)
文摘Background: Due to extensive use of antibiotics, multidrug resistance of Acinetobacter baumannii (A.b) infection has become one of the major challenges in clinic, which is difficult to treat and have a high mortality rate. Based on this, we must take pro active measures against antimicrobial resistance by improving the efficacy. To provide a high-quality clinical evidence, a meta-analysis was conducted to compare the efficacy and safety of three anti-infection therapeutic regimens for the treatment of multidrug resistance of Acinetobacter baumannii(MRAB) infection. Methods: A meta-analysis of 36 randomized controlled trials, comprising approximately 3014 patients, was conducted to compare the efficacy and safety of three anti-infection therapeutic regimens for the treatment of MRAB infection. The clinical response rate and microbiological response rate between cefbperazone-sulbactam group and tigecycline plus cefbperazone-sulbactam group were RR=1.33, 95% CI= 1.27-1.39 and RR=1.72, 95% CI=1.55-1.90, respectively;Cefoperazone-sulbactam group and tigecycline plus isepamicin group were RR=1.29, 95% CI=1.19-1.39 and RR=1.59, 95% CI=1.37-1.84, respectively. Results: There was no significant difference between tigecycline plus cefbperazone-sulbactam group and tigecycline plus isepamicin group in the clinical response rate or microbiological response rate. Neither was there any adverse events (AEs) among the three regimens. Conclusion: Our finding suggested that tigecycline combined with cefbperazone-sulbactam or isepamicin may be performed with more efficacy than cefoperazone-sulbactam monotherapy in MRAB infections treatment.
文摘Based on an investigation on the current situation of SPM in some enterprises, this paper presents the common probletns and poor fields existing in SPM in enterprise; analyzes the reasons which resulted in the situation, and then puts forward some feasible measures to improve it. Lastly, some fields that should be paid more attention in SPM are provided.
基金This work is supported by Six Big Talent Peak of Jiangsu Province,China(Grant No.JY-022).
文摘A fractional[a,b]-factor of a graph G is a function h from E(G)to[0,1]satisfying a≤d^(h)_(G)(v)≤b for every vertex v of G,where d^(h)_(G)(v)=∑e∈E(v)h(e)and E(v)={e=uv:u∈V(G)}.A graph G is called fractional[a,b]-covered if G contains a fractional[a,b]-factor h with h(e)=1 for any edge e of G.A graph G is called fractional(a,b,k)-critical covered if G—Q is fractional[a,b]-covered for any Q⊆V(G)with∣Q∣=k.In this article,we demonstrate a neighborhood condition for a graph to be fractional(a,b,k)-critical covered.Furthermore,we claim that the result is sharp.
文摘Recently, the intensive investigations of chemical constituents of Taxaceac, especially the antitumor diterpenes related to taxane, have already been stimulated by the significant discovery of antitumor activity of taxol. Such studies will eventually result in the development of a new type of chemotherapeutic antitumor agents.
