The sea surface temperature(SST)front over the northern South China Sea(NSCS)has significant impacts on regional weather,climate,and marine ecology.Based on high-resolution satellite data and reanalysis data,the long-...The sea surface temperature(SST)front over the northern South China Sea(NSCS)has significant impacts on regional weather,climate,and marine ecology.Based on high-resolution satellite data and reanalysis data,the long-term variation characteristics and possible mechanisms of the SST front intensity(SSTFI)over the NSCS in winter from 1986 to 2020 are analyzed.The results show that:(1)Based on empirical orthogonal decomposition analysis,the evolution features of SST front mainly include two types:position shift type and an intensity variation type.(2)The SSTFI is accelerating in recent two decades.From 1986 to 2003(P1),the SSTFI changed relatively smoothly[0.2℃/(km·decade)],while from 2004 to 2020(P2),there is a significant strengthening trend[1.2℃/(km·decade)].(3)The horizontal advection related to the ocean current dominates the intensification of the SST front.An anomalous cyclonic circulation in upper ocean of the NSCS and the coastal current of South China strengthen the cold advection,resulting in cooling of the coastal waters of South China.(4)The latent heat flux dominates the sea surface heat loss and cooling process,but both latent and sensible heat flux are not conducive to the enhancement of the SSTFI.(5)The increase in SSTFI is largely associated with La Niña-like pattern,which is conducive to enhance the East Asia winter monsoon,and strengthens the ocean front through air-sea interactions.This study provides a scientific reference for understanding the variations of the SSTFI.展开更多
Lesion mimic mutant（LMM） genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed l...Lesion mimic mutant（LMM） genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae（Xoo） by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A（e EF1A）-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice.展开更多
Background:Breast cancer is a major public health concern for women around the world.Breast cancer incidence increases with age,and this is an important factor for the management of this disease.The aim of this study ...Background:Breast cancer is a major public health concern for women around the world.Breast cancer incidence increases with age,and this is an important factor for the management of this disease.The aim of this study was to assess the clinical profiles of female Iraqi breast cancer patients in their fifth decade,and to evaluate patients'molecular profiles and 5-year disease-free survival(DFS).Methods:A retrospective study was conducted at Baghdad Oncology Teaching Hospital between 1 January 2012 and 12 December 2016.Of 979 individuals seen,285 were aged between 40 and 49 years.Results:The median age at diagnosis was 45 years.The highest incidence of breast cancer occurred among women in their fifth(40-49 years old)and sixth(50-59 years old)decades of life(29%and 28%,respectively).The most common stages at diagnosis were stages II and III,with 40.8%and 39.5%,respectively.Luminal A-like cancers were seen in 124 women(58.5%)and 29 women(13.7%)presented with triple-negative cancers.De novo metastatic disease comprised just 6.7%of the group studied.The median DFS was 48 months(95%CI:41.4-54.5 months).Conclusions:The highest incidence of breast cancer occurred among women in their fifth and sixth decades of life.The most common diagnosis was stage II breast cancer of the luminal A molecular subtype.HER-2(human epidermal growth factor receptor 2)overexpression and triple-negative were the least common subtypes.The median DFS was 48 months.展开更多
In the Mei-yu region,there has been noticeable increase in the occurrence of compound hot drought(CHD)events in recent years.However,the underlying causes of these occurrences remain poorly understood.To address this ...In the Mei-yu region,there has been noticeable increase in the occurrence of compound hot drought(CHD)events in recent years.However,the underlying causes of these occurrences remain poorly understood.To address this knowledge gap,we conducted a comprehensive study utilizing observational datasets,reanalysis datasets,and four numerical experiments to investigate the associated physical mechanisms.Our findings indicated that the prevalence of CHD events in the Mei-yu region is influenced strongly by two key factors:the decline in Barents Sea ice during February and the presence of a La Ni?alike pattern of sea surface temperature(SST)in April.The decline in Barents Sea ice generates an anomalous Rossby wave in the Arctic that propagates southeastward.The La Ni?a-like SST pattern regulates a Rossby wave over western America,propagating along the subtropical jet stream.These two Rossby waves induce northward movement and strengthened intensity of the subtropical westerly jet in East Asia.The local circulation patterns in the Mei-yu region are influenced by the position and intensity of the subtropical jet,leading to downward motion in accordance with the secondary circulation theory for high-altitude jet streams.Consequently,these local circulation patterns might contribute to occurrence of CHD events.Moreover,our analysis revealed that the impact of Barents Sea ice and the La Nina-like SST pattern can explain approximately two-thirds of the mild CHD events in the Mei-yu region,and that the influence of each is relatively independent.This research underscores influences of polartropical systems on climate extremes in eastern Asia.展开更多
Heavy regional precipitation(HRP)over Beijing,Tianjin,and Hebei Province(the Jing–Jin–Ji region or JJJ)in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by except...Heavy regional precipitation(HRP)over Beijing,Tianjin,and Hebei Province(the Jing–Jin–Ji region or JJJ)in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by exceptionally large population during the Chinese National Day Holidays(CNDH).What causes the year-to-year variation of the HRP during early October is investigated through an observational analysis.It is found that the HRP arises from moisture transport by southerly anomalies to the west of an anomalous low-level anticyclone over the subtropical northwestern Pacific(SNWP).Sensitivity numerical experiments reveal that the low-level anticyclonic anomaly is caused by a dipole heating pattern over tropical western and central Pacific associated with a La Niña-like SST anomaly(SSTA)pattern in the Pacific and by a negative heating anomaly over North Europe.The latter connects the SNWP anticyclone through a Rossby wave train.Anomalous ascent associated with a positive heating anomaly over the tropical western Pacific may strengthen the local Hadley Cell,contributing to maintenance of the low-level anomalous anticyclone over SNWP and extending westwards of the western Pacific subtropical high(WPSH).Therefore,both the tropical Pacific and midlatitude heating signals over North Europe may be potential predictors for HRP forecast in the JJJ region in early October.展开更多
基金The National Natural Science Foundation of China under contact No. 41905006the Natural Science Foundation from Guangdong Basic and Applied Basic Research Foundation Meteorological Joint Fund under contact Nos 2024A1515510034 and 2025A1515510014+2 种基金the Guangdong Provincial Observation and Research Station for Tropical Ocean Environment in Western Coastal Waters (GSTOEW)the Key Construction Discipline of High-level Universities-Marine Science under contact Nos 231420003 and 080503032101the Innovative Team Plan for Department of Education of Guangdong Province under contact Nos 2023KCXTD015 and2024KCXTD042
文摘The sea surface temperature(SST)front over the northern South China Sea(NSCS)has significant impacts on regional weather,climate,and marine ecology.Based on high-resolution satellite data and reanalysis data,the long-term variation characteristics and possible mechanisms of the SST front intensity(SSTFI)over the NSCS in winter from 1986 to 2020 are analyzed.The results show that:(1)Based on empirical orthogonal decomposition analysis,the evolution features of SST front mainly include two types:position shift type and an intensity variation type.(2)The SSTFI is accelerating in recent two decades.From 1986 to 2003(P1),the SSTFI changed relatively smoothly[0.2℃/(km·decade)],while from 2004 to 2020(P2),there is a significant strengthening trend[1.2℃/(km·decade)].(3)The horizontal advection related to the ocean current dominates the intensification of the SST front.An anomalous cyclonic circulation in upper ocean of the NSCS and the coastal current of South China strengthen the cold advection,resulting in cooling of the coastal waters of South China.(4)The latent heat flux dominates the sea surface heat loss and cooling process,but both latent and sensible heat flux are not conducive to the enhancement of the SSTFI.(5)The increase in SSTFI is largely associated with La Niña-like pattern,which is conducive to enhance the East Asia winter monsoon,and strengthens the ocean front through air-sea interactions.This study provides a scientific reference for understanding the variations of the SSTFI.
基金supported by the grants from the Ministry of Science and Technology of China(No.2016YFD0101801)the Ministry of Agriculture of China(No.2014ZX08001002)the National Natural Science Foundation of China(Nos.31371590 and 31571245)
文摘Lesion mimic mutant（LMM） genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae（Xoo） by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A（e EF1A）-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice.
文摘Background:Breast cancer is a major public health concern for women around the world.Breast cancer incidence increases with age,and this is an important factor for the management of this disease.The aim of this study was to assess the clinical profiles of female Iraqi breast cancer patients in their fifth decade,and to evaluate patients'molecular profiles and 5-year disease-free survival(DFS).Methods:A retrospective study was conducted at Baghdad Oncology Teaching Hospital between 1 January 2012 and 12 December 2016.Of 979 individuals seen,285 were aged between 40 and 49 years.Results:The median age at diagnosis was 45 years.The highest incidence of breast cancer occurred among women in their fifth(40-49 years old)and sixth(50-59 years old)decades of life(29%and 28%,respectively).The most common stages at diagnosis were stages II and III,with 40.8%and 39.5%,respectively.Luminal A-like cancers were seen in 124 women(58.5%)and 29 women(13.7%)presented with triple-negative cancers.De novo metastatic disease comprised just 6.7%of the group studied.The median DFS was 48 months(95%CI:41.4-54.5 months).Conclusions:The highest incidence of breast cancer occurred among women in their fifth and sixth decades of life.The most common diagnosis was stage II breast cancer of the luminal A molecular subtype.HER-2(human epidermal growth factor receptor 2)overexpression and triple-negative were the least common subtypes.The median DFS was 48 months.
基金supported by the National Natural Science Foundation of China(42088101)the National Key Research and Development Program of China(2022YFF0801704)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(316323005)。
文摘In the Mei-yu region,there has been noticeable increase in the occurrence of compound hot drought(CHD)events in recent years.However,the underlying causes of these occurrences remain poorly understood.To address this knowledge gap,we conducted a comprehensive study utilizing observational datasets,reanalysis datasets,and four numerical experiments to investigate the associated physical mechanisms.Our findings indicated that the prevalence of CHD events in the Mei-yu region is influenced strongly by two key factors:the decline in Barents Sea ice during February and the presence of a La Ni?alike pattern of sea surface temperature(SST)in April.The decline in Barents Sea ice generates an anomalous Rossby wave in the Arctic that propagates southeastward.The La Ni?a-like SST pattern regulates a Rossby wave over western America,propagating along the subtropical jet stream.These two Rossby waves induce northward movement and strengthened intensity of the subtropical westerly jet in East Asia.The local circulation patterns in the Mei-yu region are influenced by the position and intensity of the subtropical jet,leading to downward motion in accordance with the secondary circulation theory for high-altitude jet streams.Consequently,these local circulation patterns might contribute to occurrence of CHD events.Moreover,our analysis revealed that the impact of Barents Sea ice and the La Nina-like SST pattern can explain approximately two-thirds of the mild CHD events in the Mei-yu region,and that the influence of each is relatively independent.This research underscores influences of polartropical systems on climate extremes in eastern Asia.
基金Supported by the National Natural Science Foundation of China(42088101 and 41875074)China Meteorological Administration Innovation and Development Project(CXFZ2021J030 and CXFZ2021J046)+1 种基金Beijing Meterological Service Science and Technology Project(BMBKJ 201901031)Climate Change Special Fund of China Meteorological Administration(202009).
文摘Heavy regional precipitation(HRP)over Beijing,Tianjin,and Hebei Province(the Jing–Jin–Ji region or JJJ)in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by exceptionally large population during the Chinese National Day Holidays(CNDH).What causes the year-to-year variation of the HRP during early October is investigated through an observational analysis.It is found that the HRP arises from moisture transport by southerly anomalies to the west of an anomalous low-level anticyclone over the subtropical northwestern Pacific(SNWP).Sensitivity numerical experiments reveal that the low-level anticyclonic anomaly is caused by a dipole heating pattern over tropical western and central Pacific associated with a La Niña-like SST anomaly(SSTA)pattern in the Pacific and by a negative heating anomaly over North Europe.The latter connects the SNWP anticyclone through a Rossby wave train.Anomalous ascent associated with a positive heating anomaly over the tropical western Pacific may strengthen the local Hadley Cell,contributing to maintenance of the low-level anomalous anticyclone over SNWP and extending westwards of the western Pacific subtropical high(WPSH).Therefore,both the tropical Pacific and midlatitude heating signals over North Europe may be potential predictors for HRP forecast in the JJJ region in early October.
