Lesion mimic mutant（LMM） genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed l...Lesion mimic mutant（LMM） genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae（Xoo） by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A（e EF1A）-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice.展开更多
Background:Breast cancer is a major public health concern for women around the world.Breast cancer incidence increases with age,and this is an important factor for the management of this disease.The aim of this study ...Background:Breast cancer is a major public health concern for women around the world.Breast cancer incidence increases with age,and this is an important factor for the management of this disease.The aim of this study was to assess the clinical profiles of female Iraqi breast cancer patients in their fifth decade,and to evaluate patients'molecular profiles and 5-year disease-free survival(DFS).Methods:A retrospective study was conducted at Baghdad Oncology Teaching Hospital between 1 January 2012 and 12 December 2016.Of 979 individuals seen,285 were aged between 40 and 49 years.Results:The median age at diagnosis was 45 years.The highest incidence of breast cancer occurred among women in their fifth(40-49 years old)and sixth(50-59 years old)decades of life(29%and 28%,respectively).The most common stages at diagnosis were stages II and III,with 40.8%and 39.5%,respectively.Luminal A-like cancers were seen in 124 women(58.5%)and 29 women(13.7%)presented with triple-negative cancers.De novo metastatic disease comprised just 6.7%of the group studied.The median DFS was 48 months(95%CI:41.4-54.5 months).Conclusions:The highest incidence of breast cancer occurred among women in their fifth and sixth decades of life.The most common diagnosis was stage II breast cancer of the luminal A molecular subtype.HER-2(human epidermal growth factor receptor 2)overexpression and triple-negative were the least common subtypes.The median DFS was 48 months.展开更多
In the Mei-yu region,there has been noticeable increase in the occurrence of compound hot drought(CHD)events in recent years.However,the underlying causes of these occurrences remain poorly understood.To address this ...In the Mei-yu region,there has been noticeable increase in the occurrence of compound hot drought(CHD)events in recent years.However,the underlying causes of these occurrences remain poorly understood.To address this knowledge gap,we conducted a comprehensive study utilizing observational datasets,reanalysis datasets,and four numerical experiments to investigate the associated physical mechanisms.Our findings indicated that the prevalence of CHD events in the Mei-yu region is influenced strongly by two key factors:the decline in Barents Sea ice during February and the presence of a La Ni?alike pattern of sea surface temperature(SST)in April.The decline in Barents Sea ice generates an anomalous Rossby wave in the Arctic that propagates southeastward.The La Ni?a-like SST pattern regulates a Rossby wave over western America,propagating along the subtropical jet stream.These two Rossby waves induce northward movement and strengthened intensity of the subtropical westerly jet in East Asia.The local circulation patterns in the Mei-yu region are influenced by the position and intensity of the subtropical jet,leading to downward motion in accordance with the secondary circulation theory for high-altitude jet streams.Consequently,these local circulation patterns might contribute to occurrence of CHD events.Moreover,our analysis revealed that the impact of Barents Sea ice and the La Nina-like SST pattern can explain approximately two-thirds of the mild CHD events in the Mei-yu region,and that the influence of each is relatively independent.This research underscores influences of polartropical systems on climate extremes in eastern Asia.展开更多
Heavy regional precipitation(HRP)over Beijing,Tianjin,and Hebei Province(the Jing–Jin–Ji region or JJJ)in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by except...Heavy regional precipitation(HRP)over Beijing,Tianjin,and Hebei Province(the Jing–Jin–Ji region or JJJ)in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by exceptionally large population during the Chinese National Day Holidays(CNDH).What causes the year-to-year variation of the HRP during early October is investigated through an observational analysis.It is found that the HRP arises from moisture transport by southerly anomalies to the west of an anomalous low-level anticyclone over the subtropical northwestern Pacific(SNWP).Sensitivity numerical experiments reveal that the low-level anticyclonic anomaly is caused by a dipole heating pattern over tropical western and central Pacific associated with a La Niña-like SST anomaly(SSTA)pattern in the Pacific and by a negative heating anomaly over North Europe.The latter connects the SNWP anticyclone through a Rossby wave train.Anomalous ascent associated with a positive heating anomaly over the tropical western Pacific may strengthen the local Hadley Cell,contributing to maintenance of the low-level anomalous anticyclone over SNWP and extending westwards of the western Pacific subtropical high(WPSH).Therefore,both the tropical Pacific and midlatitude heating signals over North Europe may be potential predictors for HRP forecast in the JJJ region in early October.展开更多
基金supported by the grants from the Ministry of Science and Technology of China(No.2016YFD0101801)the Ministry of Agriculture of China(No.2014ZX08001002)the National Natural Science Foundation of China(Nos.31371590 and 31571245)
文摘Lesion mimic mutant（LMM） genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae（Xoo） by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A（e EF1A）-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice.
文摘Background:Breast cancer is a major public health concern for women around the world.Breast cancer incidence increases with age,and this is an important factor for the management of this disease.The aim of this study was to assess the clinical profiles of female Iraqi breast cancer patients in their fifth decade,and to evaluate patients'molecular profiles and 5-year disease-free survival(DFS).Methods:A retrospective study was conducted at Baghdad Oncology Teaching Hospital between 1 January 2012 and 12 December 2016.Of 979 individuals seen,285 were aged between 40 and 49 years.Results:The median age at diagnosis was 45 years.The highest incidence of breast cancer occurred among women in their fifth(40-49 years old)and sixth(50-59 years old)decades of life(29%and 28%,respectively).The most common stages at diagnosis were stages II and III,with 40.8%and 39.5%,respectively.Luminal A-like cancers were seen in 124 women(58.5%)and 29 women(13.7%)presented with triple-negative cancers.De novo metastatic disease comprised just 6.7%of the group studied.The median DFS was 48 months(95%CI:41.4-54.5 months).Conclusions:The highest incidence of breast cancer occurred among women in their fifth and sixth decades of life.The most common diagnosis was stage II breast cancer of the luminal A molecular subtype.HER-2(human epidermal growth factor receptor 2)overexpression and triple-negative were the least common subtypes.The median DFS was 48 months.
基金supported by the National Natural Science Foundation of China(42088101)the National Key Research and Development Program of China(2022YFF0801704)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(316323005)。
文摘In the Mei-yu region,there has been noticeable increase in the occurrence of compound hot drought(CHD)events in recent years.However,the underlying causes of these occurrences remain poorly understood.To address this knowledge gap,we conducted a comprehensive study utilizing observational datasets,reanalysis datasets,and four numerical experiments to investigate the associated physical mechanisms.Our findings indicated that the prevalence of CHD events in the Mei-yu region is influenced strongly by two key factors:the decline in Barents Sea ice during February and the presence of a La Ni?alike pattern of sea surface temperature(SST)in April.The decline in Barents Sea ice generates an anomalous Rossby wave in the Arctic that propagates southeastward.The La Ni?a-like SST pattern regulates a Rossby wave over western America,propagating along the subtropical jet stream.These two Rossby waves induce northward movement and strengthened intensity of the subtropical westerly jet in East Asia.The local circulation patterns in the Mei-yu region are influenced by the position and intensity of the subtropical jet,leading to downward motion in accordance with the secondary circulation theory for high-altitude jet streams.Consequently,these local circulation patterns might contribute to occurrence of CHD events.Moreover,our analysis revealed that the impact of Barents Sea ice and the La Nina-like SST pattern can explain approximately two-thirds of the mild CHD events in the Mei-yu region,and that the influence of each is relatively independent.This research underscores influences of polartropical systems on climate extremes in eastern Asia.
基金Supported by the National Natural Science Foundation of China(42088101 and 41875074)China Meteorological Administration Innovation and Development Project(CXFZ2021J030 and CXFZ2021J046)+1 种基金Beijing Meterological Service Science and Technology Project(BMBKJ 201901031)Climate Change Special Fund of China Meteorological Administration(202009).
文摘Heavy regional precipitation(HRP)over Beijing,Tianjin,and Hebei Province(the Jing–Jin–Ji region or JJJ)in early October(1–10 October)is a high-impact climate event because of travel and outdoor activities by exceptionally large population during the Chinese National Day Holidays(CNDH).What causes the year-to-year variation of the HRP during early October is investigated through an observational analysis.It is found that the HRP arises from moisture transport by southerly anomalies to the west of an anomalous low-level anticyclone over the subtropical northwestern Pacific(SNWP).Sensitivity numerical experiments reveal that the low-level anticyclonic anomaly is caused by a dipole heating pattern over tropical western and central Pacific associated with a La Niña-like SST anomaly(SSTA)pattern in the Pacific and by a negative heating anomaly over North Europe.The latter connects the SNWP anticyclone through a Rossby wave train.Anomalous ascent associated with a positive heating anomaly over the tropical western Pacific may strengthen the local Hadley Cell,contributing to maintenance of the low-level anomalous anticyclone over SNWP and extending westwards of the western Pacific subtropical high(WPSH).Therefore,both the tropical Pacific and midlatitude heating signals over North Europe may be potential predictors for HRP forecast in the JJJ region in early October.
