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A 16 bit Stereo Audio ΣΔ A/D Converter
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作者 陈雷 赵元富 +3 位作者 高德远 文武 王宗民 朱小飞 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2006年第7期1183-1188,共6页
A 16 bit stereo audio novel stability fifth-order ∑△ A/D converter that consists of switched capacitor ∑△ modulators, a decimation filter, and a bandgap circuit is proposed. A method for the stabilization of a hig... A 16 bit stereo audio novel stability fifth-order ∑△ A/D converter that consists of switched capacitor ∑△ modulators, a decimation filter, and a bandgap circuit is proposed. A method for the stabilization of a high order single stage ∑△ modulator is also proposed. A new multistage comb filter is used for the front end decimation filter. The ∑△ A/D converter achieves a peak SNR of 96dB and a dynamic range of 96dB. The ADC was implemented in 0. 5μm 5V CMOS technology. The chip die area occupies only 4. 1mm × 2.4mm and dissipates 90mW. 展开更多
关键词 ∑△ a/d converter switched capacitor STABILITY decimation filter bandgap circuits
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A 71mW 8b 125MSample/s A/D Converter 被引量:1
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作者 王照钢 陈诚 +1 位作者 任俊彦 许俊 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2004年第1期6-11,共6页
A 1.8V 8b 125Msample/s pipelined A/D converter is presented.Power efficiency is optimized by size scaling down scheme using low power single stage cascode amplifier with a gain boosted structure.Global clock tree and ... A 1.8V 8b 125Msample/s pipelined A/D converter is presented.Power efficiency is optimized by size scaling down scheme using low power single stage cascode amplifier with a gain boosted structure.Global clock tree and local generators are employed to avoid loss and overlap of clock period.The ADC achieves a signal-to-noise-and-distortion ratio (SNDR) of 49.5dB(7.9ENOB) for an input of 62MHz at full speed of 125MHz,consuming only 71mW.It is implemented in 0.18μm CMOS technology with a core area of 0.45mm 2. 展开更多
关键词 analog-to-digital converter PIPELINE low power low voltage
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200Ms/s 177mW 8bit Folding and Interpolating CMOS A/D Converter
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作者 陈诚 王照钢 +1 位作者 任俊彦 许俊 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2004年第11期1391-1397,共7页
A CMOS folding and interpolating analog-to-digital converter (ADC) for embedded application is described.The circuit is fully compatible with standard digital CMOS technology.A modified folding block implemented witho... A CMOS folding and interpolating analog-to-digital converter (ADC) for embedded application is described.The circuit is fully compatible with standard digital CMOS technology.A modified folding block implemented without resistor contributes to a small chip area.At the input stage,offset averaging reduces the input capacitance and the distributed track-and-hold circuits are proposed to improve signal-to-noise-plus-distortion ratio.The 200Ms/s 8bit ADC with 177mW total power consumption at 3.3V power supply is realized in standard digital 0.18μm 3.3V CMOS technology. 展开更多
关键词 analog-to-digital converter CMOS analog integrated circuits folding and interpolating
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The design of adaptive sigma-delta A/D converter 被引量:1
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作者 冯晖 Lin Zhenghui 《High Technology Letters》 EI CAS 2005年第4期367-370,共4页
The signal to noise ratio (SNR) of conventional sigma delta analog to digital converter (∑△ADC) reduces with input signal strength. The existing concept of adaptive quantization is applied to the design of ∑△A... The signal to noise ratio (SNR) of conventional sigma delta analog to digital converter (∑△ADC) reduces with input signal strength. The existing concept of adaptive quantization is applied to the design of ∑△ADC to improve SNR with high dynamic range. An adaptive algorithm and its circuit implementation is proposed. Because of the error due to the circuit implementation, an error self-calibration circuit is also designed. Simulation results indicate that SNR can he nearly independent of the signal strength. 展开更多
关键词 SIGMA-dELTA a/d AdAPTIVE ERROR SELF-CALIBRATION
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The Design of A/D Converter Circuit Adopting the Technology of PWM
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作者 Chen Ping Li Jing Zhao MingBo 《微计算机信息》 北大核心 2007年第29期272-274,共3页
This text has expounded the working principle of realizing A/D conversion that utilizes the timer within MCU and combinesthe technology of PWM. The design of hardware circuit, improved gradual approached trial arithme... This text has expounded the working principle of realizing A/D conversion that utilizes the timer within MCU and combinesthe technology of PWM. The design of hardware circuit, improved gradual approached trial arithmetic and relevant program design arediscussed in detail. And it has analyzed the resolution of A/D converter based on the technology of PWM, etc. 展开更多
关键词 PWM a/d 转换分辨率 改进逐次逼近试探算法 比较器 电路设计
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Ionizing radiation effect on 10-bit bipolar A/D converter
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作者 CHEN Rui LU Wu +6 位作者 REN Diyuan ZHENG Yuzhan WANG Yiyuan FEI Wuxiong LI Maoshun LAN Bo CUI Jiangwei 《Nuclear Science and Techniques》 SCIE CAS CSCD 2010年第3期152-156,共5页
In this article,radiation effects and annealing characteristics of a bipolar analog-to-digital converter(ADC) are investigated in different biases and dose rates.The results show that ADC is sensitive to both the bias... In this article,radiation effects and annealing characteristics of a bipolar analog-to-digital converter(ADC) are investigated in different biases and dose rates.The results show that ADC is sensitive to both the bias and dose rate. Under high-dose-rate irradiation,the ADC functions well,while under low-dose-rate irradiation,the parameters of ADC change obviously at low dose level,and the damage is significant at zero bias.Combining the fringing field with the space charge model,the underlying mechanism for this response is discussed. 展开更多
关键词 数字转换器 辐射效应 双极性 电离辐射 低剂量率 AdC 退火特性 参数变化
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Synchronous PWM Modulation to Eliminate Circulating Power in Bidirectional Dual-active-bridge Converter
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作者 Gengning Ying Jun Zeng +2 位作者 Ningrui Yang Junfeng Liu Zhixing Yan 《CSEE Journal of Power and Energy Systems》 2026年第1期294-305,共12页
To solve the problem of circulating power of dual active bridge(DAB)DC-DC converter over a wide voltage conversion ratio,this paper proposes a novel synchronous PWM(S-PWM)modulation.Existence of circulating power incr... To solve the problem of circulating power of dual active bridge(DAB)DC-DC converter over a wide voltage conversion ratio,this paper proposes a novel synchronous PWM(S-PWM)modulation.Existence of circulating power increases current stress of devices and decreases efficiency,especially under light load conditions.Several modulation methods have been proposed to overcome the problem.They can reduce or eliminate either input or output side circulating power.In contrast,S-PWM not only eliminates both sides circulating power and reduces current stress,but also achieves zero-current-switching(ZCS)turn-on for all switches and ZCS turn-off for most across the full power range.No auxiliary or snubber circuits are increased.In addition,the control can be simplified so the transmitted power is related to only one variable.The S-PWM has four cases under different gain and power conditions.The detailed operation principle and modes of DAB under S-PWM are analyzed in the paper.In addition,four modulations in literature are discussed,and corresponding comparative analyses with S-PWM are given.Finally,a laboratory prototype is built to verify advantages and effectiveness of the proposed modulation. 展开更多
关键词 Bidirectional converter circulating power dC-dC converter dual active bridge(dAB) soft switching
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A Coordinated Multi-Loop Control Strategy for Fault Ride-Through in Grid-Forming Converters
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作者 Zhuang Liu Mingwei Ren +1 位作者 Kai Shi Peifeng Xu 《Energy Engineering》 2026年第1期115-135,共21页
Grid-Forming(GFM)converters are prone to fault-induced overcurrent and power angle instability during grid fault-induced voltage sags.To address this,this paper develops a multi-loop coordinated fault ridethrough(FRT)... Grid-Forming(GFM)converters are prone to fault-induced overcurrent and power angle instability during grid fault-induced voltage sags.To address this,this paper develops a multi-loop coordinated fault ridethrough(FRT)control strategy based on a power outer loop and voltage-current inner loops,aiming to enhance the stability and current-limiting capability of GFM converters during grid fault conditions.During voltage sags,the GFM converter’s voltage source behavior is maintained by dynamically adjusting the reactive power reference to provide voltage support,thereby effectively suppressing the steady-state component of the fault current.To address the active power imbalance induced by voltage sags,a dynamic active power reference correction method based on apparent power is designed to mitigate power angle oscillations and limit transient current.Moreover,an adaptive virtual impedance loop is implemented to enhance dynamic transient current-limiting performance during the fault initiation phase.This approach improves the responsiveness of the inner loop and ensures safe system operation under various fault severities.Under asymmetric fault conditions,a negative-sequence reactive current compensation strategy is incorporated to further suppress negative-sequence voltage and improve voltage symmetry.The proposed control scheme enables coordinated operation of multiple control objectives,including voltage support,current suppression,and power angle stability,across different fault scenarios.Finally,MATLAB/Simulink simulation results validate the effectiveness of the proposed strategy,showcasing its superior performance in current limiting and power angle stability,thereby significantly enhancing the system’s fault ride-through capability. 展开更多
关键词 Grid-forming converter multi-loop coordination negative-sequence control fault ride-through
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Impacts of Reactive Power Control Dynamics on Transient Stability of Grid-forming Converters Considering Current Saturation:Analysis and Enhancement
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作者 Jinming Xu Hanxu Diao +3 位作者 Zihan Ling Jiarong Kan Yunhu Luo Shaojun Xie 《CSEE Journal of Power and Energy Systems》 2026年第1期56-70,共15页
The transient synchronization stability of grid-forming converters(GFMCs)is significantly challenged under grid voltage sags.Continuous efforts have been devoted to analyzing the GFMC transient stability,with limited ... The transient synchronization stability of grid-forming converters(GFMCs)is significantly challenged under grid voltage sags.Continuous efforts have been devoted to analyzing the GFMC transient stability,with limited attention paid to the impacts of control loop dynamics.However,the complex control dynamics,especially the interactions between the active/reactive power control loops and the current saturation process(CSP),are crucial for accurately describing the transient behavior and evaluating the stability.Thus,in this study,a new large-signal GFMC model is established,considering the reactive power control(RPC)with different kinds of controllers and the CSP simultaneously.It is revealed that GFMC does not switch to the current-limited mode immediately,and the dynamics of RPC further affect the transient behavior before the current limiting significantly.Hence,the complex control dynamics can alter the mode switching point of current saturation,thereby increasing the risk of loss of synchronization(LOS).Based on the above findings,comprehensive comparisons of typical RPC controllers are presented to facilitate practical engineering applications.A unified stability enhancement method is proposed for solving the problem of LOS.Finally,experiments validate the correctness of the analysis and the effectiveness of the proposed control strategy. 展开更多
关键词 Current limit grid-forming converter reactive power control transient stability
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Synthesis of Dynamic Virtual Impedance for Grid-forming Converters to Improve Self-stability and Stabilizing Ability
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作者 Hangyu Chen Verena Häberle +3 位作者 Ying Yang Kehao Zhuang Huanhai Xin Linbin Huang 《CSEE Journal of Power and Energy Systems》 2026年第1期44-55,共12页
In the future power-electronics-dominated power systems,grid-forming(GFM)converters have been regarded as important devices to actively establish frequency and voltage,so as to provide essential grid support.However,d... In the future power-electronics-dominated power systems,grid-forming(GFM)converters have been regarded as important devices to actively establish frequency and voltage,so as to provide essential grid support.However,due to their voltage source behavior and emulated swing dynamics,GFM converters may encounter low-frequency oscillations(LFOs)when connected to strong grids,which belongs to the self-stability problem of GFM converters.Moreover,GFM converters will also interact with grid-following(GFL)converters and thus impact the mid-frequency oscillations(MFOs)induced by phase-locked loops(PLLs).It has been preliminarily shown in the literature that GFM converters can help stabilize the PLL-induced MFOs,but currently,there is a lack of systematic design methods to coordinate the self-stability and stabilizing ability of GFM converters.This paper addresses this gap by revisiting the impedance model of a typical GFM converter and briefly analyze the oscillations caused by converters.Based on our analysis,we propose a frequency-partitioned synthesis design framework to enable dynamic virtual impedance(DVI)in GFM converters,aiming to enhance their self-stability and stabilizing ability simultaneously.Particularly,a self-stabilizing module is designed to ensure robust device-level damping,with control parameters auto-tuned using H∞methods.In parallel,a stabilizing module is introduced to stabilize GFL converters and enhance the system-level stability,which utilizes a perceive-and-optimize tuning strategy.Simulation results validate the effectiveness of the proposed synthesis DVI framework. 展开更多
关键词 Control synthesis dynamic virtual impedance grid-forming converters self-stability stabilizing ability
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Multi-phase Stacked Interleaved Buck Converter for Hydrogen-production Electrolysis with Low-voltage-stress Ripple Compensation Circuit
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作者 Le Sun Zhaoguo Liu +2 位作者 Xiaoqiang Guo Xiaochen Wang Lichong Wang 《CSEE Journal of Power and Energy Systems》 2026年第1期401-410,共10页
A multi-phase stacked interleaved buck converter(SIBC)is suitable for large-power water electrolysis applications due to its merits of high current output capability and zero output current ripple.However,the auxiliar... A multi-phase stacked interleaved buck converter(SIBC)is suitable for large-power water electrolysis applications due to its merits of high current output capability and zero output current ripple.However,the auxiliary converter used to compensate for the current ripple still has to withstand high voltage stress.This paper proposes a new multi-phase SIBC applied in the multicarrier energy system integrating electricity,heat,and hydrogen.A resistor-capacitor voltage divider is used to provide the input voltage of the auxiliary converter and as a heater for the thermal loads.Thus,the voltage stress of the auxiliary converter can be reduced at a low cost,and the size of the filter inductor can be reduced.With accurate voltage and current analysis and appropriate parameter design,the voltage stresses of both the switches and capacitors in the auxiliary converter can be further limited within an expected range.The experimental results verify the correctness of the topology,modulation,analysis,and design methods.A comparison with the conventional method is made in terms of cost,volume,and efficiency to show the advantages of the proposed method. 展开更多
关键词 Current ripple elimination low voltage stress multicarrier energy system stacked interleaved buck converter
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Fault Current Elimination for Modular Multilevel DC/DC Converter Based on Hybrid HBSM and TDM
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作者 Haijin Liu Weijie Wen +4 位作者 Rui Lyu He Yang Jiawei He Botong Li Bin Li 《CSEE Journal of Power and Energy Systems》 2026年第1期534-546,共13页
As key equipment in medium voltage DC(MVDC)systems,modular multilevel AC/DC and DC/DC converters(MM-AC/DC,MM-DC/DC)have drawn marvelous attractions.However,research on DC fault ride-through focuses on MM-AC/DC,and the... As key equipment in medium voltage DC(MVDC)systems,modular multilevel AC/DC and DC/DC converters(MM-AC/DC,MM-DC/DC)have drawn marvelous attractions.However,research on DC fault ride-through focuses on MM-AC/DC,and the fault current elimination for MM-DC/DC remains a research gap,which limits the wide application of the MVDC system.To fulfil this research gap,the contribution of this paper is revealing the fault current characteristics of MM-DC/DC based on half-bridge and full-bridge submodules(HBSM and FBSM)and proposing a novel MM-DC/DC based on hybrid HBSM and thyristor-diode module(TDM).By integrating TDM in the upper bridge arm of one phase and the down bridge arm of the other phase in MM-DC/DC,the MM-DC/DC achieves self-elimination of fault currents.The basic concept is using the energy at the healthy side to modulate a reverse voltage source(RVS)at the faulty side of MM-DC/DC,forcing fault current through TDM pass across zero.TDM can extinguish the resulting fault current.The parameter design and control strategy of the novel MM-DC/DC are discussed.Simulation is carried out for verification,and the results show that fault current can be eliminated within several milliseconds without causing excessive operating losses and costs. 展开更多
关键词 dC circuit breaker dC fault ride-through modular multilevel dC/dC converter relay protection
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Hardware-Algorithm Co-Design:SiC Bidirectional Converters with MPC-Fuzzy Logic Control for Robust Operation of Solar-Powered EV Hubs
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作者 Wan Chen Zhi Liu +6 位作者 Yingxue Ma Cuicui Wang Xinfa Gu Baolian Liu Lei Shen Hui Huang Jie Ji 《Energy Engineering》 2026年第3期96-116,共21页
In order to solve the problems of slow dynamic response and difficult multi-source coordination of solar electric vehicle charging stations under intermittent renewable energy,this paper proposes a hardware-algorithm ... In order to solve the problems of slow dynamic response and difficult multi-source coordination of solar electric vehicle charging stations under intermittent renewable energy,this paper proposes a hardware-algorithm co-design framework:the T-type three-level bidirectional converter(100 kHz switching frequency)based on silicon carbide(SiC)MOSFET is deeply integrated with fuzzy model predictive control(Fuzzy-MPC).At the hardware level,the switching trajectory and resonance suppression circuit(attenuation resonance peak 18 dB)are optimized,and the total loss is reduced by 23%compared with the traditional silicon-based IGBT.At the algorithm level,the adaptive parameter update mechanism and multi-objective rolling optimization are adopted,and the 5 ms level dynamic power allocation is realized by relying on edge computing.Experiments on 800 V DC microgrid(including 600 kW photovoltaic and 150 A·h energy storage)built based on MATLAB/Simulink hardware-in-the-loop(HIL)platform show that the system shortens the battery charging time from 42 to 28 min(the charging speed is increased by 33%).Through the 78%valley power utilization rate,the power purchase cost of high-priced power grids was significantly reduced,and the levelized electricity price decreased by 10.3%;Under the irradiation fluctuation,the renewable energy consumption rate increases by 10.1%,and the DC bus voltage fluctuation is stable within±10 V when the load step is±30%.The co-design provides an economically feasible and dynamically robust solution for the efficient integration of PV-ESG-EV in the smart grid. 展开更多
关键词 Power electronics co-design fuzzy-MPC control T-type three-level converter grid-adaptive operation PV-storage-charging integration switching loss compensation
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Integrated diagnosis of abnormal energy consumption in converter steelmaking using GWO-SVM-K-means algorithms
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作者 Fei-Xiang Dai Xiang-Jun Bao +2 位作者 Lu Zhang Xiao-Jing Yang Guang Chen 《Journal of Iron and Steel Research International》 2026年第1期458-468,共11页
To address the issue of abnormal energy consumption fluctuations in the converter steelmaking process,an integrated diagnostic method combining the gray wolf optimization(GWO)algorithm,support vector machine(SVM),and ... To address the issue of abnormal energy consumption fluctuations in the converter steelmaking process,an integrated diagnostic method combining the gray wolf optimization(GWO)algorithm,support vector machine(SVM),and K-means clustering was proposed.Eight input parameters—derived from molten iron conditions and external factors—were selected as feature variables.A GWO-SVM model was developed to accurately predict the energy consumption of individual heats.Based on the prediction results,the mean absolute percentage error and maximum relative error of the test set were employed as criteria to identify heats with abnormal energy usage.For these heats,the K-means clustering algorithm was used to determine benchmark values of influencing factors from similar steel grades,enabling root-cause diagnosis of excessive energy consumption.The proposed method was applied to real production data from a converter in a steel plant.The analysis reveals that heat sample No.44 exhibits abnormal energy consumption,due to gas recovery being 1430.28 kg of standard coal below the benchmark level.A secondary contributing factor is a steam recovery shortfall of 237.99 kg of standard coal.This integrated approach offers a scientifically grounded tool for energy management in converter operations and provides valuable guidance for optimizing process parameters and enhancing energy efficiency. 展开更多
关键词 converter smelting process Abnormal energy diagnosis Gray wolf optimization algorithm Support vector machine K-means clustering algorithm
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高剂量维生素D在儿童短肠综合征合并维生素D不足/缺乏中的应用
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作者 吴青青 曹毅 +4 位作者 陆丽娜 陶怡菁 冯海霞 颜伟慧 王莹 《上海交通大学学报(医学版)》 北大核心 2026年第1期54-59,共6页
目的·探讨单次高剂量肌内注射途径补充维生素D对儿童短肠综合征(short bowel syndrome,SBS)合并维生素D不足/缺乏的安全性和有效性。方法·回顾性纳入32例SBS合并维生素D不足/缺乏的儿童。当患儿血清25-羟维生素D[25-hydroxyvi... 目的·探讨单次高剂量肌内注射途径补充维生素D对儿童短肠综合征(short bowel syndrome,SBS)合并维生素D不足/缺乏的安全性和有效性。方法·回顾性纳入32例SBS合并维生素D不足/缺乏的儿童。当患儿血清25-羟维生素D[25-hydroxyvitamin D,25-(OH)D]浓度低于50 nmol/L时,通过肌内注射途径补充200000 IU的维生素D2。收集患儿的临床资料(性别、年龄、原发疾病、小肠剩余长度、是否保留回盲瓣以及结肠是否完整等),记录肌内注射部位皮肤情况,以及维生素D补充前和补充后1个月的血清25-(OH)D、钙、磷和碱性磷酸酶水平状况。结果·SBS患儿入组时的中位年龄为5.0(3.0,7.0)个月。小肠闭锁和坏死性小肠结肠炎是导致SBS的主要原因(分别占28.13%和21.88%),剩余小肠平均长度为(57.27±24.55)cm。在补充维生素D之前,65.63%(21/32)的患儿存在维生素D缺乏,34.38%(11/32)的患儿存在维生素D不足。在补充维生素D之后,患儿25-(OH)D水平由28.87 nmol/L显著升高至53.10 nmol/L(P<0.001);在维生素D不足的患儿中,25-(OH)D水平从37.30 nmol/L显著升高至58.51 nmol/L(P=0.010);而在维生素D缺乏的患儿中,该水平从26.91 nmol/L显著升高至44.82 nmol/L(P<0.001);62.50%(20/32)的患儿25-(OH)D浓度达到正常水平。所有患儿在研究期间均未出现维生素D中毒、高钙血症、皮肤硬结或局部感染等并发症。结论·单次、高剂量(200000 IU)肌内注射途径补充维生素D,可以安全、有效地改善SBS合并维生素D不足/缺乏婴儿的维生素D水平。 展开更多
关键词 短肠综合征 儿童 高剂量 维生素d
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基于金属纳米光栅结构修饰的D型光纤表面等离激元共振超材料传感器研究
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作者 刘琨 熊艺扬 +8 位作者 井建迎 朱枫彤 肖璐 战晓寒 刘津畅 江俊峰 徐天华 王双 刘铁根 《量子电子学报》 北大核心 2026年第1期141-150,共10页
超材料因其独特的亚波长结构设计和独特的电磁响应特性,在提升表面等离激元共振(Surface Plasmon Resonance,SPR)传感器灵敏度方面具有广阔前景。本文设计了一款金属纳米光栅结构修饰的D型光纤SPR超材料传感器,并对折射率范围在1.332~1.... 超材料因其独特的亚波长结构设计和独特的电磁响应特性,在提升表面等离激元共振(Surface Plasmon Resonance,SPR)传感器灵敏度方面具有广阔前景。本文设计了一款金属纳米光栅结构修饰的D型光纤SPR超材料传感器,并对折射率范围在1.332~1.344的低折射率溶液进行了传感检测。首先,基于倏逝波和表面等离极化激元(Surface Plasmon Polaritons,SPPs)的光波矢特性,对D型光纤SPR传感器进行了理论分析,绘制得到不同折射率下共振波长随入射角度变化的解析解曲线,以便研究光纤中不同传导模式下的SPR激发条件。进而建立了D型光纤SPR超材料传感器二维有限元仿真模型进行模式分析研究,计算了模式损耗和传感器的灵敏度。最后,基于前述的仿真模型,具体构建了分别为以不同间隔的双条带或者单条带为金属光栅单元的传感器,以及使用银/铜替代金,作为金属连续层和金属光栅材料时的传感器,对比探究了这些传感器的灵敏度性能。研究结果表明,改变双条带光栅单元的条带间隔,对灵敏度的影响并不显著,与光栅单元为单条带的传感器灵敏度几乎一致;使用银替代金作为连续金属层材料时,传感器的灵敏度性能达到最优,可达1800 nm·RIU^(-1)。 展开更多
关键词 表面等离激元共振 灵敏度优化 金属纳米光栅 d型光纤
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拉萨市不同孕期妇女血清25羟基维生素D水平的比较
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作者 尼玛顿珠 扎西央宗 +5 位作者 边珍 益西措姆 支张卓玛 詹明君 巴桑央吉 秦绪珍 《基础医学与临床》 2026年第1期120-123,共4页
目的了解西藏拉萨市不同孕期妇女血清25羟基维生素D[25-(OH)D]浓度水平,观察不同孕期妇女维生素D(VD)营养状态。方法选取在2021年7月至2023年4月在西藏自治区人民医院产科门诊就诊的健康孕妇367例为研究对象,取同期209例未妊娠的育龄期... 目的了解西藏拉萨市不同孕期妇女血清25羟基维生素D[25-(OH)D]浓度水平,观察不同孕期妇女维生素D(VD)营养状态。方法选取在2021年7月至2023年4月在西藏自治区人民医院产科门诊就诊的健康孕妇367例为研究对象,取同期209例未妊娠的育龄期体检妇女为正常对照组,采用雅培i2000化学发光仪检测血清25-(OH)D水平,用SPSS统计学软件进行统计分析。结果367例孕期妇女血清25-(OH)D总体水平为11.5(8.5,17.3)ng/mL。VD充足、不足、缺乏分别占16.6%、30.0%、53.4%;209例健康对照组妇女血清25-(OH)D总体水平为9.9(7.7,13.6)ng/mL。VD充足、不足、缺乏分别占6.7%、27.8%、65.5%。9~13^(+6)周、15~20^(+6)周孕期妇女血清25-(OH)D水平比较差异无统计学意义。结论拉萨市孕期和未妊娠育龄妇女普遍存在VD不足或缺乏现象,应在备孕及怀孕期间补充VD。 展开更多
关键词 孕妇 25羟基维生素d 维生素d
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甲型流感病毒感染相关危险因素及其25-羟基维生素D与血常规参数表达
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作者 于丽瑞 黄玉焕 周曼丽 《病毒学报》 北大核心 2026年第1期200-206,共7页
目的分析甲型流感病毒(INFA)感染相关危险因素及其25-羟基维生素D[25(OH)D]与血常规参数表达特点。方法选取我院2022年10月-2024年9月收治的212例有流感症状患儿,根据上呼吸道核酸六项检测结果分为INFA感染组(n=55)和INFA未感染组(n=15... 目的分析甲型流感病毒(INFA)感染相关危险因素及其25-羟基维生素D[25(OH)D]与血常规参数表达特点。方法选取我院2022年10月-2024年9月收治的212例有流感症状患儿,根据上呼吸道核酸六项检测结果分为INFA感染组(n=55)和INFA未感染组(n=157),采用Logistic回归模型分析INFA感染相关危险因素,采用ROC曲线分析预测变量准确性。结果212例患儿中,INFA感染55例(25.94%)。多因素结果显示:年龄、热程、咳嗽咳痰、喘息、未接种流感疫苗、住院时间是INFA感染的独立影响因素(P<0.05)。策树模型显示住院时间(≥7d)是重要预测因子。ROC分析结果显示:PLT、WBC、LYMPH、NEUT、MON、25(OH)D、HCT、MCV、Hb、CRP、SAA指标预测PICU中INFA感染均具有统计学意义(P<0.05)。结论PICU中INFA感染患儿早期具显著临床特征,应高度关注年龄、热程、咳嗽咳痰、喘息、未接种流感疫苗、住院时间等因素,加强血清25(OH)D及血常规水平监测,以预防INFA感染发生。 展开更多
关键词 甲型流感病毒感染 危险因素 25-羟基维生素d 血常规
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胎次对中国荷斯坦牛305 d产奶量及乳成分的影响
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作者 张丽 尤吉喆 +2 位作者 谢家怡 刘丽霞 王瑞 《中国草食动物科学》 北大核心 2026年第2期121-126,共6页
为了准确应用奶牛生产性能测定(DHI)报告,有针对性地提高全群泌乳水平,试验通过对宁夏某牛场7369条中国荷斯坦牛的DHI记录进行方差分析和相关与回归分析,探讨胎次对305 d产奶量和乳成分的影响及其相关关系。结果表明,胎次极显著地影响... 为了准确应用奶牛生产性能测定(DHI)报告,有针对性地提高全群泌乳水平,试验通过对宁夏某牛场7369条中国荷斯坦牛的DHI记录进行方差分析和相关与回归分析,探讨胎次对305 d产奶量和乳成分的影响及其相关关系。结果表明,胎次极显著地影响中国荷斯坦牛305 d的产奶量和乳成分(P<0.01);第4胎中国荷斯坦牛305 d产奶量、第2胎乳蛋白率、第1胎乳糖率和第7胎尿素氮含量均极显著高于其他胎次(P<0.01);乳脂率随着胎次的增加呈现先下降后上升的趋势,全群平均乳脂率保持在3.57%以上;随着胎次的增加体细胞数变化波动较大,第6胎达到最高。胎次与产奶量、体细胞数呈极显著正相关(P<0.01),与乳脂率、乳蛋白率、乳糖率、总固体含量均呈极显著负相关(P<0.01);乳脂率与乳蛋白率呈极显著正相关(P<0.01);乳蛋白率与乳糖率呈极显著负相关(P<0.01),与体细胞数、尿素氮、总固体呈极显著正相关(P<0.01);乳中体细胞数与乳糖率、尿素氮含量呈极显著负相关(P<0.01);尿素氮与乳糖率呈极显著正相关(P<0.01);乳糖率与乳脂率、乳蛋白率、体细胞数呈极显著负相关(P<0.01);总固体含量与乳脂率、乳蛋白率、乳糖率呈极显著正相关(P<0.01),与尿素氮(P<0.01)呈极显著负相关关系。说明胎次对中国荷斯坦牛产奶量和乳成分的影响有一定的变化规律,建议牛场根据变化趋势合理调整奶牛的饲粮配方,从而提高养殖场的管理水平和经济效益。 展开更多
关键词 中国荷斯坦牛 胎次 305 d产奶量 乳成分 相关分析 回归分析
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基于NLRP3/GSDMD信号通路探究栀子厚朴汤及其药对的抗抑郁作用
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作者 陈畅 郭紫文 +3 位作者 宋婷宇 王艳 夏宝妹 陶伟伟 《中国实验方剂学杂志》 北大核心 2026年第6期72-80,共9页
目的:以经典药对配伍研究为切入点,深入探讨中药复方栀子厚朴汤抗抑郁作用的物质基础与配伍规律,并重点阐明其通过调控NOD样受体蛋白3(NLRP3)/消皮素D(GSDMD)信号通路介导的神经炎症反应,改善神经元突触可塑性发挥抗抑郁作用的效应机制... 目的:以经典药对配伍研究为切入点,深入探讨中药复方栀子厚朴汤抗抑郁作用的物质基础与配伍规律,并重点阐明其通过调控NOD样受体蛋白3(NLRP3)/消皮素D(GSDMD)信号通路介导的神经炎症反应,改善神经元突触可塑性发挥抗抑郁作用的效应机制。方法:将C57BL/6J小鼠随机分为空白组、慢性不可预知温和应激(CUMS)抑郁模型组、栀子厚朴汤全方组(6 g·kg^(-1)·d^(-1))、厚朴-枳实药对组(4.2 g·kg^(-1)·d^(-1))、栀子-厚朴药对组(4.2 g·kg^(-1)·d^(-1))、栀子-枳实药对组(3.6 g·kg^(-1)·d^(-1))及阳性药组(氟西汀,12 mg·kg^(-1)·d^(-1)),通过行为学检测评估小鼠抑郁样行为;采用免疫荧光染色标记并定量小鼠前额叶皮层(PFC)组织中小胶质细胞标志物离子钙结合适配器分子1(Iba1)及嘌呤能受体P2X配体门控离子通道7(P2RX7)的表达;应用酶联免疫吸附测定法(ELISA)检测血清和PFC组织中炎症因子白细胞介素(IL-1β)、白细胞介素18(IL-18)水平;蛋白免疫印迹法(Western blot)检测PFC组织中泛连接蛋白1(Panx1)、P2RX7、NLRP3、凋亡相关斑点样蛋白(ASC)、胱天蛋白酶-1(Caspase-1)、GSDMD、突触后致密蛋白95(PSD95)及突触前蛋白突触素1(Synapsin1)的表达;通过高尔基染色评估PFC神经元树突棘密度。结果:与空白组比较,抑郁模型组小鼠表现出显著的抑郁样行为,并且PFC组织中Ibal及P2RX7免疫荧光面积显著增加(P<0.01),血清及PFC中IL-1β、IL-18水平显著升高(P<0.01),PFC组织中Panx1、P2RX7、NLRP3、ASC、Caspase-1、GSDMD蛋白表达显著上调(P<0.01),而PSD95和Synapsin1蛋白表达显著下调(P<0.01),同时神经元树突棘密度显著降低(P<0.01)。与模型组比较,栀子厚朴汤全方组、栀子-厚朴药对组上述各指标均明显改善(P<0.01),栀子-枳实药对组可改善除P2RX7、Caspase-1、GSDMD、PSD95之外的其他上述指标(P<0.05,P<0.01)。而厚朴-枳实药对组与模型组相比,对上述各指标的改善均无统计学意义。结论:栀子厚朴汤及其关键药对,即栀子-厚朴,能有效改善CUMS诱导的小鼠抑郁样行为。其核心抗抑郁机制可能在于通过抑制P2RX7/Panx1信号,阻断NLRP3/GSDMD介导的焦亡通路,从而显著降低炎症因子IL-1β、IL-18的释放;同时上调突触相关蛋白PSD95和Synapsin1的表达并增加树突棘密度,促进突触可塑性的恢复。研究结果提示,栀子在该复方抗抑郁效应中扮演关键角色,且栀子与厚朴的配伍可能是发挥核心治疗作用的主要药对组合。 展开更多
关键词 抑郁症 栀子厚朴汤 药对 NOd样受体蛋白3(NLRP3)炎症小体 消皮素d(GSdMd)
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