The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analys...The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.展开更多
Subgrade engineering is a fundamental aspect of infrastructure construction in China.As the primary structural element responsible for bearing and distributing traffic loads,the subgrade must not only withstand the su...Subgrade engineering is a fundamental aspect of infrastructure construction in China.As the primary structural element responsible for bearing and distributing traffic loads,the subgrade must not only withstand the substantial pressures exerted by vehicles,trains,and other forms of transportation,but also efficiently transfer these loads to the underlying foundation,ensuring the stability and longevity of the roadway.In recent years,advancements in subgrade engineering technology have propelled the industry towards smarter,greener,and more sustainable practices,particularly in the areas of intelligent monitoring,disaster management,and innovative construction methods.This paper reviews the application and methodologies of intelligent testing equipment,including cone penetration testing(CPT)devices,soil resistivity testers,and intelligent rebound testers,in subgrade engineering.It examines the operating principles,advantages,limitations,and application ranges of these tools in subgrade testing.Additionally,the paper evaluates the practical use of advanced equipment from both domestic and international perspectives,addressing the challenges encountered by various instruments in realworld applications.These devices enable precise,comprehensive testing and evaluation of subgrade conditions at different stages,providing real-time data analysis and intelligent early warnings.This supports effective subgrade health management and maintenance.As intelligent technologies continue to evolve and integrate,these tools will increasingly enhance the accuracy,efficiency,and sustainability of subgrade monitoring.展开更多
It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and er...It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.展开更多
Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by...Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.展开更多
Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant...Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant on traditional laptops and computers, which, while portable, lack true ultra-portability. This paper explores the potential impact of developing a dedicated, ultra-portable, low-cost device for on-the-go penetration testing. Such a device could replicate the core functionalities of advanced penetration testing tools, including those found in Kali Linux, within a compact form factor that fits easily into a pocket. By offering the convenience and portability akin to a smartphone, this innovative device could redefine the way penetration testers operate, enabling them to carry essential tools wherever they go and ensuring they are always prepared to conduct security assessments efficiently. This approach aims to revolutionize penetration testing by merging high functionality with unparalleled portability.展开更多
The China Spallation Neutron Source(CSNS)is the fourth pulsed accelerator-driven neutron source in the world,and it achieved its design target of 100 kW in 2020.The planned China Spallation Neutron Source Phase II(CSN...The China Spallation Neutron Source(CSNS)is the fourth pulsed accelerator-driven neutron source in the world,and it achieved its design target of 100 kW in 2020.The planned China Spallation Neutron Source Phase II(CSNS-II)commenced in 2024.The CSNS-II linac design primarily involves the addition of a radio-frequency ion source and a section of a superconducting linear accelerator composed of two types of superconducting cavities,namely double-spoke and six-cell elliptical cavities,after the drift tube linac(DTL).The development of the double-spoke superconducting cavity began in early 2021,and by January 2023,the welding,post-processing,and vertical tests of two 324 MHz double-spoke cavity prototypes were completed,with vertical test gradients of 11.6 and 15 MV/m,and Q_(0)≥3×10^(10)@E_(acc)≤10 MV/m.The R&D of the cryomodule began in January 2022.In October 2023,the clean assembly of the double-spoke cavity string and cold mass installation of the cryomodule commenced,with the installation of the cryomodule and valve box completing in two months.In January 2024,a horizontal test of the cryomodule was completed,making it the first double-spoke cavity cryomodule in China.The test results showed that the maximum gradients of the two superconducting cavities at a pulse width of 4 ms and repetition frequency of 25 Hz were 12.8 and 15.2 MV/m,respectively.This article provides a detailed introduction to the double-spoke superconducting cavity,tuner,coupler,and cryomodule,elaborates on the clean assembly of the cavity string and cold mass installation of the cryomodule,and provides a detailed analysis of the horizontal test results.展开更多
Knowledge of the dynamic modulus of bituminous mixtures is practical and theoretically meaningful in pavement design,construction,and monitoring.The tests in the laboratory for the determination of asphalt concrete(AC...Knowledge of the dynamic modulus of bituminous mixtures is practical and theoretically meaningful in pavement design,construction,and monitoring.The tests in the laboratory for the determination of asphalt concrete(AC)moduli include the resilient modulus through the indirect tensile test(EN 12697-26),the complex modulus through the four point bending beam(EN 12697-26),the asphalt mixture performance tester(AMPT)and the simple performance tester(SPT)(AASHTO T342).Unfortunately,the tests above are time-consuming and quite expensive.On the other hand,the standard ASTM E1876 for resonant tests applies only to very thin(stocky)cylindrical samples(with a thickness-to-radius ratio,t/r,lower than 0.5)while the typical AC samples produced in the laboratory do not satisfy the ASTM E1876 requirements.Consequently,the main objective of this study is to set up and implement a tentative method to extend the range of applicability of the standard ASTM E1876 to common AC samples.The methodology was to carry out resonant tests on slender samples and to cut each of them into stocky samples(these latter complying with ASTM E1876 requirements in terms of t/r),deriving the master curve per material.These master curves allowed for deriving the value of the dynamic modulus for the given selected sample under its particular test conditions during the resonant test(i.e.,temperature and frequency).Consequently,simplified formulae were provided for AC samples.Results were compared to Witczak's estimates.These formulae provide an approximate tool to carry out low-cost and high-speed inferences at the laboratory stage on common AC samples,whatever their thickness is.Additional studies are needed to investigate the reliability of the method further and reduce uncertainties.展开更多
In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh enviro...In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh environment leads to significant variations in the shape and size of the defects.To address this challenge,we propose the multivariate time series segmentation network(MSSN),which adopts a multiscale convolutional network with multi-stage and depth-separable convolutions for efficient feature extraction through variable-length templates.To tackle the classification difficulty caused by structural signal variance,MSSN employs logarithmic normalization to adjust instance distributions.Furthermore,it integrates classification with smoothing loss functions to accurately identify defect segments amid similar structural and defect signal subsequences.Our algorithm evaluated on both the Mackey-Glass dataset and industrial dataset achieves over 95%localization and demonstrates the capture capability on the synthetic dataset.In a nuclear plant's heat transfer tube dataset,it captures 90%of defect instances with75%middle localization F1 score.展开更多
This article introduces the composition and working principle of home appliance control board automation testing equipment,elaborates on the importance of key technical indicators,explains the integrated design of fun...This article introduces the composition and working principle of home appliance control board automation testing equipment,elaborates on the importance of key technical indicators,explains the integrated design of functional modules,signal processing modules,and data analysis modules,and covers aspects such as the application of machine learning algorithms and the establishment of fault waveform databases.Finally,it looks forward to the development of intelligent testing systems and emphasizes the importance of building a standardized testing system.展开更多
With the rapid development and commercialization of wireless communications,the execution of OTA testing requires a tremendous amount of test time.Therefore,test time reduction is of great significance.The objective o...With the rapid development and commercialization of wireless communications,the execution of OTA testing requires a tremendous amount of test time.Therefore,test time reduction is of great significance.The objective of this article is to determine optimal measurement grids for SISO OTA testing of 5G Sub-6 GHz user equipments(UEs)in anechoic chamber with satisfactory accuracy and efficiency.The effect of different grid configurations on OTA performance is analyzed quantitatively using reference radiation patterns at different bands.These patterns are utilized to mimic the worst-case radiation patterns of 5G Sub-6 GHz UEs.Subsequently,the associated measurement uncertainty(MU)terms are quantitatively analyzed and determined based on statistical analysis.According to the comparison of calculated MUs,reduction of grid points from currentlyrequired 62(30/30,Δθ/Δϕ)to 26(45/45)could achieve roughly 60%test time reduction for Sub-6 GHz,while still maintaining an uncertainty level of≤0.25 dB.These values can be further reduced to 14(60/60)with 80%reduction for Sub-3 GHz.More importantly,the recommended grid configurations in this research are applicable to both TIS and TRP testing.展开更多
Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely int...Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely integrated into routine clinical diagnostics of gastric cancer to guide personalized treatment.Human epidermal growth factor receptor 2(HER2)was the first molecular biomarker to be used in gastric cancer with trastuzumab being the first approved targeted therapy for HER2-positive gastric cancer.Programmed death-ligand 1 positivity and microsatellite instability can guide the use of immunotherapies,such as pembrolizumab and nivolumab.More recently,zolbetuximab has been approved for patients with claudin 18.2-positive diseases in some countries.More targeted therapies,including savolitinib for MET-positive patients,are currently under clinical investigation.However,the clinical application of these diagnostic approaches could be hampered by many existing challenges,including invasive and costly sampling methods,variability in immunohistochemistry interpretation,high costs and long turnaround times for next-generation sequencing,the absence of standardized and clinically validated diagnostic cut-off values for some biomarkers,and tumor heterogeneity.Novel testing and analysis techniques,such as artificial intelligence-assisted image analysis and multiplex immunohistochemistry,and emerging therapeutic strategies,including combination therapies that integrate immune checkpoint inhibitors with targeted therapies,offer potential solutions to some of these challenges.This article reviews recent progress in gastric cancer testing,outlines current challenges,and explores future directions for biomarker testing and targeted therapy for gastric cancer.展开更多
Accurate macaque paternity identification is of great significance in various fields,yet relevant research remains scarce.Our study aimed to screen effective microsatellite markers for macaque paternity testing.Initia...Accurate macaque paternity identification is of great significance in various fields,yet relevant research remains scarce.Our study aimed to screen effective microsatellite markers for macaque paternity testing.Initially,300 microsatellite markers were randomly selected from the genome of the crab-eating macaque(Macaca fascicularis),and 12 highly polymorphic tetra-nucleotide repeat markers were identified.These markers'genetic parameters and exclusion probabilities in both crab-eating and rhesus macaque(Macaca mulatta)populations were calculated,meeting the paternity testing requirements for both species.To validate the markers,16 crab-eating macaque and 10 rhesus macaque families with known pedigrees were randomly chosen for testing.The genotypes of the 12 markers in the macaques'offspring could be traced back to their parents,confirming the accuracy and applicability of the marker combination for paternity identification in both macaque species.展开更多
In heavy-duty long-distance transmission scenarios,steel wire ropes are widely used due to their unique advantages,and their safety is very important,which has also led to the rapid development of non-destructive test...In heavy-duty long-distance transmission scenarios,steel wire ropes are widely used due to their unique advantages,and their safety is very important,which has also led to the rapid development of non-destructive testing technology for steel wire ropes.The non-destructive testing technology for steel wire ropes is influenced by various factors such as its own structure and external working environment,and the testing process is relatively complex.Multiple testing methods and related types of sensors have also emerged.The electromagnetic detection method is currently the most effective method,but it also has its limitations in development and has not yet fully achieved the expected detection goals.In order to completely replace manual inspection work with the development of non-destructive testing technology for steel wire ropes,more in-depth research and long-term accumulation are still needed.展开更多
In the event of the ever-increasing growth of the beauty industry and the burgeoning market for facial masks,high-performance and high-safety mask products have emerged.Among these,light-cured collagen peptide-based h...In the event of the ever-increasing growth of the beauty industry and the burgeoning market for facial masks,high-performance and high-safety mask products have emerged.Among these,light-cured collagen peptide-based hydrogels,which are non-toxic,photocurable natural materials,exhibit significant potential for use in facial masks.We developed a novel collagen peptide-lithium chloride hydrogel-based facial mask.Light-cured collagen peptide hydrogel is a non-toxic,light-activated natural material that holds considerable promise for application in facial masks.Nonetheless,there is a significant lack of effective methodologies for real-time assessment of skin quality currently available in the market.To address this deficiency,we have developed an innovative collagen peptide-lithium chloride hydrogel mask,which is characterized by exceptional transparency(98%within the visible spectrum of 400-800 nm),commendable tensile properties(tensile strength of 428.6±2.1 kPa,with a tensile strength increase of 123.9%),substantial water retention capacity(61%),and favorable antimicrobial efficacy(89%).The incorporation of lithium chloride enhances ionic conduction at the interface between the human body and hydrogel,thereby enabling quantitative evaluation of skin quality through impedance analysis.Our collagen peptide-lithium chloride hydrogel facial mask demonstrated effectiveness in distinguishing various skin types,including D+(severely dry),D(mildly to moderately dry),N(moderate),O(mildly to moderately oily),and O+(severely oily).This study presents significant opportunities for the advancement of hydrogel masks and provides a new application platform for polymer hydrogels.展开更多
Starting with the goal and significance of software security testing,this paper introduces the main methods of software security testing in the open network environment,including formal security testing,white box test...Starting with the goal and significance of software security testing,this paper introduces the main methods of software security testing in the open network environment,including formal security testing,white box testing,fuzzy testing,model testing,and fault injection testing.A software security testing method based on a security target model is proposed.This paper provides new ideas for software security testing,better adapts to the open network environment,improves the efficiency and quality of testing,and builds a good software application environment.展开更多
The level of urinary albumin is a critical indicator for the early diagnosis and management of chronic kidney disease(CKD).However,existing methods for detecting albumin are not conducive to point-of-care testing due ...The level of urinary albumin is a critical indicator for the early diagnosis and management of chronic kidney disease(CKD).However,existing methods for detecting albumin are not conducive to point-of-care testing due to the complexity of reagent addition and incubation processes.This study presents a smartphone-integrated handheld automated biochemical analyzer(sHABA)designed for point-of-care testing of urinary albumin.The sHABA features a pre-loaded,disposable reagent cassette with reagents for the albumin assay arranged in the order of their addition within a hose.The smartphone-integrated analyzer can drive the reagents following a preset program,to enable automatic sequential addition.The sHABA has a detection limit for albumin of 5.9 mg/L and a linear detection range from 7 to 450 mg/L.The consistency of albumin level detection in 931 urine samples using sHABA with clinical tests indicates good sensitivity(95.78%)and specificity(90.16%).This research advances the field by providing an automated detection method for albumin in a portable device,allowing even untrained individuals to monitor CKD in real time at the patient's bedside.In the context of promoting tiered diagnosis and treatment,the sHABA has the potential to become an essential tool for the early diagnosis and comprehensive management of CKD and other chronic conditions.展开更多
The growing importance of maintaining and extending the functional lifespan of reinforced concrete structures has resulted in an increased emphasis on non-destructive testing techniques as essential tools for evaluati...The growing importance of maintaining and extending the functional lifespan of reinforced concrete structures has resulted in an increased emphasis on non-destructive testing techniques as essential tools for evaluating structural conditions.Non-destructive testing procedures offer a notable benefit in assessing the uniformity,homogeneity,ability to withstand compression,durability,and degree of corrosion in reinforcing bars within reinforced concrete structures.This study aimed to evaluate the existing condition of partially constructed residential buildings in Rewari district,located in the state of Haryana.The reinforced concrete structure of the building had been completed eight years ago,however,the project was abruptly stopped.Prior to recommencing the construction,it is important to assess the present state of the structure in order to evaluate the deterioration in Reinforced Cement Concrete(RCC).The building’s state was evaluated by visually inspecting the building,conducting on-site examinations,and analyzing samples in a laboratory.The findings emphasize the assessment of the robustness and durability of concrete to ascertain the degree of deterioration and degradation in the structure.The study incorporates visual inspection,and non-destructive evaluation utilizing different instruments to evaluate the corrosion condition of reinforcing bars.In addition,selected RCC columns,beams,and slabs undergo chemical testing.It has been observed that the strength results and chemical results were within permissible limits.展开更多
Objective:To analyze the diagnostic value of combined testing of C-reactive protein(CRP)and procalcitonin(PCT)in elderly patients with bacterial pneumonia.Methods:This study included 50 elderly patients with bacterial...Objective:To analyze the diagnostic value of combined testing of C-reactive protein(CRP)and procalcitonin(PCT)in elderly patients with bacterial pneumonia.Methods:This study included 50 elderly patients with bacterial pneumonia as the observation group and 50 patients with non-bacterial pneumonia as the control group,recruited from May 2022 to October 2023.Fasting venous blood samples were collected in the morning from all 100 participants.CRP levels were measured using a fully automated biochemical analyzer,while PCT levels were detected using the immunoturbidimetric luminescence method.Results:CRP and PCT levels were significantly higher in bacterial pneumonia patients[(98.25±11.59)mg/L and(3.57±1.35)μg/L,respectively]compared to the control group[(5.55±2.78)mg/L and(0.25±0.12)μg/L,respectively],with significant intergroup differences(P<0.05).Patients with severe bacterial pneumonia exhibited higher serum CRP and PCT levels compared to those with moderate or mild disease(P<0.05).The combined testing of CRP and PCT showed higher sensitivity and specificity than individual tests.In the observation group,CRP and PCT levels significantly decreased after treatment compared to pre-treatment levels.Conclusion:The combination of CRP and PCT testing provides high diagnostic accuracy for bacterial pneumonia in elderly patients.It effectively differentiates bacterial from non-bacterial infections,offering valuable data to guide clinical treatment.展开更多
Current sway test platforms for marine nuclear equipment face challenges in meeting the GJB 150.23A requirements.This is primarily because of the performance limitations of conventional actuators under extreme marine ...Current sway test platforms for marine nuclear equipment face challenges in meeting the GJB 150.23A requirements.This is primarily because of the performance limitations of conventional actuators under extreme marine conditions.This study aimed to overcome these constraints using an innovative parallel mechanism design.We developed a novel 6-PUS parallel platform featuring six kinematic chains with hybrid series-parallel actuators.Each chain combines(1)force-speed adaptive transmission,(2)redundant motor-driven dual-screw actuation,and(3)passive load-balancing mechanisms.Comprehensive kinematic/dynamic modeling and experimental validation were conducted.Tests demonstrated the capability of the platform to achieve cyclic speeds of±45°/7 s and±30°/3 s while supporting 10-ton loads.Successful sway tests on nuclear components(reactor pressurizer and control rod drive mechanism)confirmed the operational reliability.This work presented three key innovations:(1)a new parallel-platform architecture that overcomes the limitations of conventional actuators;(2)integrated hybrid actuation with adaptive transmission;and(3)high-speed,heavy-load performance that meets stringent marine testing standards.This solution significantly advances nuclear equipment qualification testing technology.展开更多
To obtain the certificate of airworthiness,it is essential to conduct a full-scale aircraft static test.During such test,accurate and comprehensive wing deformation measurement is crucial for assessing its strength,st...To obtain the certificate of airworthiness,it is essential to conduct a full-scale aircraft static test.During such test,accurate and comprehensive wing deformation measurement is crucial for assessing its strength,stiffness,and bearing capability.This paper proposes a novel and cost-effective videogrammetric method using multi-camera system to achieve the non-contact,highprecision,and 3D measurement of overall static deformation for the large-scale wing structure.To overcome the difficulties of making,carrying,and employing the large 2D or 3D target for calibrating the cameras with large field of view,a flexible stereo cameras calibration method combining 1D target and epipolar geometry is proposed.The global calibration method,aided by a total station,is employed to unify the 3D data obtained from various binocular subsystems.A series of static load tests using a 10-meter-long large-scale wing have been conducted to validate the proposed system and methods.Furthermore,the proposed method was applied to the practical wing deformation measurement of both wings with a wingspan of 33.6 m in the full-size civil aircraft static test.The overall 3D profile and displacement data of the tested wing under various loads can be accurately obtained.The maximum error of distance and displacement measurement is less than 4.5 mm within the measurement range of 35 m in all load cases.These results demonstrate that the proposed method achieves effective,high-accuracy,on-site,and visualized wing deformation measurement,making it a promising approach for full-scale aircraft wing static test.展开更多
文摘The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.
基金supported by the National Natural Science Foundation of China for Distinguished Young Scholars(Grant No.42225206)National Natural Science Foundation of China(42207180,42477209,42302320).
文摘Subgrade engineering is a fundamental aspect of infrastructure construction in China.As the primary structural element responsible for bearing and distributing traffic loads,the subgrade must not only withstand the substantial pressures exerted by vehicles,trains,and other forms of transportation,but also efficiently transfer these loads to the underlying foundation,ensuring the stability and longevity of the roadway.In recent years,advancements in subgrade engineering technology have propelled the industry towards smarter,greener,and more sustainable practices,particularly in the areas of intelligent monitoring,disaster management,and innovative construction methods.This paper reviews the application and methodologies of intelligent testing equipment,including cone penetration testing(CPT)devices,soil resistivity testers,and intelligent rebound testers,in subgrade engineering.It examines the operating principles,advantages,limitations,and application ranges of these tools in subgrade testing.Additionally,the paper evaluates the practical use of advanced equipment from both domestic and international perspectives,addressing the challenges encountered by various instruments in realworld applications.These devices enable precise,comprehensive testing and evaluation of subgrade conditions at different stages,providing real-time data analysis and intelligent early warnings.This supports effective subgrade health management and maintenance.As intelligent technologies continue to evolve and integrate,these tools will increasingly enhance the accuracy,efficiency,and sustainability of subgrade monitoring.
文摘It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.
文摘Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical laboratories.It has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and microfluidics.Microfluidic paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low cost.SeveralμPADs have been successfully commercialized and received excellent feedback during the past several decades.This review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative examples.The future perspectives of the development inμPADs are also provided.
文摘Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant on traditional laptops and computers, which, while portable, lack true ultra-portability. This paper explores the potential impact of developing a dedicated, ultra-portable, low-cost device for on-the-go penetration testing. Such a device could replicate the core functionalities of advanced penetration testing tools, including those found in Kali Linux, within a compact form factor that fits easily into a pocket. By offering the convenience and portability akin to a smartphone, this innovative device could redefine the way penetration testers operate, enabling them to carry essential tools wherever they go and ensuring they are always prepared to conduct security assessments efficiently. This approach aims to revolutionize penetration testing by merging high functionality with unparalleled portability.
文摘The China Spallation Neutron Source(CSNS)is the fourth pulsed accelerator-driven neutron source in the world,and it achieved its design target of 100 kW in 2020.The planned China Spallation Neutron Source Phase II(CSNS-II)commenced in 2024.The CSNS-II linac design primarily involves the addition of a radio-frequency ion source and a section of a superconducting linear accelerator composed of two types of superconducting cavities,namely double-spoke and six-cell elliptical cavities,after the drift tube linac(DTL).The development of the double-spoke superconducting cavity began in early 2021,and by January 2023,the welding,post-processing,and vertical tests of two 324 MHz double-spoke cavity prototypes were completed,with vertical test gradients of 11.6 and 15 MV/m,and Q_(0)≥3×10^(10)@E_(acc)≤10 MV/m.The R&D of the cryomodule began in January 2022.In October 2023,the clean assembly of the double-spoke cavity string and cold mass installation of the cryomodule commenced,with the installation of the cryomodule and valve box completing in two months.In January 2024,a horizontal test of the cryomodule was completed,making it the first double-spoke cavity cryomodule in China.The test results showed that the maximum gradients of the two superconducting cavities at a pulse width of 4 ms and repetition frequency of 25 Hz were 12.8 and 15.2 MV/m,respectively.This article provides a detailed introduction to the double-spoke superconducting cavity,tuner,coupler,and cryomodule,elaborates on the clean assembly of the cavity string and cold mass installation of the cryomodule,and provides a detailed analysis of the horizontal test results.
文摘Knowledge of the dynamic modulus of bituminous mixtures is practical and theoretically meaningful in pavement design,construction,and monitoring.The tests in the laboratory for the determination of asphalt concrete(AC)moduli include the resilient modulus through the indirect tensile test(EN 12697-26),the complex modulus through the four point bending beam(EN 12697-26),the asphalt mixture performance tester(AMPT)and the simple performance tester(SPT)(AASHTO T342).Unfortunately,the tests above are time-consuming and quite expensive.On the other hand,the standard ASTM E1876 for resonant tests applies only to very thin(stocky)cylindrical samples(with a thickness-to-radius ratio,t/r,lower than 0.5)while the typical AC samples produced in the laboratory do not satisfy the ASTM E1876 requirements.Consequently,the main objective of this study is to set up and implement a tentative method to extend the range of applicability of the standard ASTM E1876 to common AC samples.The methodology was to carry out resonant tests on slender samples and to cut each of them into stocky samples(these latter complying with ASTM E1876 requirements in terms of t/r),deriving the master curve per material.These master curves allowed for deriving the value of the dynamic modulus for the given selected sample under its particular test conditions during the resonant test(i.e.,temperature and frequency).Consequently,simplified formulae were provided for AC samples.Results were compared to Witczak's estimates.These formulae provide an approximate tool to carry out low-cost and high-speed inferences at the laboratory stage on common AC samples,whatever their thickness is.Additional studies are needed to investigate the reliability of the method further and reduce uncertainties.
基金supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(2024ZD0608100)the National Natural Science Foundation of China(62332017,U22A2022)
文摘In high-risk industrial environments like nuclear power plants,precise defect identification and localization are essential for maintaining production stability and safety.However,the complexity of such a harsh environment leads to significant variations in the shape and size of the defects.To address this challenge,we propose the multivariate time series segmentation network(MSSN),which adopts a multiscale convolutional network with multi-stage and depth-separable convolutions for efficient feature extraction through variable-length templates.To tackle the classification difficulty caused by structural signal variance,MSSN employs logarithmic normalization to adjust instance distributions.Furthermore,it integrates classification with smoothing loss functions to accurately identify defect segments amid similar structural and defect signal subsequences.Our algorithm evaluated on both the Mackey-Glass dataset and industrial dataset achieves over 95%localization and demonstrates the capture capability on the synthetic dataset.In a nuclear plant's heat transfer tube dataset,it captures 90%of defect instances with75%middle localization F1 score.
文摘This article introduces the composition and working principle of home appliance control board automation testing equipment,elaborates on the importance of key technical indicators,explains the integrated design of functional modules,signal processing modules,and data analysis modules,and covers aspects such as the application of machine learning algorithms and the establishment of fault waveform databases.Finally,it looks forward to the development of intelligent testing systems and emphasizes the importance of building a standardized testing system.
基金supported by the Beijing Natural Science Foundation under Grant L253002.
文摘With the rapid development and commercialization of wireless communications,the execution of OTA testing requires a tremendous amount of test time.Therefore,test time reduction is of great significance.The objective of this article is to determine optimal measurement grids for SISO OTA testing of 5G Sub-6 GHz user equipments(UEs)in anechoic chamber with satisfactory accuracy and efficiency.The effect of different grid configurations on OTA performance is analyzed quantitatively using reference radiation patterns at different bands.These patterns are utilized to mimic the worst-case radiation patterns of 5G Sub-6 GHz UEs.Subsequently,the associated measurement uncertainty(MU)terms are quantitatively analyzed and determined based on statistical analysis.According to the comparison of calculated MUs,reduction of grid points from currentlyrequired 62(30/30,Δθ/Δϕ)to 26(45/45)could achieve roughly 60%test time reduction for Sub-6 GHz,while still maintaining an uncertainty level of≤0.25 dB.These values can be further reduced to 14(60/60)with 80%reduction for Sub-3 GHz.More importantly,the recommended grid configurations in this research are applicable to both TIS and TRP testing.
基金support by grants from Capital’s Funds for Health Improvement and Research(Grant No.2024-2-1024)Beijing Natural Science Foundation(Grant No.7232018).
文摘Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely integrated into routine clinical diagnostics of gastric cancer to guide personalized treatment.Human epidermal growth factor receptor 2(HER2)was the first molecular biomarker to be used in gastric cancer with trastuzumab being the first approved targeted therapy for HER2-positive gastric cancer.Programmed death-ligand 1 positivity and microsatellite instability can guide the use of immunotherapies,such as pembrolizumab and nivolumab.More recently,zolbetuximab has been approved for patients with claudin 18.2-positive diseases in some countries.More targeted therapies,including savolitinib for MET-positive patients,are currently under clinical investigation.However,the clinical application of these diagnostic approaches could be hampered by many existing challenges,including invasive and costly sampling methods,variability in immunohistochemistry interpretation,high costs and long turnaround times for next-generation sequencing,the absence of standardized and clinically validated diagnostic cut-off values for some biomarkers,and tumor heterogeneity.Novel testing and analysis techniques,such as artificial intelligence-assisted image analysis and multiplex immunohistochemistry,and emerging therapeutic strategies,including combination therapies that integrate immune checkpoint inhibitors with targeted therapies,offer potential solutions to some of these challenges.This article reviews recent progress in gastric cancer testing,outlines current challenges,and explores future directions for biomarker testing and targeted therapy for gastric cancer.
基金Nanhu Laboratory Self-Initiated Research Project,Grant/Award Number:NSS2023A00001-2。
文摘Accurate macaque paternity identification is of great significance in various fields,yet relevant research remains scarce.Our study aimed to screen effective microsatellite markers for macaque paternity testing.Initially,300 microsatellite markers were randomly selected from the genome of the crab-eating macaque(Macaca fascicularis),and 12 highly polymorphic tetra-nucleotide repeat markers were identified.These markers'genetic parameters and exclusion probabilities in both crab-eating and rhesus macaque(Macaca mulatta)populations were calculated,meeting the paternity testing requirements for both species.To validate the markers,16 crab-eating macaque and 10 rhesus macaque families with known pedigrees were randomly chosen for testing.The genotypes of the 12 markers in the macaques'offspring could be traced back to their parents,confirming the accuracy and applicability of the marker combination for paternity identification in both macaque species.
文摘In heavy-duty long-distance transmission scenarios,steel wire ropes are widely used due to their unique advantages,and their safety is very important,which has also led to the rapid development of non-destructive testing technology for steel wire ropes.The non-destructive testing technology for steel wire ropes is influenced by various factors such as its own structure and external working environment,and the testing process is relatively complex.Multiple testing methods and related types of sensors have also emerged.The electromagnetic detection method is currently the most effective method,but it also has its limitations in development and has not yet fully achieved the expected detection goals.In order to completely replace manual inspection work with the development of non-destructive testing technology for steel wire ropes,more in-depth research and long-term accumulation are still needed.
基金financially supported by the National Natural Science Foundation of China(Nos.52275290 and 51905222)Natural Science Foundation of Jiangsu Province(No.BK20211068)+2 种基金Research Project of State Key Laboratory of Mechanical System and Vibration(No.MSV202419)Major Program of the National Natural Science Foundation of China for Basic Theory and Key Technology of Tri-Co Robots(No.92248301)the Opening Project of the Key Laboratory of Bionic Engineering(Ministry of Education),Jilin University(No.KF2023006)。
文摘In the event of the ever-increasing growth of the beauty industry and the burgeoning market for facial masks,high-performance and high-safety mask products have emerged.Among these,light-cured collagen peptide-based hydrogels,which are non-toxic,photocurable natural materials,exhibit significant potential for use in facial masks.We developed a novel collagen peptide-lithium chloride hydrogel-based facial mask.Light-cured collagen peptide hydrogel is a non-toxic,light-activated natural material that holds considerable promise for application in facial masks.Nonetheless,there is a significant lack of effective methodologies for real-time assessment of skin quality currently available in the market.To address this deficiency,we have developed an innovative collagen peptide-lithium chloride hydrogel mask,which is characterized by exceptional transparency(98%within the visible spectrum of 400-800 nm),commendable tensile properties(tensile strength of 428.6±2.1 kPa,with a tensile strength increase of 123.9%),substantial water retention capacity(61%),and favorable antimicrobial efficacy(89%).The incorporation of lithium chloride enhances ionic conduction at the interface between the human body and hydrogel,thereby enabling quantitative evaluation of skin quality through impedance analysis.Our collagen peptide-lithium chloride hydrogel facial mask demonstrated effectiveness in distinguishing various skin types,including D+(severely dry),D(mildly to moderately dry),N(moderate),O(mildly to moderately oily),and O+(severely oily).This study presents significant opportunities for the advancement of hydrogel masks and provides a new application platform for polymer hydrogels.
文摘Starting with the goal and significance of software security testing,this paper introduces the main methods of software security testing in the open network environment,including formal security testing,white box testing,fuzzy testing,model testing,and fault injection testing.A software security testing method based on a security target model is proposed.This paper provides new ideas for software security testing,better adapts to the open network environment,improves the efficiency and quality of testing,and builds a good software application environment.
基金funding by the China Postdoctoral Science Foundation(Grant No.:2021M701628)the National Natural Science Foundation of China(Grant No.:82202625)+3 种基金Science and Technology Projects in Guangzhou,China(Grant No.:SL2022A04J02086)President Foundation of Nanfang Hospital,Southern Medical University,China(Grant Nos.:2021B012,and 2021C050)National Science Fund for Distinguished Young Scholars,China(Grant No.:82025024)Key project of the National Natural Science Foundation of China(Grant No.:82230080).
文摘The level of urinary albumin is a critical indicator for the early diagnosis and management of chronic kidney disease(CKD).However,existing methods for detecting albumin are not conducive to point-of-care testing due to the complexity of reagent addition and incubation processes.This study presents a smartphone-integrated handheld automated biochemical analyzer(sHABA)designed for point-of-care testing of urinary albumin.The sHABA features a pre-loaded,disposable reagent cassette with reagents for the albumin assay arranged in the order of their addition within a hose.The smartphone-integrated analyzer can drive the reagents following a preset program,to enable automatic sequential addition.The sHABA has a detection limit for albumin of 5.9 mg/L and a linear detection range from 7 to 450 mg/L.The consistency of albumin level detection in 931 urine samples using sHABA with clinical tests indicates good sensitivity(95.78%)and specificity(90.16%).This research advances the field by providing an automated detection method for albumin in a portable device,allowing even untrained individuals to monitor CKD in real time at the patient's bedside.In the context of promoting tiered diagnosis and treatment,the sHABA has the potential to become an essential tool for the early diagnosis and comprehensive management of CKD and other chronic conditions.
文摘The growing importance of maintaining and extending the functional lifespan of reinforced concrete structures has resulted in an increased emphasis on non-destructive testing techniques as essential tools for evaluating structural conditions.Non-destructive testing procedures offer a notable benefit in assessing the uniformity,homogeneity,ability to withstand compression,durability,and degree of corrosion in reinforcing bars within reinforced concrete structures.This study aimed to evaluate the existing condition of partially constructed residential buildings in Rewari district,located in the state of Haryana.The reinforced concrete structure of the building had been completed eight years ago,however,the project was abruptly stopped.Prior to recommencing the construction,it is important to assess the present state of the structure in order to evaluate the deterioration in Reinforced Cement Concrete(RCC).The building’s state was evaluated by visually inspecting the building,conducting on-site examinations,and analyzing samples in a laboratory.The findings emphasize the assessment of the robustness and durability of concrete to ascertain the degree of deterioration and degradation in the structure.The study incorporates visual inspection,and non-destructive evaluation utilizing different instruments to evaluate the corrosion condition of reinforcing bars.In addition,selected RCC columns,beams,and slabs undergo chemical testing.It has been observed that the strength results and chemical results were within permissible limits.
文摘Objective:To analyze the diagnostic value of combined testing of C-reactive protein(CRP)and procalcitonin(PCT)in elderly patients with bacterial pneumonia.Methods:This study included 50 elderly patients with bacterial pneumonia as the observation group and 50 patients with non-bacterial pneumonia as the control group,recruited from May 2022 to October 2023.Fasting venous blood samples were collected in the morning from all 100 participants.CRP levels were measured using a fully automated biochemical analyzer,while PCT levels were detected using the immunoturbidimetric luminescence method.Results:CRP and PCT levels were significantly higher in bacterial pneumonia patients[(98.25±11.59)mg/L and(3.57±1.35)μg/L,respectively]compared to the control group[(5.55±2.78)mg/L and(0.25±0.12)μg/L,respectively],with significant intergroup differences(P<0.05).Patients with severe bacterial pneumonia exhibited higher serum CRP and PCT levels compared to those with moderate or mild disease(P<0.05).The combined testing of CRP and PCT showed higher sensitivity and specificity than individual tests.In the observation group,CRP and PCT levels significantly decreased after treatment compared to pre-treatment levels.Conclusion:The combination of CRP and PCT testing provides high diagnostic accuracy for bacterial pneumonia in elderly patients.It effectively differentiates bacterial from non-bacterial infections,offering valuable data to guide clinical treatment.
基金Supported by Shanghai Nuclear Engineering Research&Design Institute Co.,Ltd.
文摘Current sway test platforms for marine nuclear equipment face challenges in meeting the GJB 150.23A requirements.This is primarily because of the performance limitations of conventional actuators under extreme marine conditions.This study aimed to overcome these constraints using an innovative parallel mechanism design.We developed a novel 6-PUS parallel platform featuring six kinematic chains with hybrid series-parallel actuators.Each chain combines(1)force-speed adaptive transmission,(2)redundant motor-driven dual-screw actuation,and(3)passive load-balancing mechanisms.Comprehensive kinematic/dynamic modeling and experimental validation were conducted.Tests demonstrated the capability of the platform to achieve cyclic speeds of±45°/7 s and±30°/3 s while supporting 10-ton loads.Successful sway tests on nuclear components(reactor pressurizer and control rod drive mechanism)confirmed the operational reliability.This work presented three key innovations:(1)a new parallel-platform architecture that overcomes the limitations of conventional actuators;(2)integrated hybrid actuation with adaptive transmission;and(3)high-speed,heavy-load performance that meets stringent marine testing standards.This solution significantly advances nuclear equipment qualification testing technology.
文摘To obtain the certificate of airworthiness,it is essential to conduct a full-scale aircraft static test.During such test,accurate and comprehensive wing deformation measurement is crucial for assessing its strength,stiffness,and bearing capability.This paper proposes a novel and cost-effective videogrammetric method using multi-camera system to achieve the non-contact,highprecision,and 3D measurement of overall static deformation for the large-scale wing structure.To overcome the difficulties of making,carrying,and employing the large 2D or 3D target for calibrating the cameras with large field of view,a flexible stereo cameras calibration method combining 1D target and epipolar geometry is proposed.The global calibration method,aided by a total station,is employed to unify the 3D data obtained from various binocular subsystems.A series of static load tests using a 10-meter-long large-scale wing have been conducted to validate the proposed system and methods.Furthermore,the proposed method was applied to the practical wing deformation measurement of both wings with a wingspan of 33.6 m in the full-size civil aircraft static test.The overall 3D profile and displacement data of the tested wing under various loads can be accurately obtained.The maximum error of distance and displacement measurement is less than 4.5 mm within the measurement range of 35 m in all load cases.These results demonstrate that the proposed method achieves effective,high-accuracy,on-site,and visualized wing deformation measurement,making it a promising approach for full-scale aircraft wing static test.
