A paper titled"The CRISPR-Cas13 a gene-editing system induces collateral cleavage of RNA in glioma cells",recently published in Advanced Science by the Kang group,reports the promising application of the CRI...A paper titled"The CRISPR-Cas13 a gene-editing system induces collateral cleavage of RNA in glioma cells",recently published in Advanced Science by the Kang group,reports the promising application of the CRISPR-Cas13 a system in cancer cells1.展开更多
Uncertainty in determining optimum conjunctive water use lies not only on variability of hydrological cycle and climate but also on lack of adequate data and perfect knowledge about groundwater-surface water system in...Uncertainty in determining optimum conjunctive water use lies not only on variability of hydrological cycle and climate but also on lack of adequate data and perfect knowledge about groundwater-surface water system interactions, errors in historic data and inherent variability of system parameters both in space and time. Simulation-optimization models are used for conjunctive water use management under uncertain conditions. However, direct application of such approach whereby all realizations are considered at every-iteration of the optimization process leads to a highly computational time-consuming optimization problem as the number of realizations increases. Hence, this study proposes a novel approach—a Retrospective Optimization Approximation (ROA) approach. In this approach, a simulation model was used to determine aquifer system responses (draw-downs) which were assembled as response matrices and incorporated in the optimization model (procedure) as coefficients in the constraints. The sample optimization sub-problems generated, were solved and analyzed through ROA-Active-Set procedure implemented under MATLAB code. The ROA-Active Set procedure solves and evaluates a sequence of sample path optimization sub-problems in an increasing number of realizations. The methodology was applied to a real-world conjunctive water use management problem found in Great Letaba River basin, South Africa. In the River basin, surface water source contributes 87% of the existing un-optimized total conjunctive water use withdrawal rate (6512.04 m<sup>3</sup>/day) and the remaining 13% is contributed by groundwater source. Through ROA approach, results indicate that the optimum percentages contribution of the surface and subsurface sources to the total water demand are 58% and 42% respectively. This implies that the existing percentage contribution can be increased or reduced by ±29% that is groundwater source can be increased by 29% while the surface water source contribution can be reduced by 29%. This reveals that the existing conjunctive water use practice is unsustainable wherein surface water system is overstressed while groundwater system is under-utilized. Through k-means sampling technique ROA-Active Set procedure was able to attain a converged maximum expected total optimum conjunctive water use withdrawal rate of 4.35 × 10<sup>4</sup> m<sup>3</sup>/day within a relatively few numbers of iterations (6 to 8 iterations) in about 2.30 Hrs. In conclusion, results demonstrated that ROA approach is capable of managing real-world regional aquifers sustainable conjunctive water use practice under hydro-geological uncertainty conditions.展开更多
a Pole voltage waveforms (VA20 and VA40) for modulation index 0.4 (middle trace is A-phase voltage waveform) x-axis: 1 div.=10ms, y-axis: 1 div.= 100V b Normalized harmonic spectrum for pole voltage of Fig. 9a c A-pha...a Pole voltage waveforms (VA20 and VA40) for modulation index 0.4 (middle trace is A-phase voltage waveform) x-axis: 1 div.=10ms, y-axis: 1 div.= 100V b Normalized harmonic spectrum for pole voltage of Fig. 9a c A-phase current and phase voltage for modulation index 0.4 (reference space vector is in inner layer)展开更多
a Pole voltage waveforms (VA20 and VA40) for modulation index 0.4 (middle trace is A-phase voltage waveform) x-axis: 1 div.=10ms, y-axis: 1 div.= 100V b Normalized harmonic spectrum for pole voltage of Fig. 9a c A-pha...a Pole voltage waveforms (VA20 and VA40) for modulation index 0.4 (middle trace is A-phase voltage waveform) x-axis: 1 div.=10ms, y-axis: 1 div.= 100V b Normalized harmonic spectrum for pole voltage of Fig. 9a c A-phase current and phase voltage for modulation index 0.4 (reference space vector is in inner layer)展开更多
We present a new scheme to allocate/de-allocate Transport Network Assigned (TN A) address using Link Management Protocol (LMP) and to register/resolution these addresses using Lightweight Directory Access Protocol (LD...We present a new scheme to allocate/de-allocate Transport Network Assigned (TN A) address using Link Management Protocol (LMP) and to register/resolution these addresses using Lightweight Directory Access Protocol (LDAP) for Automatically Switched Optical Network (ASON).展开更多
In this paper, it is presented that an approach based on Continuous Wavelet Thansform(CWT) and Fourier Transform(FT) for identifying ultrasonic echoes in inspecting oil well cementing quality. First, CWT is used to pr...In this paper, it is presented that an approach based on Continuous Wavelet Thansform(CWT) and Fourier Transform(FT) for identifying ultrasonic echoes in inspecting oil well cementing quality. First, CWT is used to process echo signals. Then spectra of the processing results in some specilic scale-time segments are calculated as pattern features. The research results show that theoretical calculations basically agree with experimental results. Compared with the aPproach based on the spectra or Discrete Wavlet Transform, our approach has advantages of fine analyzing scales, stable features and high recognizing rate. It is very suitable to identify echo signals whose spectra vary with time.展开更多
Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous socia...Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.展开更多
DEAR EDITOR,Somatic mutations are a large category of genetic variations,which play an essential role in tumorigenesis. Detection of somatic single nucleotide variants(SNVs) could facilitate downstream analysis of tum...DEAR EDITOR,Somatic mutations are a large category of genetic variations,which play an essential role in tumorigenesis. Detection of somatic single nucleotide variants(SNVs) could facilitate downstream analysis of tumorigenesis. Many computational methods have been developed to detect SNVs, but most require normal matched samples to differentiate somatic SNVs from the normal state, which can be difficult to obtain.展开更多
基金supported by grants from the National Natural Science Foundation of China(Grant No.81772682,81974389)Jiangsu Province’s Key Discipline of Medicine(Grant No.ZDXKA2016001)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘A paper titled"The CRISPR-Cas13 a gene-editing system induces collateral cleavage of RNA in glioma cells",recently published in Advanced Science by the Kang group,reports the promising application of the CRISPR-Cas13 a system in cancer cells1.
文摘Uncertainty in determining optimum conjunctive water use lies not only on variability of hydrological cycle and climate but also on lack of adequate data and perfect knowledge about groundwater-surface water system interactions, errors in historic data and inherent variability of system parameters both in space and time. Simulation-optimization models are used for conjunctive water use management under uncertain conditions. However, direct application of such approach whereby all realizations are considered at every-iteration of the optimization process leads to a highly computational time-consuming optimization problem as the number of realizations increases. Hence, this study proposes a novel approach—a Retrospective Optimization Approximation (ROA) approach. In this approach, a simulation model was used to determine aquifer system responses (draw-downs) which were assembled as response matrices and incorporated in the optimization model (procedure) as coefficients in the constraints. The sample optimization sub-problems generated, were solved and analyzed through ROA-Active-Set procedure implemented under MATLAB code. The ROA-Active Set procedure solves and evaluates a sequence of sample path optimization sub-problems in an increasing number of realizations. The methodology was applied to a real-world conjunctive water use management problem found in Great Letaba River basin, South Africa. In the River basin, surface water source contributes 87% of the existing un-optimized total conjunctive water use withdrawal rate (6512.04 m<sup>3</sup>/day) and the remaining 13% is contributed by groundwater source. Through ROA approach, results indicate that the optimum percentages contribution of the surface and subsurface sources to the total water demand are 58% and 42% respectively. This implies that the existing percentage contribution can be increased or reduced by ±29% that is groundwater source can be increased by 29% while the surface water source contribution can be reduced by 29%. This reveals that the existing conjunctive water use practice is unsustainable wherein surface water system is overstressed while groundwater system is under-utilized. Through k-means sampling technique ROA-Active Set procedure was able to attain a converged maximum expected total optimum conjunctive water use withdrawal rate of 4.35 × 10<sup>4</sup> m<sup>3</sup>/day within a relatively few numbers of iterations (6 to 8 iterations) in about 2.30 Hrs. In conclusion, results demonstrated that ROA approach is capable of managing real-world regional aquifers sustainable conjunctive water use practice under hydro-geological uncertainty conditions.
文摘a Pole voltage waveforms (VA20 and VA40) for modulation index 0.4 (middle trace is A-phase voltage waveform) x-axis: 1 div.=10ms, y-axis: 1 div.= 100V b Normalized harmonic spectrum for pole voltage of Fig. 9a c A-phase current and phase voltage for modulation index 0.4 (reference space vector is in inner layer)
文摘a Pole voltage waveforms (VA20 and VA40) for modulation index 0.4 (middle trace is A-phase voltage waveform) x-axis: 1 div.=10ms, y-axis: 1 div.= 100V b Normalized harmonic spectrum for pole voltage of Fig. 9a c A-phase current and phase voltage for modulation index 0.4 (reference space vector is in inner layer)
基金This work is supported by the 863 Program and Shanghai Program of Optical Science and Technology.
文摘We present a new scheme to allocate/de-allocate Transport Network Assigned (TN A) address using Link Management Protocol (LMP) and to register/resolution these addresses using Lightweight Directory Access Protocol (LDAP) for Automatically Switched Optical Network (ASON).
文摘In this paper, it is presented that an approach based on Continuous Wavelet Thansform(CWT) and Fourier Transform(FT) for identifying ultrasonic echoes in inspecting oil well cementing quality. First, CWT is used to process echo signals. Then spectra of the processing results in some specilic scale-time segments are calculated as pattern features. The research results show that theoretical calculations basically agree with experimental results. Compared with the aPproach based on the spectra or Discrete Wavlet Transform, our approach has advantages of fine analyzing scales, stable features and high recognizing rate. It is very suitable to identify echo signals whose spectra vary with time.
基金supported in part by the New York State Office of People with Developmental Disabilities(OPWDD)Zenith Award ZEN-12-241233 from Alzheimer’s Associationa research grant#20121203 from Alzheimer’s Drug Discovery Foundation,New York
文摘Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.
基金supported by the CAS Pioneer Hundred Talents Program and National Natural Science Foundation of China (32070683) to Y.P.C。
文摘DEAR EDITOR,Somatic mutations are a large category of genetic variations,which play an essential role in tumorigenesis. Detection of somatic single nucleotide variants(SNVs) could facilitate downstream analysis of tumorigenesis. Many computational methods have been developed to detect SNVs, but most require normal matched samples to differentiate somatic SNVs from the normal state, which can be difficult to obtain.
