目的采用系统评价方法确定前蛋白转化酶枯草溶菌素9型抑制剂(PCSK9i)治疗冠状动脉粥样硬化斑块的有效性和安全性。方法计算机检索PubMed、Web of Science、Cochrane Library、EmBase、CNKI数据库、万方数据库、维普中文科技期刊数据库...目的采用系统评价方法确定前蛋白转化酶枯草溶菌素9型抑制剂(PCSK9i)治疗冠状动脉粥样硬化斑块的有效性和安全性。方法计算机检索PubMed、Web of Science、Cochrane Library、EmBase、CNKI数据库、万方数据库、维普中文科技期刊数据库和中国生物医学文献数据库,时间限定为从建库起至2023年3月。由2名独立评价者按照纳入与排除标准筛选文献、提取数据并评价纳入研究的质量。采用RevMan 5.4和Stata 16.0软件进行Meta分析。结果共纳入6项随机对照试验,包括2003例冠状动脉粥样硬化性心脏病(冠心病)患者。与他汀类药物治疗组相比,联合PCSK9i后显著降低了斑块体积百分比(PAV)[均数差(MD)=-1.02,95%CI:-1.34~-0.69,P<0.001]及最大脂质弧度(MD=-11.25,95%CI:-22.39~-0.11,P=0.050),同时增加了最小纤维帽厚度(FCTmin)(MD=20.33 mm^(3),95%CI:10.73~29.93,P<0.001)及平均纤维帽厚度(FCTmean)(MD=27.74,95%CI:4.56~50.91,P<0.050)。PCSK9i联合他汀类药物治疗组与单用他汀类药物治疗组相比,两组间神经认知功能受损、新发糖尿病和肌痛差异无统计学意义(P>0.050)。亚组分析显示,不同治疗时间、PCSK9i类型、冠心病亚型对PAV结果无显著影响(P>0.050)。灵敏度分析未见显著影响PAV结果的研究(P>0.050)。漏斗图和Egger检验示无明显发表偏倚。结论PCSK9i联合他汀类药物可明显逆转冠心病患者的斑块进展,并增加斑块稳定性,期待进一步确定PCSK9i对斑块的作用是否能够改善患者预后。展开更多
A novel Fe-doping three-dimensional fiower-like Bi_(7)O_(9)I_(3) microspheres with plasmonic Bi and rich surface oxygen vacancies(Fe-Bi/Bi_(7)O_(9)I_(3)/OVs)was prepared as catalysts,and further coupled with natural a...A novel Fe-doping three-dimensional fiower-like Bi_(7)O_(9)I_(3) microspheres with plasmonic Bi and rich surface oxygen vacancies(Fe-Bi/Bi_(7)O_(9)I_(3)/OVs)was prepared as catalysts,and further coupled with natural air diffusion electrode(NADE)to construct the heterogeneous visible-light-driven photoelectro-Fenton(HEVL-PEF)process to enhance the degradation and mineralization of tetracycline(TC).Interfacial≡Fe sites,OVs and Bi metal were simultaneously constructed via Fe doping,which effectively improved visible light absorption and the separation efficiency of photogenerated carriers to further accelerate the transformation of Fe(Ⅲ)to Fe(Ⅱ),achieving Fenton reaction recycling.HE-VL-PEF process could achieve enhanced treatment of pollutants,thanks to the synergistic effect of electro-Fenton(EF)and photo-Fenton(PF).NADE exhibited excellent H_(2)O_(2) electrosynthesis without external oxygen-pumping equipment.Under the irradiation of visible light,Fe-Bi/Bi_(7)O_(9)I_(3)/OVs could achieve more photoelectrons to accelerate the transformation of Fe(Ⅲ)to Fe(Ⅱ)or directly activate H2O2.DFT calculations also clearly demonstrated that except for the fast charge separation and transfer,Fe-Bi/Bi_(7)O_(9)I_(3)/OVs could achieve a faster electron transport between Fe-O,facilitating Fe site acquire more electron.Consequently,the Fe-Bi/Bi_(7)O_(9)I_(3)/OVs in HE-VL-PEF process presented performance superiorities including excellent pollutant removal(91.91%),low electric energy consumption of 66.34 k Wh/kg total organic carbon(TOC),excellent reusability and wide p H adaptability(3–9).展开更多
基金financially supported by Key Project of Natural Science Foundation of Tianjin(No.21JCZDJC00320)National Key R&D Program International Cooperation Project(No.2021YFE0106500)+3 种基金Natural Science Foundation of China(No.52170085)Fundamental Research Funds for the Central UniversitiesNankai UniversityNational Research Foundation IRGChina/South Africa Research Cooperation Programme(No.132793)。
文摘A novel Fe-doping three-dimensional fiower-like Bi_(7)O_(9)I_(3) microspheres with plasmonic Bi and rich surface oxygen vacancies(Fe-Bi/Bi_(7)O_(9)I_(3)/OVs)was prepared as catalysts,and further coupled with natural air diffusion electrode(NADE)to construct the heterogeneous visible-light-driven photoelectro-Fenton(HEVL-PEF)process to enhance the degradation and mineralization of tetracycline(TC).Interfacial≡Fe sites,OVs and Bi metal were simultaneously constructed via Fe doping,which effectively improved visible light absorption and the separation efficiency of photogenerated carriers to further accelerate the transformation of Fe(Ⅲ)to Fe(Ⅱ),achieving Fenton reaction recycling.HE-VL-PEF process could achieve enhanced treatment of pollutants,thanks to the synergistic effect of electro-Fenton(EF)and photo-Fenton(PF).NADE exhibited excellent H_(2)O_(2) electrosynthesis without external oxygen-pumping equipment.Under the irradiation of visible light,Fe-Bi/Bi_(7)O_(9)I_(3)/OVs could achieve more photoelectrons to accelerate the transformation of Fe(Ⅲ)to Fe(Ⅱ)or directly activate H2O2.DFT calculations also clearly demonstrated that except for the fast charge separation and transfer,Fe-Bi/Bi_(7)O_(9)I_(3)/OVs could achieve a faster electron transport between Fe-O,facilitating Fe site acquire more electron.Consequently,the Fe-Bi/Bi_(7)O_(9)I_(3)/OVs in HE-VL-PEF process presented performance superiorities including excellent pollutant removal(91.91%),low electric energy consumption of 66.34 k Wh/kg total organic carbon(TOC),excellent reusability and wide p H adaptability(3–9).
