Albira SI小动物单光子发射断层显像-X线计算机体层成像仪(SPECT-CT)是单光子放射性药物临床前研究的先进影像工具,其质量控制及检测性能是图像质量和实验数据可靠性的基本保障。为评价Albira SI SPECT-CT设备应用的真实性、可靠性,采...Albira SI小动物单光子发射断层显像-X线计算机体层成像仪(SPECT-CT)是单光子放射性药物临床前研究的先进影像工具,其质量控制及检测性能是图像质量和实验数据可靠性的基本保障。为评价Albira SI SPECT-CT设备应用的真实性、可靠性,采用临床常用单光子核素^(99m)Tc对Albira SI小动物SPECT-CT进行季度性质量控制,同时进行测量结果的线性、稳定性、偏差的检测,并初步尝试小动物骨代谢扫描。结果表明,该设备与放射性活度之间线性关系良好,稳定性强,与常用活度测量设备测量结果差异较小。Albira SI小动物SPECT-CT能够准确反映单光子核素^(99m)Tc的放射性活度分布,小鼠骨代谢显像效果好,适用于临床前放射性药物研究。本研究中建立的系统研究SPECT-CT性能的方法可为类似设备的操作提供方法学依据。展开更多
BACKGROUND^(68)Ga(gallium)-PSMA PET-CT(prostate-specific membrane antigen-directed Positron emission tomography-computed tomography)has established its role in prostate cancer management as targeted molecular imaging....BACKGROUND^(68)Ga(gallium)-PSMA PET-CT(prostate-specific membrane antigen-directed Positron emission tomography-computed tomography)has established its role in prostate cancer management as targeted molecular imaging.However,limited studies are available on the diagnostic accuracy of^(99m)Tc(Technetium)-PSMASPECT/CT.Due to its cost effectiveness and better feasibility,it needs to be explored more extensively for its incorporation into routine clinical practice.AIM To analyse the diagnostic accuracy of^(99m)Tc-PSMA-SPECT/CT for detection of primary prostate carcinoma.METHODS As a prospective study in a tertiary hospital,^(99m)Tc-PSMA-SPECT/CT was performed in 29 outpatients with suspected prostate cancer,with a median age of 66(range:50-82)years.The findings were compared to histopathology as the gold standard.RESULTS Nineteen of twenty-nine patients were positive on^(99m)Tc-PSMA-SPECT/CT,of which 16(84.2%)had prostate cancer on histopathology,while the remaining ten were negative on imaging,of which three had prostate cancer,leading to an overall sensitivity,specificity,and accuracy of 84.2%,70%,and 79.3%,respectively,on visual analysis.Prostate:background and prostate:liver ratios were 37.18±48.85 and 5.35±7.35 in the malignant group,while 6.65±5.17 and 1.14±0.56 in the benign group,respectively.The area under the curve values for prostate:background and prostate:liver ratios were 0.833(95%confidence interval[CI]:0.677-0.990,P=0.005)and 0.767(95%CI:0.596-0.937,P=0.024),respectively,on receiver operator curve analysis.A cut-off value>10.45 for prostate:background ratio(sensitivity 85%and specificity 88.9%),and>1.15 for prostate:liver ratio(sensitivity 75%and specificity of 77.8%respectively)was found to be pertinent to differentiate between the malignant vs benign groups.CONCLUSION^(99m)Tc-PSMA-SPECT/CT shows a promising role in the diagnosis of primary prostate cancer.展开更多
文摘BACKGROUND^(68)Ga(gallium)-PSMA PET-CT(prostate-specific membrane antigen-directed Positron emission tomography-computed tomography)has established its role in prostate cancer management as targeted molecular imaging.However,limited studies are available on the diagnostic accuracy of^(99m)Tc(Technetium)-PSMASPECT/CT.Due to its cost effectiveness and better feasibility,it needs to be explored more extensively for its incorporation into routine clinical practice.AIM To analyse the diagnostic accuracy of^(99m)Tc-PSMA-SPECT/CT for detection of primary prostate carcinoma.METHODS As a prospective study in a tertiary hospital,^(99m)Tc-PSMA-SPECT/CT was performed in 29 outpatients with suspected prostate cancer,with a median age of 66(range:50-82)years.The findings were compared to histopathology as the gold standard.RESULTS Nineteen of twenty-nine patients were positive on^(99m)Tc-PSMA-SPECT/CT,of which 16(84.2%)had prostate cancer on histopathology,while the remaining ten were negative on imaging,of which three had prostate cancer,leading to an overall sensitivity,specificity,and accuracy of 84.2%,70%,and 79.3%,respectively,on visual analysis.Prostate:background and prostate:liver ratios were 37.18±48.85 and 5.35±7.35 in the malignant group,while 6.65±5.17 and 1.14±0.56 in the benign group,respectively.The area under the curve values for prostate:background and prostate:liver ratios were 0.833(95%confidence interval[CI]:0.677-0.990,P=0.005)and 0.767(95%CI:0.596-0.937,P=0.024),respectively,on receiver operator curve analysis.A cut-off value>10.45 for prostate:background ratio(sensitivity 85%and specificity 88.9%),and>1.15 for prostate:liver ratio(sensitivity 75%and specificity of 77.8%respectively)was found to be pertinent to differentiate between the malignant vs benign groups.CONCLUSION^(99m)Tc-PSMA-SPECT/CT shows a promising role in the diagnosis of primary prostate cancer.
