AIM:To study the bioadhesive property of carbomer934 indog alimentary tract.METHODS:Carbomer934 and ethylcallulose wereradiolabelled with technetium-99m;and gastrointestinalemptying rate of materials was measured usin...AIM:To study the bioadhesive property of carbomer934 indog alimentary tract.METHODS:Carbomer934 and ethylcallulose wereradiolabelled with technetium-99m;and gastrointestinalemptying rate of materials was measured using thetechnique of gamma scintigraphy.RESULTS:After oral administration,the maximum intestinalradioactivity of non-bioadhesive granules and bioadhesivegranules were observed in the second hour and the sixthhour respectively.Constants of stomach emptying rate ofnonadheaive granules,bioadhesive granules Ⅰ andbioadhesive granules Ⅱ were 0.774h^(-1),0.265h^(-1)and0.321h^(-1)respectively on the base of gastric residualamount.Compared to nonadhesive material(ethylcellulose),the migration rate of adhesive material(carbomer934)was remarkably slower in dog alimentarycanal.CONCLUSION:It is concluded that,in the dog,interactionsbetween gastrointestinal mucus layer and adhesive materialor nonadhesive material were significantly different.Carbomer934 had stronger in vivo bioadhesive property thanethylcellulose.展开更多
基金the National Distinguished Youth Scientific Fund,No.39925039
文摘AIM:To study the bioadhesive property of carbomer934 indog alimentary tract.METHODS:Carbomer934 and ethylcallulose wereradiolabelled with technetium-99m;and gastrointestinalemptying rate of materials was measured using thetechnique of gamma scintigraphy.RESULTS:After oral administration,the maximum intestinalradioactivity of non-bioadhesive granules and bioadhesivegranules were observed in the second hour and the sixthhour respectively.Constants of stomach emptying rate ofnonadheaive granules,bioadhesive granules Ⅰ andbioadhesive granules Ⅱ were 0.774h^(-1),0.265h^(-1)and0.321h^(-1)respectively on the base of gastric residualamount.Compared to nonadhesive material(ethylcellulose),the migration rate of adhesive material(carbomer934)was remarkably slower in dog alimentarycanal.CONCLUSION:It is concluded that,in the dog,interactionsbetween gastrointestinal mucus layer and adhesive materialor nonadhesive material were significantly different.Carbomer934 had stronger in vivo bioadhesive property thanethylcellulose.
