A modified method for preparation and purification of Schiff base and protonated Schiff base from 9-cis-retinal has been suggested. Reaction took place in chloroform phase and purification was conducted by using water...A modified method for preparation and purification of Schiff base and protonated Schiff base from 9-cis-retinal has been suggested. Reaction took place in chloroform phase and purification was conducted by using water to remove the excess solvent, base and acid.展开更多
Ordered thin organic films deposited on solid substrates by the Langmuir-Blodgett(LB) technique have attracted much attention because of their possibility of being applied tofunctional molecular device architectures, ...Ordered thin organic films deposited on solid substrates by the Langmuir-Blodgett(LB) technique have attracted much attention because of their possibility of being applied tofunctional molecular device architectures, such as electronic, nonlinear optical and bio-logical sensors. Very elegant work has been carried out by Kuhn and his展开更多
It has been investigated for a long time by many authors to mimic the vision pro-cess.The most important step is to synthesize pigments having similar function ofrhodopsin,for example,to combine ll-cis-retinal with op...It has been investigated for a long time by many authors to mimic the vision pro-cess.The most important step is to synthesize pigments having similar function ofrhodopsin,for example,to combine ll-cis-retinal with opsin to form rhodopsin.Sinceit is difficult to obtain the ll-cis-retinal,Hubbard et al.suggested an“isorhodopsin”from9-cis-retinal and amine to mimic the rhodopsin,and a photoisomerization effect can be ob-served in this system.However,there were no reports about the photoelectric response ofthis“isorhodopsin”.In this article,we measure the photoresponse of展开更多
目的通过研究缺氧缺血性脑病(HIE)新生儿血清神经纤维轻链(NF-L)、水通道蛋白9(AQP9)、纤维蛋白原样蛋白2(FGL2)水平的变化,分析三者与新生儿行为神经评估(NABA)评分的相关性。方法选取2022年1月~2024年7月山西省儿童医院收治的203例HI...目的通过研究缺氧缺血性脑病(HIE)新生儿血清神经纤维轻链(NF-L)、水通道蛋白9(AQP9)、纤维蛋白原样蛋白2(FGL2)水平的变化,分析三者与新生儿行为神经评估(NABA)评分的相关性。方法选取2022年1月~2024年7月山西省儿童医院收治的203例HIE患儿为研究组,根据病情程度分为轻度组(n=63)、中度组(n=81)和重度组(n=59),另选同期的健康新生儿203例为对照组,酶联免疫吸附试验(ELISA)检测血清NF-L、AQP9、FGL2水平,收集分析一般临床资料。受试者操作特征(ROC)曲线分析NF-L、AQP9、FGL2及NABA评分对新生儿重度HIE的诊断价值;Pearson法分析血清NF-L、AQP9、FGL2与NABA评分的相关性。结果与对照组相比,研究组血清NF-L(14.78±1.67ng/ml vs 10.65±1.21ng/ml)、AQP9(61.82±6.29pg/ml vs 42.62±4.31pg/ml)、FGL2(189.69±20.26ng/ml vs 132.51±14.84ng/ml)水平显著升高,差异具有统计学意义(t=28.533、35.877、32.440,均P<0.05);中度组、重度组血清NF-L(14.68±1.67ng/ml、18.62±2.03ng/ml),AQP9(63.51±6.44pg/ml、69.63±7.03pg/ml),FGL2(195.68±20.84ng/ml、210.65±22.36ng/ml)水平显著高于轻度组(11.32±1.33ng/ml、52.32±5.41pg/ml、162.35±17.55ng/ml),NABA(34.89±3.51分、29.88±3.43分)评分显著低于轻度组(36.54±1.52分),差异具有统计学意义(t_(中度组)=4.616~16.729,t_(重度组)=17.276~33.701,均P<0.05);NF-L、AQP9、FGL2与NABA评分均呈负相关(r=-0.432、-0.421、-0.402,均P<0.05);NF-L、AQP9、FGL2、NABA联合诊断患儿重度病情的曲线下面积(AUC)显著高于各项单独诊断,差异具有统计学意义(Z=2.066~3.307,均P<0.05)。结论HIE患儿血清NF-L、AQP9、FGL2水平显著升高,与NABA评分相关,可能成为评估HIE患儿病情的标志物。展开更多
文摘A modified method for preparation and purification of Schiff base and protonated Schiff base from 9-cis-retinal has been suggested. Reaction took place in chloroform phase and purification was conducted by using water to remove the excess solvent, base and acid.
基金Project supported by the National Natural Science Foundation of China.
文摘Ordered thin organic films deposited on solid substrates by the Langmuir-Blodgett(LB) technique have attracted much attention because of their possibility of being applied tofunctional molecular device architectures, such as electronic, nonlinear optical and bio-logical sensors. Very elegant work has been carried out by Kuhn and his
文摘It has been investigated for a long time by many authors to mimic the vision pro-cess.The most important step is to synthesize pigments having similar function ofrhodopsin,for example,to combine ll-cis-retinal with opsin to form rhodopsin.Sinceit is difficult to obtain the ll-cis-retinal,Hubbard et al.suggested an“isorhodopsin”from9-cis-retinal and amine to mimic the rhodopsin,and a photoisomerization effect can be ob-served in this system.However,there were no reports about the photoelectric response ofthis“isorhodopsin”.In this article,we measure the photoresponse of
文摘目的通过研究缺氧缺血性脑病(HIE)新生儿血清神经纤维轻链(NF-L)、水通道蛋白9(AQP9)、纤维蛋白原样蛋白2(FGL2)水平的变化,分析三者与新生儿行为神经评估(NABA)评分的相关性。方法选取2022年1月~2024年7月山西省儿童医院收治的203例HIE患儿为研究组,根据病情程度分为轻度组(n=63)、中度组(n=81)和重度组(n=59),另选同期的健康新生儿203例为对照组,酶联免疫吸附试验(ELISA)检测血清NF-L、AQP9、FGL2水平,收集分析一般临床资料。受试者操作特征(ROC)曲线分析NF-L、AQP9、FGL2及NABA评分对新生儿重度HIE的诊断价值;Pearson法分析血清NF-L、AQP9、FGL2与NABA评分的相关性。结果与对照组相比,研究组血清NF-L(14.78±1.67ng/ml vs 10.65±1.21ng/ml)、AQP9(61.82±6.29pg/ml vs 42.62±4.31pg/ml)、FGL2(189.69±20.26ng/ml vs 132.51±14.84ng/ml)水平显著升高,差异具有统计学意义(t=28.533、35.877、32.440,均P<0.05);中度组、重度组血清NF-L(14.68±1.67ng/ml、18.62±2.03ng/ml),AQP9(63.51±6.44pg/ml、69.63±7.03pg/ml),FGL2(195.68±20.84ng/ml、210.65±22.36ng/ml)水平显著高于轻度组(11.32±1.33ng/ml、52.32±5.41pg/ml、162.35±17.55ng/ml),NABA(34.89±3.51分、29.88±3.43分)评分显著低于轻度组(36.54±1.52分),差异具有统计学意义(t_(中度组)=4.616~16.729,t_(重度组)=17.276~33.701,均P<0.05);NF-L、AQP9、FGL2与NABA评分均呈负相关(r=-0.432、-0.421、-0.402,均P<0.05);NF-L、AQP9、FGL2、NABA联合诊断患儿重度病情的曲线下面积(AUC)显著高于各项单独诊断,差异具有统计学意义(Z=2.066~3.307,均P<0.05)。结论HIE患儿血清NF-L、AQP9、FGL2水平显著升高,与NABA评分相关,可能成为评估HIE患儿病情的标志物。
