A chiral lanthanide metal-organic framework based on enantiopure camphoric acid （D-H2cam）, [Nd3（D-cam）8（H2O）4Cl]n （1）, has been synthesized and characterized by single-crystal X-ray structural analysis, elemen...A chiral lanthanide metal-organic framework based on enantiopure camphoric acid （D-H2cam）, [Nd3（D-cam）8（H2O）4Cl]n （1）, has been synthesized and characterized by single-crystal X-ray structural analysis, elemental analysis, IR, thermal gravimetric, and X-ray powder diffraction. Crystal data for the title compound are as follows： orthorhombic system, space group P212121 with a = 13.8287（7）, b = 14.0715（7）, c = 25.7403（12） A^°, V = 5008.8（4） A^°3, Mr = 1333.08, Z = 4, F（000） = 2644, Dc = 1.768 g/cm^3, μ（MoKα） = 3.189 mm^-1, the final R = 0.0351 and wR = 0.0814 （I 〉 2σ（I））. Compound 1 displays an 8-connected bcu topology 3D framework and hydrogen-bonding interactions stabilize the solid-state structure. The vibrational circular dichroism （VCD） spectrum and second-order nonlinear optical effect of compound 1 have been studied in the solid state.展开更多
A new metal-organic framework, {[Cd（DPA）（OBA）]＇（HzO）}n （1, DPA = 4,4＂-dipyri- dylamine, H2OBA = 4,4＂-oxybisbenzoic acid）, has been synthesized and characterized by elemental analysis, IR and single-crystal ...A new metal-organic framework, {[Cd（DPA）（OBA）]＇（HzO）}n （1, DPA = 4,4＂-dipyri- dylamine, H2OBA = 4,4＂-oxybisbenzoic acid）, has been synthesized and characterized by elemental analysis, IR and single-crystal X-ray diffraction. Single-crystal X-ray analysis shows that it is a 3-D framework. Complex 1 crystallizes in monoclinic, space group C2/c with a = 21.699（7）, b = 12.192（4）, c = 17.566（5） A, β = 105.254（5）°, V = 4483.43 A3, Z = 8, Dc = 1.653 g/cm3, p = 1.021 mm^-1], F（000） = 2240, the final R = 0.0307, wR = 0.0867 （I 〉 2σ（I））. Complex I exhibits a rare three-dimensional highly 8-connected LOMFOI topology with a point symbol of {424＂64}. Thermogravimetric analysis shows that the decomposition temperature of the host framework of the complex is above 400 ℃.展开更多
目的探讨炎调方调过Fas/Caspase-8信号通路减轻脓毒症急性胃肠损伤小鼠炎症的机制。方法取70只BALB/c小鼠随机分为空白组、假手术组和造模小鼠组。通过盲肠结扎穿孔术(cecum ligation and puncture,CLP)构建脓毒症急性胃肠损伤小鼠模型...目的探讨炎调方调过Fas/Caspase-8信号通路减轻脓毒症急性胃肠损伤小鼠炎症的机制。方法取70只BALB/c小鼠随机分为空白组、假手术组和造模小鼠组。通过盲肠结扎穿孔术(cecum ligation and puncture,CLP)构建脓毒症急性胃肠损伤小鼠模型,将造模成功的小鼠随机分为模型组,炎调方低、中、高剂量组,ROCK抑制剂组。苏木素-伊红(HE)染色观察小鼠回肠组织病理学改变;ELISA法检测各组小鼠血清IL-17、IL-23水平;蛋白印迹法检测回肠组织Fas/Caspase-8信号通路蛋白Fas、FADD和Caspase-8的相对表达;TUNEL染色法检测回肠组织细胞凋亡情况。结果与空白组相比,模型组小鼠回肠组织肠黏膜萎缩明显、绒毛排列杂乱,可见断裂、脱落,上皮细胞细胞坏死脱落,炎症细胞浸润明显,小鼠血清中IL-17、IL-23水平升高(P<0.05),回肠组织中Fas、FADD和Caspase-8蛋白的表达升高(P<0.05),肠上皮细胞呈现明显的凋亡现象(P<0.05)。与模型组相比,炎调方组小鼠的回肠组织病理学改变均得到不同程度的改善,血清中IL-17、IL-23水平降低(P<0.05),且回肠组织中Fas、FADD和Caspase-8蛋白的表达降低(P<0.05),肠上皮细胞凋亡减少(P<0.05)。结论炎调方可以减轻肠黏膜组织损伤和肠道组织炎症反应,可能是通过调控Fas/Caspase-8信号通路抑制脓毒症急性胃肠损伤小鼠的肠上皮细胞凋亡来发挥作用的。展开更多
为精准识别与分类不同花期杭白菊,满足自动化采摘要求,该研究提出一种基于改进YOLOv8s的杭白菊检测模型-YOLOv8s-RDL。首先,该研究将颈部网络(neck)的C2f(faster implementation of CSP bottleneck with 2 convolutions)模块替换为RCS-O...为精准识别与分类不同花期杭白菊,满足自动化采摘要求,该研究提出一种基于改进YOLOv8s的杭白菊检测模型-YOLOv8s-RDL。首先,该研究将颈部网络(neck)的C2f(faster implementation of CSP bottleneck with 2 convolutions)模块替换为RCS-OSA(one-shot aggregation of reparameterized convolution based on channel shuffle)模块,以提升骨干网络(backbone)特征融合效率;其次,将检测头更换为DyHead(dynamic head),并融合DCNv3(deformable convolutional networks v3),借助多头自注意力机制增强目标检测头的表达能力;最后,采用LAMP(layer-adaptive magnitude-based pruning)通道剪枝算法减少参数量,降低模型复杂度。试验结果表明,YOLOv8s-RDL模型在菊米和胎菊的花期分类中平均精度分别达到96.3%和97.7%,相较于YOLOv8s模型,分别提升了3.8和1.5个百分点,同时权重文件大小较YOLOv8s减小了6 MB。该研究引入TIDE(toolkit for identifying detection and segmentation errors)评估指标,结果显示,YOLOv8s-RDL模型分类错误和背景检测错误相较YOLOv8s模型分别降低0.55和1.26。该研究为杭白菊分花期自动化采摘提供了理论依据和技术支撑。展开更多
基金supported by National Natural Science Foundation of China(21401147)Basic Research Program of Natural Science from Shaanxi Provincial Government(2015JQ2032)+2 种基金Scientific Research Program from Education Department of Shaanxi Provincial Government(2013JK0654)Opening Foundation from State Key Laboratory of Coordination Chemistry in Nanjing University(201219)the Program for Distinguished Young Scholars of Xi’an Polytechnic University(201403)
文摘A chiral lanthanide metal-organic framework based on enantiopure camphoric acid （D-H2cam）, [Nd3（D-cam）8（H2O）4Cl]n （1）, has been synthesized and characterized by single-crystal X-ray structural analysis, elemental analysis, IR, thermal gravimetric, and X-ray powder diffraction. Crystal data for the title compound are as follows： orthorhombic system, space group P212121 with a = 13.8287（7）, b = 14.0715（7）, c = 25.7403（12） A^°, V = 5008.8（4） A^°3, Mr = 1333.08, Z = 4, F（000） = 2644, Dc = 1.768 g/cm^3, μ（MoKα） = 3.189 mm^-1, the final R = 0.0351 and wR = 0.0814 （I 〉 2σ（I））. Compound 1 displays an 8-connected bcu topology 3D framework and hydrogen-bonding interactions stabilize the solid-state structure. The vibrational circular dichroism （VCD） spectrum and second-order nonlinear optical effect of compound 1 have been studied in the solid state.
基金supported by the National Ministry of Science and Technology of China(2012CB821702)the National Science Foundation of China(21073192,21203194 and 21233009)the Science Foundation of CAS and Fujian Province for research funding support(KJCX2-YW-H20)
文摘A new metal-organic framework, {[Cd（DPA）（OBA）]＇（HzO）}n （1, DPA = 4,4＂-dipyri- dylamine, H2OBA = 4,4＂-oxybisbenzoic acid）, has been synthesized and characterized by elemental analysis, IR and single-crystal X-ray diffraction. Single-crystal X-ray analysis shows that it is a 3-D framework. Complex 1 crystallizes in monoclinic, space group C2/c with a = 21.699（7）, b = 12.192（4）, c = 17.566（5） A, β = 105.254（5）°, V = 4483.43 A3, Z = 8, Dc = 1.653 g/cm3, p = 1.021 mm^-1], F（000） = 2240, the final R = 0.0307, wR = 0.0867 （I 〉 2σ（I））. Complex I exhibits a rare three-dimensional highly 8-connected LOMFOI topology with a point symbol of {424＂64}. Thermogravimetric analysis shows that the decomposition temperature of the host framework of the complex is above 400 ℃.
文摘目的探讨炎调方调过Fas/Caspase-8信号通路减轻脓毒症急性胃肠损伤小鼠炎症的机制。方法取70只BALB/c小鼠随机分为空白组、假手术组和造模小鼠组。通过盲肠结扎穿孔术(cecum ligation and puncture,CLP)构建脓毒症急性胃肠损伤小鼠模型,将造模成功的小鼠随机分为模型组,炎调方低、中、高剂量组,ROCK抑制剂组。苏木素-伊红(HE)染色观察小鼠回肠组织病理学改变;ELISA法检测各组小鼠血清IL-17、IL-23水平;蛋白印迹法检测回肠组织Fas/Caspase-8信号通路蛋白Fas、FADD和Caspase-8的相对表达;TUNEL染色法检测回肠组织细胞凋亡情况。结果与空白组相比,模型组小鼠回肠组织肠黏膜萎缩明显、绒毛排列杂乱,可见断裂、脱落,上皮细胞细胞坏死脱落,炎症细胞浸润明显,小鼠血清中IL-17、IL-23水平升高(P<0.05),回肠组织中Fas、FADD和Caspase-8蛋白的表达升高(P<0.05),肠上皮细胞呈现明显的凋亡现象(P<0.05)。与模型组相比,炎调方组小鼠的回肠组织病理学改变均得到不同程度的改善,血清中IL-17、IL-23水平降低(P<0.05),且回肠组织中Fas、FADD和Caspase-8蛋白的表达降低(P<0.05),肠上皮细胞凋亡减少(P<0.05)。结论炎调方可以减轻肠黏膜组织损伤和肠道组织炎症反应,可能是通过调控Fas/Caspase-8信号通路抑制脓毒症急性胃肠损伤小鼠的肠上皮细胞凋亡来发挥作用的。
文摘为精准识别与分类不同花期杭白菊,满足自动化采摘要求,该研究提出一种基于改进YOLOv8s的杭白菊检测模型-YOLOv8s-RDL。首先,该研究将颈部网络(neck)的C2f(faster implementation of CSP bottleneck with 2 convolutions)模块替换为RCS-OSA(one-shot aggregation of reparameterized convolution based on channel shuffle)模块,以提升骨干网络(backbone)特征融合效率;其次,将检测头更换为DyHead(dynamic head),并融合DCNv3(deformable convolutional networks v3),借助多头自注意力机制增强目标检测头的表达能力;最后,采用LAMP(layer-adaptive magnitude-based pruning)通道剪枝算法减少参数量,降低模型复杂度。试验结果表明,YOLOv8s-RDL模型在菊米和胎菊的花期分类中平均精度分别达到96.3%和97.7%,相较于YOLOv8s模型,分别提升了3.8和1.5个百分点,同时权重文件大小较YOLOv8s减小了6 MB。该研究引入TIDE(toolkit for identifying detection and segmentation errors)评估指标,结果显示,YOLOv8s-RDL模型分类错误和背景检测错误相较YOLOv8s模型分别降低0.55和1.26。该研究为杭白菊分花期自动化采摘提供了理论依据和技术支撑。
