The hydrophobic sonosensitizer IR780 iodide(IR780)was loaded into liposomes to form Liposome@IR780 nanoparticles(NPs)for triple-negative breast cancer(TNBC)to enhance SDT via low-intensity ultrasound(LIU)irradiation.T...The hydrophobic sonosensitizer IR780 iodide(IR780)was loaded into liposomes to form Liposome@IR780 nanoparticles(NPs)for triple-negative breast cancer(TNBC)to enhance SDT via low-intensity ultrasound(LIU)irradiation.The NPs were characterized using various physicochemical methods including size distribution,zeta potential,and morphology.In vitro experiments show that the Liposome@IR780 NPs can generate more reactive oxygen species(ROS)upon LIU irradiation.The apoptosis experiment results further demonstrate that Liposome@IR780 NPs show better apoptosis rate against 4T1 cells.Our results indicate that Liposome@IR780 NPs will provide a promising approach for TNBC upon SDT treatment.展开更多
This study deals with the development of a 780-MPa-class hot-rolled advanced high-strength steel(AHSS)with an ultrahigh elongation at break of approximately 30%and strength-ductility product exceeding 24 GPa·%,in...This study deals with the development of a 780-MPa-class hot-rolled advanced high-strength steel(AHSS)with an ultrahigh elongation at break of approximately 30%and strength-ductility product exceeding 24 GPa·%,indicating the excellent formability of the newly developed AHSS.The microstructure of the newly developed 780-MPa-class AHSS consists mainly of the triplex phase of ferrite,bainite,and retained austenite with a volume fraction of 10%±2%.The stability of the retained austenite in the newly developed AHSS is much higher than that of conventional transformation-induced plasticity steels,in which the retained austenite is prone to transformation into martensite under deformation.At a pre-strain lower than 1.2%,the volume fraction of the retained austenite and the elongation at break of the present 780-MPa-class AHSS remain almost unchanged,showing a high tolerance in the process window during leveling or straightening.Therefore,the present 780-MPa-class AHSS is particularly suitable for the production of components with complex shapes.展开更多
Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate ...Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ROS) to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT. However, the photosensitizer and chemotherapy drugs used in PDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.展开更多
文摘The hydrophobic sonosensitizer IR780 iodide(IR780)was loaded into liposomes to form Liposome@IR780 nanoparticles(NPs)for triple-negative breast cancer(TNBC)to enhance SDT via low-intensity ultrasound(LIU)irradiation.The NPs were characterized using various physicochemical methods including size distribution,zeta potential,and morphology.In vitro experiments show that the Liposome@IR780 NPs can generate more reactive oxygen species(ROS)upon LIU irradiation.The apoptosis experiment results further demonstrate that Liposome@IR780 NPs show better apoptosis rate against 4T1 cells.Our results indicate that Liposome@IR780 NPs will provide a promising approach for TNBC upon SDT treatment.
文摘This study deals with the development of a 780-MPa-class hot-rolled advanced high-strength steel(AHSS)with an ultrahigh elongation at break of approximately 30%and strength-ductility product exceeding 24 GPa·%,indicating the excellent formability of the newly developed AHSS.The microstructure of the newly developed 780-MPa-class AHSS consists mainly of the triplex phase of ferrite,bainite,and retained austenite with a volume fraction of 10%±2%.The stability of the retained austenite in the newly developed AHSS is much higher than that of conventional transformation-induced plasticity steels,in which the retained austenite is prone to transformation into martensite under deformation.At a pre-strain lower than 1.2%,the volume fraction of the retained austenite and the elongation at break of the present 780-MPa-class AHSS remain almost unchanged,showing a high tolerance in the process window during leveling or straightening.Therefore,the present 780-MPa-class AHSS is particularly suitable for the production of components with complex shapes.
基金the National Natural Science Foundation of China(NSFC,Nos.32171318,32222090 and 32101069)the Faculty of Health Sciences,University of Macao,the Multi-Year Research Grant(MYRG)of University of Macao(No.MYRG2022-00011-FHS)+2 种基金the Science and Technology Development Fund,Macao SAR(Nos.0103/2021/A and 0002/2021/AKP)Shenzhen Science and Technology Innovation Commission,Shenzhen-Hong Kong-Macao Science and Technology Plan C(No.SGDX20201103093600004)Dr.Stanley Ho Medical Development Foundation(No.SHMDF-OIRFS/2022/002)。
文摘Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ROS) to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT. However, the photosensitizer and chemotherapy drugs used in PDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.
