To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-en...To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-environment contact,as well as the implementation of new M72/AS01_(E)vaccine.Motivated by this,a coupled age-structured tuberculosis(TB)model is proposed.Its well-posedness requirement is verified using the integrated semigroup theory.Furthermore,this study presents a comprehensive analysis of threshold dynamics associated with the proposed model.Specifically,the global stability of the disease-free and positive steady states is demonstrated by employing Lyapunov functionals.Lastly,the effects of the vaccination with M72/AS01_(E)and contaminated environments on TB control are numerically simulated.Experimental results indicate that high concentrations of Mycobacterium tuberculosis in contaminated environments may somewhat impede TB control efforts,but that large-scale deployment of new vaccine could significantly reduce the prevalence of TB.展开更多
文摘To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-environment contact,as well as the implementation of new M72/AS01_(E)vaccine.Motivated by this,a coupled age-structured tuberculosis(TB)model is proposed.Its well-posedness requirement is verified using the integrated semigroup theory.Furthermore,this study presents a comprehensive analysis of threshold dynamics associated with the proposed model.Specifically,the global stability of the disease-free and positive steady states is demonstrated by employing Lyapunov functionals.Lastly,the effects of the vaccination with M72/AS01_(E)and contaminated environments on TB control are numerically simulated.Experimental results indicate that high concentrations of Mycobacterium tuberculosis in contaminated environments may somewhat impede TB control efforts,but that large-scale deployment of new vaccine could significantly reduce the prevalence of TB.
文摘MG53(mitsugumin 53)蛋白,是E3泛素连接酶多功能三结构域(tripartite motif,TRIM)蛋白家族成员之一,又被称为TRIM72。MG53是一种细胞膜修复蛋白,广泛表达于心肌和骨骼肌,可在膜损伤部位快速积累,在骨骼肌和心肌细胞膜修复中发挥重要作用。近年来,大量研究发现,MG53可以参与缺血预适应和缺血后适应的心肌保护作用,减轻心肌缺血再灌注损伤;并且在生理或病理状态下,MG53在许多器官中均有表达,促进细胞膜修复。然而MG53过表达则会导致泛素依赖的胰岛素受体表达下降,进而导致代谢综合征和糖尿病性心脏病。本文综述了近年来MG53的生理功能及其相关作用机制研究进展,以期为重组人MG53(recombinant human mitsugumin53,rhMG53)的临床应用提供参考。
