Objective:To investigate the effect of“72-hour proactive follow-up”led by respiratory specialist nurses on reducing the 30-day readmission rate in patients with acute exacerbation of chronic obstructive pulmonary di...Objective:To investigate the effect of“72-hour proactive follow-up”led by respiratory specialist nurses on reducing the 30-day readmission rate in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)after hospital discharge.Methods:A randomized controlled trial was conducted involving 60 patients with acute exacerbation of COPD admitted from September 2024 to September 2025.The participants were divided into a control group and an observation group,with 30 individuals in each group.The control group received routine discharge guidance nursing measures,including instructions on medication use,key points for condition monitoring,and scheduling of follow-up appointments.The observation group implemented“72-hour proactive follow-up”nursing measures,which included telephone follow-up within 72 hours after discharge,quantitative assessment of respiratory symptoms,dynamic adjustment of medication regimens,and personalized health education.The 30-day readmission rate,mMRC dyspnea index,CAT quality of life score,and other parameters were compared between the two groups.Results:The 30-day readmission rate in the observation group was significantly lower than that in the control group(p<0.05).The mMRC dyspnea index(1.8±0.5)in the observation group was significantly lower than that in the control group(2.5±0.7)(p<0.05).The CAT quality of life score(18.2±3.1)in the observation group was significantly higher than that in the control group(22.4±4.2)(p<0.05).The patient satisfaction score(92.5±4.3)in the observation group was higher than that in the control group(85.6±5.8)(p<0.05).Conclusion:The“72-hour proactive follow-up”nursing intervention demonstrates a favorable effect in reducing readmission rates,exhibiting significant clinical practical value.It can optimize the allocation of medical resources,effectively enhance patients’self-management efficacy,and holds prominent value for clinical promotion and application.展开更多
To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-en...To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-environment contact,as well as the implementation of new M72/AS01_(E)vaccine.Motivated by this,a coupled age-structured tuberculosis(TB)model is proposed.Its well-posedness requirement is verified using the integrated semigroup theory.Furthermore,this study presents a comprehensive analysis of threshold dynamics associated with the proposed model.Specifically,the global stability of the disease-free and positive steady states is demonstrated by employing Lyapunov functionals.Lastly,the effects of the vaccination with M72/AS01_(E)and contaminated environments on TB control are numerically simulated.Experimental results indicate that high concentrations of Mycobacterium tuberculosis in contaminated environments may somewhat impede TB control efforts,but that large-scale deployment of new vaccine could significantly reduce the prevalence of TB.展开更多
文摘Objective:To investigate the effect of“72-hour proactive follow-up”led by respiratory specialist nurses on reducing the 30-day readmission rate in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)after hospital discharge.Methods:A randomized controlled trial was conducted involving 60 patients with acute exacerbation of COPD admitted from September 2024 to September 2025.The participants were divided into a control group and an observation group,with 30 individuals in each group.The control group received routine discharge guidance nursing measures,including instructions on medication use,key points for condition monitoring,and scheduling of follow-up appointments.The observation group implemented“72-hour proactive follow-up”nursing measures,which included telephone follow-up within 72 hours after discharge,quantitative assessment of respiratory symptoms,dynamic adjustment of medication regimens,and personalized health education.The 30-day readmission rate,mMRC dyspnea index,CAT quality of life score,and other parameters were compared between the two groups.Results:The 30-day readmission rate in the observation group was significantly lower than that in the control group(p<0.05).The mMRC dyspnea index(1.8±0.5)in the observation group was significantly lower than that in the control group(2.5±0.7)(p<0.05).The CAT quality of life score(18.2±3.1)in the observation group was significantly higher than that in the control group(22.4±4.2)(p<0.05).The patient satisfaction score(92.5±4.3)in the observation group was higher than that in the control group(85.6±5.8)(p<0.05).Conclusion:The“72-hour proactive follow-up”nursing intervention demonstrates a favorable effect in reducing readmission rates,exhibiting significant clinical practical value.It can optimize the allocation of medical resources,effectively enhance patients’self-management efficacy,and holds prominent value for clinical promotion and application.
文摘To assess the effectiveness of vaccination in contaminated environments,this study introduces a modeling framework that encompasses two transmission routes,namely direct human-to-human contact and indirect human-to-environment contact,as well as the implementation of new M72/AS01_(E)vaccine.Motivated by this,a coupled age-structured tuberculosis(TB)model is proposed.Its well-posedness requirement is verified using the integrated semigroup theory.Furthermore,this study presents a comprehensive analysis of threshold dynamics associated with the proposed model.Specifically,the global stability of the disease-free and positive steady states is demonstrated by employing Lyapunov functionals.Lastly,the effects of the vaccination with M72/AS01_(E)and contaminated environments on TB control are numerically simulated.Experimental results indicate that high concentrations of Mycobacterium tuberculosis in contaminated environments may somewhat impede TB control efforts,but that large-scale deployment of new vaccine could significantly reduce the prevalence of TB.
文摘MG53(mitsugumin 53)蛋白,是E3泛素连接酶多功能三结构域(tripartite motif,TRIM)蛋白家族成员之一,又被称为TRIM72。MG53是一种细胞膜修复蛋白,广泛表达于心肌和骨骼肌,可在膜损伤部位快速积累,在骨骼肌和心肌细胞膜修复中发挥重要作用。近年来,大量研究发现,MG53可以参与缺血预适应和缺血后适应的心肌保护作用,减轻心肌缺血再灌注损伤;并且在生理或病理状态下,MG53在许多器官中均有表达,促进细胞膜修复。然而MG53过表达则会导致泛素依赖的胰岛素受体表达下降,进而导致代谢综合征和糖尿病性心脏病。本文综述了近年来MG53的生理功能及其相关作用机制研究进展,以期为重组人MG53(recombinant human mitsugumin53,rhMG53)的临床应用提供参考。
