目的:观察黄褐斑患者采用694 nm调Q激光联合氨甲环酸皮内注射治疗的美学效果。方法:将2020年1月-2023年4月就诊于笔者医院门诊的黄褐斑患者98例,按照随机数字表法分成实验组(694 nm调Q激光与氨甲环酸皮内注射治疗,n=49)和对照组(氨甲环...目的:观察黄褐斑患者采用694 nm调Q激光联合氨甲环酸皮内注射治疗的美学效果。方法:将2020年1月-2023年4月就诊于笔者医院门诊的黄褐斑患者98例,按照随机数字表法分成实验组(694 nm调Q激光与氨甲环酸皮内注射治疗,n=49)和对照组(氨甲环酸皮内注射治疗,n=49),比较两组总有效率、黄褐斑面积及严重程度(Melasma Area and Severity Index,MASI)评分,色素斑、皱纹、纹理、毛孔评分,美学改善效果,不良反应和复发情况。结果:相较于对照组,经6个月治疗后实验组总有效率更高(P<0.05),MASI评分更低;实验组VISIA皮肤检测(色素斑、皱纹、纹理、毛孔)评分较对照组低,实验组美学改善效果评分较对照组高(P<0.05);两组均未发生严重不良反应,两组不良反应发生率比较差异无统计学意义,实验组1年后复发率较对照组低(P<0.05)。结论:对黄褐斑患者采用694 nm调Q激光与氨甲环酸皮内注射联合治疗,其临床效果显著,可降低患者MASI评分、改善皮肤状态,提高美学效果、降低复发率,且安全性良好。展开更多
To determine the effects of HOE 694, a new and potent Na＋- H＋ exchanger blocker, on transient inward current (Iti) and Na＋- Ca2＋ exchange during hypoxia- reoxygenation in guinea pig cardiomyocytes. Methods. Cardio...To determine the effects of HOE 694, a new and potent Na＋- H＋ exchanger blocker, on transient inward current (Iti) and Na＋- Ca2＋ exchange during hypoxia- reoxygenation in guinea pig cardiomyocytes. Methods. Cardiomyocytes were isolated from adult guinea pig ventricle. Experiment was performed in an experimental chamber that allowed the cells to be exposed to a sufficiently low O2 pressure. The cells were subjected to hypoxia and reoxygenation. The ionic currents were studied with patch clamp technique. Results. In the absence of HOE 694, hypoxia- reoxygenation induced Iti in 12 of 15 experiments; but in cardiomyocytes pretreated with HOE 694 (10～ 50μ mol/L), the incidence of Iti observed during reoxygenation was reduced to 5 of 11 experiments and 3 of 10 experiments, P Conclusions. Blockade of the Na＋- H＋ exchange by HOE 694 could reduce Ca2＋ overload upon hypoxia- reoxygenation, and inhibition of Na＋- H＋ exchange may also indirectly decrease Na＋- Ca2＋ exchange activity during hypoxia.展开更多
文摘目的:观察黄褐斑患者采用694 nm调Q激光联合氨甲环酸皮内注射治疗的美学效果。方法:将2020年1月-2023年4月就诊于笔者医院门诊的黄褐斑患者98例,按照随机数字表法分成实验组(694 nm调Q激光与氨甲环酸皮内注射治疗,n=49)和对照组(氨甲环酸皮内注射治疗,n=49),比较两组总有效率、黄褐斑面积及严重程度(Melasma Area and Severity Index,MASI)评分,色素斑、皱纹、纹理、毛孔评分,美学改善效果,不良反应和复发情况。结果:相较于对照组,经6个月治疗后实验组总有效率更高(P<0.05),MASI评分更低;实验组VISIA皮肤检测(色素斑、皱纹、纹理、毛孔)评分较对照组低,实验组美学改善效果评分较对照组高(P<0.05);两组均未发生严重不良反应,两组不良反应发生率比较差异无统计学意义,实验组1年后复发率较对照组低(P<0.05)。结论:对黄褐斑患者采用694 nm调Q激光与氨甲环酸皮内注射联合治疗,其临床效果显著,可降低患者MASI评分、改善皮肤状态,提高美学效果、降低复发率,且安全性良好。
基金This work was supported by Leading Specialty Funding of Shanghai, Grant No.94- III- 001.
文摘To determine the effects of HOE 694, a new and potent Na＋- H＋ exchanger blocker, on transient inward current (Iti) and Na＋- Ca2＋ exchange during hypoxia- reoxygenation in guinea pig cardiomyocytes. Methods. Cardiomyocytes were isolated from adult guinea pig ventricle. Experiment was performed in an experimental chamber that allowed the cells to be exposed to a sufficiently low O2 pressure. The cells were subjected to hypoxia and reoxygenation. The ionic currents were studied with patch clamp technique. Results. In the absence of HOE 694, hypoxia- reoxygenation induced Iti in 12 of 15 experiments; but in cardiomyocytes pretreated with HOE 694 (10～ 50μ mol/L), the incidence of Iti observed during reoxygenation was reduced to 5 of 11 experiments and 3 of 10 experiments, P Conclusions. Blockade of the Na＋- H＋ exchange by HOE 694 could reduce Ca2＋ overload upon hypoxia- reoxygenation, and inhibition of Na＋- H＋ exchange may also indirectly decrease Na＋- Ca2＋ exchange activity during hypoxia.
