A new solid acid catalyst,SO4^2-/TiO2 modified with tin,was prepared using a sol-gel method and its physicochemical properties were revealed by nitrogen adsorption-desorption,X-ray powder diffraction,scanning electron...A new solid acid catalyst,SO4^2-/TiO2 modified with tin,was prepared using a sol-gel method and its physicochemical properties were revealed by nitrogen adsorption-desorption,X-ray powder diffraction,scanning electron microscopy,Fourier transform infrared spectroscopy,infrared spectroscopy of adsorbed pyridine,temperature-programmed desorption of ammonia and thermal gravimetric analysis.The structure,acidity and thermal stability of the SO4^2-/TiO2-SnO2 catalyst were studied.Incorporating tin enlarged the specific surface area and decreased crystallite size of the SO4^2-/TiO2 catalyst.The total acid sites of the modified catalyst increased and Bronsted acid strength remarkably increased with increasing tin content.The decomposition temperature of sulfate radical in the modified catalyst was 100 ℃ greater and its mass loss was more than twice that of the SO4^2-/TiO2 catalyst.The SO4^2-/TiO2-SnO2 catalyst was designed to synthesize 1,6-hexanediol diacrylate by esterification of 1,6-hexanediol with crylic acid.The yield of 1,6-hexanediol diacrylate exceeded 87% under the optimal reaction conditions：crylic acid to 1,6-hexanediol molar ratio = 3.5,catalyst loading = 7%,reaction temperature = 130 ℃ and reaction time = 3 h.The modified catalyst exhibited excellent reusability and after 10 cycles the conversion of 1,6-hexanediol was above 81%.展开更多
目的探讨肠道屏障功能、IL-6、血沉(erythrocyte sedimentation rate,ESR)指标在克罗恩病合并贫血患者中的变化及应用价值。方法选取2022年6月至2023年4月至南京市第二医院就诊的克罗恩病患者155例。根据血红蛋白检测结果将患者分为贫血...目的探讨肠道屏障功能、IL-6、血沉(erythrocyte sedimentation rate,ESR)指标在克罗恩病合并贫血患者中的变化及应用价值。方法选取2022年6月至2023年4月至南京市第二医院就诊的克罗恩病患者155例。根据血红蛋白检测结果将患者分为贫血组(55例)及非贫血组(100例),对两组间DAO、D-LA、BT、IL-6及ESR水平进行比较,并进行相关统计学分析。结果与非贫血组相比,贫血组患者D-LA水平明显降低,IL-6及ESR水平显著升高,差异有统计学意义(P<0.05),两组间DAO、BT水平差异无统计学意义(P>0.05);在贫血组中,血清D-LA水平与BT水平呈正相关、与IL-6呈负相关;二元Logistic回归分析结果显示,ESR水平是克罗恩病患者贫血的独立影响因素(OR=1.963,P<0.05);D-LA、IL-6及ESR判断克罗恩病合并贫血的ROC曲线下面积(area under the curve,AUC)分别为0.322、0.714、0.737(P均<0.05),DAO及BT的AUC差异无统计学意义。结论克罗恩病合并贫血患者肠道屏障功能、IL-6及ESR水平发生明显变化,做好其分析对克罗恩病患者的贫血发生机制研究以及临床诊疗具有积极意义。展开更多
文摘A new solid acid catalyst,SO4^2-/TiO2 modified with tin,was prepared using a sol-gel method and its physicochemical properties were revealed by nitrogen adsorption-desorption,X-ray powder diffraction,scanning electron microscopy,Fourier transform infrared spectroscopy,infrared spectroscopy of adsorbed pyridine,temperature-programmed desorption of ammonia and thermal gravimetric analysis.The structure,acidity and thermal stability of the SO4^2-/TiO2-SnO2 catalyst were studied.Incorporating tin enlarged the specific surface area and decreased crystallite size of the SO4^2-/TiO2 catalyst.The total acid sites of the modified catalyst increased and Bronsted acid strength remarkably increased with increasing tin content.The decomposition temperature of sulfate radical in the modified catalyst was 100 ℃ greater and its mass loss was more than twice that of the SO4^2-/TiO2 catalyst.The SO4^2-/TiO2-SnO2 catalyst was designed to synthesize 1,6-hexanediol diacrylate by esterification of 1,6-hexanediol with crylic acid.The yield of 1,6-hexanediol diacrylate exceeded 87% under the optimal reaction conditions：crylic acid to 1,6-hexanediol molar ratio = 3.5,catalyst loading = 7%,reaction temperature = 130 ℃ and reaction time = 3 h.The modified catalyst exhibited excellent reusability and after 10 cycles the conversion of 1,6-hexanediol was above 81%.
文摘目的探讨肠道屏障功能、IL-6、血沉(erythrocyte sedimentation rate,ESR)指标在克罗恩病合并贫血患者中的变化及应用价值。方法选取2022年6月至2023年4月至南京市第二医院就诊的克罗恩病患者155例。根据血红蛋白检测结果将患者分为贫血组(55例)及非贫血组(100例),对两组间DAO、D-LA、BT、IL-6及ESR水平进行比较,并进行相关统计学分析。结果与非贫血组相比,贫血组患者D-LA水平明显降低,IL-6及ESR水平显著升高,差异有统计学意义(P<0.05),两组间DAO、BT水平差异无统计学意义(P>0.05);在贫血组中,血清D-LA水平与BT水平呈正相关、与IL-6呈负相关;二元Logistic回归分析结果显示,ESR水平是克罗恩病患者贫血的独立影响因素(OR=1.963,P<0.05);D-LA、IL-6及ESR判断克罗恩病合并贫血的ROC曲线下面积(area under the curve,AUC)分别为0.322、0.714、0.737(P均<0.05),DAO及BT的AUC差异无统计学意义。结论克罗恩病合并贫血患者肠道屏障功能、IL-6及ESR水平发生明显变化,做好其分析对克罗恩病患者的贫血发生机制研究以及临床诊疗具有积极意义。
