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Robustness Optimization Algorithm with Multi-Granularity Integration for Scale-Free Networks Against Malicious Attacks 被引量:1
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作者 ZHANG Yiheng LI Jinhai 《昆明理工大学学报(自然科学版)》 北大核心 2025年第1期54-71,共18页
Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently... Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms. 展开更多
关键词 complex network model MULTI-GRANULARITY scale-free networks robustness algorithm integration
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RTP-based broadcast streaming of high definition H.264/AVC video: an error robustness evaluation 被引量:1
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作者 HILLESTAD Odd Inge JETLUND Ola PERKIS Andrew 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2006年第z1期19-26,共8页
In this work, we present an evaluation of the performance and error robustness of RTP-based broadcast streaming of high-quality high-definition (HD) H.264/AVC video. Using a fully controlled IP test bed (Hillestad et ... In this work, we present an evaluation of the performance and error robustness of RTP-based broadcast streaming of high-quality high-definition (HD) H.264/AVC video. Using a fully controlled IP test bed (Hillestad et al., 2005), we broadcast high-definition video over RTP/UDP, and use an IP network emulator to introduce a varying amount of randomly distributed packet loss. A high-performance network interface monitoring card is used to capture the video packets into a trace file. Purpose-built software parses the trace file, analyzes the RTP stream and assembles the correctly received NAL units into an H.264/AVC Annex B byte stream file, which is subsequently decoded by JVT JM 10.1 reference software. The proposed measurement setup is a novel, practical and intuitive approach to perform error resilience testing of real-world H.264/AVC broadcast applications. Through a series of experiments, we evaluate some of the error resilience features of the H.264/AVC standard, and see how they perform at packet loss rates from 0.01% to 5%. The results confirmed that an appropriate slice partitioning scheme is essential to have a graceful degradation in received quality in the case of packet loss. While flexible macroblock ordering reduces the compression efficiency about 1 dB for our test material, reconstructed video quality is improved for loss rates above 0.25%. 展开更多
关键词 H.264/AVC Video streaming Error robustness
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A robustness assessment approach for transportation networks with cyber-physical interdependencies
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作者 Konstantinos Ntafloukas Liliana Pasquale +1 位作者 Beatriz Martinez-Pastor Daniel P.McCrum 《Resilient Cities and Structures》 2025年第1期71-82,共12页
While in the past the robustness of transportation networks was studied considering the cyber and physical space as isolated environments this is no longer the case.Integrating the Internet of Things devices in the se... While in the past the robustness of transportation networks was studied considering the cyber and physical space as isolated environments this is no longer the case.Integrating the Internet of Things devices in the sensing area of transportation infrastructure has resulted in ubiquitous cyber-physical systems and increasing interdependen-cies between the physical and cyber networks.As a result,the robustness of transportation networks relies on the uninterrupted serviceability of physical and cyber networks.Current studies on interdependent networks overlook the civil engineering aspect of cyber-physical systems.Firstly,they rely on the assumption of a uniform and strong level of interdependency.That is,once a node within a network fails its counterpart fails immedi-ately.Current studies overlook the impact of earthquake and other natural hazards on the operation of modern transportation infrastructure,that now serve as a cyber-physical system.The last is responsible not only for the physical operation(e.g.,flow of vehicles)but also for the continuous data transmission and subsequently the cy-ber operation of the entire transportation network.Therefore,the robustness of modern transportation networks should be modelled from a new cyber-physical perspective that includes civil engineering aspects.In this paper,we propose a new robustness assessment approach for modern transportation networks and their underlying in-terdependent physical and cyber network,subjected to earthquake events.The novelty relies on the modelling of interdependent networks,in the form of a graph,based on their interdependency levels.We associate the service-ability level of the coupled physical and cyber network with the damage states induced by earthquake events.Robustness is then measured as a degradation of the cyber-physical serviceability level.The application of the approach is demonstrated by studying an illustrative transportation network using seismic data from real-world transportation infrastructure.Furthermore,we propose the integration of a robustness improvement indicator based on physical and cyber attributes to enhance the cyber-physical serviceability level.Results indicate an improvement in robustness level(i.e.,41%)by adopting the proposed robustness improvement indicator.The usefulness of our approach is highlighted by comparing it with other methods that consider strong interdepen-dencies and key node protection strategies.The approach is of interest to stakeholders who are attempting to incorporate cyber-physical systems into civil engineering systems. 展开更多
关键词 Transportation network Cyber-physical robustness Interdependencies Natural hazards robustness improvement indicator
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A Robustness Evaluation Method for the Robust Control of Electrical Drive Systems based on Six-sigma Methodology
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作者 Nabil Farah Gang Lei +1 位作者 Jianguo Zhu Youguang Guo 《CES Transactions on Electrical Machines and Systems》 2025年第2期131-145,共15页
Numerous uncertainties in practical production and operation can seriously affect the drive performance of permanent magnet synchronous machines(PMSMs).Various robust control methods have been developed to mitigate or... Numerous uncertainties in practical production and operation can seriously affect the drive performance of permanent magnet synchronous machines(PMSMs).Various robust control methods have been developed to mitigate or eliminate the effects of these uncertainties.However,the robustness to uncertainties of electrical drive systems has not been clearly defined.No systemic procedures have been proposed to evaluate a control system's robustness(how robust it is).This paper proposes a systemic method for evaluating control systems'robustness to uncertainties.The concept and fundamental theory of robust control are illustrated by considering a simple uncertain feedback control system.The effects of uncertainties on the control performance and stability are analyzed and discussed.The concept of design for six-sigma(a robust design method)is employed to numerically evaluate the robustness levels of control systems.To show the effectiveness of the proposed robustness evaluation method,case studies are conducted for second-order systems,DC motor drive systems,and PMSM drive systems.Besides the conventional predictive control of PMSM drive,three different robust predictive control methods are evaluated in terms of two different parametric uncertainty ranges and three application requirements against parametric uncertainties. 展开更多
关键词 Permanent magnet synchronous machines(PMSMs) Predictive control UNCERTAINTIES robustness evaluation robust control Six-sigma
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Laser-based fabrication of superhydrophobic glass with high transparency and robustness
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作者 LIU Chao WANG Qing-hua +4 位作者 GE Zhi-qiang LI Hao-yu FU Jia-jun WANG Hui-xin ZHANG Tai-rui 《Journal of Central South University》 2025年第1期160-173,共14页
Superhydrophobic glass has inspiring development prospects in endoscopes,solar panels and other engineering and medical fields.However,the surface topography required to achieve superhydrophobicity will inevitably aff... Superhydrophobic glass has inspiring development prospects in endoscopes,solar panels and other engineering and medical fields.However,the surface topography required to achieve superhydrophobicity will inevitably affect the surface transparency and limit the application of glass materials.To resolve the contradiction between the surface transparency and the robust superhydrophobicity,an efficient and low-cost laser-chemical surface functionalization process was utilized to fabricate superhydrophobic glass surface.The results show that the air can be effectively trapped in surface micro/nanostructure induced by laser texturing,thus reducing the solid-liquid contact area and interfacial tension.The deposition of hydrophobic carbon-containing groups on the surface can be accelerated by chemical treatment,and the surface energy is significantly reduced.The glass surface exhibits marvelous robust superhydrophobicity with a contact angle of 155.8°and a roll-off angle of 7.2°under the combination of hierarchical micro/nanostructure and low surface energy.Moreover,the surface transparency of the prepared superhydrophobic glass was only 5.42%lower than that of the untreated surface.This superhydrophobic glass with high transparency still maintains excellent superhydrophobicity after durability and stability tests.The facile fabrication of superhydrophobic glass with high transparency and robustness provides a strong reference for further expanding the application value of glass materials. 展开更多
关键词 superhydrophobic glass laser-chemical functionalization TRANSPARENCY robustness highly efficient
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Stabilized adaptive waveform inversion for enhanced robustness in Gaussian penalty matrix parameterization and transcranial ultrasound imaging
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作者 Jun-Jie Zhao Shan-Mu Jin +2 位作者 Yue-Kun Wang Yu Wang Ya-Hui Peng 《Chinese Physics B》 2025年第8期606-621,共16页
Achieving high-resolution intracranial imaging in a safe and portable manner is critical for the diagnosis of intracranial diseases,preoperative planning of craniotomies and intraoperative management during craniotomy... Achieving high-resolution intracranial imaging in a safe and portable manner is critical for the diagnosis of intracranial diseases,preoperative planning of craniotomies and intraoperative management during craniotomy procedures.Adaptive waveform inversion(AWI),a variant of full waveform inversion(FWI),has shown potential in intracranial ultrasound imaging.However,the robustness of AWI is affected by the parameterization of the Gaussian penalty matrix and the challenges posed by transcranial scenarios.Conventional AWI struggles to produce accurate images in these cases,limiting its application in critical medical settings.To address these issues,we propose a stabilized adaptive waveform inversion(SAWI)method,which introduces a user-defined zero-lag position for theWiener filter.Numerical experiments demonstrate that SAWI can achieve accurate imaging under Gaussian penalty matrix parameter settings where AWI fails,perform successful transcranial imaging in configurations where AWI cannot,and maintain the same imaging accuracy as AWI.The advantage of this method is that it achieves these advancements without modifying the AWI framework or increasing computational costs,which helps to promote the application of AWI in medical fields,particularly in transcranial scenarios. 展开更多
关键词 ultrasound brain imaging full waveform inversion robustness PARAMETERIZATION
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Exploring the Robustness of Emergency Response Networks by Considering Task Association and Reassignment:An Extreme Rainstorm Case
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作者 Chenxi Lian Yanan Guo Jida Liu 《International Journal of Disaster Risk Science》 2025年第5期817-831,共15页
In the face of disasters,a strong organizational network is the foundation for eff ectively accomplishing emergency relief tasks.In an emergency response network comprising tasks and organizations,the failure of certa... In the face of disasters,a strong organizational network is the foundation for eff ectively accomplishing emergency relief tasks.In an emergency response network comprising tasks and organizations,the failure of certain organizations may cause large systemic losses owing to internal component associations.To analyze the response system’s robustness,we developed emergency response networks based on the associations between organizations and tasks.A cascading failure model was established considering task reassignment after organizational failure,and indicators in terms of tasks and structures were identified to observe robustness.In the proposed model,we developed random,bond-based,and bridge-based organizational failure modes,and average,capacity-based,and surplus-based reassignment programs.To validate the model,simulation experiments were conducted in the context of extreme rainstorms.The results show that bridge-based failures were the most damaging to network systems,and the average reassignment program was the least eff ective.The analysis of model parameters illustrates the critical eff ectiveness of individual organizational capability in enhancing system robustness.The proposed framework and model enrich the study of emergency response networks with favorable applicability,and the results can provide theoretical references for emergency management practices. 展开更多
关键词 Cascading effect Emergency organizational network Emergency response RAINSTORM robustness
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Improving Robustness for Tag Recommendation via Self-Paced Adversarial Metric Learning
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作者 Zhengshun Fei Jianxin Chen +1 位作者 Gui Chen Xinjian Xiang 《Computers, Materials & Continua》 2025年第3期4237-4261,共25页
Tag recommendation systems can significantly improve the accuracy of information retrieval by recommending relevant tag sets that align with user preferences and resource characteristics.However,metric learning method... Tag recommendation systems can significantly improve the accuracy of information retrieval by recommending relevant tag sets that align with user preferences and resource characteristics.However,metric learning methods often suffer from high sensitivity,leading to unstable recommendation results when facing adversarial samples generated through malicious user behavior.Adversarial training is considered to be an effective method for improving the robustness of tag recommendation systems and addressing adversarial samples.However,it still faces the challenge of overfitting.Although curriculum learning-based adversarial training somewhat mitigates this issue,challenges still exist,such as the lack of a quantitative standard for attack intensity and catastrophic forgetting.To address these challenges,we propose a Self-Paced Adversarial Metric Learning(SPAML)method.First,we employ a metric learning model to capture the deep distance relationships between normal samples.Then,we incorporate a self-paced adversarial training model,which dynamically adjusts the weights of adversarial samples,allowing the model to progressively learn from simpler to more complex adversarial samples.Finally,we jointly optimize the metric learning loss and self-paced adversarial training loss in an adversarial manner,enhancing the robustness and performance of tag recommendation tasks.Extensive experiments on the MovieLens and LastFm datasets demonstrate that SPAML achieves F1@3 and NDCG@3 scores of 22%and 32.7%on the MovieLens dataset,and 19.4%and 29%on the LastFm dataset,respectively,outperforming the most competitive baselines.Specifically,F1@3 improves by 4.7%and 6.8%,and NDCG@3 improves by 5.0%and 6.9%,respectively. 展开更多
关键词 Tag recommendation metric learning adversarial training self-paced adversarial training robustness
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Enhancing the robustness of object detection via 6G vehicular edge computing 被引量:1
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作者 Chen Chen Guorun Yao +2 位作者 Chenyu Wang Sotirios Goudos Shaohua Wan 《Digital Communications and Networks》 SCIE CSCD 2022年第6期923-931,共9页
Academic and industrial communities have been paying significant attention to the 6th Generation(6G)wireless communication systems after the commercial deployment of 5G cellular communications.Among the emerging techn... Academic and industrial communities have been paying significant attention to the 6th Generation(6G)wireless communication systems after the commercial deployment of 5G cellular communications.Among the emerging technologies,Vehicular Edge Computing(VEC)can provide essential assurance for the robustness of Artificial Intelligence(AI)algorithms to be used in the 6G systems.Therefore,in this paper,a strategy for enhancing the robustness of AI model deployment using 6G-VEC is proposed,taking the object detection task as an example.This strategy includes two stages:model stabilization and model adaptation.In the former,the state-of-the-art methods are appended to the model to improve its robustness.In the latter,two targeted compression methods are implemented,namely model parameter pruning and knowledge distillation,which result in a trade-off between model performance and runtime resources.Numerical results indicate that the proposed strategy can be smoothly deployed in the onboard edge terminals,where the introduced trade-off outperforms the other strategies available. 展开更多
关键词 6G Vehicular edge computing Object detection Feature fusion Model compression Model deployment
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Face-Pedestrian Joint Feature Modeling with Cross-Category Dynamic Matching for Occlusion-Robust Multi-Object Tracking
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作者 Qin Hu Hongshan Kong 《Computers, Materials & Continua》 2026年第1期870-900,共31页
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba... To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions. 展开更多
关键词 Cross-category dynamic binding joint feature modeling face-pedestrian association multi object tracking occlusion robustness
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Predictable and Unpredictable Modes of Northern Hemisphere Atmospheric Circulation in CMIP6:Evaluation and Projections
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作者 Kairan YING Dabang JIANG Linhao ZHONG 《Advances in Atmospheric Sciences》 2026年第1期135-156,共22页
Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both g... Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations. 展开更多
关键词 interannual mode of atmospheric circulation CMIP6 predictable unpredictable EVALUATION PROJECTION
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Artificial Intelligence (AI)-Enabled Unmanned Aerial Vehicle (UAV) Systems for Optimizing User Connectivity in Sixth-Generation (6G) Ubiquitous Networks
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作者 Zeeshan Ali Haider Inam Ullah +2 位作者 Ahmad Abu Shareha Rashid Nasimov Sufyan Ali Memon 《Computers, Materials & Continua》 2026年第1期534-549,共16页
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener... The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment. 展开更多
关键词 6G networks UAV-based communication cooperative reinforcement learning network optimization user connectivity energy efficiency
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西安汉族人群CYP2A6基因拷贝数多态性及其与吸烟行为的关联分析
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作者 刘金辉 方亚妮 《实用心脑肺血管病杂志》 2026年第1期56-59,共4页
目的分析西安汉族人群CYP2A6基因拷贝数多态性及其与吸烟行为的关联性。方法选取2021年9月—2023年6月在西安区域医学检验中心体检的西安汉族居民3500例为研究对象。根据受试者是否吸烟,将其分为吸烟组(2233例)和不吸烟组(1267例),根据... 目的分析西安汉族人群CYP2A6基因拷贝数多态性及其与吸烟行为的关联性。方法选取2021年9月—2023年6月在西安区域医学检验中心体检的西安汉族居民3500例为研究对象。根据受试者是否吸烟,将其分为吸烟组(2233例)和不吸烟组(1267例),根据吸烟组受试者吸烟程度将其进一步分为轻度吸烟亚组(476例)和重度吸烟亚组(1757例)。采用TaqMan®Copy Number Assays试剂盒检测受试者CYP2A6基因拷贝数多态性。结果3500例受试者中,CYP2A6基因拷贝数为0者32例(0.91%),CYP2A6基因拷贝数为1拷贝者632例(18.06%),CYP2A6基因拷贝数为2拷贝者2737例(78.20%),CYP2A6基因拷贝数为≥3拷贝者99例(2.83%)。吸烟组CYP2A6基因拷贝数为0、1拷贝者占比低于不吸烟组,CYP2A6基因拷贝数为2拷贝、≥3拷贝者占比高于不吸烟组(P<0.05)。轻度吸烟亚组与重度吸烟亚组CYP2A6基因拷贝数多态性比较,差异无统计学意义(P>0.05)。结论西安汉族人群CYP2A6基因缺失率较高,达18.97%;西安汉族人群CYP2A6基因拷贝数多态性与吸烟行为可能存在关联,且CYP2A6基因缺失个体不易形成烟草依赖,而CYP2A6基因拷贝数多态性可能与吸烟程度不存在关联。 展开更多
关键词 DNA拷贝数变异 拷贝数多态性 CYP2A6基因 吸烟 西安 汉族
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Fat mass and obesity-mediated N^(6)-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury
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作者 Xiangrong Chen Jinqing Lai +4 位作者 Zhe Wu Jianlong Chen Baoya Yang Chunnuan Chen Chenyu Ding 《Neural Regeneration Research》 2026年第2期730-741,共12页
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiqui... The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiquitous in the immune response of the central nervous system.The fat mass and obesity-related protein catalyzes the demethylation of N^(6)-methyladenosine modifications on mRNA and is widely expressed in various tissues,participating in the regulation of multiple diseases’biological processes.However,the role of fat mass and obesity in microglial activation and the subsequent neuroinflammatory response after traumatic brain injury is unclear.In this study,we found that the expression of fat mass and obesity was significantly down-regulated in both lipopolysaccharide-treated BV2 cells and a traumatic brain injury mouse model.After fat mass and obesity interference,BV2 cells exhibited a pro-inflammatory phenotype as shown by the increased proportion of CD11b^(+)/CD86^(+)cells and the secretion of pro-inflammatory cytokines.Fat mass and obesity-mediated N^(6)-methyladenosine demethylation accelerated the degradation of ADAM17 mRNA,while silencing of fat mass and obesity enhanced the stability of ADAM17 mRNA.Therefore,down-regulation of fat mass and obesity expression leads to the abnormally high expression of ADAM17 in microglia.These results indicate that the activation of microglia and neuroinflammatory response regulated by fat mass and obesity-related N^(6)-methyladenosine modification plays an important role in the pro-inflammatory process of secondary injury following traumatic brain injury. 展开更多
关键词 ADAM17 epigenetic modification fat mass and obesity N6-methyladenosine MICROGLIA mRNA nerve injury NEUROINFLAMMATION traumatic brain injury tumor necrosis factorα
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浅议structural robustness在结构工程中的定名 被引量:2
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作者 方召欣 《中国科技术语》 2009年第5期58-60,共3页
structural robustness的意义在结构工程领域已受到广泛认可,但在国内还没有公认合适的译名,这不利于国内技术人员对此概念的理解和交流。通过简要回顾structural robustness的产生思路,探讨了结构鲁棒性等几种定名。
关键词 STRUCTURAL robustness 结构工程 结构鲁棒性 减灾
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基于转录组学分析昆布多糖对C57BL/6小鼠非增生性糖尿病视网膜病变的影响 被引量:3
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作者 张蕾 张素梅 +7 位作者 杨振 胡韦康 白红枚 周文静 王子涵 李名聪 张胜权 廖荣丰 《安徽医科大学学报》 北大核心 2025年第3期392-398,共7页
目的采用高通量测序技术(RNA-seq)探讨昆布多糖(LAM)对非增生性糖尿病视网膜病变(NPDR)的影响。方法采用链脲佐菌素(STZ)腹腔注射建立糖尿病模型,观察LAM对糖尿病小鼠的影响。将C57BL/6小鼠随机分为对照(Control)、模型(Model)、昆布多... 目的采用高通量测序技术(RNA-seq)探讨昆布多糖(LAM)对非增生性糖尿病视网膜病变(NPDR)的影响。方法采用链脲佐菌素(STZ)腹腔注射建立糖尿病模型,观察LAM对糖尿病小鼠的影响。将C57BL/6小鼠随机分为对照(Control)、模型(Model)、昆布多糖治疗(LAM)组,每组8只小鼠。在建模8周后,LAM组接受为期4周的LAM腹腔注射治疗。记录3组小鼠血糖体质量变化,HE染色检查视网膜病变情况,采用RNA-seq挖掘STZ及LAM作用下糖尿病视网膜病变(DR)的关键差异基因(DEGs)。结果使用STZ可以成功建立DR模型,而LAM可以在一定程度上降低糖尿病小鼠血糖并改善糖尿病小鼠视网膜结构疏松的病理形态。经过RNA-seq对DEG挖掘发现与Control组相比,Model组小鼠视网膜共有214个DEGs,通过富集分析发现DR可通过PI3K-Akt信号通路加重病变程度。Model组与LAM组小鼠视网膜共有DEGs 42个,富集后显示LAM通过中性粒细胞胞外陷阱通路改善其病变程度。早期生长反应因子1(Egr1),FBJ骨肉瘤致癌基因(Fos),核受体亚家族4A成员1(Nr4a1),盐诱导激酶1(Sik1)受STZ调节,而LAM能显著回调其表达,可能与LAM对糖尿病视网膜病变的治疗密切相关。结论DEG可通过PI3K-Akt信号通路加重糖尿病视网膜病变程度。LAM可以通过中性粒细胞胞外陷阱通路减轻糖尿病视网膜病变,Egr1、Fos、Nr4a1、Sik1是LAM治疗STZ诱导DR的关键基因。 展开更多
关键词 高通量测序 昆布多糖 糖尿病视网膜病变 C57BL/6
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鄂尔多斯盆地马岭-乔川地区长6油层组砂体叠置关系及展布规律 被引量:2
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作者 张晓磊 唐玮玮 +3 位作者 李继宏 赵凱莉 时孜伟 王梓烨 《矿物岩石》 北大核心 2025年第2期186-199,共14页
鄂尔多斯盆地西南部马岭-乔川地区延长组长6油层组发育规模不等的各种储集砂体。为明确其砂体叠置关系及展布规律,通过岩芯观察、测井综合解释等手段探讨砂体的叠置类型和展布规律,并分析砂体成因与油气储集性能。研究认为:(1)砂体叠置... 鄂尔多斯盆地西南部马岭-乔川地区延长组长6油层组发育规模不等的各种储集砂体。为明确其砂体叠置关系及展布规律,通过岩芯观察、测井综合解释等手段探讨砂体的叠置类型和展布规律,并分析砂体成因与油气储集性能。研究认为:(1)砂体叠置类型可分为多期厚层型、厚砂-薄泥型、砂泥互层型和薄砂-厚泥型4类;(2)砂体叠置关系与重力流类型相关,多期厚层型砂体指示连续型砂质碎屑流沉积,厚砂-薄泥型砂体表明具有事件停顿的多期砂质碎屑流沉积,停滞期发生湖相泥质沉积和明显的浊积韵律层,砂泥互层型砂体主要是牛顿流体状态的浊流沉积的结果,牛顿流体湍动的特性和强度多变的水动力导致流体内悬浮的不同粒级沉积物交互沉积,薄砂-厚泥型砂体则体现浊流搬运末期水动力减弱,流体内泥质细粒沉积物增多的沉积结果;(3)4类砂体的纵向连通性是控制油气运聚的关键,多期厚层型砂体的纵向连通性最好,厚砂-薄泥型次之,砂泥互层型较差,厚泥-薄砂型最差,多期厚层型和厚砂-薄泥型砂体的油层、差油层厚度远高于后两种纵向连通性稍差的砂体。长6_(3)亚段康岔-华池以及Luo225等井区域此两类砂体连片展布,是有利于油气富集的优势区域。本研究对马岭-乔川地区长6油层组砂体叠置关系和分布做出了系统解释,亦可为深水湖盆区重力流致密储层的评价提供参考。 展开更多
关键词 马岭-乔川地区 6油层组 砂体叠置关系 砂体展布规律
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18CrNiMo7-6渗碳钢超声滚压工艺及疲劳性能研究 被引量:1
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作者 刘治华 刘鸿宇 +3 位作者 李建鹏 张鸣文 郭鹏 周洋 《组合机床与自动化加工技术》 北大核心 2025年第3期155-159,164,共6页
为了探究18CrNiMo7-6渗碳钢的超声滚压工艺及超声滚压对试样疲劳性能的影响,设计了关于静压力、振幅、滚压遍数的正交试验,通过灰色关联分析对试验结果进行参数优化,得到分别针对表面残余压应力、表面硬度、表面粗糙度的单工艺目标和多... 为了探究18CrNiMo7-6渗碳钢的超声滚压工艺及超声滚压对试样疲劳性能的影响,设计了关于静压力、振幅、滚压遍数的正交试验,通过灰色关联分析对试验结果进行参数优化,得到分别针对表面残余压应力、表面硬度、表面粗糙度的单工艺目标和多工艺目标的显著性影响顺序、最优单目标和综合最优加工参数,综合最优组试样较原始试样的表面残余压应力提升了3.88倍,表面硬度提升了14.8%,表面粗糙度降低了75.7%。通过拉伸试验和旋转弯曲疲劳试验,得到综合最优参数组试验的屈服强度、抗拉强度分别为1225.4 MPa、1902.7 MPa,较原始试样提升了12.5%和7.4%,疲劳极限较原始试样提高了超过190 MPa,最优参数组在应力水平1200 MPa时疲劳寿命为714656次,疲劳性能提升明显。 展开更多
关键词 18CrNiMo7-6渗碳钢 超声滚压 灰色关联分析 疲劳性能
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原位聚合尼龙6热塑性复合材料成型工艺方法研究进展 被引量:1
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作者 沈登雄 赵文宇 +2 位作者 周子玥 王超 司道然 《宇航材料工艺》 北大核心 2025年第1期19-28,共10页
尼龙热塑性复合材料的制备方法主要有热熔预浸料法和原位聚合法。相较于原位聚合法,热熔预浸料方法制备其复合材料成本高、效率低。针对尼龙热塑性复合材料高效、低成本制造的迫切需求,本文以纤维增强尼龙6复合材料为研究对象,综述了原... 尼龙热塑性复合材料的制备方法主要有热熔预浸料法和原位聚合法。相较于原位聚合法,热熔预浸料方法制备其复合材料成本高、效率低。针对尼龙热塑性复合材料高效、低成本制造的迫切需求,本文以纤维增强尼龙6复合材料为研究对象,综述了原位聚合制备尼龙6热塑性复合材料的工艺方法的研究进展,主要的工艺方法包括浇注、离心与旋转、拉挤以及液体模塑成型,着重论述了该种热塑性复合材料液体模塑成型工艺方法,并对其发展方向进行了简述。 展开更多
关键词 尼龙6 热塑性 复合材料 工艺方法
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小茴香荧光碳点的制备及水中Cr^(6+)的检测 被引量:1
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作者 张丽珍 张利娜 +2 位作者 杨冬业 黄晓艳 覃思银 《化工新型材料》 北大核心 2025年第2期247-251,257,共6页
以自然界中生物质为前体合成功能性碳量子点(C-CDs)是一种绿色环保的合成策略。本研究以小茴香阴干草质茎作为碳源,通过简单的一步水热法合成水溶性良好的C-CDs。该C-CDs在紫外灯照射下能够发出明亮的蓝色荧光,最佳激发波长和最佳发射... 以自然界中生物质为前体合成功能性碳量子点(C-CDs)是一种绿色环保的合成策略。本研究以小茴香阴干草质茎作为碳源,通过简单的一步水热法合成水溶性良好的C-CDs。该C-CDs在紫外灯照射下能够发出明亮的蓝色荧光,最佳激发波长和最佳发射波长分别为381nm和460nm。实验发现,C-CDs具有良好的抗光漂白性,以及优秀的pH稳定性。此外,C-CDs对金属Cr^(6+)具有较高的选择性,在460nm处的荧光强度随Cr^(6+)浓度的增加而降低,具有显著的荧光猝灭效应。C-CDs的荧光猝灭与Cr^(6+)浓度在0~100μmol/L范围内呈线性关系(R^(2)=0.9964),最低检出限为0.30nmol/L。在实际应用中,自来水和湖水中的Cr^(6+)检测回收率在97.1%~100.25%。因此,小茴香C-CDs可作为荧光探针检测Cr^(6+)。 展开更多
关键词 小茴香 荧光碳点 水热法 荧光探针 Cr^(6+)
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