The Taihang Mountains area is an area in North China where serious mudflow hazards take place frequently. The hazards often obstrust traffic and make it difficult to carry out conventional ground investigations of the...The Taihang Mountains area is an area in North China where serious mudflow hazards take place frequently. The hazards often obstrust traffic and make it difficult to carry out conventional ground investigations of the mudflow hazards. This paper introduces the feasibility study of mudflow hazards by using Landsat-5TM data. The study has achieved a great success through adopting both the faint spectral enhancement technique for mudflow fans (or other depositional areas) and comprehensive study of the environmental background of pregnant mudflows. Thus, remote sensing as a fast, convenient, low-cost and effective technical method can be used to recognise the situation of mudflow hazards so that effective rescue can be provided.展开更多
On the basis of the obtained intensity parameters Ω λ(λ =2,4,6) of Tm 3+ in the Na 5Tm(WO 4) 4 crystal, we performed calculations on the radiative transition probability, radiative lifetime, branching ...On the basis of the obtained intensity parameters Ω λ(λ =2,4,6) of Tm 3+ in the Na 5Tm(WO 4) 4 crystal, we performed calculations on the radiative transition probability, radiative lifetime, branching ratios and stimulated emission integrated cross sections between the two excited J manifolds of Tm 3+ , and discussed potentiality for the usage of this crystal as a laser material.展开更多
Objective Hepatocyte nuclear factor 4-alpha(HNF4A)is a critical transcription factor in the liver and pancreas.Dysfunctions of HNF4A lead to maturity onset diabetes of the young 1(MODY1).Notably,MODY1 patients with HN...Objective Hepatocyte nuclear factor 4-alpha(HNF4A)is a critical transcription factor in the liver and pancreas.Dysfunctions of HNF4A lead to maturity onset diabetes of the young 1(MODY1).Notably,MODY1 patients with HNF4A pathogenic mutations exhibit decreased responses to arginine and reduced plasma triglyceride levels,but the mechanisms remain unclear.This study aims to investigate the potential target genes transcriptionally regulated by HNF4A and explore its role in these metabolic pathways.Methods A stable 293T cell line expressing the HNF1A reporter was overexpressed with HNF4A.RNA sequencing(RNA-seq)was performed to analyze transcriptional differences.Transcription factor binding site prediction was then conducted to identify HNF4A binding motifs in the promoter regions of relevant target genes.Results RNA-seq results revealed a significant upregulation of transmembrane 4 L six family member 5(TM4SF5)mRNA in HNF4A-overexpressing cells.Transcription factor binding predictions suggested the presence of five potential HNF4A binding motifs in the TM4SF5 promoter.Finally,we confirmed that the DR1 site in the-57 to-48 region of the TM4SF5 promoter is the key binding motif for HNF4A.Conclusion This study identified TM4SF5 as a target gene of HNF4A and determined the key binding motif involved in its regulation.Given the role of TM4SF5 as an arginine sensor in mTOR signaling activation and triglyceride secretion,which closely aligns with phenotypes observed in MODY1 patients,our findings provide novel insights into the possible mechanisms by which HNF4A regulates triglyceride secretion in the liver and arginine-stimulated insulin secretion in the pancreas.展开更多
文摘The Taihang Mountains area is an area in North China where serious mudflow hazards take place frequently. The hazards often obstrust traffic and make it difficult to carry out conventional ground investigations of the mudflow hazards. This paper introduces the feasibility study of mudflow hazards by using Landsat-5TM data. The study has achieved a great success through adopting both the faint spectral enhancement technique for mudflow fans (or other depositional areas) and comprehensive study of the environmental background of pregnant mudflows. Thus, remote sensing as a fast, convenient, low-cost and effective technical method can be used to recognise the situation of mudflow hazards so that effective rescue can be provided.
文摘On the basis of the obtained intensity parameters Ω λ(λ =2,4,6) of Tm 3+ in the Na 5Tm(WO 4) 4 crystal, we performed calculations on the radiative transition probability, radiative lifetime, branching ratios and stimulated emission integrated cross sections between the two excited J manifolds of Tm 3+ , and discussed potentiality for the usage of this crystal as a laser material.
文摘以内蒙古锡林浩特市南部中国科学院草原生态系统定位研究站周围的草场为研究对象,分析比较了统计模型和亚像元分解模型进行草地植被覆盖度(vegetation coverage,VC)遥感估算的适用性。结果表明,根据Landsat-5TM影像数据计算的比值植被指数(simple ratio vegetation index,SR)与观测的VC的相关性最高(R2=0.761);统计模型和亚像元分解模型生成的VC空间分布特征相似,但亚像元分解模型得到的VC平均值比统计模型的结果高0.091;在VC的低值和高值区,两种方法得到的VC结果相似;但在VC的中值区,亚像元模型得到的结果较统计模型的结果偏高。
文摘Objective Hepatocyte nuclear factor 4-alpha(HNF4A)is a critical transcription factor in the liver and pancreas.Dysfunctions of HNF4A lead to maturity onset diabetes of the young 1(MODY1).Notably,MODY1 patients with HNF4A pathogenic mutations exhibit decreased responses to arginine and reduced plasma triglyceride levels,but the mechanisms remain unclear.This study aims to investigate the potential target genes transcriptionally regulated by HNF4A and explore its role in these metabolic pathways.Methods A stable 293T cell line expressing the HNF1A reporter was overexpressed with HNF4A.RNA sequencing(RNA-seq)was performed to analyze transcriptional differences.Transcription factor binding site prediction was then conducted to identify HNF4A binding motifs in the promoter regions of relevant target genes.Results RNA-seq results revealed a significant upregulation of transmembrane 4 L six family member 5(TM4SF5)mRNA in HNF4A-overexpressing cells.Transcription factor binding predictions suggested the presence of five potential HNF4A binding motifs in the TM4SF5 promoter.Finally,we confirmed that the DR1 site in the-57 to-48 region of the TM4SF5 promoter is the key binding motif for HNF4A.Conclusion This study identified TM4SF5 as a target gene of HNF4A and determined the key binding motif involved in its regulation.Given the role of TM4SF5 as an arginine sensor in mTOR signaling activation and triglyceride secretion,which closely aligns with phenotypes observed in MODY1 patients,our findings provide novel insights into the possible mechanisms by which HNF4A regulates triglyceride secretion in the liver and arginine-stimulated insulin secretion in the pancreas.
