目的探讨白细胞介素-6(interleukin 6,IL-6)-572、IL-6-174基因多态性与高血压肾损害及贝那普利治疗反应的相关性。方法入选284例初次诊断高血压病的患者,根据24h尿蛋白排泄率(urinary albumin excretion,UAER)水平分为高血压组(UAER<...目的探讨白细胞介素-6(interleukin 6,IL-6)-572、IL-6-174基因多态性与高血压肾损害及贝那普利治疗反应的相关性。方法入选284例初次诊断高血压病的患者,根据24h尿蛋白排泄率(urinary albumin excretion,UAER)水平分为高血压组(UAER<20μg/min)和高血压肾损害组(UAER≥20μg/min)。检测IL-6水平及IL-6-572、IL-6-174基因多态性。然后用贝那普利干预,观察具备IL-6-572、IL-6-174的不同基因型的患者的治疗反应。结果高血压肾损害组中,IL-6-572的CG基因型、IL-6-174的GG基因型比例最高。贝那普利治疗对具有IL-6-572GG基因型、IL-6-174CC基因型的高血压肾损害患者治疗效果最佳。结论IL-6-572、IL-6-174基因多态性与高血压肾损害及其对贝那普利治疗的反应相关。展开更多
目的系统评价东亚人群IL-6-572C/G基因多态性与乙型肝炎病毒(HBV)感染易感性的关系。方法在PubMed、Web of Science、中国知网、万方数据库、维普网中搜索基于东亚人群的IL-6-572C/G(rs1800796C>G)基因多态性与HBV感染关系的病例对...目的系统评价东亚人群IL-6-572C/G基因多态性与乙型肝炎病毒(HBV)感染易感性的关系。方法在PubMed、Web of Science、中国知网、万方数据库、维普网中搜索基于东亚人群的IL-6-572C/G(rs1800796C>G)基因多态性与HBV感染关系的病例对照研究,检索时限均为建库至2021年10月,采用Stata S12.0软件进行meta分析。结果最终纳入10篇文献,包括3532例乙型肝炎病毒感染者和4020例对照者。meta分析结果显示:携带G等位基因和GG+GC、GG、GC基因型是东亚人群HBV感染的保护因素[G vs C(OR=0.80,95%CI:0.74~0.87,P<0.001);GG+GC vs CC(OR=0.77,95%CI:0.70~0.85,P<0.001);GG vs CG+CC(OR=0.72,95%CI:0.59~0.87,P=0.001);GC vs CC(OR=0.79,95%CI:0.72~0.87,P<0.001);GG vs CC(OR=0.66,95%CI:0.54~0.80,P<0.001)]。结论东亚人群中IL-6-572基因多态性改变(C>G)可能会降低HBV感染的风险。展开更多
Extraction of Y(III) and Dy(III) from hydrochloric and nitric acids by Cy-572 in kerosene was studied. The factors affecting the extraction were separately investigated. The stoichiometry of the extracted species was ...Extraction of Y(III) and Dy(III) from hydrochloric and nitric acids by Cy-572 in kerosene was studied. The factors affecting the extraction were separately investigated. The stoichiometry of the extracted species was deduced on the basis of slope analysis method. Evaluation of extraction equilibrium and stripping investigation was studied as well as saponification effect of Cy-572. The composition of the extracted metal species in the organic phase was found to be [MA·(HA)] for Y(III) or Dy(III) in both media.1.0 mol/L HCI is the best stripping agent for each metal ion from the studied acidic media in one step.Saponified Cy-572 does not exhibit any selectivity towards the extraction of Y(III) or Dy(III) from both HCI and HNOsolutions. Based on the obtained results, the data were compared and the separation feasibility between lanthanides and Y(III) in the two media was discussed.展开更多
文摘目的探讨白细胞介素-6(interleukin 6,IL-6)-572、IL-6-174基因多态性与高血压肾损害及贝那普利治疗反应的相关性。方法入选284例初次诊断高血压病的患者,根据24h尿蛋白排泄率(urinary albumin excretion,UAER)水平分为高血压组(UAER<20μg/min)和高血压肾损害组(UAER≥20μg/min)。检测IL-6水平及IL-6-572、IL-6-174基因多态性。然后用贝那普利干预,观察具备IL-6-572、IL-6-174的不同基因型的患者的治疗反应。结果高血压肾损害组中,IL-6-572的CG基因型、IL-6-174的GG基因型比例最高。贝那普利治疗对具有IL-6-572GG基因型、IL-6-174CC基因型的高血压肾损害患者治疗效果最佳。结论IL-6-572、IL-6-174基因多态性与高血压肾损害及其对贝那普利治疗的反应相关。
文摘目的系统评价东亚人群IL-6-572C/G基因多态性与乙型肝炎病毒(HBV)感染易感性的关系。方法在PubMed、Web of Science、中国知网、万方数据库、维普网中搜索基于东亚人群的IL-6-572C/G(rs1800796C>G)基因多态性与HBV感染关系的病例对照研究,检索时限均为建库至2021年10月,采用Stata S12.0软件进行meta分析。结果最终纳入10篇文献,包括3532例乙型肝炎病毒感染者和4020例对照者。meta分析结果显示:携带G等位基因和GG+GC、GG、GC基因型是东亚人群HBV感染的保护因素[G vs C(OR=0.80,95%CI:0.74~0.87,P<0.001);GG+GC vs CC(OR=0.77,95%CI:0.70~0.85,P<0.001);GG vs CG+CC(OR=0.72,95%CI:0.59~0.87,P=0.001);GC vs CC(OR=0.79,95%CI:0.72~0.87,P<0.001);GG vs CC(OR=0.66,95%CI:0.54~0.80,P<0.001)]。结论东亚人群中IL-6-572基因多态性改变(C>G)可能会降低HBV感染的风险。
文摘Extraction of Y(III) and Dy(III) from hydrochloric and nitric acids by Cy-572 in kerosene was studied. The factors affecting the extraction were separately investigated. The stoichiometry of the extracted species was deduced on the basis of slope analysis method. Evaluation of extraction equilibrium and stripping investigation was studied as well as saponification effect of Cy-572. The composition of the extracted metal species in the organic phase was found to be [MA·(HA)] for Y(III) or Dy(III) in both media.1.0 mol/L HCI is the best stripping agent for each metal ion from the studied acidic media in one step.Saponified Cy-572 does not exhibit any selectivity towards the extraction of Y(III) or Dy(III) from both HCI and HNOsolutions. Based on the obtained results, the data were compared and the separation feasibility between lanthanides and Y(III) in the two media was discussed.
