目的研究新佐剂-Montanide ISA 50V2在马免疫中的应用,制定合理的免疫程序,提高马免疫血清效价。方法用Montanide ISA 50V2乳化A型和F型肉毒类毒素制备成油乳抗原,免疫家兔和马,并与福氏不完全佐剂进行对比。结果在马免疫程序中,Montani...目的研究新佐剂-Montanide ISA 50V2在马免疫中的应用,制定合理的免疫程序,提高马免疫血清效价。方法用Montanide ISA 50V2乳化A型和F型肉毒类毒素制备成油乳抗原,免疫家兔和马,并与福氏不完全佐剂进行对比。结果在马免疫程序中,Montanide ISA 50V2与福氏不完全佐剂交替使用效果更好,免疫效价较高。结论在进一步试验确证后,将Montanide ISA 50V2作为佐剂应用于马免疫中,以获得更高的免疫血清的效价。展开更多
Honeycombing Lung(HCL)is a chronic lung condition marked by advanced fibrosis,resulting in enlarged air spaces with thick fibrotic walls,which are visible on Computed Tomography(CT)scans.Differentiating between normal...Honeycombing Lung(HCL)is a chronic lung condition marked by advanced fibrosis,resulting in enlarged air spaces with thick fibrotic walls,which are visible on Computed Tomography(CT)scans.Differentiating between normal lung tissue,honeycombing lungs,and Ground Glass Opacity(GGO)in CT images is often challenging for radiologists and may lead to misinterpretations.Although earlier studies have proposed models to detect and classify HCL,many faced limitations such as high computational demands,lower accuracy,and difficulty distinguishing between HCL and GGO.CT images are highly effective for lung classification due to their high resolution,3D visualization,and sensitivity to tissue density variations.This study introduces Honeycombing Lungs Network(HCL Net),a novel classification algorithm inspired by ResNet50V2 and enhanced to overcome the shortcomings of previous approaches.HCL Net incorporates additional residual blocks,refined preprocessing techniques,and selective parameter tuning to improve classification performance.The dataset,sourced from the University Malaya Medical Centre(UMMC)and verified by expert radiologists,consists of CT images of normal,honeycombing,and GGO lungs.Experimental evaluations across five assessments demonstrated that HCL Net achieved an outstanding classification accuracy of approximately 99.97%.It also recorded strong performance in other metrics,achieving 93%precision,100%sensitivity,89%specificity,and an AUC-ROC score of 97%.Comparative analysis with baseline feature engineering methods confirmed the superior efficacy of HCL Net.The model significantly reduces misclassification,particularly between honeycombing and GGO lungs,enhancing diagnostic precision and reliability in lung image analysis.展开更多
Achieving reliable and efficient weather classification for autonomous vehicles is crucial for ensuring safety and operational effectiveness.However,accurately classifying diverse and complex weather conditions remain...Achieving reliable and efficient weather classification for autonomous vehicles is crucial for ensuring safety and operational effectiveness.However,accurately classifying diverse and complex weather conditions remains a significant challenge.While advanced techniques such as Vision Transformers have been developed,they face key limitations,including high computational costs and limited generalization across varying weather conditions.These challenges present a critical research gap,particularly in applications where scalable and efficient solutions are needed to handle weather phenomena’intricate and dynamic nature in real-time.To address this gap,we propose a Multi-level Knowledge Distillation(MLKD)framework,which leverages the complementary strengths of state-of-the-art pre-trained models to enhance classification performance while minimizing computational overhead.Specifically,we employ ResNet50V2 and EfficientNetV2B3 as teacher models,known for their ability to capture complex image features and distil their knowledge into a custom lightweight Convolutional Neural Network(CNN)student model.This framework balances the trade-off between high classification accuracy and efficient resource consumption,ensuring real-time applicability in autonomous systems.Our Response-based Multi-level Knowledge Distillation(R-MLKD)approach effectively transfers rich,high-level feature representations from the teacher models to the student model,allowing the student to perform robustly with significantly fewer parameters and lower computational demands.The proposed method was evaluated on three public datasets(DAWN,BDD100K,and CITS traffic alerts),each containing seven weather classes with 2000 samples per class.The results demonstrate the effectiveness of MLKD,achieving a 97.3%accuracy,which surpasses conventional deep learning models.This work improves classification accuracy and tackles the practical challenges of model complexity,resource consumption,and real-time deployment,offering a scalable solution for weather classification in autonomous driving systems.展开更多
文摘目的研究新佐剂-Montanide ISA 50V2在马免疫中的应用,制定合理的免疫程序,提高马免疫血清效价。方法用Montanide ISA 50V2乳化A型和F型肉毒类毒素制备成油乳抗原,免疫家兔和马,并与福氏不完全佐剂进行对比。结果在马免疫程序中,Montanide ISA 50V2与福氏不完全佐剂交替使用效果更好,免疫效价较高。结论在进一步试验确证后,将Montanide ISA 50V2作为佐剂应用于马免疫中,以获得更高的免疫血清的效价。
文摘Honeycombing Lung(HCL)is a chronic lung condition marked by advanced fibrosis,resulting in enlarged air spaces with thick fibrotic walls,which are visible on Computed Tomography(CT)scans.Differentiating between normal lung tissue,honeycombing lungs,and Ground Glass Opacity(GGO)in CT images is often challenging for radiologists and may lead to misinterpretations.Although earlier studies have proposed models to detect and classify HCL,many faced limitations such as high computational demands,lower accuracy,and difficulty distinguishing between HCL and GGO.CT images are highly effective for lung classification due to their high resolution,3D visualization,and sensitivity to tissue density variations.This study introduces Honeycombing Lungs Network(HCL Net),a novel classification algorithm inspired by ResNet50V2 and enhanced to overcome the shortcomings of previous approaches.HCL Net incorporates additional residual blocks,refined preprocessing techniques,and selective parameter tuning to improve classification performance.The dataset,sourced from the University Malaya Medical Centre(UMMC)and verified by expert radiologists,consists of CT images of normal,honeycombing,and GGO lungs.Experimental evaluations across five assessments demonstrated that HCL Net achieved an outstanding classification accuracy of approximately 99.97%.It also recorded strong performance in other metrics,achieving 93%precision,100%sensitivity,89%specificity,and an AUC-ROC score of 97%.Comparative analysis with baseline feature engineering methods confirmed the superior efficacy of HCL Net.The model significantly reduces misclassification,particularly between honeycombing and GGO lungs,enhancing diagnostic precision and reliability in lung image analysis.
文摘Achieving reliable and efficient weather classification for autonomous vehicles is crucial for ensuring safety and operational effectiveness.However,accurately classifying diverse and complex weather conditions remains a significant challenge.While advanced techniques such as Vision Transformers have been developed,they face key limitations,including high computational costs and limited generalization across varying weather conditions.These challenges present a critical research gap,particularly in applications where scalable and efficient solutions are needed to handle weather phenomena’intricate and dynamic nature in real-time.To address this gap,we propose a Multi-level Knowledge Distillation(MLKD)framework,which leverages the complementary strengths of state-of-the-art pre-trained models to enhance classification performance while minimizing computational overhead.Specifically,we employ ResNet50V2 and EfficientNetV2B3 as teacher models,known for their ability to capture complex image features and distil their knowledge into a custom lightweight Convolutional Neural Network(CNN)student model.This framework balances the trade-off between high classification accuracy and efficient resource consumption,ensuring real-time applicability in autonomous systems.Our Response-based Multi-level Knowledge Distillation(R-MLKD)approach effectively transfers rich,high-level feature representations from the teacher models to the student model,allowing the student to perform robustly with significantly fewer parameters and lower computational demands.The proposed method was evaluated on three public datasets(DAWN,BDD100K,and CITS traffic alerts),each containing seven weather classes with 2000 samples per class.The results demonstrate the effectiveness of MLKD,achieving a 97.3%accuracy,which surpasses conventional deep learning models.This work improves classification accuracy and tackles the practical challenges of model complexity,resource consumption,and real-time deployment,offering a scalable solution for weather classification in autonomous driving systems.
