Aim To synthesize trans and cis-3, 4′, 5-trihydroxystilbene by a new convenient route. Methods The reaction of 3, 5-dimethoxybenzaldehyde （3） and 4-methoxy phenylacetonitrile （4） formed the stilbene skeleton. Aft...Aim To synthesize trans and cis-3, 4′, 5-trihydroxystilbene by a new convenient route. Methods The reaction of 3, 5-dimethoxybenzaldehyde （3） and 4-methoxy phenylacetonitrile （4） formed the stilbene skeleton. After hydrolyzation, decarboxylation, and demethylation, we obtained trans-3, 4′, 5-trihydroxystilbene （resveratrol）, which can be converted to its cis-isomer by photochemical isomerization. Results Starting from 3 and 4, trans and cis-3, 4′, 5-trihydroxystilbene were synthesized, respectively. Conclusion A facile method for the synthesis of trans and cis-hydroxystilbenes from readily available materials was established.展开更多
Study was carried out in rabbits to determine whether 3,4’,5-trihydroxystibene-3-β-nono-D-glucoside(PD)has wasodilative action using volumetric method.The result showed PD(1.71 mol/L)caused a right shift of the cumu...Study was carried out in rabbits to determine whether 3,4’,5-trihydroxystibene-3-β-nono-D-glucoside(PD)has wasodilative action using volumetric method.The result showed PD(1.71 mol/L)caused a right shift of the cumulative concentration-reponse curve of uorepinephfine(NE)and lowered the maximal response of rabbit’s pulmonary arteries.It implies that PD couldinhibit the vasoconstfictive effect of NE in a noncompetitive manner.PD dilated the pulmonaryarteries(4.09 and 5.12mmol/L)and the carotid(5.12mmol/L)of rabbits.This PD-induced relax-ation of puhnonary artenes was weakened by propranolol(87.8μmol/L).展开更多
文摘Aim To synthesize trans and cis-3, 4′, 5-trihydroxystilbene by a new convenient route. Methods The reaction of 3, 5-dimethoxybenzaldehyde （3） and 4-methoxy phenylacetonitrile （4） formed the stilbene skeleton. After hydrolyzation, decarboxylation, and demethylation, we obtained trans-3, 4′, 5-trihydroxystilbene （resveratrol）, which can be converted to its cis-isomer by photochemical isomerization. Results Starting from 3 and 4, trans and cis-3, 4′, 5-trihydroxystilbene were synthesized, respectively. Conclusion A facile method for the synthesis of trans and cis-hydroxystilbenes from readily available materials was established.
基金This project was supprted by the Natonal Natural Science Foundation of China No 3880738
文摘Study was carried out in rabbits to determine whether 3,4’,5-trihydroxystibene-3-β-nono-D-glucoside(PD)has wasodilative action using volumetric method.The result showed PD(1.71 mol/L)caused a right shift of the cumulative concentration-reponse curve of uorepinephfine(NE)and lowered the maximal response of rabbit’s pulmonary arteries.It implies that PD couldinhibit the vasoconstfictive effect of NE in a noncompetitive manner.PD dilated the pulmonaryarteries(4.09 and 5.12mmol/L)and the carotid(5.12mmol/L)of rabbits.This PD-induced relax-ation of puhnonary artenes was weakened by propranolol(87.8μmol/L).
