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2.5-dimensional Voronoi numerical simulation method for migration of direct roof in a longwall face
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作者 Bin Yu Yong Li +2 位作者 Yang Tai Weibing Zhu Wenyang Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第9期5560-5579,共20页
The fracture and migration patterns of direct roofs play a critical role in excavation stability and mining pressure.However,current methods fail to capture the irregular three-dimensional(3D)behavior of these roofs.I... The fracture and migration patterns of direct roofs play a critical role in excavation stability and mining pressure.However,current methods fail to capture the irregular three-dimensional(3D)behavior of these roofs.In this study,the problem was solved by introducing an innovative 2.5-dimensional(2.5D)Voronoi numerical simulation method,dividing rock layers into 2.5D Voronoi blocks and developing cohesive element-based failure models,supported by a strain-softening HoekeBrown model.The method was applied to the 8311 working face in the Taishan Mine in China,and its accuracy was confirmed through physical experiments.The following conclusions were drawn.The first roof break typically followed an"O-X"pattern.The direct roof did not break randomly over time;instead,it followed three distinct scenarios:(1)A complete break of the direct roof occurred,followed by a sequential collapse(ScenarioⅠ).(2)Regional irregular stacking in one area was followed by sequential collapse in other zones(ScenarioⅡ).(3)The staged breakdown of the direct roof led to separate and sequential collapses on the left and right flanks(ScenarioⅢ).Scenario I was quite common during the 400 m advance of the working face and occurred five times.The fracture characteristics in Scenario I led to widespread pressure on the hydraulic supports in the middle of the working face.Finally,the direct roof from the working face towards the goaf area underwent phases of overhanging,hinging,and collapsing plates.After the first and periodic breaks,the basic roof formed stable hinged plate structures reinforced by overhanging plates and irregular accumulations of the direct roof. 展开更多
关键词 2.5-dimensional(2.5D)Voronoi Direct roof Migration law Longwall face
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A 2.5-dimensional Analytical Model of Cold Leveling for Plates with Transverse Wave Defects 被引量:5
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作者 Wei-hua CHEN Juan LIU +2 位作者 Zhen-shan CUI Ying-jie WANG Ying-rui WANG 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2015年第8期664-671,共8页
Waves occurring in cold-rolled plates or sheets can be divided into longitudinal and transverse waves. Classical leveling theories merely solve the problem of longitudinal waves, while no well accepted method can be e... Waves occurring in cold-rolled plates or sheets can be divided into longitudinal and transverse waves. Classical leveling theories merely solve the problem of longitudinal waves, while no well accepted method can be employed for transverse waves. In order to investigate the essential deformation law of leveling for plates with transverse waves, a 2.5-dimensional (2.5- D) analytical approach was proposed. In this model, the plate was transversely divided into some strips with equal width; the strips are considered to be in the state of plane strain and each group of adjacent strips are assumed to be deformation compatible under stress. After calculation, the bending deformation of each strip and the leveling effect of overall plate were obtained by comprehensNe consideration of various strips along with the width. Bending of roller is a main approach to eliminate the transverse waves, which is widely accepted by the industry, but the essential effect of bending of roller on the deformation of plates and the calculation of bending of roller are unknown. According to the 2.5-D analytical model, it can be found that, for plates, it is neutral plane offsetting and middle plane elongation or contraction under inner stress that can effectively improve plate shape. Taking double side waves as an example, the appropriate values of bending of roller were obtained by the 2.5-D analytical model related to different initial unevenness, which was applicable to the current on-line adjusting of bending of roller in rolling industry. 展开更多
关键词 plate leveling 2.5-dimensional analytical model transverse wave middle plane deformation
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Hyperverse, 5-Dimensional Gravity and Multiverses as Nested Gogberashvili Shells
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作者 Igor Yu. Potemine 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2022年第4期983-989,共7页
We consider the Hyperverse as a collection of multiverses in 5-dimensional spacetime with gravitational constant G. Each multiverse in our simplified model is a bouquet of nested spherical Gogberashvili shells. If g&l... We consider the Hyperverse as a collection of multiverses in 5-dimensional spacetime with gravitational constant G. Each multiverse in our simplified model is a bouquet of nested spherical Gogberashvili shells. If g<sub>k</sub> is the gravitational constant of a thin shell S<sub>k</sub> and ε<sub>k</sub>, its thickness then G ~ ε<sub>k</sub>g<sub>k</sub>. The physical universe is supposed to be one of those shells inside the local nested bouquet called Local Multiverse. We relate this construction to Robinson-Trautman metrics describing expanding spacetimes with spherical gravitational waves. Supermassive astronomical black holes, located at cores of elliptic/spiral galaxies, are also conjecturally described within this theory. Our constructions are equally consistent with the modern theory of cosmological coupling. 展开更多
关键词 5-dimensional Gravity Black Hole MULTIVERSE Spherical Shell
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The Mass and Size of Photons in the 5-Dimensional Extended Space Model
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作者 V. A. Andreev D. Yu. Tsipenyuk 《Journal of Modern Physics》 2016年第11期1308-1315,共8页
We propose the generalization of Einstein’s special theory of relativity (STR). In our model, we use the (1 + 4)-dimensional space G, which is the extension of the (1 + 3)-dimensional Minkowski space M. As a fifth ad... We propose the generalization of Einstein’s special theory of relativity (STR). In our model, we use the (1 + 4)-dimensional space G, which is the extension of the (1 + 3)-dimensional Minkowski space M. As a fifth additional coordinate, the interval S is used. This value is constant under the usual Lorentz transformations in M, but it changes when the transformations in the extended space G are used. We call this model the Extended space model (ESM). From a physical point of view, our expansion means that processes in which the rest mass of the particles changes are acceptable now. In the ESM, gravity and electromagnetism are combined in one field. In the ESM, a photon can have a nonzero mass and this mass can be either positive or negative. It is also possible to establish in the frame of ESM connection between mass of a particle and its size. 展开更多
关键词 Photon MASS SIZE 5-dimensional Space Extended Space Model GRAVITATION Special Theory of Relativity
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The 5-dimensional model for electromagnetism and gravity
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作者 V. A. Andreev D. Yu. Tsipenyuk 《Natural Science》 2014年第4期248-253,共6页
The generalization of Einstein’s special theory of relativity (SRT) is proposed. In this model, the possibility of unification of scalar gravity and electromagnetism into a single unified field is considered. Formall... The generalization of Einstein’s special theory of relativity (SRT) is proposed. In this model, the possibility of unification of scalar gravity and electromagnetism into a single unified field is considered. Formally, the generalization of the SRT is that instead of (1+3)-dimensional Minkowski space the (1+4)-dimensional extension G is considered. As the fifth additional coordinate the interval S is used. This value is saved under the usual Lorentz transformations in Minkowski space M, but it changes when the transformations in the extended space G are used. We call this model the extended space model (ESM). From a physical point of view, our expansion means that processes in which the rest mass of the particles changes are acceptable now. If the rest mass of a particle does not change and the physical quantities do not depend on an additional variable S, then the electromagnetic and gravitational fields exist independently of each other. But if the rest mass is variable and there is a dependence on S, then these two fields are combined into a single unified field. In the extended space model a photon can have a nonzero mass and this mass can be either positive or negative. In this model the 5- vectors which components correspond to energy, pulse and mass of a particle are isotropic both for massive and massless particles. The rotations in the (1+4) dimensional extended space G can transform massive particles into massless and vice versa. 展开更多
关键词 GRAVITY Electromagnetism (1+4)-dimensional SPACE MASS of PHOTON NEGATIVE MASS
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A multi-dimensional trust attestation solution in 5G-IoT
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作者 Xiangrong Li Yu Zhang +2 位作者 Haotian Zhu Yubo Wang Junjia Huang 《Digital Communications and Networks》 2025年第1期225-233,共9页
The core missions of IoT are to sense data,transmit data and give feedback to the real world based on the calculation of the sensed data.The trust of sensing source data and transmission network is extremely important... The core missions of IoT are to sense data,transmit data and give feedback to the real world based on the calculation of the sensed data.The trust of sensing source data and transmission network is extremely important to IoT security.5G-IoT with its low latency,wide connectivity and high-speed transmission extends the business scenarios of IoT,yet it also brings new challenges to trust proof solutions of IoT.Currently,there is a lack of efficient and reliable trust proof solutions for massive dynamically connected nodes,while the existing solutions have high computational complexity and can't adapt to time-sensitive services in 5G-IoT scenarios.In order to solve the above problems,this paper proposes an adaptive multi-dimensional trust proof solution.Firstly,the static and dynamic attributes of sensing nodes are metricized,and the historical interaction as well as the recommendation information are combined with the comprehensive metric of sensing nodes,and a multi-dimensional fine-grained trusted metric model is established in this paper.Then,based on the comprehensive metrics,the sensing nodes are logically grouped and assigned with service levels to achieve the screening and isolation of malicious nodes.At the same time,the proposed solution reduces the energy consumption of the metric process and optimizes the impact of real-time metrics on the interaction latency.Simulation experiments show that the solution can accurately and efficiently identify malicious nodes and effectively guarantee the safe and trustworthy operation of 5G-IoT nodes,while having a small impact on the latency of the 5G network. 展开更多
关键词 5G-IoT Trusted metrics Trust model
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Amorphous-to-crystalline transition-induced two-step thin film growth of quasi-one-dimensional penta-telluride ZrTe_(5)
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作者 Yi Shuang Yuta Saito +3 位作者 Shogo Hatayama Paul Fons Ando Daisuke Yuji Sutou 《Journal of Materials Science & Technology》 2025年第7期246-253,共8页
Quasi-one-dimensional(quasi-1D)van der Waals(vdWs)materials,such as ZrTe_(5),exhibit unique elec-trical properties and quantum phenomena,making them attractive for advanced electronic applications.However,large-scale ... Quasi-one-dimensional(quasi-1D)van der Waals(vdWs)materials,such as ZrTe_(5),exhibit unique elec-trical properties and quantum phenomena,making them attractive for advanced electronic applications.However,large-scale growth of ZrTe_(5) thin films presents challenges.We address this by employing sput-tering,a common semiconductor industry technique.The as-deposited ZrTe_(5) film is amorphous,and post-annealing induces a crystallization process akin to transition-metal dichalcogenides.Our study in-vestigates the electrical and optical properties during this amorphous-to-crystalline transition,reveal-ing insights into the underlying mechanism.This work contributes to the fundamental understanding of quasi-1D materials and introduces a scalable fabrication method for ZrTe_(5) which offers the possibility of fabricating unique future electronic and optical devices. 展开更多
关键词 QUASI-ONE-dimensional ZrTe_(5) Large-scale Thin film PHASE-CHANGE
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Application of CPML to truncate the open boundaries of cylindrical waveguides in 2.5-dimensional problems 被引量:1
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作者 WANG Yue WANG Jianguo ZHANG Dianhui 《Science in China(Series F)》 2005年第5期656-669,共14页
In order to solve the problem of truncating the open boundaries of cylindrical waveguides used in the simulation of high power microwave (HPM) sources, this paper studies the convolutional PML (CPML) in the cylind... In order to solve the problem of truncating the open boundaries of cylindrical waveguides used in the simulation of high power microwave (HPM) sources, this paper studies the convolutional PML (CPML) in the cylindrical coordinate system. The electromagnetic field's FDTD equations and the expressions of axis boundary conditions are presented. Numerical experiments are conducted to validate the equations and axis boundary conditions. The performance of CPML is simulated when it is used to truncate the cylindrical waveguides excited by the sources with different frequencies and modes in the 2.5-dimensional problems. Numerical results show that the maximum relative errors are all less than -90 dB. The CPML method is introduced in the 2.5-dimensional electromagnetic PIC software, and the relativistic backward wave oscillator is simulated by using this method. The results show that the property of CPML is much better than that of the Mur-type absorbing boundary condition when they are used to truncate the open boundaries of waveguides. The CPML is especially suitable for truncating the open boundaries of the dispersive waveguide devices in the simulation of HPM sources. 展开更多
关键词 convolutional perfectly matched layer FDTD 2-5-dimensional problem WAVEGUIDE backwardwave oscillator TRUNCATION particle simulation.
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格拉瑟菌血清5型cpxAR双组分基因缺失株的生物学特性研究
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作者 徐引弟 王治方 +8 位作者 蔡旭旺 徐晓娟 张立宪 焦文强 朱文豪 李海利 游一 张家庆 雷亚楠 《河南农业科学》 北大核心 2026年第2期126-135,共10页
为研究cpxAR双组分基因在格拉瑟菌中的致病机制,同时筛选格拉瑟菌血清5型缺失弱毒株,构建格拉瑟菌血清5型临床分离株(GPS5)的cpxAR双基因缺失株(ΔcpxAR),并对缺失株的生长特性、生物膜形成能力、环境胁迫抗性及豚鼠致病力等生物学特性... 为研究cpxAR双组分基因在格拉瑟菌中的致病机制,同时筛选格拉瑟菌血清5型缺失弱毒株,构建格拉瑟菌血清5型临床分离株(GPS5)的cpxAR双基因缺失株(ΔcpxAR),并对缺失株的生长特性、生物膜形成能力、环境胁迫抗性及豚鼠致病力等生物学特性进行系统研究。结果表明,cpxAR基因缺失后,ΔcpxAR与亲本株GPS5相比,菌落形态和生长速率无明显差异,但生物膜形成能力明显减弱,对渗透压、热休克、氧化应激及碱性胁迫的抗性显著降低,对豚鼠的毒力也显著减弱。综上,cpxAR基因对GPS5的生长无明显调控作用,但对其生物膜形成、环境胁迫抗性及毒力均具有重要调控作用,为深入探究cpxAR双组分系统在格拉瑟菌中的生物学功能,以及筛选格拉瑟菌血清5型弱毒株奠定了基础。 展开更多
关键词 格拉瑟菌血清5 cpxAR基因缺失株 生长 生物膜 抗性 毒力
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乙酰丙酸改性对HZSM-5甲醇芳构化催化剂积炭行为的影响
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作者 李剑 乔永伟 +1 位作者 刘冲 杨丽娜 《石油学报(石油加工)》 北大核心 2026年第1期76-85,共10页
采用乙酰丙酸对HZSM-5甲醇芳构化催化剂进行酸处理改性,制得改性催化剂样品Lx-Z5(x为乙酰丙酸溶液质量分数,%)。为研究改性对催化剂积炭行为的影响,采用XRD、N_(2)吸附-脱附、NH_(3)-TPD、Py-FTIR和TGA/DTG等分析手段对新鲜的HZSM-5和Lx... 采用乙酰丙酸对HZSM-5甲醇芳构化催化剂进行酸处理改性,制得改性催化剂样品Lx-Z5(x为乙酰丙酸溶液质量分数,%)。为研究改性对催化剂积炭行为的影响,采用XRD、N_(2)吸附-脱附、NH_(3)-TPD、Py-FTIR和TGA/DTG等分析手段对新鲜的HZSM-5和Lx-Z5及失活的HZSM-5和Lx-Z5催化剂进行表征并评价其催化性能。结果表明,改性未破坏HZSM-5拓扑结构,但使其孔径、介孔孔体积增加,酸量及酸强度降低,Brønsted(B)/Lewis(L)酸量比(A_(B)/A_(L))增加,其中,L1.0-Z5催化剂样品的变化最显著。Lx-Z5催化剂的孔径、介孔孔体积及A_(B)/A_(L)的增加提升了苯-甲苯-二甲苯(BTX)选择性,孔径和介孔孔体积的增大、酸量及酸强度的降低减少了平均积炭速率、内积炭比例,提高了轻质积炭量,改性后再生性能更优。不同含量乙酰丙酸溶液改性中,L1.0-Z5样品的BTX选择性最高,使用寿命最长,平均积炭速率最低,容炭能力最强;相比HZSM-5催化剂,L1.0-Z5样品的BTX选择性、使用寿命分别增加5.55百分点和82 h,平均积炭速率降低0.36%/h。 展开更多
关键词 HZSM-5 乙酰丙酸改性 甲醇芳构化 寿命 积炭行为
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WO_(3)和TiO_(2)共掺V_(2)O_(5)复合薄膜的制备及其光电特性
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作者 王伟 李毅 +1 位作者 刘红薇 施张庆 《电子元件与材料》 北大核心 2026年第1期9-17,共9页
选用五氧化二钒、三氧化钨、二氧化钛粉末和过氧化氢溶液为原料,采用溶胶-凝胶法和后退火工艺在氟掺杂氧化锡导电玻璃基底上制备了三氧化钨和二氧化钛共掺五氧化二钒复合薄膜。通过场发射扫描电子显微镜、X射线衍射仪和X射线光电子能谱... 选用五氧化二钒、三氧化钨、二氧化钛粉末和过氧化氢溶液为原料,采用溶胶-凝胶法和后退火工艺在氟掺杂氧化锡导电玻璃基底上制备了三氧化钨和二氧化钛共掺五氧化二钒复合薄膜。通过场发射扫描电子显微镜、X射线衍射仪和X射线光电子能谱仪等表征了最佳配比下复合薄膜的表面形貌、结构和化学组成,利用分光光度计等测试手段分析了复合薄膜的光电特性。结果表明,在400~1200 nm波长范围内,复合薄膜在室温下的平均透过率为52.99%。当温度从室温升至400℃时,复合薄膜的电阻和透过率变化幅度分别达到83.7%和16.12%。在0~3.1 V的偏压下,复合薄膜的透过率随电压的增大而升高,在400~1200 nm波长范围内,平均透过率升高约12.21%;当偏压大于3.1 V时,复合薄膜的透过率随电压的增大而降低。经过多次高低温循环测试,该复合薄膜的光电特性具有较好的可逆热致光电性,在新型光电器件和传感器等领域展现出潜在应用前景。 展开更多
关键词 复合薄膜 V_(2)O_(5) TiO_(2) WO_(3) 溶胶-凝胶 光电特性
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5-羟甲基糠醛电催化氧化制备2,5-呋喃二羧酸的工艺研究
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作者 郑华均 杭怡欣 +3 位作者 郑文彬 赵浙菲 吕卓清 郑灵霞 《浙江工业大学学报》 北大核心 2026年第1期1-7,共7页
对5-羟甲基糠醛(HMF)电催化氧化制备2,5-呋喃二羧酸(FDCA)体系进行工艺优化和放大研究。通过简单的一步水热合成Ni_(3)S_(2)/NF,采用扫描电子显微镜(SEM)对其进行表征,通过线性扫描伏安法对制备的材料进行电化学测试,结果表明,放大面积... 对5-羟甲基糠醛(HMF)电催化氧化制备2,5-呋喃二羧酸(FDCA)体系进行工艺优化和放大研究。通过简单的一步水热合成Ni_(3)S_(2)/NF,采用扫描电子显微镜(SEM)对其进行表征,通过线性扫描伏安法对制备的材料进行电化学测试,结果表明,放大面积后水热法仍可制得表面均一、性能良好的电极。单因素实验结果表明:电解性能与反应温度、电解液流量等操作参数有关。在温度为35℃、电解液流量为150 L/h、恒电流为4.5 A的条件下进行HMF电合成FDCA实验,电流效率和转化率分别达到86.50%和99.58%,FDCA产率高达93.60%。 展开更多
关键词 5-羟甲基糠醛 2 5-呋喃二羧酸 电催化氧化 生产工艺
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HPLC-DAD法测定益气养血口服液中5-羟甲基糠醛
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作者 马彧 王丹彧 +2 位作者 马晓静 宋瑩 崔业波 《质量安全与检验检测》 2026年第1期34-37,共4页
本研究建立了益气养血口服液中5-羟甲基糠醛(5-HMF)的检测方法。采用HPLC-DAD法,Caprisil C_(18)-IP为色谱柱(250 mm×4.6 mm,5μm);流动相为甲醇-0.05%磷酸,梯度洗脱;体积流量为1.0 mL/min;柱温25℃;检测波长284 nm。结果显示,5-... 本研究建立了益气养血口服液中5-羟甲基糠醛(5-HMF)的检测方法。采用HPLC-DAD法,Caprisil C_(18)-IP为色谱柱(250 mm×4.6 mm,5μm);流动相为甲醇-0.05%磷酸,梯度洗脱;体积流量为1.0 mL/min;柱温25℃;检测波长284 nm。结果显示,5-羟甲基糠醛在2.539~55.389μg/mL内线性关系良好(r=1.0000),平均加样回收率为97.0%,RSD为0.2%。不同企业生产的样品中均检出5-羟甲基糠醛。5-羟甲基糠醛的产生可能与益气养血口服液生产工艺相关,建议在益气养血口服液的标准中增加5-羟甲基糠醛检查项。本研究建立的方法简便、准确,可为企业质量控制提供参考。 展开更多
关键词 5-羟甲基糠醛 益气养血口服液 高效液相色谱法
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5-氨基酮戊酸光动力疗法对CO_(2)激光治疗后持续阴道上皮内瘤变1级的疗效观察
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作者 王晶晶 姚红霞 +5 位作者 周卫强 高月清 陈瑞英 王潇 柳洁 浦筱雯 《同济大学学报(医学版)》 2026年第1期81-87,共7页
目的探讨5-氨基酮戊酸光动力疗法(5-aminolevulinic acid-based photodynamic therapy,ALA-PDT)治疗CO_(2)激光治疗后持续阴道上皮内瘤变1级(vaginal intraepithelial neoplasia 1,VaIN1)的临床疗效。方法回顾性收集2022年7月—2024年7... 目的探讨5-氨基酮戊酸光动力疗法(5-aminolevulinic acid-based photodynamic therapy,ALA-PDT)治疗CO_(2)激光治疗后持续阴道上皮内瘤变1级(vaginal intraepithelial neoplasia 1,VaIN1)的临床疗效。方法回顾性收集2022年7月—2024年7月在同济大学附属妇产科医院经CO_(2)激光治疗后持续VaIN1的57例患者。分别进行ALA-PDT(32例)和CO_(2)激光治疗(25例)。进行至少6个月的随访,比较HPV转阴率、VaIN1治愈率、不良反应和进展情况。结果治疗后3个月,ALA-PDT组和CO_(2)激光组HPV转阴率分别为46.9%和40.0%;治疗后6个月,ALA-PDT组和CO_(2)激光组HPV转阴率分别为50.0%和40.0%;治疗后3、6个月,两组HPV转阴率差异均无统计学意义(P>0.05)。治疗后3个月,ALA-PDT组和CO_(2)激光组VaIN1治愈率为78.1%和72.0%;治疗后6个月PDT组和CO_(2)激光组VaIN1治愈率为87.5%和72.0%;两组治疗后3个月和6个月VaIN1治愈率差异均无统计学意义(P>0.05)。两组治疗后阴道出血、分泌物增多、宫颈管或阴道壁粘连、溃疡发生率差异均存在统计学意义(P<0.05)。ALA-PDT组治疗后不良反应轻微,均在1周内好转。CO_(2)激光组出现5例患者宫颈管或阴道局部粘连,4例阴道溃疡。治疗后6个月ALA-PDT组1例患者进展为VaIN3。结论ALA-PDT是治疗CO_(2)激光治疗后持续VaIN1的新疗法,具有较高的治愈率和HPV清除率。 展开更多
关键词 阴道上皮内瘤变 人乳头瘤病毒感染 5-氨基酮戊酸光动力疗法 二氧化碳激光
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肺炎支原体肺炎患儿血清LXA4和KLF5表达的临床意义
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作者 张润春 李树华 +1 位作者 王玉珍 王巧文 《天津医药》 2026年第3期269-274,共6页
目的探讨肺炎支原体肺炎(MPP)患儿血清脂氧素A4(LXA4)、Kruppel样因子5(KLF5)的表达及其临床意义。方法纳入158例MPP患儿(MPP组)并根据病情分为重症组97例,轻症组61例,另根据患儿28 d预后情况分为预后良好组(105例)和预后不良组(53例),... 目的探讨肺炎支原体肺炎(MPP)患儿血清脂氧素A4(LXA4)、Kruppel样因子5(KLF5)的表达及其临床意义。方法纳入158例MPP患儿(MPP组)并根据病情分为重症组97例,轻症组61例,另根据患儿28 d预后情况分为预后良好组(105例)和预后不良组(53例),再同期选取健康儿童91例作为对照组。采用酶联免疫吸附试验(ELISA)检测血清LXA4、KLF5水平,多因素Logistic回归分析影响预后的因素,受试者工作特征(ROC)曲线分析血清LXA4、KLF5水平对病情的诊断及对预后的预测价值。结果与对照组相比,MPP组血清LXA4水平降低,KLF5水平升高(P<0.05);与轻症组相比,重症组血清LXA4水平降低,KLF5水平升高(P<0.05);血清LXA4、KLF5联合诊断患儿病情的ROC曲线下面积(AUC)为0.936(95%CI:0.886~0.969),二者联合优于各自单独诊断(Z二者联合-LXA4=2.728、Z二者联合-KLF5=4.208,P<0.05);预后不良组重症患儿占比、降钙素原(PCT)、C反应蛋白、住院时间以及血清KLF5水平较预后良好组升高,血清LXA4水平较预后良好组降低(P<0.05);重症病情,PCT、KLF5水平升高是影响MPP患儿预后不良的危险因素,而LXA4水平升高是保护因素(P<0.05);血清LXA4、KLF5联合预测预后AUC为0.935(95%CI:0.885~0.968),二者联合优于各自单独预测(Z二者联合-LXA4=4.270、Z二者联合-KLF5=3.136,P<0.05)。结论MPP患儿血清LXA4水平降低,KLF5水平升高,二者联合对诊断MPP患儿病情及预测预后有较高的临床应用价值。 展开更多
关键词 肺炎 支原体 脂氧素类 Kruppel样转录因子类 预后 脂氧素A4 Kruppel样因子5
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前馈控制干预联合综合运动在慢性肾脏病5期血液透析患者中的应用
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作者 陈英 王丹 《河南医学研究》 2026年第1期161-164,共4页
目的观察前馈控制干预联合综合运动在慢性肾脏病(CKD)5期患者中的应用效果。方法回顾分析,收集2022年4—9月于郑州市第一人民医院完成血液透析治疗和综合运动干预的30例CKD5期患者资料,作为对照组;收集2022年10月至2023年3月于医院完成... 目的观察前馈控制干预联合综合运动在慢性肾脏病(CKD)5期患者中的应用效果。方法回顾分析,收集2022年4—9月于郑州市第一人民医院完成血液透析治疗和综合运动干预的30例CKD5期患者资料,作为对照组;收集2022年10月至2023年3月于医院完成血液透析治疗和前馈控制干预联合综合运动干预的30例CKD 5期患者资料,作为观察组。两组患者干预时间均为3个月。记录干预前后心肺耐力相关指标水平[最大摄氧量(VO_(2 max))和代谢当量(METs)]、生活质量[采用肾脏疾病生活质量简表(KDQOL-SFTM 1.3)评估];记录患者干预期间并发症发生情况。结果干预前,两组患者心肺耐力、生活质量评分比较,差异无统计学意义(P>0.05),干预后,两组患者心肺耐力指标水平升高、生活质量量表评分升高,且观察组高于对照组(P<0.05);观察组并发症总发生率低于对照组(P<0.05)。结论前馈控制干预联合综合运动用于CKD 5期血液透析患者,能更好地提高患者心肺耐力,患者干预期间并发症发生情况减少,生活质量明显改善。 展开更多
关键词 慢性肾脏病5 血液透析 前馈控制 综合运动 心肺耐力 生活质量 并发症
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一种用于口罩佩戴检测的轻量级YOLOv5s改进算法
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作者 沈记全 马帅 +1 位作者 罗军伟 张霄宏 《河南理工大学学报(自然科学版)》 北大核心 2026年第1期153-160,共8页
目的为了在公共场所准确地检测口罩佩戴并根据检测结果进行人性化提醒,提出一种轻量化的YOLOv5s网络结构,并以此为基础构建一种快速的口罩佩戴检测方案,以应对真实场景中对口罩佩戴检测速度和准确性的双重要求。方法首先,对快速空间金... 目的为了在公共场所准确地检测口罩佩戴并根据检测结果进行人性化提醒,提出一种轻量化的YOLOv5s网络结构,并以此为基础构建一种快速的口罩佩戴检测方案,以应对真实场景中对口罩佩戴检测速度和准确性的双重要求。方法首先,对快速空间金字塔池化进行改进,用深度卷积替换原来的卷积,以达到对快速空间金字塔池化进行轻量化的目的;其次,提出自校准通道注意力机制,它由两级通道交互构成,第一级交互用于获取邻近通道之间的相关性并根据相关性计算通道权重,第二级交互用于在更大的通道范围内对第一级交互得到的通道权重进行校准,该机制已经应用在网络的Neck部分;再次,对加权双向特征金字塔网络进行改进,增加大尺度特征图和小尺度特征图的融合路径,以丰富融合后的小尺度特征图中包含的细节信息;最后,利用GhostConv模块和C3Ghost模块分别替换Backbone和Neck部分的Conv模块和C3模块,从而降低网络的计算量和参数量,达到对Backbone和Neck进行轻量化的目的。结果在自制数据集和公共数据集Moxa3K上的实验结果表明,所提方法与YOLOv5s相比,mAP分别提高了3.1%和2.9%,参数量分别降低了46.8%和46.8%,检测速度分别提升了25%和29.1%。结论实验结果证明了所提方法的有效性。 展开更多
关键词 口罩佩戴检测 YOLOv5 轻量化 注意力机制 双向特征融合
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Sirt5通过调控Ucp 1表达对白色脂肪组织褐变改善肥胖的影响研究
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作者 薛彦琼 张林霞 《医学理论与实践》 2026年第5期721-725,761,共6页
目的:探讨Sirt5通过调控Ucp 1表达对白色脂肪组织(WAT)褐变改善肥胖的影响。方法:将30只C57BL/6J雄性小鼠随机分为对照组、模型组和Sirt 5过表达组,每组10只。对照组进行正常饮食,模型组和Sirt 5过表达组进行高脂饮食构建肥胖模型。进... 目的:探讨Sirt5通过调控Ucp 1表达对白色脂肪组织(WAT)褐变改善肥胖的影响。方法:将30只C57BL/6J雄性小鼠随机分为对照组、模型组和Sirt 5过表达组,每组10只。对照组进行正常饮食,模型组和Sirt 5过表达组进行高脂饮食构建肥胖模型。进行糖耐量和胰岛素耐量检测,采用RT-PCR检测Sirt 5 mRNA相对表达水平,通过HE染色检测小鼠肝组织和WAT中的脂质堆积情况,进行组织称重和TG、TC水平检测,采用免疫组化染色检测Ucp1蛋白。结果:与对照组相比,模型组小鼠WAT中Sirt 5 mRNA相对表达及Ucp1蛋白阳性面积百分比均明显降低(P<0.05);与模型组相比,Sirt 5过表达组小鼠WAT中Sirt 5 mRNA相对表达及Ucp1蛋白阳性面积百分比显著升高(P<0.05)。与对照组相比,模型组小鼠的肝组织和WAT的TG、TC水平及肝组织和WAT的重量明显升高(P<0.05);与模型组相比,Sirt 5过表达组小鼠的肝组织和WAT的TG、TC水平及肝组织和WAT的重量显著降低(P<0.05),小鼠肝组织和WAT中的脂质堆积明显得到改善(P<0.05)。结论:Sirt 5过表达可以调节脂质水平,减轻肥胖相关症状,促进了WAT的褐变,从而为肥胖的干预提供了新的靶点。 展开更多
关键词 肥胖 白色脂肪组织褐变 Sirt 5 Ucp 1 脂质蓄积
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超声参数联合血清miR-129-5p、miR-654-5p对乳腺癌的诊断价值
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作者 代妮娜 张文君 张华 《检验医学与临床》 2026年第1期1-6,共6页
目的探讨超声参数联合血清miR-129-5p、miR-654-5p对乳腺癌的诊断价值。方法选取2021年12月至2023年12月在湖北省十堰市太和医院住院进行手术治疗的93例女性乳腺癌患者作为乳腺癌组,同期收治的93例女性乳腺良性病变患者作为良性组,另选... 目的探讨超声参数联合血清miR-129-5p、miR-654-5p对乳腺癌的诊断价值。方法选取2021年12月至2023年12月在湖北省十堰市太和医院住院进行手术治疗的93例女性乳腺癌患者作为乳腺癌组,同期收治的93例女性乳腺良性病变患者作为良性组,另选取同期在湖北省十堰市太和医院体检的93例女性健康体检者作为对照组。所有研究对象均进行超声检查,并记录相关参数[最大血流速度(V_(max))、血流阻力指数(RI)、搏动指数(PI)];采用实时荧光定量反转录聚合酶链反应检测所有研究对象血清miR-129-5p、miR-654-5p水平;绘制受试者工作特征(ROC)曲线分析V_(max)、RI、PI及血清miR-129-5p、miR-654-5p对乳腺癌的诊断价值。结果良性组、乳腺癌组血清miR-129-5p、miR-654-5p水平均明显低于对照组,且乳腺癌组血清miR-129-5p、miR-654-5p水平均低于良性组,差异均有统计学意义(P<0.05)。良性组、乳腺癌组V_(max)、RI、PI均明显高于对照组,且乳腺癌组V_(max)、RI、PI均高于良性组,差异均有统计学意义(P<0.05)。TNM分期为Ⅲ~Ⅳ期、有淋巴结转移、中低分化程度的乳腺癌患者血清miR-129-5p、miR-654-5p低表达比例均高于TNM分期为Ⅰ~Ⅱ期、无淋巴结转移、高分化程度的乳腺癌患者,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,V_(max)、RI、PI、miR-129-5p、miR-654-5p联合诊断乳腺癌的曲线下面积(AUC)为0.892,大于5项单独诊断的AUC(0.712、0.783、0.720、0.648、0.718),差异均有统计学意义(Z=4.013、4.215、3.889、6.223、3.887,P<0.05)。结论乳腺癌患者血清miR-129-5p、miR-654-5p水平均降低,超声参数(V_(max)、RI、PI)均升高,超声参数联合血清miR-129-5p、miR-654-5p诊断乳腺癌的价值较高。 展开更多
关键词 超声参数 miR-129-5p miR-654-5p 乳腺癌 诊断价值 微小RNA
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m^(5)C RNA甲基化修饰与前庭功能异常和老年性耳聋的相关性研究
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作者 周旭 司峰志 《河北医学》 2026年第1期117-122,共6页
目的:探讨m^(5)C RNA甲基化修饰在前庭功能和老年性耳聋中的相关性。方法:总计24只近交系C57BL/6J小鼠,5月龄(成年小鼠组)、12月龄(中年小鼠组)、20月龄(老年小鼠组)各8只。听觉脑干反应阈值分析评价小鼠听力。DCFH-DA(二氯二氢荧光素-... 目的:探讨m^(5)C RNA甲基化修饰在前庭功能和老年性耳聋中的相关性。方法:总计24只近交系C57BL/6J小鼠,5月龄(成年小鼠组)、12月龄(中年小鼠组)、20月龄(老年小鼠组)各8只。听觉脑干反应阈值分析评价小鼠听力。DCFH-DA(二氯二氢荧光素-乙酰乙酸酯)法测定耳蜗和前庭组织ROS水平。TAMRA探针法测定其中组织线粒体DNA的完整性。m^(5)C RNA甲基化修饰免疫共沉淀法分析小鼠耳蜗和前庭组织GRM7 mRNA m^(5)C水平。Western blot法测定其中NSUN2的水平。结果:与成年小鼠组和中年小鼠组相比,老年小鼠组在8、16和32 kHz时的平均ABR阈值升高(P<0.05);耳蜗组织和前庭组织ROS相对水平均升高(P<0.05);含CD mtDNA占比(%)均降低(P<0.05);NSUN2相对表达水平均降低(P<0.05);GRM7 Input mRNA相对表达水平均降低(P<0.05);GRM7 m^(5)C mRNA相对表达水平降低(P<0.05)。老年小鼠组,与耳蜗组织组相比,前庭组织组ROS相对水平较低(P<0.05),GRM7 Input mRNA和GRM7 m^(5)C mRNA相对表达水平较高(P<0.05)。结论:m^(5)C甲基化修饰RNA水平下调及NSUN2表达水平降低与前庭功能和老年性耳聋相关。 展开更多
关键词 老年性耳聋 前庭功能 C57BL/6J小鼠 m^(5)C RNA甲基化修饰 NOP2/Sun RNA甲基转移酶2
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