SF_6因具有良好的绝缘效果而被广泛地应用于电力系统中。但同时,SF_6也是一种温室气体,随着环境问题日益恶化,人们迫切需要找到替代SF_6的绝缘气体。为此,通过实验研究了环境友好气体c-C_4F_8及c-C_4F_8/N_2混合气体替代SF_6的可行性。...SF_6因具有良好的绝缘效果而被广泛地应用于电力系统中。但同时,SF_6也是一种温室气体,随着环境问题日益恶化,人们迫切需要找到替代SF_6的绝缘气体。为此,通过实验研究了环境友好气体c-C_4F_8及c-C_4F_8/N_2混合气体替代SF_6的可行性。通过调节电极间隙(1~6 mm)和气压(150~350 k Pa),测量了气体在不同条件下的击穿电压及击穿电流波形,得到了气体的绝缘特性并与SF_6气体进行了对比分析。实验结果表明:纯净的c-C_4F_8气体的绝缘强度约为SF_6的1.3倍,体积比为1:1的c-C_4F_8/N_2混合气体的绝缘强度约为与SF_6的0.9倍。通过计算,c-C_4F_8/N_2混合气体的液化温度可以达到电力系统使用要求。考虑到c-C_4F_8气体对于环境的影响较小,使用c-C_4F_8/N_2混合气体作为替代SF_6的绝缘气体,有着良好的应用前景。展开更多
Hearing relies on the structural and functional integrity of cochlear hair cells,particularly their apical F-actin-filled stereocilia.Phospholipid scramblases are important for maintaining membrane asymmetry,but their...Hearing relies on the structural and functional integrity of cochlear hair cells,particularly their apical F-actin-filled stereocilia.Phospholipid scramblases are important for maintaining membrane asymmetry,but their roles in the stereocilia and auditory functions are not fully understood.Here,we identify Plscr5 as a downstream target of the transcription factor POU4F3 essential for hair cell function,whose mutation causes human DFNA15 deafness.Plscr5 knockout mice exhibit progressive hearing loss due to stereocilia degeneration and hair cell loss.Functional analyses reveal that PLSCR5 contributes to phosphatidylserine externalization in hair cell apical membranes,particularly in inner hair cells,and is important for outer hair cell and stereocilia maintenance.Our findings highlight PLSCR5 as an important downstream effector of POU4F3 and regulator of phosphatidylserine externalization and membrane dynamics required for auditory functions.展开更多
本文从分析目前研学实践活动开展所存在的问题出发,提出将4F教学模式融入研学实践活动方案设计的优势,并以内蒙古集宁区霸王河国家湿地公园为例,确立基于地理学科核心素养的研学目标,依据4F教学模式的四个阶段设计研学活动实施过程,同...本文从分析目前研学实践活动开展所存在的问题出发,提出将4F教学模式融入研学实践活动方案设计的优势,并以内蒙古集宁区霸王河国家湿地公园为例,确立基于地理学科核心素养的研学目标,依据4F教学模式的四个阶段设计研学活动实施过程,同时制定了基于4F模式的评价量表,对学生的研学过程与研学结果进行全方位多角度评价,以期提高研学效果,为相关研究者和一线地理教师更好地设计基于4F模式的研学实践活动方案提供参考。Based on the analysis of the existing problems in the development of current research practice activities, this paper proposes the advantages of integrating 4F teaching mode into the design of research practice activities. Taking Bawanghe National Wetland Park in Jining District, Inner Mongolia as an example, this paper establishes research objectives based on the core accomplishment of geography, and designs the implementation process of research activities according to the four stages of 4F teaching mode. At the same time, an evaluation scale based on 4F model is developed to evaluate students’ research process and research results from a comprehensive and multi-angle, in order to improve the research effect and provide references for relevant researchers and front-line geography teachers to better design research practice activities based on 4F model.展开更多
研学旅行可以让学生在真实的自然和社会情境中,通过亲身体验和观察,开阔视野、增长能力和培养素养。4F教学模式作为一种符合学生认知规律的教学模式,与地理研学旅行具有一定的适切性,本文以包头钢铁集团的研学资源为依托,依据4F教学模...研学旅行可以让学生在真实的自然和社会情境中,通过亲身体验和观察,开阔视野、增长能力和培养素养。4F教学模式作为一种符合学生认知规律的教学模式,与地理研学旅行具有一定的适切性,本文以包头钢铁集团的研学资源为依托,依据4F教学模式的四个环节Fact (事实)、Feel (感受)、Find (发现)、Future (未来)设计了以工业为主题的研学活动,激发学生的学习兴趣,培养学生的探究精神和地理学科核心素养,此外,还设计了基于4F教学模式的评价量表对学生的研学过程和研学成果进行评价。Research travel allows students to broaden their horizons, develop their abilities and cultivate their literacy through personal experience and observation in real natural and social situations. 4F teaching mode, as a teaching mode that conforms to the cognitive law of students, is of certain relevance to geographical research travel. This paper relies on the research resources of Baotou Iron and Steel Group. According to the four links of 4F teaching mode, namely Fact, Feel, Find and Future, research activities with industry as the theme are designed to stimulate students’ interest in learning, cultivate students’ spirit of inquiry and the core quality of geography. In addition, the evaluation scale based on 4F teaching model is also designed to evaluate students’ research process and research results.展开更多
文摘SF_6因具有良好的绝缘效果而被广泛地应用于电力系统中。但同时,SF_6也是一种温室气体,随着环境问题日益恶化,人们迫切需要找到替代SF_6的绝缘气体。为此,通过实验研究了环境友好气体c-C_4F_8及c-C_4F_8/N_2混合气体替代SF_6的可行性。通过调节电极间隙(1~6 mm)和气压(150~350 k Pa),测量了气体在不同条件下的击穿电压及击穿电流波形,得到了气体的绝缘特性并与SF_6气体进行了对比分析。实验结果表明:纯净的c-C_4F_8气体的绝缘强度约为SF_6的1.3倍,体积比为1:1的c-C_4F_8/N_2混合气体的绝缘强度约为与SF_6的0.9倍。通过计算,c-C_4F_8/N_2混合气体的液化温度可以达到电力系统使用要求。考虑到c-C_4F_8气体对于环境的影响较小,使用c-C_4F_8/N_2混合气体作为替代SF_6的绝缘气体,有着良好的应用前景。
基金supported by the National Natural Science Foundation of China(82171136 and 92368110 to G.W.,82201291 to G.-J.Z.,82192861 to Z.X.,81970884 and 82192862 to X.G.)the Natural Science Foundation of Jiangsu Province(BK20220188 to Q.L.,BK20220189 to G.-J.Z.)the Fundamental Research Funds for the Central Universities(021414380533 to G.W.).
文摘Hearing relies on the structural and functional integrity of cochlear hair cells,particularly their apical F-actin-filled stereocilia.Phospholipid scramblases are important for maintaining membrane asymmetry,but their roles in the stereocilia and auditory functions are not fully understood.Here,we identify Plscr5 as a downstream target of the transcription factor POU4F3 essential for hair cell function,whose mutation causes human DFNA15 deafness.Plscr5 knockout mice exhibit progressive hearing loss due to stereocilia degeneration and hair cell loss.Functional analyses reveal that PLSCR5 contributes to phosphatidylserine externalization in hair cell apical membranes,particularly in inner hair cells,and is important for outer hair cell and stereocilia maintenance.Our findings highlight PLSCR5 as an important downstream effector of POU4F3 and regulator of phosphatidylserine externalization and membrane dynamics required for auditory functions.
文摘本文从分析目前研学实践活动开展所存在的问题出发,提出将4F教学模式融入研学实践活动方案设计的优势,并以内蒙古集宁区霸王河国家湿地公园为例,确立基于地理学科核心素养的研学目标,依据4F教学模式的四个阶段设计研学活动实施过程,同时制定了基于4F模式的评价量表,对学生的研学过程与研学结果进行全方位多角度评价,以期提高研学效果,为相关研究者和一线地理教师更好地设计基于4F模式的研学实践活动方案提供参考。Based on the analysis of the existing problems in the development of current research practice activities, this paper proposes the advantages of integrating 4F teaching mode into the design of research practice activities. Taking Bawanghe National Wetland Park in Jining District, Inner Mongolia as an example, this paper establishes research objectives based on the core accomplishment of geography, and designs the implementation process of research activities according to the four stages of 4F teaching mode. At the same time, an evaluation scale based on 4F model is developed to evaluate students’ research process and research results from a comprehensive and multi-angle, in order to improve the research effect and provide references for relevant researchers and front-line geography teachers to better design research practice activities based on 4F model.
文摘研学旅行可以让学生在真实的自然和社会情境中,通过亲身体验和观察,开阔视野、增长能力和培养素养。4F教学模式作为一种符合学生认知规律的教学模式,与地理研学旅行具有一定的适切性,本文以包头钢铁集团的研学资源为依托,依据4F教学模式的四个环节Fact (事实)、Feel (感受)、Find (发现)、Future (未来)设计了以工业为主题的研学活动,激发学生的学习兴趣,培养学生的探究精神和地理学科核心素养,此外,还设计了基于4F教学模式的评价量表对学生的研学过程和研学成果进行评价。Research travel allows students to broaden their horizons, develop their abilities and cultivate their literacy through personal experience and observation in real natural and social situations. 4F teaching mode, as a teaching mode that conforms to the cognitive law of students, is of certain relevance to geographical research travel. This paper relies on the research resources of Baotou Iron and Steel Group. According to the four links of 4F teaching mode, namely Fact, Feel, Find and Future, research activities with industry as the theme are designed to stimulate students’ interest in learning, cultivate students’ spirit of inquiry and the core quality of geography. In addition, the evaluation scale based on 4F teaching model is also designed to evaluate students’ research process and research results.
