With the increasing maturity of 5G technology and the comprehensive development of video apps on the Internet,the landscape of video app downloads shows that Migu Video lags behind giants like iQiyi,Tencent Video,Youk...With the increasing maturity of 5G technology and the comprehensive development of video apps on the Internet,the landscape of video app downloads shows that Migu Video lags behind giants like iQiyi,Tencent Video,Youku,and Mango TV.However,during the Tokyo Olympics and the Beijing Winter Olympics,Migu Video’s focus on sports coverage and commentary led to increased public use and app downloads.This study analyzes the marketing status and strategy of the Migu Video App.It conducts a detailed analysis using the 4I theory-interest,interaction,individuality,and initiative-and proposes a brand marketing strategy tailored for Migu Video.This aims to provide insights into the marketing strategies of other mobile Internet companies.展开更多
Memory deficits with aging are related to the neurodegeneration in the brain, including a reduction in arginine vasopressin(AVP) in the brain of patients with Alzheimer’s disease(AD). AVP(4-8), different from its pre...Memory deficits with aging are related to the neurodegeneration in the brain, including a reduction in arginine vasopressin(AVP) in the brain of patients with Alzheimer’s disease(AD). AVP(4-8), different from its precursor AVP, plays memory enhancement roles in the CNS without peripheral side-effects. However, it is not clear whether AVP(4-8) can improve cognitive behaviors and synaptic plasticity in the APP/PS1 mouse model of AD. Here, we investigated for the first time the neuroprotective effects of AVP(4-8) on memory behaviors and in vivo long-term potentiation(LTP) in APP/PS1-AD mice.The results showed that:(1) APP/PS1-AD mice had lower spontaneous alternation in the Y-maze than wild-type(WT) mice, and this was significantly reversed by AVP(4-8);(2) the prolonged escape latency of APP/PS1-AD mice in the Morris water maze was significantly decreased by AVP(4-8), and the decreased swimming time in target quadrant recovered significantly after AVP(4-8) treatment;(3) in vivo hippocampal LTP induced by high-frequency stimulation had a significant deficit in the AD mice, and this was partly rescued by AVP(4-8);(4) AVP(4-8)significantly up-regulated the expression levels of postsynaptic density 95(PSD95) and nerve growth factor(NGF)in the hippocampus of AD mice. These results reveal the beneficial effects of AVP(4-8) in APP/PS1-AD mice,showing that the intranasal administration of AVP(4-8)effectively improved the working memory and long-term spatial memory of APP/PS1-AD mice, which may be associated with the elevation of PSD95 and NGF levels in the brain and the maintenance of hippocampal synaptic plasticity.展开更多
基金Suihua University 2022 Project“Exploration and Practice of the Connotation Construction of Agricultural Product Circulation Discipline Professional Cluster”(Project No.2022007)。
文摘With the increasing maturity of 5G technology and the comprehensive development of video apps on the Internet,the landscape of video app downloads shows that Migu Video lags behind giants like iQiyi,Tencent Video,Youku,and Mango TV.However,during the Tokyo Olympics and the Beijing Winter Olympics,Migu Video’s focus on sports coverage and commentary led to increased public use and app downloads.This study analyzes the marketing status and strategy of the Migu Video App.It conducts a detailed analysis using the 4I theory-interest,interaction,individuality,and initiative-and proposes a brand marketing strategy tailored for Migu Video.This aims to provide insights into the marketing strategies of other mobile Internet companies.
基金the National Natural Science Foundation of China(31471080)the Scientific Program for“Sanjin Scholars”of Shanxi Province,Shanxi“1331 Project”Key Subjects Construction(1331KSC)Science Foundation for Excellent Young Scholars of Shanxi Province,China(201801D211005)。
文摘Memory deficits with aging are related to the neurodegeneration in the brain, including a reduction in arginine vasopressin(AVP) in the brain of patients with Alzheimer’s disease(AD). AVP(4-8), different from its precursor AVP, plays memory enhancement roles in the CNS without peripheral side-effects. However, it is not clear whether AVP(4-8) can improve cognitive behaviors and synaptic plasticity in the APP/PS1 mouse model of AD. Here, we investigated for the first time the neuroprotective effects of AVP(4-8) on memory behaviors and in vivo long-term potentiation(LTP) in APP/PS1-AD mice.The results showed that:(1) APP/PS1-AD mice had lower spontaneous alternation in the Y-maze than wild-type(WT) mice, and this was significantly reversed by AVP(4-8);(2) the prolonged escape latency of APP/PS1-AD mice in the Morris water maze was significantly decreased by AVP(4-8), and the decreased swimming time in target quadrant recovered significantly after AVP(4-8) treatment;(3) in vivo hippocampal LTP induced by high-frequency stimulation had a significant deficit in the AD mice, and this was partly rescued by AVP(4-8);(4) AVP(4-8)significantly up-regulated the expression levels of postsynaptic density 95(PSD95) and nerve growth factor(NGF)in the hippocampus of AD mice. These results reveal the beneficial effects of AVP(4-8) in APP/PS1-AD mice,showing that the intranasal administration of AVP(4-8)effectively improved the working memory and long-term spatial memory of APP/PS1-AD mice, which may be associated with the elevation of PSD95 and NGF levels in the brain and the maintenance of hippocampal synaptic plasticity.
