The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.H...The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.展开更多
Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability...Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability of the triazine ring structure within cyanate ester(CE)crosslinked networks after molding posed significant challenges for both recycling,repairing,and degradation of resin.To address these obstacles,dynamic thiocyanate ester(TCE)bonds and photocurable group were incorporated into CE,obtaining the recyclable and 3D printable CE covalent adaptable networks(CANs),denoted as PTCE1.5.This material exhibits a Young's modulus of 810 MPa and a tensile strength of 50.8 MPa.Notably,damaged printed PTCE1.5 objects can be readily repaired through reprinting and interface rejoining by thermal treatment.Leveraging the solid-state plasticity,PTCE1.5 also demonstrated attractive shape memory ability and permanent shape reconfigurability,enabling its reconfigurable 4D printing.The printed PTCE1.5 hinges and a main body were assembled into a deployable and retractable satellite model,validating its potential application as a controllable component in the aerospace field.Moreover,printed PTCE1.5 can be fully degraded into thiol-modified intermediate products.Overall,this material not only enriches the application range of CE resin,but also provides a reliable approach to addressing environmental issue.展开更多
Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopo...Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopogonis radix,and Clematidis radix et rhizoma,as well as nephrotoxicity-related targets,were screened through databases such as TCMSP,Swiss Target Prediction,GeneCards,and ETCM.Venny 2.1.0 was used to identify the main components of Lianqiao-4 and nephrotoxicity targets.The STRING platform and David database were utilized to construct a protein-protein interaction(PPI)network diagram,while gene function(GO)enrichment analysis and KEGG pathway analysis were conducted.The“Lianqiao-4 active ingredients-nephrotoxicity targets-signaling pathways”network model was constructed using Cytoscape 3.9.1 software.Results:Network pharmacology and molecular docking analysis revealed that the core active ingredients responsible for the nephrotoxicity mechanism of Mongolian medicine Lianqiao-4 include steroidal saponins such as ophiopogonin A,flavonoids like kaempferol and quercetin,steroidal compounds such asβ-sitosterol and sitosterol,and other key regulatory targets including STAT3,ABCG2,HSP90AA1,MMP9,PTGS2,and EGFR.Major pathways involved include lipid and atherosclerosis,chemical carcinogenesis-DNA adducts,and arachidonic acid metabolism.Conclusion:Mongolian medicine Lianqiao-4 exerts its therapeutic effect on nephrotoxicity through multiple components,targets,and pathways,pending experimental verification.展开更多
为了有效实现高谐波抑制并提高功率附加效率,提出了一种适用于4G-LTE无线通信系统的高效F类功率放大器。该功率放大器使用了低电压p-HEMT晶体管和小型微带抑制单元,能够在低射频输入功率下产生n次谐波抑制和较高的功率附加效率PAE(Power...为了有效实现高谐波抑制并提高功率附加效率,提出了一种适用于4G-LTE无线通信系统的高效F类功率放大器。该功率放大器使用了低电压p-HEMT晶体管和小型微带抑制单元,能够在低射频输入功率下产生n次谐波抑制和较高的功率附加效率PAE(Power Added Efficiency)。采用谐波平衡法对提出的功率放大器进行了仿真分析。测量结果显示,提出功率放大器的工作频率为1.8 GHz,带宽为100 MHz,平均PAE为76.9%,且具有2 V的极低漏极电压。射频输入功率范围分别为0~12 d Bm时,最大输出功率和增益分别为23.4 d Bm和17.5 d Bm。展开更多
We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from Drug Bank, SuperT arget, TTD(Therapeutic Targets Database) and other databases and the relevant signali...We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from Drug Bank, SuperT arget, TTD(Therapeutic Targets Database) and other databases and the relevant signaling pathways from the KEGG(Kyoto Encyclopedia of Genes and Genomes) database and established models of the chemical composition-target network and chemical composition-target- disease network using Cytoscape software, the analysis indicated that the chemical composition had at least nine different types of targets that acted together to exert effects on the diseases, suggesting a "multi-component, multi-target" feature of the traditional Mongolian medicine. We also employed the rat model of rheumatoid arthritis induced by Collgen Type II to validate the key targets of the chemical components of Sendeng-4, and three of the key targets were validated through laboratory experiments, further confirming the anti-inflammatory effects of Sendeng-4. In all, this study predicted the active ingredients and targets of Sendeng-4, and explored its mechanism of action, which provided new strategies and methods for further research and development of Sendeng-4 and other traditional Mongolian medicines as well.展开更多
A new three-dimensional supramolecular [Ce2（2,5-pydc）3（H2O）2]（1） has been hydrothermally synthesized at 180 ℃ and characterized by single-crystal X-ray diffraction.X-ray crystal analyses reveal that the compoun...A new three-dimensional supramolecular [Ce2（2,5-pydc）3（H2O）2]（1） has been hydrothermally synthesized at 180 ℃ and characterized by single-crystal X-ray diffraction.X-ray crystal analyses reveal that the compound belongs to the monoclinic system,space group P21/c,C21H13Ce2N3O14,a = 6.561（1）,b = 17.986（5）,c = 9.411（3） ,β = 95.558（5）° and Z = 2.In the structure of 1,each Ce（1） center is surrounded by 2,5-pydc ligands,forming the 6-connected node,and the 2,5-pydc ligand coordinates to the Ce（Ⅲ） in two different coordination modes.In mode 1,the four oxygen atoms of two carboxyl groups connect neighboring Ce（Ⅲ） ions,giving 4-connected（4-c） second building unit（SBU-1）.Furthermore,the structure is extended into a 2-D layer from SBU-1 by sharing Ce（1） atoms.In mode 2,the ligand coordinates to the Ce（Ⅲ） ion from the adjacent chain with the 4-connected（4-c） second building unit（SBU-2）,generating a 1-D ladder from SBU-2 by sharing Ce（1） atoms.Finally,the structure is extended into a 6,4,4-c network.Its photoluminescence property was also investigated.展开更多
A fuzzy neural network (FNN) model is developed to predict the 4-CBA concentration of the oxidation unit in purified terephthalic acid process. Several technologies are used to deal with the process data before modeli...A fuzzy neural network (FNN) model is developed to predict the 4-CBA concentration of the oxidation unit in purified terephthalic acid process. Several technologies are used to deal with the process data before modeling.First,a set of preliminary input variables is selected according to prior knowledge and experience. Secondly,a method based on the maximum correlation coefficient is proposed to detect the dead time between the process variables and response variables. Finally, the fuzzy curve method is used to reduce the unimportant input variables.The simulation results based on industrial data show that the relative error range of the FNN model is narrower than that of the American Oil Company (AMOCO) model. Furthermore, the FNN model can predict the trend of the 4-CBA concentration more accurately.展开更多
基金supported by the National Key Research and Development Program of China under Grant 2022YFB2901501in part by the Science and Technology Innovation leading Talents Subsidy Project of Central Plains under Grant 244200510038.
文摘The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.
基金supported by the National Natural Science Foundation of China(Nos.52473080,52403167 and 52173079)the Fundamental Research Funds for the Central Universities(Nos.xtr052023001 and xzy012023037)+1 种基金the Postdoctoral Research Project of Shaanxi Province(No.2024BSHSDZZ054)the Shaanxi Laboratory of Advanced Materials(No.2024ZY-JCYJ-04-12).
文摘Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability of the triazine ring structure within cyanate ester(CE)crosslinked networks after molding posed significant challenges for both recycling,repairing,and degradation of resin.To address these obstacles,dynamic thiocyanate ester(TCE)bonds and photocurable group were incorporated into CE,obtaining the recyclable and 3D printable CE covalent adaptable networks(CANs),denoted as PTCE1.5.This material exhibits a Young's modulus of 810 MPa and a tensile strength of 50.8 MPa.Notably,damaged printed PTCE1.5 objects can be readily repaired through reprinting and interface rejoining by thermal treatment.Leveraging the solid-state plasticity,PTCE1.5 also demonstrated attractive shape memory ability and permanent shape reconfigurability,enabling its reconfigurable 4D printing.The printed PTCE1.5 hinges and a main body were assembled into a deployable and retractable satellite model,validating its potential application as a controllable component in the aerospace field.Moreover,printed PTCE1.5 can be fully degraded into thiol-modified intermediate products.Overall,this material not only enriches the application range of CE resin,but also provides a reliable approach to addressing environmental issue.
文摘Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopogonis radix,and Clematidis radix et rhizoma,as well as nephrotoxicity-related targets,were screened through databases such as TCMSP,Swiss Target Prediction,GeneCards,and ETCM.Venny 2.1.0 was used to identify the main components of Lianqiao-4 and nephrotoxicity targets.The STRING platform and David database were utilized to construct a protein-protein interaction(PPI)network diagram,while gene function(GO)enrichment analysis and KEGG pathway analysis were conducted.The“Lianqiao-4 active ingredients-nephrotoxicity targets-signaling pathways”network model was constructed using Cytoscape 3.9.1 software.Results:Network pharmacology and molecular docking analysis revealed that the core active ingredients responsible for the nephrotoxicity mechanism of Mongolian medicine Lianqiao-4 include steroidal saponins such as ophiopogonin A,flavonoids like kaempferol and quercetin,steroidal compounds such asβ-sitosterol and sitosterol,and other key regulatory targets including STAT3,ABCG2,HSP90AA1,MMP9,PTGS2,and EGFR.Major pathways involved include lipid and atherosclerosis,chemical carcinogenesis-DNA adducts,and arachidonic acid metabolism.Conclusion:Mongolian medicine Lianqiao-4 exerts its therapeutic effect on nephrotoxicity through multiple components,targets,and pathways,pending experimental verification.
文摘为了有效实现高谐波抑制并提高功率附加效率,提出了一种适用于4G-LTE无线通信系统的高效F类功率放大器。该功率放大器使用了低电压p-HEMT晶体管和小型微带抑制单元,能够在低射频输入功率下产生n次谐波抑制和较高的功率附加效率PAE(Power Added Efficiency)。采用谐波平衡法对提出的功率放大器进行了仿真分析。测量结果显示,提出功率放大器的工作频率为1.8 GHz,带宽为100 MHz,平均PAE为76.9%,且具有2 V的极低漏极电压。射频输入功率范围分别为0~12 d Bm时,最大输出功率和增益分别为23.4 d Bm和17.5 d Bm。
基金supported by the National Natural Science Foundation of China(No.81160550)Inner Mongolia Natural Science Foundation(No.2013JQ03)2010 Science and Technology Project of social development in Inner Mongolia
文摘We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from Drug Bank, SuperT arget, TTD(Therapeutic Targets Database) and other databases and the relevant signaling pathways from the KEGG(Kyoto Encyclopedia of Genes and Genomes) database and established models of the chemical composition-target network and chemical composition-target- disease network using Cytoscape software, the analysis indicated that the chemical composition had at least nine different types of targets that acted together to exert effects on the diseases, suggesting a "multi-component, multi-target" feature of the traditional Mongolian medicine. We also employed the rat model of rheumatoid arthritis induced by Collgen Type II to validate the key targets of the chemical components of Sendeng-4, and three of the key targets were validated through laboratory experiments, further confirming the anti-inflammatory effects of Sendeng-4. In all, this study predicted the active ingredients and targets of Sendeng-4, and explored its mechanism of action, which provided new strategies and methods for further research and development of Sendeng-4 and other traditional Mongolian medicines as well.
文摘A new three-dimensional supramolecular [Ce2（2,5-pydc）3（H2O）2]（1） has been hydrothermally synthesized at 180 ℃ and characterized by single-crystal X-ray diffraction.X-ray crystal analyses reveal that the compound belongs to the monoclinic system,space group P21/c,C21H13Ce2N3O14,a = 6.561（1）,b = 17.986（5）,c = 9.411（3） ,β = 95.558（5）° and Z = 2.In the structure of 1,each Ce（1） center is surrounded by 2,5-pydc ligands,forming the 6-connected node,and the 2,5-pydc ligand coordinates to the Ce（Ⅲ） in two different coordination modes.In mode 1,the four oxygen atoms of two carboxyl groups connect neighboring Ce（Ⅲ） ions,giving 4-connected（4-c） second building unit（SBU-1）.Furthermore,the structure is extended into a 2-D layer from SBU-1 by sharing Ce（1） atoms.In mode 2,the ligand coordinates to the Ce（Ⅲ） ion from the adjacent chain with the 4-connected（4-c） second building unit（SBU-2）,generating a 1-D ladder from SBU-2 by sharing Ce（1） atoms.Finally,the structure is extended into a 6,4,4-c network.Its photoluminescence property was also investigated.
基金Supported by the National Outstanding Youth Science Foundation of China (No. 60025308).
文摘A fuzzy neural network (FNN) model is developed to predict the 4-CBA concentration of the oxidation unit in purified terephthalic acid process. Several technologies are used to deal with the process data before modeling.First,a set of preliminary input variables is selected according to prior knowledge and experience. Secondly,a method based on the maximum correlation coefficient is proposed to detect the dead time between the process variables and response variables. Finally, the fuzzy curve method is used to reduce the unimportant input variables.The simulation results based on industrial data show that the relative error range of the FNN model is narrower than that of the American Oil Company (AMOCO) model. Furthermore, the FNN model can predict the trend of the 4-CBA concentration more accurately.
