原发性高血压(essential hypertension,EH)主要特征为循环动脉血压增高,伴有器官功能损害^([1])。EH发病率逐年上升,并有年轻化趋势^([2])。长期持续的高血压会造成心脏和血管等发生改变,其中左心室肥厚为常见并发症,会导致心律失常、...原发性高血压(essential hypertension,EH)主要特征为循环动脉血压增高,伴有器官功能损害^([1])。EH发病率逐年上升,并有年轻化趋势^([2])。长期持续的高血压会造成心脏和血管等发生改变,其中左心室肥厚为常见并发症,会导致心律失常、心肌梗死等,严重威胁患者的生命健康^([3-4])。因此寻找早期评估左心室肥厚的指标可有效改善患者病情。分泌型卷曲相关蛋白2(secreted frizzled-related protein 2,SFRP2)作为Wnt结合蛋白家族的一员,可通过双向调控Wnt等通路调控心肌纤维化、心肌肥大^([5-6])。可溶性信号素4D(soluble signalling element 4D,sSema4D)参与心房颤动、冠心病以及高血压等疾病的进展^([7-8])。本研究旨在探讨EH患者血清SFRP2、sSema4D水平与左心室肥厚的关系。展开更多
This paper studies urban waterlog_draining decision support system based on the 4D data fusion technique.4D data includes DEM,DOQ,DLG and DRG.It supplies entire databases for waterlog forecast and analysis together wi...This paper studies urban waterlog_draining decision support system based on the 4D data fusion technique.4D data includes DEM,DOQ,DLG and DRG.It supplies entire databases for waterlog forecast and analysis together with non_spatial fundamental database.Data composition and reasoning are two key steps of 4D data fusion.Finally,this paper gives a real case: Ezhou Waterlog_Draining Decision Support System (EWDSS) with two application models,i.e.,DEM application model,water generating and draining model.展开更多
Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical trea...Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.展开更多
This paper presents chaos synchronization between two different four-dimensional （4D） hyperchaotic Chen systems by nonlinear feedback control laws. A modified 4D hyperchaotic Chen system is obtained by changing the ...This paper presents chaos synchronization between two different four-dimensional （4D） hyperchaotic Chen systems by nonlinear feedback control laws. A modified 4D hyperchaotic Chen system is obtained by changing the nonlinear function of the 4D hyperchaotic Chen system, furthermore, an electronic circuit to realize two different 4D hyperchaotic Chen systems is designed. With nonlinear feedback control method, chaos synchronization between two different 4D hyperchaotic Chen systems is achieved. Based on the stability theory~ the functions of the nonlinear feedback control for synchronization of two different 4D hyperchaotic Chen systems is derived, the range of feedback gains is determined. Numerical simulations are shown to verify the theoretical results.展开更多
文摘原发性高血压(essential hypertension,EH)主要特征为循环动脉血压增高,伴有器官功能损害^([1])。EH发病率逐年上升,并有年轻化趋势^([2])。长期持续的高血压会造成心脏和血管等发生改变,其中左心室肥厚为常见并发症,会导致心律失常、心肌梗死等,严重威胁患者的生命健康^([3-4])。因此寻找早期评估左心室肥厚的指标可有效改善患者病情。分泌型卷曲相关蛋白2(secreted frizzled-related protein 2,SFRP2)作为Wnt结合蛋白家族的一员,可通过双向调控Wnt等通路调控心肌纤维化、心肌肥大^([5-6])。可溶性信号素4D(soluble signalling element 4D,sSema4D)参与心房颤动、冠心病以及高血压等疾病的进展^([7-8])。本研究旨在探讨EH患者血清SFRP2、sSema4D水平与左心室肥厚的关系。
文摘This paper studies urban waterlog_draining decision support system based on the 4D data fusion technique.4D data includes DEM,DOQ,DLG and DRG.It supplies entire databases for waterlog forecast and analysis together with non_spatial fundamental database.Data composition and reasoning are two key steps of 4D data fusion.Finally,this paper gives a real case: Ezhou Waterlog_Draining Decision Support System (EWDSS) with two application models,i.e.,DEM application model,water generating and draining model.
文摘Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.
基金Project supported by the National Natural Science Foundation of China （Grant No 90405011）, the Natural Science Foundation of Jiangsu Province, China （Grant No 05KJD120083） and the Natural Science Foundation of Nanjing Institute of Technology, China （Grant No KXJ06047）.
文摘This paper presents chaos synchronization between two different four-dimensional （4D） hyperchaotic Chen systems by nonlinear feedback control laws. A modified 4D hyperchaotic Chen system is obtained by changing the nonlinear function of the 4D hyperchaotic Chen system, furthermore, an electronic circuit to realize two different 4D hyperchaotic Chen systems is designed. With nonlinear feedback control method, chaos synchronization between two different 4D hyperchaotic Chen systems is achieved. Based on the stability theory~ the functions of the nonlinear feedback control for synchronization of two different 4D hyperchaotic Chen systems is derived, the range of feedback gains is determined. Numerical simulations are shown to verify the theoretical results.
文摘目的基于4D Flow MRI技术探究急性心肌梗死患者左心室(left ventricular,LV)腔内局部血流动能(kinetic energy,KE)改变。方法纳入30名急性心肌梗死(acute myocardial infarction,AMI)患者和20名对照者。应用4D Flow MRI技术定量评价左心室腔内血流动能,包括左心室平均动能、最小动能、收缩期动能、舒张期动能以及平面内动能(in-plane kinetic energy,In-plane KE)百分比。比较心肌梗死组和对照组之间以及梗死节段与非梗死节段之间血流动能参数的差异。结果与对照组相比,急性心肌梗死组左心室整体平均动能(10.7μJ/mL±3.3 vs 14.7μJ/mL±3.6,P<0.001)、收缩期动能(14.6μJ/mL±5.1 vs 18.9μJ/mL±3.9,P=0.003)及舒张期动能(7.9μJ/mL±2.5 vs 10.6μJ/mL±3.8,P=0.018)均显著降低,其中梗死节段较非梗死节段邻近心腔血流的平均动能降低而收缩期平面内动能百分比增加(49.5μJ/mL±18.7 vs 126.3μJ/mL±50.7,P<0.001;61.8%±11.5 vs 42.9%±14.4,P=0.001)。结论4D Flow MRI技术可定量评价左心室腔内局部血流动能参数。急性心肌梗死后整体心腔血流动能减低,而梗死节段邻近心腔局部血流平面内动能百分比增加。
