原发性高血压(essential hypertension,EH)主要特征为循环动脉血压增高,伴有器官功能损害^([1])。EH发病率逐年上升,并有年轻化趋势^([2])。长期持续的高血压会造成心脏和血管等发生改变,其中左心室肥厚为常见并发症,会导致心律失常、...原发性高血压(essential hypertension,EH)主要特征为循环动脉血压增高,伴有器官功能损害^([1])。EH发病率逐年上升,并有年轻化趋势^([2])。长期持续的高血压会造成心脏和血管等发生改变,其中左心室肥厚为常见并发症,会导致心律失常、心肌梗死等,严重威胁患者的生命健康^([3-4])。因此寻找早期评估左心室肥厚的指标可有效改善患者病情。分泌型卷曲相关蛋白2(secreted frizzled-related protein 2,SFRP2)作为Wnt结合蛋白家族的一员,可通过双向调控Wnt等通路调控心肌纤维化、心肌肥大^([5-6])。可溶性信号素4D(soluble signalling element 4D,sSema4D)参与心房颤动、冠心病以及高血压等疾病的进展^([7-8])。本研究旨在探讨EH患者血清SFRP2、sSema4D水平与左心室肥厚的关系。展开更多
Four-dimensional(4D)printing technology is a revolutionary development that produces structures that can adapt in response to external stimuli.However,the responsiveness and printability of smart materials with shape ...Four-dimensional(4D)printing technology is a revolutionary development that produces structures that can adapt in response to external stimuli.However,the responsiveness and printability of smart materials with shape memory properties,which are necessary for 4D printing,remain limited.Biomass materials derived from nature have offered an effective solution due to their various excellent and unique properties.Biomass materials have been abundant in resources and low in carbon content,contributing to the then-current global green energy-saving goals,including carbon peaking and carbon neutrality.This review focused on different sources of biomass materials used in 4D printing,including plant-based,animal-based,and microbial-based biomass materials.It systematically outlined the responsive deformation mechanisms of printed objects that contained biomass materials and delved into the roles and unique advantages of biomass materials in those printed objects.Leveraging these advantages,the review discussed the potential applications of biomass materials in biomedicine,food printing,and other fields to support ongoing development and application efforts.Additionally,it emphasized the crucial role played by bio-fabrication technologies utilizing biomass materials in the integration of biomass materials with 4D printing.Finally,this paper discussed the then-current challenges and potential future directions of biomass materials in 4D printing,aiming to promote the effective development of biomass materials in 4D printing applications.展开更多
【目的】为了探讨应用4D左心房自动定量分析(4D Auto LAQ)软件测定的左房容积和应变值对鉴别毛细血管前肺动脉高压和毛细血管后肺动脉高压的价值,并与肺-左心房应变偶联指数(ePLAGS)的鉴别能力进行比较。【方法】本研究为回顾性研究,共...【目的】为了探讨应用4D左心房自动定量分析(4D Auto LAQ)软件测定的左房容积和应变值对鉴别毛细血管前肺动脉高压和毛细血管后肺动脉高压的价值,并与肺-左心房应变偶联指数(ePLAGS)的鉴别能力进行比较。【方法】本研究为回顾性研究,共纳入了自2021年7月至2022年4月就诊于中山大学附属第一医院门诊或住院部的98例高概率肺动脉高压(PH)患者,收集所有患者的临床病史及实验室资料。根据肺动脉楔压(PAWP)将所有患者分为2组:毛细血管前PH组(PAWP≤15 mmHg)及毛细血管后PH组(PAWP>15 mmHg)。所纳入的患者均接受了经胸超声心动图检查,并应用4D Auto LAQ软件自动测量左房容积和应变参数。【结果】根据PAWP的数值,入选患者分为两组:毛细血管前PH组[n=39,年龄(53±24)岁]和毛细血管后PH组[n=59,年龄(57±18)岁]。与毛细血管前PH组相比,毛细血管后PH组的最大左心房容量指数(LAVImax)、最小左心房容量指数(LAVImin)和左心房射血前的容量指数(LAVIpreA)显著增加,而左心房储备期纵向应变值(LASr)和左心房导管期纵向应变值(LAScd)明显降低。多元逻辑回归分析显示,LAVImax[OR:1.40;95%CI:(1.052,1.872);P=0.021]和LAScd[OR:1.76;95%CI:(1.183,2.489);P=0.004]是检测毛细血管后PH的强大独立预测因子。ROC曲线分析表明,LAVImax(AUC=0.82,P<0.001)和LAScd(AUC=0.78,P<0.001)在预测毛细血管后PH组方面具有很高的辨别力,其临界值分别为35.69 mL/m^(2)(敏感性86%,特异性74%)和-9%(敏感性80%,特异性70%)。【结论】:应用4D auto LAQ测量的LAVImax和LAScd是区分毛细血管前和毛细血管后PH患者有价值的参数,且其鉴别能力优于肺-左心房应变偶联指数(ePLAGS)。展开更多
文摘原发性高血压(essential hypertension,EH)主要特征为循环动脉血压增高,伴有器官功能损害^([1])。EH发病率逐年上升,并有年轻化趋势^([2])。长期持续的高血压会造成心脏和血管等发生改变,其中左心室肥厚为常见并发症,会导致心律失常、心肌梗死等,严重威胁患者的生命健康^([3-4])。因此寻找早期评估左心室肥厚的指标可有效改善患者病情。分泌型卷曲相关蛋白2(secreted frizzled-related protein 2,SFRP2)作为Wnt结合蛋白家族的一员,可通过双向调控Wnt等通路调控心肌纤维化、心肌肥大^([5-6])。可溶性信号素4D(soluble signalling element 4D,sSema4D)参与心房颤动、冠心病以及高血压等疾病的进展^([7-8])。本研究旨在探讨EH患者血清SFRP2、sSema4D水平与左心室肥厚的关系。
基金the support by National Natural Science Foundation of China(No.52375314,12472147,U23A20412)the National Key R&D Program of China(No.2024YFB4710205,2024YFD2200700)Heilongjiang Provincial Natural Science Foundation of China(No.2022ZX02C25).
文摘Four-dimensional(4D)printing technology is a revolutionary development that produces structures that can adapt in response to external stimuli.However,the responsiveness and printability of smart materials with shape memory properties,which are necessary for 4D printing,remain limited.Biomass materials derived from nature have offered an effective solution due to their various excellent and unique properties.Biomass materials have been abundant in resources and low in carbon content,contributing to the then-current global green energy-saving goals,including carbon peaking and carbon neutrality.This review focused on different sources of biomass materials used in 4D printing,including plant-based,animal-based,and microbial-based biomass materials.It systematically outlined the responsive deformation mechanisms of printed objects that contained biomass materials and delved into the roles and unique advantages of biomass materials in those printed objects.Leveraging these advantages,the review discussed the potential applications of biomass materials in biomedicine,food printing,and other fields to support ongoing development and application efforts.Additionally,it emphasized the crucial role played by bio-fabrication technologies utilizing biomass materials in the integration of biomass materials with 4D printing.Finally,this paper discussed the then-current challenges and potential future directions of biomass materials in 4D printing,aiming to promote the effective development of biomass materials in 4D printing applications.
文摘目的基于4D Flow MRI技术探究急性心肌梗死患者左心室(left ventricular,LV)腔内局部血流动能(kinetic energy,KE)改变。方法纳入30名急性心肌梗死(acute myocardial infarction,AMI)患者和20名对照者。应用4D Flow MRI技术定量评价左心室腔内血流动能,包括左心室平均动能、最小动能、收缩期动能、舒张期动能以及平面内动能(in-plane kinetic energy,In-plane KE)百分比。比较心肌梗死组和对照组之间以及梗死节段与非梗死节段之间血流动能参数的差异。结果与对照组相比,急性心肌梗死组左心室整体平均动能(10.7μJ/mL±3.3 vs 14.7μJ/mL±3.6,P<0.001)、收缩期动能(14.6μJ/mL±5.1 vs 18.9μJ/mL±3.9,P=0.003)及舒张期动能(7.9μJ/mL±2.5 vs 10.6μJ/mL±3.8,P=0.018)均显著降低,其中梗死节段较非梗死节段邻近心腔血流的平均动能降低而收缩期平面内动能百分比增加(49.5μJ/mL±18.7 vs 126.3μJ/mL±50.7,P<0.001;61.8%±11.5 vs 42.9%±14.4,P=0.001)。结论4D Flow MRI技术可定量评价左心室腔内局部血流动能参数。急性心肌梗死后整体心腔血流动能减低,而梗死节段邻近心腔局部血流平面内动能百分比增加。
文摘【目的】为了探讨应用4D左心房自动定量分析(4D Auto LAQ)软件测定的左房容积和应变值对鉴别毛细血管前肺动脉高压和毛细血管后肺动脉高压的价值,并与肺-左心房应变偶联指数(ePLAGS)的鉴别能力进行比较。【方法】本研究为回顾性研究,共纳入了自2021年7月至2022年4月就诊于中山大学附属第一医院门诊或住院部的98例高概率肺动脉高压(PH)患者,收集所有患者的临床病史及实验室资料。根据肺动脉楔压(PAWP)将所有患者分为2组:毛细血管前PH组(PAWP≤15 mmHg)及毛细血管后PH组(PAWP>15 mmHg)。所纳入的患者均接受了经胸超声心动图检查,并应用4D Auto LAQ软件自动测量左房容积和应变参数。【结果】根据PAWP的数值,入选患者分为两组:毛细血管前PH组[n=39,年龄(53±24)岁]和毛细血管后PH组[n=59,年龄(57±18)岁]。与毛细血管前PH组相比,毛细血管后PH组的最大左心房容量指数(LAVImax)、最小左心房容量指数(LAVImin)和左心房射血前的容量指数(LAVIpreA)显著增加,而左心房储备期纵向应变值(LASr)和左心房导管期纵向应变值(LAScd)明显降低。多元逻辑回归分析显示,LAVImax[OR:1.40;95%CI:(1.052,1.872);P=0.021]和LAScd[OR:1.76;95%CI:(1.183,2.489);P=0.004]是检测毛细血管后PH的强大独立预测因子。ROC曲线分析表明,LAVImax(AUC=0.82,P<0.001)和LAScd(AUC=0.78,P<0.001)在预测毛细血管后PH组方面具有很高的辨别力,其临界值分别为35.69 mL/m^(2)(敏感性86%,特异性74%)和-9%(敏感性80%,特异性70%)。【结论】:应用4D auto LAQ测量的LAVImax和LAScd是区分毛细血管前和毛细血管后PH患者有价值的参数,且其鉴别能力优于肺-左心房应变偶联指数(ePLAGS)。
