A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ~1H NMR,^(13)C NMR,IR and HRMS.The biological activities were primarily evaluated ...A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ~1H NMR,^(13)C NMR,IR and HRMS.The biological activities were primarily evaluated against Eimeria tenella according to Anticoccidial Index(ACI) method in vivo.The results showed that compounds 5e,5f and 5i exhibited anticoccidial activities against E.tenella at 27 mg kg^(-1).展开更多
The thermal behavior and kinetic parameters of the major exothermic decomposition reaction of the title compound in a temperature-programmed mode were studied by means of TG-DTG and DSC. The critical temperature of th...The thermal behavior and kinetic parameters of the major exothermic decomposition reaction of the title compound in a temperature-programmed mode were studied by means of TG-DTG and DSC. The critical temperature of thermal explosion was calculated. The effect of the title compound on the combustion characteristic of composition modifier double base propellant containing RDX was explored with a strand burner. The results show that the kinetic model function in differential forms, the apparent activation energy(E a) and the pre-exponential factor(A) of the major exothermic decomposition reaction are 3(1-α)[-ln(1-α)] 2/3, 190.56 kJ/mol and 10 13.39 s -1, respectively. The critical temperature of thermal explosion of the compound is 353.08 ℃. The kinetic equation of the major exothermic decomposition process of the title compound at 0.1 MPa could be expressed as dα/dT=10 14.65(1-α)[-ln(1-α)] 2/3 e -2.2920×104/T. As an auxiliary catalyzer, the title compound can help the main catalyzer of lead salt of 4-hydroxy-3,5-dinitropyridine to accelerate the burning rate and reduce the pressure exponent of RDX-CMDB propellant.展开更多
A study on catalytic dehydration of 4-hydroxy-3-hexanone （HH） to 4-hexen-3-one （HO） was carried out through conversion of HH over HZSM-5 zeolite catalyst in a fixed-bed reactor （FBR） operating under almospheric ...A study on catalytic dehydration of 4-hydroxy-3-hexanone （HH） to 4-hexen-3-one （HO） was carried out through conversion of HH over HZSM-5 zeolite catalyst in a fixed-bed reactor （FBR） operating under almospheric pressure. The test indicated a relatively high activity of the HZSM-5 zeolite capable of achieving a HH conversion of 99.2% and a HO yield of 83.5%. Catalyst deactivation could be prevented by increasing the reaction temperature by 10 ＂C for every 20 h and adding 2.0% of piperidine in the feed. A catalyst stability test （for 100 h） in FBR showed that the catalyst was active even after 100 h of time-on-stream with HH conversion remaining at 99.2% and HO yield still reaching over 83.5%. Regenera- tion experiment showed that the regenerated catalyst demonstrated a catalytic performance comparable to the fresh one.展开更多
The title compound [2-hydroxy-5-（4-hydroxy-3-phenyliminomethyl-benzyl）-benzylidene]-phenyl-amine （C27H22N2O2, Mr = 406.47） was synthesized by 5,5′-methylene-bissalicylal- dehyde with aminobenezene, and its crysta...The title compound [2-hydroxy-5-（4-hydroxy-3-phenyliminomethyl-benzyl）-benzylidene]-phenyl-amine （C27H22N2O2, Mr = 406.47） was synthesized by 5,5′-methylene-bissalicylal- dehyde with aminobenezene, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 4.4026（6）, b = 1.501（13）, c = 0.95818（12） nm, β = 90.868（2）°, V= 4.2813（9） nm^3, Z= 8, Dc= 1.292 g/cm^3,μ = 0.010, F（000） = 1744, R = 0.0576 and wR = 0.1450 for 3766 observed reflections with I 〉 2σ（I）. X-ray analysis reveals that the molecule has a pair of intramolecular OH…N hydrogen bonds.展开更多
基金support from the National Science Foundation of China(No.20372052)
文摘A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ~1H NMR,^(13)C NMR,IR and HRMS.The biological activities were primarily evaluated against Eimeria tenella according to Anticoccidial Index(ACI) method in vivo.The results showed that compounds 5e,5f and 5i exhibited anticoccidial activities against E.tenella at 27 mg kg^(-1).
文摘The thermal behavior and kinetic parameters of the major exothermic decomposition reaction of the title compound in a temperature-programmed mode were studied by means of TG-DTG and DSC. The critical temperature of thermal explosion was calculated. The effect of the title compound on the combustion characteristic of composition modifier double base propellant containing RDX was explored with a strand burner. The results show that the kinetic model function in differential forms, the apparent activation energy(E a) and the pre-exponential factor(A) of the major exothermic decomposition reaction are 3(1-α)[-ln(1-α)] 2/3, 190.56 kJ/mol and 10 13.39 s -1, respectively. The critical temperature of thermal explosion of the compound is 353.08 ℃. The kinetic equation of the major exothermic decomposition process of the title compound at 0.1 MPa could be expressed as dα/dT=10 14.65(1-α)[-ln(1-α)] 2/3 e -2.2920×104/T. As an auxiliary catalyzer, the title compound can help the main catalyzer of lead salt of 4-hydroxy-3,5-dinitropyridine to accelerate the burning rate and reduce the pressure exponent of RDX-CMDB propellant.
基金supported by the Science and Technology Planning Program of Tianjin(Project No.12ZXCXGX21900)
文摘A study on catalytic dehydration of 4-hydroxy-3-hexanone （HH） to 4-hexen-3-one （HO） was carried out through conversion of HH over HZSM-5 zeolite catalyst in a fixed-bed reactor （FBR） operating under almospheric pressure. The test indicated a relatively high activity of the HZSM-5 zeolite capable of achieving a HH conversion of 99.2% and a HO yield of 83.5%. Catalyst deactivation could be prevented by increasing the reaction temperature by 10 ＂C for every 20 h and adding 2.0% of piperidine in the feed. A catalyst stability test （for 100 h） in FBR showed that the catalyst was active even after 100 h of time-on-stream with HH conversion remaining at 99.2% and HO yield still reaching over 83.5%. Regenera- tion experiment showed that the regenerated catalyst demonstrated a catalytic performance comparable to the fresh one.
基金supported by the Project for Distinguished Young Scholars from Hubei Provincial Department of Education (No. Q20082601)
文摘The title compound [2-hydroxy-5-（4-hydroxy-3-phenyliminomethyl-benzyl）-benzylidene]-phenyl-amine （C27H22N2O2, Mr = 406.47） was synthesized by 5,5′-methylene-bissalicylal- dehyde with aminobenezene, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 4.4026（6）, b = 1.501（13）, c = 0.95818（12） nm, β = 90.868（2）°, V= 4.2813（9） nm^3, Z= 8, Dc= 1.292 g/cm^3,μ = 0.010, F（000） = 1744, R = 0.0576 and wR = 0.1450 for 3766 observed reflections with I 〉 2σ（I）. X-ray analysis reveals that the molecule has a pair of intramolecular OH…N hydrogen bonds.
