During the hyperacute phase of intracerebral hemorrhage(ICH),the mass effect and blood components mechanically lead to brain damage and neurotoxicity.Our findings revealed that the mass effect and transferrin precipit...During the hyperacute phase of intracerebral hemorrhage(ICH),the mass effect and blood components mechanically lead to brain damage and neurotoxicity.Our findings revealed that the mass effect and transferrin precipitate neuronal oxidative stress and iron uptake,culminating in ferroptosis in neurons.M6A(N6-methyladenosine)modification,the most prevalent mRNA modification,plays a critical role in various cell death pathways.The Fto(fat mass and obesity-associated protein)demethylase has been implicated in numerous signaling pathways of neurological diseases by modulating m6A mRNA levels.Regulation of Fto protein levels in neurons effectively mitigated mass effect-induced neuronal ferroptosis.Applying nanopore direct RNA sequencing,we identified voltage-dependent anion channel 3(Vdac3)as a potential target associated with ferroptosis.Fto influenced neuronal ferroptosis by regulating the m6A methylation of Vdac3 mRNA.These findings elucidate the intricate interplay between Fto,Vdac3,m6A methylation,and ferroptosis in neurons during the hyperacute phase post-ICH and suggest novel therapeutic strategies for ICH.展开更多
NH_(3)-SCR(SCR:Selective catalytic reduction)is an effective technology for the de-NO_(x)process from both mobile and stationary pollution sources,and the most commonly used catalysts are the vanadia-based catalysts.A...NH_(3)-SCR(SCR:Selective catalytic reduction)is an effective technology for the de-NO_(x)process from both mobile and stationary pollution sources,and the most commonly used catalysts are the vanadia-based catalysts.An innovative V_(2)O_(5)-CeO_(2)/TaTiO_(x)catalyst for NO_(x)removal was prepared in this study.The influences of Ce and Ta in the V_(2)O_(5)-CeO_(2)/TaTiO_(x)catalyst on the SCR performance and physicochemical properties were investigated.The V_(2)O_(5)-CeO_(2)/TaTiO_(x)catalyst not only exhibited excellent SCR activity in a wide temperature window,but also presented strong resistance to H_(2)Oand SO_(2)at 275◦C.A series of characterizationmethods was used to study the catalysts,including H2-temperature programmed reduction,X-ray photoelectron spectroscopy,NH_(3)-temperature programmed desorption,etc.It was discovered that a synergistic effect existed between Ce and Ta species.The introduction of Ce and Ta enlarged the specific surface area,increased the amount of acid sites and the ratio of Ce^(3+),(V^(3+)+V^(4+))and Oα,and strengthened the redox capability which were related to synergistic effect between Ce and Ta species,significantly improving the NH_(3)-SCR activity.展开更多
β-Ga_(2)O_(3),as one of the important 4th generation semiconductors,is widely used in solar-blind ultraviolet(UV)detectors with a short detection range of 200-280 nm benefiting from its ultra-wide bandgap,strong radi...β-Ga_(2)O_(3),as one of the important 4th generation semiconductors,is widely used in solar-blind ultraviolet(UV)detectors with a short detection range of 200-280 nm benefiting from its ultra-wide bandgap,strong radiation resistance,and excellent chemical and thermal stabilities.Here,a self-powered photodetector(PD)based on an Ag/β-Ga_(2)O_(3) Schottky heterojunction was designed and fabricated.Through a subtle design of electrodes,the pyro-phototronic effect was discovered,which can be coupled to the common photovoltaic effect and further enhance the performance of the PD.Compared to traditional Ga_(2)O_(3)-based PD,the as-used PD exhibited a self-driving property and a broadband response beyond the bandgap lim-itations,ranging from 200 nm(deep UV)to 980 nm(infrared).Moreover,the photoresponse time was greatly shrunk owing to the coupling effect.Under laser irradiation,with a wavelength of 450 nm and a power density of 8 mW cm-2,the photocurrent could be improved by around 41 times compared with the sole photovoltaic effect.Besides,the performances of the Schottky PD were enhanced at both high and low temperatures.The device also possessed long-term working stability.This paper not only re-veals basic physics lying in the 4th generation semiconductor Ga_(2)O_(3) but also sheds light on the multi-encryption transmission of light information using this PD.展开更多
Ulcerative colitis(UC)is a chronic inflammatory disorder with a complex etiology,characterized by intestinal inflammation and barrier dysfunction.Platycodon grandiflorus polysaccharides(PGP),the primary component of P...Ulcerative colitis(UC)is a chronic inflammatory disorder with a complex etiology,characterized by intestinal inflammation and barrier dysfunction.Platycodon grandiflorus polysaccharides(PGP),the primary component of Platycodon grandiflorus,and hesperidin(Hesp),a prominent active component in Citrus aurantium L.(CAL),have both demonstrated anti-inflammatory properties.This study aims to elucidate the underlying mechanism of the synergistic effect of PGP combined with Hesp on UC,focusing on the coordinated interaction between the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)and Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathways.A mouse model of UC induced by dextran sulfate sodium(DSS)and a cell model using lipopolysaccharide(LPS)-induced RAW264.7/IEC6 cells were employed to investigate the in vitro and in vivo anti-inflammatory effects of PGP combined with Hesp on UC and its potential mechanism of action.The results indicated that compared to the effects of either drug alone,the combination of PGP and Hesp significantly modulated inflammatory factor levels,inhibited oxidative stress,regulated colonic mucosal immunity,suppressed apoptosis,and restored intestinal barrier function in vitro and in vivo.Further in vitro studies revealed that PGP significantly inhibited the PI3K/AKT signaling pathway,while Hesp significantly inhibited the JAK2/STAT3 signaling pathway.The use of inhibitors and activators targeting both pathways validated the synergistic effects of PGP combined with Hesp on the PI3K/AKT and JAK2/STAT3 signaling pathways.These findings suggest that PGP combined with Hesp exhibits a synergistic effect on DSS-induced colitis,potentially mediated through the phosphatase and tensin homolog(PTEN)/PI3K/AKT and interleukin-6(IL-6)/JAK2/STAT3 signaling pathways.展开更多
Naru Sanwei Pill,also known as Naru-3,a Mongolian medicine originating from Zhigao Pharmacopoeia,is a classic prescription used in the treatment of rheumatism.It is composed of Terminalia chebula,processed Aconitum ku...Naru Sanwei Pill,also known as Naru-3,a Mongolian medicine originating from Zhigao Pharmacopoeia,is a classic prescription used in the treatment of rheumatism.It is composed of Terminalia chebula,processed Aconitum kusnezoffii Reichb.,and Piper longum,and is known for its effects in eliminating“mucus,”relieving pain,and reducing swelling,with significant efficacy in treating joint effusion and lumbar pain.In recent years,researchers have summarized its chemical components and pharmacological effects,and employed network pharmacology methods based on the core theory of Traditional Chinese Medicine quality markers(Q-Markers)to analyze and predict its markers.The results identified potential Q-Markers for Naru-3,providing a scientific basis for quality control and further research.展开更多
Research on scale effects on flows over weirs has been conducted on a limited basis, primarily focusing on flows upstream of a single-type weir, such as ogee, broad-crested, and sharp-crested (linear and non-linear) w...Research on scale effects on flows over weirs has been conducted on a limited basis, primarily focusing on flows upstream of a single-type weir, such as ogee, broad-crested, and sharp-crested (linear and non-linear) weirs. However, the scale effects downstream of these single-type weirs have not been thoroughly investigated. This study examined the scale effects on flows over a combined weir system consisting of an ogee weir and a sharp-crested weir, both upstream and downstream, utilizing physical modeling at a 1:33.33 scale based on Froude similarity and three-dimensional (3D) computational fluid dynamics (CFD) modeling. The sharp-crested weir in this study was represented by two sluice gates that remain closed and submerged during flood events. The experimental data confirmed that the equivalent discharge coefficients of the combined weir system behaved similarly to those of a sharp-crested weir across various H/P (where H is the total head, and P is the weir height) values. However, scale effects on the discharge rating curve due to surface tension and viscosity could only be minimized when H/P > 0.4, Re > 26 959, and We > 240 (where Re and We are the Reynolds and Weber numbers, respectively), provided that the water depth exceeded 0.042 m above the crest. Additionally, Re greater than 4 × 104 was necessary to minimize scale effects caused by viscosity in flows in the spillway channel and stilling basin (with baffle blocks). The limiting criteria aligned closely with existing literature. This study offers valuable insights for practical applications in hydraulic engineering in the future.展开更多
Multistage fracturing technology has been used to enhance tight hydrocarbon resource recovery.Determining the proper well spacing and fracturing strategy is crucial for generating a complex fracture network that facil...Multistage fracturing technology has been used to enhance tight hydrocarbon resource recovery.Determining the proper well spacing and fracturing strategy is crucial for generating a complex fracture network that facilitates oil and gas flow in reservoirs.The stress-shadow effect that occurs between multiple wells significantly affects the development of fracture networks in reservoirs.However,the quantification of the stress-shadow effect and its influence on fracture networks has not been satisfactorily resolved because of the difficulties in detecting and identifying fracture propagation and reorientation in reservoirs.In this study,based on the geological information from the Shengli oilfield,we applied a hybrid finite element-discrete element method to analyze engineering-scale three-dimensional fracture propagation and reorientation by altering well spacings and fracturing strategies.The results indicate that the fracturing area generated by the synchronous fracturing scheme is much smaller than those generated by the sequential and alternative schemes.An alternative hydrofracturing scheme is optimal with respect to fracturing area.The stress-blind area was defined to quantify the mechanical disturbance between adjacent wells.Our study improves the understanding of the effect of fracturing schemes on fracture networks and the impact of independent factors contributing to stress-shadow effects.展开更多
Currently,simultaneous regulation of external morphology and internal electronic structure for Na_(3)V_(2)(PO_(4))_(3)(NVP)is rarely realized.Herein,complexes of β-cyclodextrin(βCD)and ethylenediaminetetraacetic aci...Currently,simultaneous regulation of external morphology and internal electronic structure for Na_(3)V_(2)(PO_(4))_(3)(NVP)is rarely realized.Herein,complexes of β-cyclodextrin(βCD)and ethylenediaminetetraacetic acid ferric sodium salt(EDTAFeNa)are utilized for the one-step preparation of NVP with spherical morphology as well as Fe substitution.βCD is initially hydrolyzed into glucose,and then carbon microspheres with numerous pores are formed through continuous dehydration and carbonization.The intermediate hydroxymethylfurfural is rich in active functional groups,which are attractive for the V/P-contained raw materials.Accordingly,the nucleation sites for NVP are successfully limited in the spherical framework,possessing a superior surface area of 97.15 g m^(-2).Furthermore,the beneficial Fe in EDTAFeNa enters into the NVP bulk to construct a novel Fe-doped Na_(3)V_(1.95)Fe_(0.05)(PO_(4))_(3)(NVP/β-ISC)material.Fe-substitution induces significant optimizations of electronic structure for NVP,which has been verified by the newly generated abundant oxygen vacancies and extended V-O bond length.Moreover,a multielectron reaction is activated,resulting from the V^(4+)/V^(5+)redox couple.The charge compensation mechanism of NVP/β-ISC is also deeply investigated.Density functional theory(DFT)calculations theoretically elaborate the mechanism of Fe-doping.Consequently,NVP/β-ISC reveals superior sodium storage performance in both half and full cells and even at different extreme conditions(needling,soaking,bending,and freezing).展开更多
Lithium-sulfur batteries(LSBs)have attracted widespread attention due to their high theoretical energy density.However,the dissolution of long-chain polysulfides into the electrolyte(the“shuttle effect”)leads to rap...Lithium-sulfur batteries(LSBs)have attracted widespread attention due to their high theoretical energy density.However,the dissolution of long-chain polysulfides into the electrolyte(the“shuttle effect”)leads to rapid capacity decay.Therefore,finding suitable materials to mitigate the shuttle effect of polysulfides is crucial for enhancing the electrochemical performance of lithium-sulfur batteries.In this study,LSBs’separator is modified with Ni_(3)V_(2)O_(8)nanoparticles@carboxylated carbon nanotubes(Ni_(3)V_(2)O_(8)@CNTs)composite.There are abundant oxygen vacancies in Ni_(3)V_(2)O_(8)@CNTs composite which plays a synergistic effect on shuttle effect.The Ni_(3)V_(2)O_(8)can tightly anchor soluble polysulfides through oxygen vacancies,while the CNTs not only facilitate the transport of ions and electrons but also weaken the migration of polysulfides,limiting shuttle effect.As a result,the cycling stability of LSBs using Ni_(3)V_(2)O_(8)@CNTs-modified separator has been significantly improved(with a capacity decay rate of only 0.0334%after 1500 cycles at 4.0C).This study proposes a strategy to design modified separator for high-performance LSBs.展开更多
Directional design of efficient catalysts for volatile organic compounds degradation remains a complex,yet effective and challenging process.Herein,oxygen-rich vacancy Co_(3)O_(4)-anchored Pt catalysts were prepared t...Directional design of efficient catalysts for volatile organic compounds degradation remains a complex,yet effective and challenging process.Herein,oxygen-rich vacancy Co_(3)O_(4)-anchored Pt catalysts were prepared through atom-trapping strategy and relevant vacancy defect inductive effect was proposed.The 0.6Pt/VO-Co_(3)O_(4)catalyst presented a reaction rate value of 32.2×10^(-5)mol·g_(cat)^(-1)·s^(-1)at 160℃for catalytic propane total oxidation,which was nearly 5 times the reaction rate of Co_(3)O_(4)(6.7×10^(-5)mol·g_(cat)^(-1)·s^(-1)).Also,it exhibited excellent water-resistance and catalytic stability.The Pt atoms were stabilized on the Co_(3)O_(4)surface by vacancy defects to improve dispersion.Meanwhile,the vacancy defect inductive effect induced stronger electron interaction between Pt and Co_(3)O_(4)on the surface,thus promote the redox ability at low-temperature.The mobility and oxygen-activating ability of surface lattice oxygen were also strengthened by the vacancy defect inductive effect.This facilitated the generation of more surface-active oxygen species for the cleavage of C-H bond and the deep oxidation of intermediate species.Overall,this study proposed a novel concept the fabrication of highly efficient catalysts for the purpose of catalytic oxidation.展开更多
Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfa...Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfacial structure and properties of halide perovskites hybrid is still a big challenge owing to the growth uncontrollability and incompatibility between different constituents.Here we use Bi OBr nanosheets as the start-template to in situ epitaxially grow Cs_(3)Bi_(2)Br_(9)nanosheets by“cosharing”Bi and Br atoms strategy for designing a 2D/2D Cs_(3)Bi_(2)Br_(9)/BiOBr heterojunction.Systematic studies show that the epitaxial heterojunction can optimize the synergistic effect of Bi OBr and Cs_(3)Bi_(2)Br_(9)via the formation of tight-contact interfaces,strong interfacial electronic coupling and charge redistribution,which can not only drive the Z-scheme charge transfer mechanism to greatly promote the spatial separation of electronhole pairs,but also modulate the interfacial electronic structure to facilitate the adsorption and activation of toluene molecules.The heterojunction exhibited 62.3 and 2.4-fold photoactivity improvement for toluene oxidation to benzaldehyde than parental Bi OBr and Cs_(3)Bi_(2)Br_(9),respectively.This study not only proposed a novel dual atom-bridge protocol to engineer high-quality perovskite heterojunctions,but also uncovered the potential of heterojunction in promoting electron-hole separation as well as the application in photocatalytic organic synthesis.展开更多
The thickness dependence of linearly polarized light-induced momentum anisotropy and the inverse spin Hall effect(PISHE)in topological insulator(TI)Bi_(2)Te_(3)films has been investigated.A significant enhancement of ...The thickness dependence of linearly polarized light-induced momentum anisotropy and the inverse spin Hall effect(PISHE)in topological insulator(TI)Bi_(2)Te_(3)films has been investigated.A significant enhancement of the PISHE signal is observed in the 12-quintuple-layer(QL)Bi_(2)Te_(3)film compared with that of the 3-and 5-QL samples,whereas a minimal value of photoinduced momentum anisotropy is found in the 12-QL sample.The photoinduced momentum anisotropy and the PISHE in Bi_(2)Te_(3)films are more than three and two orders of magnitude larger than those in Bi2Se3 films grown on SrTiO_(3)substrates,respectively.The 3-QL sample exhibits a sinusoidal dependence of the PISHE current on the light spot position,while the 5-QL and 12-QL samples show aW-shaped dependence,which arises from the different angles between the coordinate axis x and the in-plane crystallographic axis of the Bi_(2)Te_(3)films.Our findings demonstrate the critical role of film thickness in modulating both the photoinduced momentum anisotropy and the PISHE current,thereby suggesting a thickness-engineering strategy for designing novel optoelectronic devices based on TIs.展开更多
Ni-La2O3/CeO2 composite films were prepared by electrodeposition from a nickel sulfate bath containing certain content of micrometer and nanometer La2O3/CeO2 particles. The effect of La2O3 or CeO2 particle size on the...Ni-La2O3/CeO2 composite films were prepared by electrodeposition from a nickel sulfate bath containing certain content of micrometer and nanometer La2O3/CeO2 particles. The effect of La2O3 or CeO2 particle size on the oxidation resistance of the electrodeposited Ni-La2O3/CeO2 composites in air at 1000 °C was studied. The results indicate that, compared with the electrodeposited Ni-film, Ni-La2O3/CeO2 composites exhibit a superior oxidation resistance due to the codeposited La2O3 or CeO2 particles blocking the outward diffusion of nickel. Moreover, compared with nanoparticles, La2O3 or CeO2 microparticles have stronger effect because La2O3 or CeO2 microparticles also act as a diffusion barrier layer at the onset of oxidation.展开更多
[Objective] The study aimed to explore the influences of Plant growth-promoting rhizobacteria（PGPR）on salt tolerance and physiological effect of seedlings of Medicago sative L.[Method] Three different kinds of growt...[Objective] The study aimed to explore the influences of Plant growth-promoting rhizobacteria（PGPR）on salt tolerance and physiological effect of seedlings of Medicago sative L.[Method] Three different kinds of growth-promoting rhizobacteria solutions were used to spray on M.sative seedlings and the influences of different kinds of growth-promoting rhizobacteria on physiological and biochemical characteristics of M.sative seedlings under 75 mmol/L of Na2CO3 were studied.[Results] Compared with the control group,the chlorophyll,free proline,soluble sugar and soluble protein content of M.sative seedlings treated with different kinds of growth-promoting rhizobacteria were increased,while the effect of CS3 treatment was the best.[Conclusion] The growth-promoting rhizobacteria could promote growth and development of M.sative as well as increased its resistance.展开更多
BACKGROUND Study shows that signal transducer and activator of transcription 3(STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate de...BACKGROUND Study shows that signal transducer and activator of transcription 3(STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma. STAT3 and pyruvate kinase M2(PKM2) can also be activated and enhance the Warburg effect in hepatocellular carcinoma. Precancerous lesions are critical to human and rodent hepatocarcinogenesis. However, the underlying molecular mechanism for the development of liver precancerous lesions remains unknown. We hypothesized that STAT3 promotes the Warburg effect possibly by upregulating p-PKM2 in liver precancerous lesions in rats.AIM To investigate the mechanism of the Warburg effect in liver precancerous lesions in rats.METHODS A model of liver precancerous lesions was established by a modified Solt-Farber method. The liver pathological changes were observed by HE staining and immunohistochemistry. The transformation of WB-F344 cells induced with Nmethyl-N'-nitro-N-nitrosoguanidine and hydrogen peroxide was evaluated by the soft agar assay and aneuploidy. The levels of glucose and lactate in the tissue and culture medium were detected with a spectrophotometer. The protein levels of glutathione S-transferase-π, proliferating cell nuclear antigen(PCNA), STAT3,and PKM2 were examined by Western blot and immunofluorescence.RESULTS We found that the Warburg effect was increased in liver precancerous lesions in rats. PKM2 and p-STAT3 were upregulated in activated oval cells in liverprecancerous lesions in rats. The Warburg effect, p-PKM2, and p-STAT3 expression were also increased in transformed WB-F344 cells. STAT3 activation promoted the clonal formation rate, aneuploidy, alpha-fetoprotein expression,PCNA expression, G1/S phase transition, the Warburg effect, PKM2 phosphorylation, and nuclear translocation in transformed WB-F344 cells.Moreover, the Warburg effect was inhibited by stattic, a specific inhibitor of STAT3, and further reduced in transformed WB-F344 cells after the intervention for PKM2.CONCLUSION The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells.展开更多
In recent years,engineered nanoparticles,as a new group of contaminants emerging in natural water,have been given more attention AlCl3 In order to understand the behavior of nanoparticles in the conventional water tre...In recent years,engineered nanoparticles,as a new group of contaminants emerging in natural water,have been given more attention AlCl3 In order to understand the behavior of nanoparticles in the conventional water treatment process,three kinds of nanoparticle suspensions,namely multi-walled carbon nanotube-humic acid（MWCNT-HA）,multiwalled carbon nanotube-N,N-dimethylformamide（MWCNT-DMF） and nano TiO2-humic acid（TiO2-HA） were employed to investigate their coagulation removal efficiencies with varying aluminum chloride（AlCl3） concentrations AlCl3 Results showed that nanoparticle removal rate curves had a reverse ＂U＂ shape with increasing concentration of aluminum ion（Al^（3＋） ）AlCl3 More than 90% of nanoparticles could be effectively removed by an appropriate Al^（3＋） concentration AlCl3 At higher Al^（3＋） concentration,nanoparticles would be restabilized AlCl3 The hydrodynamic particle size of nanoparticles was found to be the crucial factor influencing the effective concentration range（ECR） of Al^（3＋） for nanoparticle removal AlCl3 The ECR of Al^（3＋） followed the order MWCNT-DMF 〉 MWCNT-HA 〉 TiO2-HA,which is the reverse of the nanoparticle size trend AlCl3 At a given concentration,smaller nanoparticles carry more surface charges,and thus consume more coagulants for neutralization AlCl3 Therefore,over-saturation occurred at relatively higher Al^（3＋） concentration and a wider ECR was obtained AlCl3 The ECR became broader with increasing p H because of the smaller hydrodynamic particle size of nanoparticles at higher p H values AlCl3 A high ionic strength of Na Cl can also widen the ECR due to its strong potential to compress the electric double layer AlCl3 It was concluded that it is important to adjust the dose of Al^（3＋） in the ECR for nanoparticle removal in water treatment.展开更多
Increasing use of pyrethroid insecticides has resulted in concerns regarding potential effects on human health and ecosystems. Cypermethrin and its metabolite 3-phenoxybenzoic acid(PBA) have exerted adverse biological...Increasing use of pyrethroid insecticides has resulted in concerns regarding potential effects on human health and ecosystems. Cypermethrin and its metabolite 3-phenoxybenzoic acid(PBA) have exerted adverse biological impacts on the environment;therefore,it is critically important to develop different methods to enhance their degradation. In this study,incubation experiments were conducted using samples of an Aquic Inceptisol supplied with nitrogen(N) in the form of NH4NO3 at different levels to investigate the effect of nitrogen on the degradation of cypermethrin and PBA in soil. The results indicated that appropriate N application can promote the degradation of cypermethrin and PBA in soil. The maximum degradation rates were 80.0% for cypermethrin after 14 days of incubation in the treatment with N at a rate of 122.1 kg ha-1 and 41.0% for PBA after 60 days of incubation in the treatment with N at a rate of 182.7 kg ha-1. The corresponding rates in the treatments without nitrogen were 62.7% for cypermethrin and 27.8% for PBA. However,oversupplying N significantly reduced degradation of these compounds. Enhancement of degradation could be explained by the stimulation of microbial activity after the addition of N. In particular,dehydrogenase activities in the soil generally increased with the addition of N,except in the soil where N was applied at the highest level. The lower degradation rate measured in the treatment with an oversupply of N may be attributed to the microbial metabolism shifts induced by high N.展开更多
Epigallocatechin-3-gallate （EGCG）, a naturally occurring compound in green tea, has been widely used as an antioxidant agent. In the present study, model rats with acute spinal cord injury were intraperitoneally inj...Epigallocatechin-3-gallate （EGCG）, a naturally occurring compound in green tea, has been widely used as an antioxidant agent. In the present study, model rats with acute spinal cord injury were intraperitoneally injected with 25, 50, and 100 mg/kg EGCG, and spinal cord ultrastructure, oxidative stress reaction, inflammatory factors, and apoptosis-associated gene expression were observed. Results showed that EGCG attenuated neuronal and axonal injury 24 hours post injury. It also decreased serum intedeukin-113, tumor necrosis factor-a, and intercellular adhesion molecule-1 release, and decreased apoptosis-associated gene expression. Furthermore, it increased the level of the superoxide anion （O2-）, superoxide dismutase, and B-cell lymphoma/leukemia-2, and reduced malondialdehyde levels. Furthermore, it reduced the expression of the pro-apoptotic protein Bax. Noticeably, EGCG at the 100 mg/kg dosage exhibited similar effects as methylprednisolone sodium succinate, which has been frequently used for clinical acute spinal cord injury. The results demonstrated that EGCG can significantly inhibit inflammation, suppress oxidation, and reduce apoptosis in acute spinal cord injury.展开更多
We have shown that some phenylethynylsilicon compounds are good cure crosslinkersof heat-curable silicone rubber(HCSR). In this paper the effects of 1, 1, 3, 3-tetramethyl-1, 3-diphenylethynyldisiloxane (TMDPDS) as a ...We have shown that some phenylethynylsilicon compounds are good cure crosslinkersof heat-curable silicone rubber(HCSR). In this paper the effects of 1, 1, 3, 3-tetramethyl-1, 3-diphenylethynyldisiloxane (TMDPDS) as a crosslinker on HCSR were studied. Thevulcanizates with fine mechanical properties could be obtained with suitable amounts ofTMDPDS. Sol fractions, and crosslinking density of vulcanizates and vulcanizationretardation effect of TMDPDS on hydrosilation curing silicone rubber were also discussed.展开更多
基金supported by the National Key R&D Program of China(2022YFE0131000)the National Natural Science Foundation of China(82220108012,82271306,and 82071307)+1 种基金The Science and Education for Health Foundation of Suzhou for Youth(KJXW2023001)the Boxi Youth Natural Science Foundation(BXQN2023028).
文摘During the hyperacute phase of intracerebral hemorrhage(ICH),the mass effect and blood components mechanically lead to brain damage and neurotoxicity.Our findings revealed that the mass effect and transferrin precipitate neuronal oxidative stress and iron uptake,culminating in ferroptosis in neurons.M6A(N6-methyladenosine)modification,the most prevalent mRNA modification,plays a critical role in various cell death pathways.The Fto(fat mass and obesity-associated protein)demethylase has been implicated in numerous signaling pathways of neurological diseases by modulating m6A mRNA levels.Regulation of Fto protein levels in neurons effectively mitigated mass effect-induced neuronal ferroptosis.Applying nanopore direct RNA sequencing,we identified voltage-dependent anion channel 3(Vdac3)as a potential target associated with ferroptosis.Fto influenced neuronal ferroptosis by regulating the m6A methylation of Vdac3 mRNA.These findings elucidate the intricate interplay between Fto,Vdac3,m6A methylation,and ferroptosis in neurons during the hyperacute phase post-ICH and suggest novel therapeutic strategies for ICH.
基金supported by the National Natural Science Foundation of China(Nos.22276182 and 22188102)the Natural Science Foundation of Fujian Province,China(No.2023J06048)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2021303).
文摘NH_(3)-SCR(SCR:Selective catalytic reduction)is an effective technology for the de-NO_(x)process from both mobile and stationary pollution sources,and the most commonly used catalysts are the vanadia-based catalysts.An innovative V_(2)O_(5)-CeO_(2)/TaTiO_(x)catalyst for NO_(x)removal was prepared in this study.The influences of Ce and Ta in the V_(2)O_(5)-CeO_(2)/TaTiO_(x)catalyst on the SCR performance and physicochemical properties were investigated.The V_(2)O_(5)-CeO_(2)/TaTiO_(x)catalyst not only exhibited excellent SCR activity in a wide temperature window,but also presented strong resistance to H_(2)Oand SO_(2)at 275◦C.A series of characterizationmethods was used to study the catalysts,including H2-temperature programmed reduction,X-ray photoelectron spectroscopy,NH_(3)-temperature programmed desorption,etc.It was discovered that a synergistic effect existed between Ce and Ta species.The introduction of Ce and Ta enlarged the specific surface area,increased the amount of acid sites and the ratio of Ce^(3+),(V^(3+)+V^(4+))and Oα,and strengthened the redox capability which were related to synergistic effect between Ce and Ta species,significantly improving the NH_(3)-SCR activity.
基金supported by the National Natural Science Foundation of China(Grant Nos.52192610 and 52192613)the National Key R&D Project from the Minister of Science and Technology(No.2021YFA1201601)the CAS-TWAS President’s Fellow-ship(A.B).
文摘β-Ga_(2)O_(3),as one of the important 4th generation semiconductors,is widely used in solar-blind ultraviolet(UV)detectors with a short detection range of 200-280 nm benefiting from its ultra-wide bandgap,strong radiation resistance,and excellent chemical and thermal stabilities.Here,a self-powered photodetector(PD)based on an Ag/β-Ga_(2)O_(3) Schottky heterojunction was designed and fabricated.Through a subtle design of electrodes,the pyro-phototronic effect was discovered,which can be coupled to the common photovoltaic effect and further enhance the performance of the PD.Compared to traditional Ga_(2)O_(3)-based PD,the as-used PD exhibited a self-driving property and a broadband response beyond the bandgap lim-itations,ranging from 200 nm(deep UV)to 980 nm(infrared).Moreover,the photoresponse time was greatly shrunk owing to the coupling effect.Under laser irradiation,with a wavelength of 450 nm and a power density of 8 mW cm-2,the photocurrent could be improved by around 41 times compared with the sole photovoltaic effect.Besides,the performances of the Schottky PD were enhanced at both high and low temperatures.The device also possessed long-term working stability.This paper not only re-veals basic physics lying in the 4th generation semiconductor Ga_(2)O_(3) but also sheds light on the multi-encryption transmission of light information using this PD.
基金supported by the Major Fund Project of Anhui Province Department of Education(No.2022AH040077)the Academic Funding for Top Talents in Disciplines(Specialities)of Anhui Provincial High Education Institutes(No.gxbjzD2021056)the Program for New Era Cultivate Talents of Anhui province(Postgraduate Education)(No.2022xscx099).
文摘Ulcerative colitis(UC)is a chronic inflammatory disorder with a complex etiology,characterized by intestinal inflammation and barrier dysfunction.Platycodon grandiflorus polysaccharides(PGP),the primary component of Platycodon grandiflorus,and hesperidin(Hesp),a prominent active component in Citrus aurantium L.(CAL),have both demonstrated anti-inflammatory properties.This study aims to elucidate the underlying mechanism of the synergistic effect of PGP combined with Hesp on UC,focusing on the coordinated interaction between the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)and Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathways.A mouse model of UC induced by dextran sulfate sodium(DSS)and a cell model using lipopolysaccharide(LPS)-induced RAW264.7/IEC6 cells were employed to investigate the in vitro and in vivo anti-inflammatory effects of PGP combined with Hesp on UC and its potential mechanism of action.The results indicated that compared to the effects of either drug alone,the combination of PGP and Hesp significantly modulated inflammatory factor levels,inhibited oxidative stress,regulated colonic mucosal immunity,suppressed apoptosis,and restored intestinal barrier function in vitro and in vivo.Further in vitro studies revealed that PGP significantly inhibited the PI3K/AKT signaling pathway,while Hesp significantly inhibited the JAK2/STAT3 signaling pathway.The use of inhibitors and activators targeting both pathways validated the synergistic effects of PGP combined with Hesp on the PI3K/AKT and JAK2/STAT3 signaling pathways.These findings suggest that PGP combined with Hesp exhibits a synergistic effect on DSS-induced colitis,potentially mediated through the phosphatase and tensin homolog(PTEN)/PI3K/AKT and interleukin-6(IL-6)/JAK2/STAT3 signaling pathways.
文摘Naru Sanwei Pill,also known as Naru-3,a Mongolian medicine originating from Zhigao Pharmacopoeia,is a classic prescription used in the treatment of rheumatism.It is composed of Terminalia chebula,processed Aconitum kusnezoffii Reichb.,and Piper longum,and is known for its effects in eliminating“mucus,”relieving pain,and reducing swelling,with significant efficacy in treating joint effusion and lumbar pain.In recent years,researchers have summarized its chemical components and pharmacological effects,and employed network pharmacology methods based on the core theory of Traditional Chinese Medicine quality markers(Q-Markers)to analyze and predict its markers.The results identified potential Q-Markers for Naru-3,providing a scientific basis for quality control and further research.
基金supported by the Ministry of Public Works and Housing of Indonesia and Parahyangan Catholic University(Grant No.II/PD/2023-07/02-SJ).
文摘Research on scale effects on flows over weirs has been conducted on a limited basis, primarily focusing on flows upstream of a single-type weir, such as ogee, broad-crested, and sharp-crested (linear and non-linear) weirs. However, the scale effects downstream of these single-type weirs have not been thoroughly investigated. This study examined the scale effects on flows over a combined weir system consisting of an ogee weir and a sharp-crested weir, both upstream and downstream, utilizing physical modeling at a 1:33.33 scale based on Froude similarity and three-dimensional (3D) computational fluid dynamics (CFD) modeling. The sharp-crested weir in this study was represented by two sluice gates that remain closed and submerged during flood events. The experimental data confirmed that the equivalent discharge coefficients of the combined weir system behaved similarly to those of a sharp-crested weir across various H/P (where H is the total head, and P is the weir height) values. However, scale effects on the discharge rating curve due to surface tension and viscosity could only be minimized when H/P > 0.4, Re > 26 959, and We > 240 (where Re and We are the Reynolds and Weber numbers, respectively), provided that the water depth exceeded 0.042 m above the crest. Additionally, Re greater than 4 × 104 was necessary to minimize scale effects caused by viscosity in flows in the spillway channel and stilling basin (with baffle blocks). The limiting criteria aligned closely with existing literature. This study offers valuable insights for practical applications in hydraulic engineering in the future.
基金supported in part by the National Key Research and Development Project of China(No.2022YFC3004602)in part by the National Natural Science Foundation of China(Nos.52121003 and 52342403).
文摘Multistage fracturing technology has been used to enhance tight hydrocarbon resource recovery.Determining the proper well spacing and fracturing strategy is crucial for generating a complex fracture network that facilitates oil and gas flow in reservoirs.The stress-shadow effect that occurs between multiple wells significantly affects the development of fracture networks in reservoirs.However,the quantification of the stress-shadow effect and its influence on fracture networks has not been satisfactorily resolved because of the difficulties in detecting and identifying fracture propagation and reorientation in reservoirs.In this study,based on the geological information from the Shengli oilfield,we applied a hybrid finite element-discrete element method to analyze engineering-scale three-dimensional fracture propagation and reorientation by altering well spacings and fracturing strategies.The results indicate that the fracturing area generated by the synchronous fracturing scheme is much smaller than those generated by the sequential and alternative schemes.An alternative hydrofracturing scheme is optimal with respect to fracturing area.The stress-blind area was defined to quantify the mechanical disturbance between adjacent wells.Our study improves the understanding of the effect of fracturing schemes on fracture networks and the impact of independent factors contributing to stress-shadow effects.
基金financially supported by the Key Research and Development(R&D)Projects of Shanxi Province(202202040201005)the Graduate Innovation Project of Shanxi Province(No.2024SJ261)。
文摘Currently,simultaneous regulation of external morphology and internal electronic structure for Na_(3)V_(2)(PO_(4))_(3)(NVP)is rarely realized.Herein,complexes of β-cyclodextrin(βCD)and ethylenediaminetetraacetic acid ferric sodium salt(EDTAFeNa)are utilized for the one-step preparation of NVP with spherical morphology as well as Fe substitution.βCD is initially hydrolyzed into glucose,and then carbon microspheres with numerous pores are formed through continuous dehydration and carbonization.The intermediate hydroxymethylfurfural is rich in active functional groups,which are attractive for the V/P-contained raw materials.Accordingly,the nucleation sites for NVP are successfully limited in the spherical framework,possessing a superior surface area of 97.15 g m^(-2).Furthermore,the beneficial Fe in EDTAFeNa enters into the NVP bulk to construct a novel Fe-doped Na_(3)V_(1.95)Fe_(0.05)(PO_(4))_(3)(NVP/β-ISC)material.Fe-substitution induces significant optimizations of electronic structure for NVP,which has been verified by the newly generated abundant oxygen vacancies and extended V-O bond length.Moreover,a multielectron reaction is activated,resulting from the V^(4+)/V^(5+)redox couple.The charge compensation mechanism of NVP/β-ISC is also deeply investigated.Density functional theory(DFT)calculations theoretically elaborate the mechanism of Fe-doping.Consequently,NVP/β-ISC reveals superior sodium storage performance in both half and full cells and even at different extreme conditions(needling,soaking,bending,and freezing).
基金supported by the Key Research and Development Projects of Anhui Province(No.202304a05020031).
文摘Lithium-sulfur batteries(LSBs)have attracted widespread attention due to their high theoretical energy density.However,the dissolution of long-chain polysulfides into the electrolyte(the“shuttle effect”)leads to rapid capacity decay.Therefore,finding suitable materials to mitigate the shuttle effect of polysulfides is crucial for enhancing the electrochemical performance of lithium-sulfur batteries.In this study,LSBs’separator is modified with Ni_(3)V_(2)O_(8)nanoparticles@carboxylated carbon nanotubes(Ni_(3)V_(2)O_(8)@CNTs)composite.There are abundant oxygen vacancies in Ni_(3)V_(2)O_(8)@CNTs composite which plays a synergistic effect on shuttle effect.The Ni_(3)V_(2)O_(8)can tightly anchor soluble polysulfides through oxygen vacancies,while the CNTs not only facilitate the transport of ions and electrons but also weaken the migration of polysulfides,limiting shuttle effect.As a result,the cycling stability of LSBs using Ni_(3)V_(2)O_(8)@CNTs-modified separator has been significantly improved(with a capacity decay rate of only 0.0334%after 1500 cycles at 4.0C).This study proposes a strategy to design modified separator for high-performance LSBs.
文摘Directional design of efficient catalysts for volatile organic compounds degradation remains a complex,yet effective and challenging process.Herein,oxygen-rich vacancy Co_(3)O_(4)-anchored Pt catalysts were prepared through atom-trapping strategy and relevant vacancy defect inductive effect was proposed.The 0.6Pt/VO-Co_(3)O_(4)catalyst presented a reaction rate value of 32.2×10^(-5)mol·g_(cat)^(-1)·s^(-1)at 160℃for catalytic propane total oxidation,which was nearly 5 times the reaction rate of Co_(3)O_(4)(6.7×10^(-5)mol·g_(cat)^(-1)·s^(-1)).Also,it exhibited excellent water-resistance and catalytic stability.The Pt atoms were stabilized on the Co_(3)O_(4)surface by vacancy defects to improve dispersion.Meanwhile,the vacancy defect inductive effect induced stronger electron interaction between Pt and Co_(3)O_(4)on the surface,thus promote the redox ability at low-temperature.The mobility and oxygen-activating ability of surface lattice oxygen were also strengthened by the vacancy defect inductive effect.This facilitated the generation of more surface-active oxygen species for the cleavage of C-H bond and the deep oxidation of intermediate species.Overall,this study proposed a novel concept the fabrication of highly efficient catalysts for the purpose of catalytic oxidation.
基金financially supported by the National Natural Science Foundation of China(Nos.22175202,22005351,22365016)the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515010180)+3 种基金Program of Guangzhou Science and Technology(No.202201011591)the Science and Technology Innovation Program of Hunan Province(No.2023RC3179)Scientific Research Start-up Fund of Jishou University(No.1122003)support of National Supercomputer Center in Sun Yat-sen University,Guangzhou。
文摘Optimizing the interfacial quality of halide perovskites heterojunction to promote the photogenerated charge separation is of great significance in photocatalytic reactions.However,the delicately regulation of interfacial structure and properties of halide perovskites hybrid is still a big challenge owing to the growth uncontrollability and incompatibility between different constituents.Here we use Bi OBr nanosheets as the start-template to in situ epitaxially grow Cs_(3)Bi_(2)Br_(9)nanosheets by“cosharing”Bi and Br atoms strategy for designing a 2D/2D Cs_(3)Bi_(2)Br_(9)/BiOBr heterojunction.Systematic studies show that the epitaxial heterojunction can optimize the synergistic effect of Bi OBr and Cs_(3)Bi_(2)Br_(9)via the formation of tight-contact interfaces,strong interfacial electronic coupling and charge redistribution,which can not only drive the Z-scheme charge transfer mechanism to greatly promote the spatial separation of electronhole pairs,but also modulate the interfacial electronic structure to facilitate the adsorption and activation of toluene molecules.The heterojunction exhibited 62.3 and 2.4-fold photoactivity improvement for toluene oxidation to benzaldehyde than parental Bi OBr and Cs_(3)Bi_(2)Br_(9),respectively.This study not only proposed a novel dual atom-bridge protocol to engineer high-quality perovskite heterojunctions,but also uncovered the potential of heterojunction in promoting electron-hole separation as well as the application in photocatalytic organic synthesis.
基金supported by the National Natural Science Foundation of China(Grant Nos.62074036,61674038,and 11574302)the Foreign Cooperation Project of Fujian Province,China(Grant No.2023I0005)+2 种基金the Open Research Fund Program of the State Key Laboratory of Low Dimensional Quantum Physics(Grant No.KF202108)the National Key Research and Development Program of China(Grant No.2016YFB0402303)the Foundation of the Fujian Provincial Department of Industry and Information Technology of China(Grant No.82318075).
文摘The thickness dependence of linearly polarized light-induced momentum anisotropy and the inverse spin Hall effect(PISHE)in topological insulator(TI)Bi_(2)Te_(3)films has been investigated.A significant enhancement of the PISHE signal is observed in the 12-quintuple-layer(QL)Bi_(2)Te_(3)film compared with that of the 3-and 5-QL samples,whereas a minimal value of photoinduced momentum anisotropy is found in the 12-QL sample.The photoinduced momentum anisotropy and the PISHE in Bi_(2)Te_(3)films are more than three and two orders of magnitude larger than those in Bi2Se3 films grown on SrTiO_(3)substrates,respectively.The 3-QL sample exhibits a sinusoidal dependence of the PISHE current on the light spot position,while the 5-QL and 12-QL samples show aW-shaped dependence,which arises from the different angles between the coordinate axis x and the in-plane crystallographic axis of the Bi_(2)Te_(3)films.Our findings demonstrate the critical role of film thickness in modulating both the photoinduced momentum anisotropy and the PISHE current,thereby suggesting a thickness-engineering strategy for designing novel optoelectronic devices based on TIs.
基金Project(GC13A113)supported by the Technology Research and Development Program of Heilongjiang Provincial Science and Technology DepartmentProject(12511469)supported by Heilongjiang Provincial Science and Technology Department
文摘Ni-La2O3/CeO2 composite films were prepared by electrodeposition from a nickel sulfate bath containing certain content of micrometer and nanometer La2O3/CeO2 particles. The effect of La2O3 or CeO2 particle size on the oxidation resistance of the electrodeposited Ni-La2O3/CeO2 composites in air at 1000 °C was studied. The results indicate that, compared with the electrodeposited Ni-film, Ni-La2O3/CeO2 composites exhibit a superior oxidation resistance due to the codeposited La2O3 or CeO2 particles blocking the outward diffusion of nickel. Moreover, compared with nanoparticles, La2O3 or CeO2 microparticles have stronger effect because La2O3 or CeO2 microparticles also act as a diffusion barrier layer at the onset of oxidation.
基金Supported by National Natural Science Foundation of China(30970554)~~
文摘[Objective] The study aimed to explore the influences of Plant growth-promoting rhizobacteria（PGPR）on salt tolerance and physiological effect of seedlings of Medicago sative L.[Method] Three different kinds of growth-promoting rhizobacteria solutions were used to spray on M.sative seedlings and the influences of different kinds of growth-promoting rhizobacteria on physiological and biochemical characteristics of M.sative seedlings under 75 mmol/L of Na2CO3 were studied.[Results] Compared with the control group,the chlorophyll,free proline,soluble sugar and soluble protein content of M.sative seedlings treated with different kinds of growth-promoting rhizobacteria were increased,while the effect of CS3 treatment was the best.[Conclusion] The growth-promoting rhizobacteria could promote growth and development of M.sative as well as increased its resistance.
基金Supported by the National Natural Science Foundation of China,No.81070319the Beijing Natural Science Foundation of China,No.7102013the Beijing Municipal Education Commission Research Program,China,No.KM201610025004
文摘BACKGROUND Study shows that signal transducer and activator of transcription 3(STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma. STAT3 and pyruvate kinase M2(PKM2) can also be activated and enhance the Warburg effect in hepatocellular carcinoma. Precancerous lesions are critical to human and rodent hepatocarcinogenesis. However, the underlying molecular mechanism for the development of liver precancerous lesions remains unknown. We hypothesized that STAT3 promotes the Warburg effect possibly by upregulating p-PKM2 in liver precancerous lesions in rats.AIM To investigate the mechanism of the Warburg effect in liver precancerous lesions in rats.METHODS A model of liver precancerous lesions was established by a modified Solt-Farber method. The liver pathological changes were observed by HE staining and immunohistochemistry. The transformation of WB-F344 cells induced with Nmethyl-N'-nitro-N-nitrosoguanidine and hydrogen peroxide was evaluated by the soft agar assay and aneuploidy. The levels of glucose and lactate in the tissue and culture medium were detected with a spectrophotometer. The protein levels of glutathione S-transferase-π, proliferating cell nuclear antigen(PCNA), STAT3,and PKM2 were examined by Western blot and immunofluorescence.RESULTS We found that the Warburg effect was increased in liver precancerous lesions in rats. PKM2 and p-STAT3 were upregulated in activated oval cells in liverprecancerous lesions in rats. The Warburg effect, p-PKM2, and p-STAT3 expression were also increased in transformed WB-F344 cells. STAT3 activation promoted the clonal formation rate, aneuploidy, alpha-fetoprotein expression,PCNA expression, G1/S phase transition, the Warburg effect, PKM2 phosphorylation, and nuclear translocation in transformed WB-F344 cells.Moreover, the Warburg effect was inhibited by stattic, a specific inhibitor of STAT3, and further reduced in transformed WB-F344 cells after the intervention for PKM2.CONCLUSION The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells.
基金supported by the Hundreds Talents Program of Chinese Academy of SciencesOpen Foundation of State Key Laboratory of Environmental Criteria and Risk Assessment+1 种基金Chinese Research Academy of Environmental Sciences (SKLECRA2015OFP10)Natural Science Foundation of Heilong Jiang Province
文摘In recent years,engineered nanoparticles,as a new group of contaminants emerging in natural water,have been given more attention AlCl3 In order to understand the behavior of nanoparticles in the conventional water treatment process,three kinds of nanoparticle suspensions,namely multi-walled carbon nanotube-humic acid（MWCNT-HA）,multiwalled carbon nanotube-N,N-dimethylformamide（MWCNT-DMF） and nano TiO2-humic acid（TiO2-HA） were employed to investigate their coagulation removal efficiencies with varying aluminum chloride（AlCl3） concentrations AlCl3 Results showed that nanoparticle removal rate curves had a reverse ＂U＂ shape with increasing concentration of aluminum ion（Al^（3＋） ）AlCl3 More than 90% of nanoparticles could be effectively removed by an appropriate Al^（3＋） concentration AlCl3 At higher Al^（3＋） concentration,nanoparticles would be restabilized AlCl3 The hydrodynamic particle size of nanoparticles was found to be the crucial factor influencing the effective concentration range（ECR） of Al^（3＋） for nanoparticle removal AlCl3 The ECR of Al^（3＋） followed the order MWCNT-DMF 〉 MWCNT-HA 〉 TiO2-HA,which is the reverse of the nanoparticle size trend AlCl3 At a given concentration,smaller nanoparticles carry more surface charges,and thus consume more coagulants for neutralization AlCl3 Therefore,over-saturation occurred at relatively higher Al^（3＋） concentration and a wider ECR was obtained AlCl3 The ECR became broader with increasing p H because of the smaller hydrodynamic particle size of nanoparticles at higher p H values AlCl3 A high ionic strength of Na Cl can also widen the ECR due to its strong potential to compress the electric double layer AlCl3 It was concluded that it is important to adjust the dose of Al^（3＋） in the ECR for nanoparticle removal in water treatment.
基金the National Key Basic Research Program of China (No.2002CB410810) and the PPI/PPIC Chinaprogram.
文摘Increasing use of pyrethroid insecticides has resulted in concerns regarding potential effects on human health and ecosystems. Cypermethrin and its metabolite 3-phenoxybenzoic acid(PBA) have exerted adverse biological impacts on the environment;therefore,it is critically important to develop different methods to enhance their degradation. In this study,incubation experiments were conducted using samples of an Aquic Inceptisol supplied with nitrogen(N) in the form of NH4NO3 at different levels to investigate the effect of nitrogen on the degradation of cypermethrin and PBA in soil. The results indicated that appropriate N application can promote the degradation of cypermethrin and PBA in soil. The maximum degradation rates were 80.0% for cypermethrin after 14 days of incubation in the treatment with N at a rate of 122.1 kg ha-1 and 41.0% for PBA after 60 days of incubation in the treatment with N at a rate of 182.7 kg ha-1. The corresponding rates in the treatments without nitrogen were 62.7% for cypermethrin and 27.8% for PBA. However,oversupplying N significantly reduced degradation of these compounds. Enhancement of degradation could be explained by the stimulation of microbial activity after the addition of N. In particular,dehydrogenase activities in the soil generally increased with the addition of N,except in the soil where N was applied at the highest level. The lower degradation rate measured in the treatment with an oversupply of N may be attributed to the microbial metabolism shifts induced by high N.
文摘Epigallocatechin-3-gallate （EGCG）, a naturally occurring compound in green tea, has been widely used as an antioxidant agent. In the present study, model rats with acute spinal cord injury were intraperitoneally injected with 25, 50, and 100 mg/kg EGCG, and spinal cord ultrastructure, oxidative stress reaction, inflammatory factors, and apoptosis-associated gene expression were observed. Results showed that EGCG attenuated neuronal and axonal injury 24 hours post injury. It also decreased serum intedeukin-113, tumor necrosis factor-a, and intercellular adhesion molecule-1 release, and decreased apoptosis-associated gene expression. Furthermore, it increased the level of the superoxide anion （O2-）, superoxide dismutase, and B-cell lymphoma/leukemia-2, and reduced malondialdehyde levels. Furthermore, it reduced the expression of the pro-apoptotic protein Bax. Noticeably, EGCG at the 100 mg/kg dosage exhibited similar effects as methylprednisolone sodium succinate, which has been frequently used for clinical acute spinal cord injury. The results demonstrated that EGCG can significantly inhibit inflammation, suppress oxidation, and reduce apoptosis in acute spinal cord injury.
文摘We have shown that some phenylethynylsilicon compounds are good cure crosslinkersof heat-curable silicone rubber(HCSR). In this paper the effects of 1, 1, 3, 3-tetramethyl-1, 3-diphenylethynyldisiloxane (TMDPDS) as a crosslinker on HCSR were studied. Thevulcanizates with fine mechanical properties could be obtained with suitable amounts ofTMDPDS. Sol fractions, and crosslinking density of vulcanizates and vulcanizationretardation effect of TMDPDS on hydrosilation curing silicone rubber were also discussed.
