Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies.Conventional two-dimensional(2D)cell cultures cannot replicate the complexity of t...Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies.Conventional two-dimensional(2D)cell cultures cannot replicate the complexity of the in vivo tumor microenvironment(TME),limiting their utility for drug resistance research.Therefore,three-dimensional(3D)tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms.In this review,various cancer 3D models,including spheroids,organoids,scaffold-based models,and bioprinted models,are comprehensively evaluated with a focus on their application in drug resistance studies.We discuss the materials,properties,and advantages of each model,highlighting their ability to better mimic the TME and represent complex mechanisms of drug resistance such as epithelial-mesenchymal transition(EMT),drug efflux,and tumor-stroma interactions.Furthermore,we investigate the limitations of these models,including scalability,reproducibility and technical challenges,as well as their potential therapeutic impact on personalized medicine.Through a thorough comparison of model performance,we provide insights into the strengths and weaknesses of each approach and offer guidance for model selection based on specific research needs.展开更多
The formation heterogeneity is considered as one of the major factors limiting the application of foam flooding.In this paper,influences of formation properties,such as permeability,permeability distribution,interlaye...The formation heterogeneity is considered as one of the major factors limiting the application of foam flooding.In this paper,influences of formation properties,such as permeability,permeability distribution,interlayer,sedimentary rhythm and 3D heterogeneity,on the mobility control capability and oil displacement efficiency of foam flooding,were systematically investigated using 2D homogeneous and 2D/3D heterogeneous models under 120°C and salinity of 20×10~4 mg/L.The flow resistance of foam was promoted as the permeability increased,which thus resulted in a considerable oil recovery behavior.In the scenario of the vertical heterogeneous formations,it was observed that the permeability of the high-permeable layer was crucial to foam mobility control,and the positive rhythm appeared favorable to improve the foam flooding performance.The additional oil recovery increased to about 40%.The interlayer was favorable for the increases in mobility reduction factor and oil recovery of foam flooding when the low permeability ratio was involved.For the 3D heterogeneous formations,foam could efficiently adjust the areal and vertical heterogeneity through mobility control and gravity segregation,and thus enhancing the oil recovery to 11%–14%.The results derived from this work may provide some insight for the field test designs of foam flooding.展开更多
Soil-rock mixture （SRM） is a unique type of geomaterial characterized by a heterogeneous composition and a complicated structure. It is intractable for the continuum-based soil and rock mechanics theories to accurat...Soil-rock mixture （SRM） is a unique type of geomaterial characterized by a heterogeneous composition and a complicated structure. It is intractable for the continuum-based soil and rock mechanics theories to accurately characterize and predict the SRM＇s mechanical properties. This study reports a novel numerical method incorporating microfocus computed tomography and PFC3D codes to probe the deformation and failure processes of SRM. The three-dimensional （3D） PFC models that represent the SRM＇s complex structures were built. By simulating the entire failure process in PFC3D, the SRM＇s strength, elastic modulus and crack growth were obtained. The influence of rock ratios on the SRM＇s strength, deformation and failure processes, as well as its internal mesoscale mechanism, were analyzed. By comparing simulation results with experimental data, it was verified that the 3D PFC models were in good agreement with SRM＇s real structure and the SRM＇s compression process, deformation and failure patterns; its intrinsic mesomechanism can be effectively analyzed based on such 3D PFC models.展开更多
Background With the rapid development of Web3D technologies, the online Web3D visualization, particularly for complex models or scenes, has been in a great demand. Owing to the major conflict between the Web3D system ...Background With the rapid development of Web3D technologies, the online Web3D visualization, particularly for complex models or scenes, has been in a great demand. Owing to the major conflict between the Web3D system load and resource consumption in the processing of these huge models, the huge 3D model lightweighting methods for online Web3D visualization are reviewed in this paper. Methods By observing the geometry redundancy introduced by man-made operations in the modeling procedure, several categories of light-weighting related work that aim at reducing the amount of data and resource consumption are elaborated for Web3D visualization. Results By comparing perspectives, the characteristics of each method are summarized, and among the reviewed methods, the geometric redundancy removal that achieves the lightweight goal by detecting and removing the repeated components is an appropriate method for current online Web3D visualization. Meanwhile, the learning algorithm, still in improvement period at present, is our expected future research topic. Conclusions Various aspects should be considered in an efficient lightweight method for online Web3D visualization, such as characteristics of original data, combination or extension of existing methods, scheduling strategy, cache man-agement, and rendering mechanism. Meanwhile, innovation methods, particularly the learning algorithm, are worth exploring.展开更多
In this article we present our system for scalable,robust,and fast city-scale reconstruction from Internet photo collections(IPC)obtaining geo-registered dense 3D models.The major achievements of our system are the ef...In this article we present our system for scalable,robust,and fast city-scale reconstruction from Internet photo collections(IPC)obtaining geo-registered dense 3D models.The major achievements of our system are the efficient use of coarse appearance descriptors combined with strong geometric constraints to reduce the computational complexity of the image overlap search.This unique combination of recognition and geometric constraints allows our method to reduce from quadratic complexity in the number of images to almost linear complexity in the IPC size.Accordingly,our 3D-modeling framework is inherently better scalable than other state of the art methods and in fact is currently the only method to support modeling from millions of images.In addition,we propose a novel mechanism to overcome the inherent scale ambiguity of the reconstructed models by exploiting geo-tags of the Internet photo collection images and readily available StreetView panoramas for fully automatic geo-registration of the 3D model.Moreover,our system also exploits image appearance clustering to tackle the challenge of computing dense 3D models from an image collection that has significant variation in illumination between images along with a wide variety of sensors and their associated different radiometric camera parameters.Our algorithm exploits the redundancy of the data to suppress estimation noise through a novel depth map fusion.The fusion simultaneously exploits surface and free space constraints during the fusion of a large number of depth maps.Cost volume compression during the fusion achieves lower memory requirements for high-resolution models.We demonstrate our system on a variety of scenes from an Internet photo collection of Berlin containing almost three million images from which we compute dense models in less than the span of a day on a single computer.展开更多
Effectively managing extensive,multi-source,and multi-level real-scene 3D models for responsive retrieval scheduling and rapid visualization in the Web environment is a significant challenge in the current development...Effectively managing extensive,multi-source,and multi-level real-scene 3D models for responsive retrieval scheduling and rapid visualization in the Web environment is a significant challenge in the current development of real-scene 3D applications in China.In this paper,we address this challenge by reorganizing spatial and temporal information into a 3D geospatial grid.It introduces the Global 3D Geocoding System(G_(3)DGS),leveraging neighborhood similarity and uniqueness for efficient storage,retrieval,updating,and scheduling of these models.A combination of G_(3)DGS and non-relational databases is implemented,enhancing data storage scalability and flexibility.Additionally,a model detail management scheduling strategy(TLOD)based on G_(3)DGS and an importance factor T is designed.Compared with mainstream commercial and open-source platforms,this method significantly enhances the loadable capacity of massive multi-source real-scene 3D models in the Web environment by 33%,improves browsing efficiency by 48%,and accelerates invocation speed by 40%.展开更多
This paper describes a novel algorithm for fragile watermarking of 3D models. Fragile watermarking requires detection of even minute intentional changes to the 3D model along with the location of the change. This pose...This paper describes a novel algorithm for fragile watermarking of 3D models. Fragile watermarking requires detection of even minute intentional changes to the 3D model along with the location of the change. This poses a challenge since inserting random amount of watermark in all the vertices of the model would generally introduce perceptible distortion. The proposed algorithm overcomes this challenge by using genetic algorithm to modify every vertex location in the model so that there is no perceptible distortion. Various experimental results are used to justify the choice of the genetic algorithm design parameters. Experimental results also indicate that the proposed algorithm can accurately detect location of any mesh modification.展开更多
Auspicious patterns are an important manifestation of traditional crafts aesthetics for Chinese culture, and it not only exhibits the clever tricks of folk art, showing more personality and characteristics of Chinese ...Auspicious patterns are an important manifestation of traditional crafts aesthetics for Chinese culture, and it not only exhibits the clever tricks of folk art, showing more personality and characteristics of Chinese culture in the humanities and arts aesthetic concerns. It shows the traditional aesthetics, based on the harmonious and success, constructed by intelligence and humbleness, shaped by symmetry and balance. This thesis contains two topics: they are the 2D image materialization and the 3D model flattening. First is analyzing the image of the auspicious pattern, and transformed the 2D image into a solid model. The second is through the mathematical operation skills of the geometric model, the existing auspicious 3D model of the triangular mesh is scaled, appropriately rotated and divided to form a flattening model of different visual effects. Finally, these models by means of other modeling software were combined into a new 3D model, then through the 3D printer to quickly print out part of the unique personalized products, to promote the natural beauty of traditional Chinese culture.展开更多
In 3D models retrieval, feature description and retrieval of non-rigid model face more complex problems due to the isometry transformation of itself. We introduce the hierarchical combination matching into the feature...In 3D models retrieval, feature description and retrieval of non-rigid model face more complex problems due to the isometry transformation of itself. We introduce the hierarchical combination matching into the feature comparison, and build a map between the divided regions of two models, and then achieve accurate feature matching based on patch-by-patch, which successfully introduces the spatial information into feature matching. Verified by experiment, the 3D model retrieval method proposed in this paper based on hierarchical combination matching can make sure more accurate feature matching, so as to enhance the precision of retrieval.展开更多
Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual pat...Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual patient responses towards different drugs.This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations.Methods:Tumor and adjacent tissues from female breast cancer patients were collected during surgery.Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models.The obtained patient-derived conditional reprogramming breast cancer(CRBC)cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres to form 3D culture models.Comparisons between 2D and 3D models were made using immunohistochemistry(tumor markers),MTS assays(cell viability),flow cytometry(apoptosis),transwell assays(migration),and Western blotting(protein expression).Drug sensitivity tests were conducted to evaluate patient-specific responses to anti-cancer agents.Results:2D and 3D culture models were successfully established using samples from eight patients.The 3D models retained histological and marker characteristics of the original tumors.Compared to 2D cultures,3D models exhibited increased apoptosis,enhanced drug resistance,elevated stem cell marker expression,and greater migration ability—features more reflective of in vivo tumor behavior.Conclusion:Patient-derived 3D CRBC models effectively mimic the in vivo tumor microenvironment and demonstrate stronger resistance to anti-cancer drugs than 2D models.These hydrogel-based models offer a cost-effective and clinically relevant platform for drug screening and personalized breast cancer treatment.展开更多
The three-dimensional(3D)geometry of a fault is a critical control on earthquake nucleation,dynamic rupture,stress triggering,and related seismic hazards.Therefore,a 3D model of an active fault can significantly impro...The three-dimensional(3D)geometry of a fault is a critical control on earthquake nucleation,dynamic rupture,stress triggering,and related seismic hazards.Therefore,a 3D model of an active fault can significantly improve our understanding of seismogenesis and our ability to evaluate seismic hazards.Utilising the SKUA GoCAD software,we constructed detailed seismic fault models for the 2021 M_(S)6.4 Yangbi earthquake in Yunnan,China,using two sets of relocated earthquake catalogs and focal mechanism solutions following a convenient 3D fault modeling workflow.Our analysis revealed a NW-striking main fault with a high-angle SW dip,accompanied by two branch faults.Interpretation of one dataset revealed a single NNW-striking branch fault SW of the main fault,whereas the other dataset indicated four steep NNE-striking segments with a left-echelon pattern.Additionally,a third ENE-striking short fault was identified NE of the main fault.In combination with the spatial distribution of pre-existing faults,our 3D fault models indicate that the Yangbi earthquake reactivated pre-existing NW-and NE-striking fault directions rather than the surface-exposed Weixi-Qiaohou-Weishan Fault zone.The occurrence of the Yangbi earthquake demonstrates that the reactivation of pre-existing faults away from active fault zones,through either cascade or conjugate rupture modes,can cause unexpected moderate-large earthquakes and severe disasters,necessitating attention in regions like southeast Xizang,which have complex fault systems.展开更多
Accurate retrieval of casting 3D models is crucial for process reuse.Current methods primarily focus on shape similarity,neglecting process design features,which compromises reusability.In this study,a novel deep lear...Accurate retrieval of casting 3D models is crucial for process reuse.Current methods primarily focus on shape similarity,neglecting process design features,which compromises reusability.In this study,a novel deep learning retrieval method for process reuse was proposed,which integrates process design features into the retrieval of casting 3D models.This method leverages the comparative language-image pretraining(CLIP)model to extract shape features from the three views and sectional views of the casting model and combines them with process design features such as modulus,main wall thickness,symmetry,and length-to-height ratio to enhance process reusability.A database of 230 production casting models was established for model validation.Results indicate that incorporating process design features improves model accuracy by 6.09%,reaching 97.82%,and increases process similarity by 30.25%.The reusability of the process was further verified using the casting simulation software EasyCast.The results show that the process retrieved after integrating process design features produces the least shrinkage in the target model,demonstrating this method’s superior ability for process reuse.This approach does not require a large dataset for training and optimization,making it highly applicable to casting process design and related manufacturing processes.展开更多
The increasing incidence of bone diseases has driven research towards Bone Tissue Engineering(BTE),an innovative discipline that uses biomaterials to develop three-dimensional(3D)scafolds capable of mimicking the natu...The increasing incidence of bone diseases has driven research towards Bone Tissue Engineering(BTE),an innovative discipline that uses biomaterials to develop three-dimensional(3D)scafolds capable of mimicking the natural environment of bone tissue.Traditional approaches relying on two-dimensional(2D)models have exhibited signifcant limitations in simulating cellular interactions and the complexity of the bone microenvironment.In response to these challenges,3D models such as organoids and cellular spheroids have emerged as efective tools for studying bone regeneration.Adult mesenchymal stem cells have proven crucial in this context,as they can diferentiate into osteoblasts and contribute to bone tissue repair.Furthermore,the integration of composite biomaterials has shown substantial potential in enhancing bone healing.Advanced technologies like microfuidics ofer additional opportunities to create controlled environments for cell culture,facilitating more detailed studies on bone regeneration.These advancements represent a fundamental step forward in the treatment of bone pathologies and the promotion of skeletal health.In this review,we report on the evolution of in vitro culture models applied to the study of bone healing/regrowth,starting from 2 to 3D cultures and microfuids.The diferent methodologies of in vitro model generation,cells and biomaterials are presented and discussed.展开更多
Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical si...Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical simulation plays a significant role in quantitatively evaluating current processes and making targeted improvements,but its limitations lie in the inability to dynamically reflect the formation outcomes of castings under varying process conditions,making real-time adjustments to gating and riser designs challenging.In this study,an automated design model for gating and riser systems based on integrated parametric 3D modeling-simulation framework is proposed,which enhances the flexibility and usability of evaluating the casting process by simulation.Firstly,geometric feature extraction technology is employed to obtain the geometric information of the target casting.Based on this information,an automated design framework for gating and riser systems is established,incorporating multiple structural parameters for real-time process control.Subsequently,the simulation results for various structural parameters are analyzed,and the influence of these parameters on casting formation is thoroughly investigated.Finally,the optimal design scheme is generated and validated through experimental verification.Simulation analysis and experimental results show that using a larger gate neck(24 mm in side length) and external risers promotes a more uniform temperature distribution and a more stable flow state,effectively eliminating shrinkage cavities and enhancing process yield by 15%.展开更多
The intracontinental subduction of a>200-km-long section of the Tajik-Tarim lithosphere beneath the Pamir Mountains is proposed to explain nearly 30 km of shortening in the Tajik fold-thrust belt and the Pamir upli...The intracontinental subduction of a>200-km-long section of the Tajik-Tarim lithosphere beneath the Pamir Mountains is proposed to explain nearly 30 km of shortening in the Tajik fold-thrust belt and the Pamir uplift.Seismic imaging revealed that the upper slab was scraped and that the lower slab had subducted to a depth of>150 km.These features constitute the tectonic complexity of the Pamirs,as well as the thermal subduction mechanism involved,which remains poorly understood.Hence,in this study,high-resolution three-dimensional(3D)kinematic modeling is applied to investigate the thermal structure and geometry of the subducting slab beneath the Pamirs.The modeled slab configuration reveals distinct along-strike variations,with a steeply dipping slab beneath the southern Pamirs,a more gently inclined slab beneath the northern Pamirs,and apparent upper slab termination at shallow depths beneath the Pamirs.The thermal field reveals a cold slab core after delamination,with temperatures ranging from 400℃to 800℃,enveloped by a hotter mantle reaching~1400℃.The occurrence of intermediate-depth earthquakes aligns primarily with colder slab regions,particularly near the slab tear-off below the southwestern Pamirs,indicating a strong correlation between slab temperature and seismicity.In contrast,the northern Pamirs exhibit reduced seismicity at depth,which is likely associated with thermal weakening and delamination.The central Pamirs show a significant thermal anomaly caused by a concave slab,where the coldest crust does not descend deeply,further suggesting crustal detachment or mechanical failure.The lateral asymmetry in slab temperature possibly explains the mechanism of lateral tearing and differential slab-mantle coupling.展开更多
The development of unmanned aerial vehicle(UAV)oblique photogrammetric technology provides a good foundation for the rapid construction of large-scale and high-definition real-scene 3D models.However,due to the limita...The development of unmanned aerial vehicle(UAV)oblique photogrammetric technology provides a good foundation for the rapid construction of large-scale and high-definition real-scene 3D models.However,due to the limitations of the modeling process,irrelevant feature data cannot be eliminated in the modeling stage.The built models contain irrelevant features and model distortions caused by errors.At present,most existing clipping algorithms cannot effectively clip real-scene 3D models that are organized as a whole or with levels of detail(LODs).Therefore,this paper proposes a novel algorithm for clipping real-scene 3D models from any perspective based on clipping boundary lines thatfit the surfaces of the models.The results of the clipping experiments for 3D models constructed with oblique UAV images show that this algorithm can effectively clip any part of the 3D models,that the clipping results of each level model closelyfit the corresponding clipping boundary lines,and that the accuracy of the clipping results is very high.Additionally,the time complexity of the algorithm is O(n^(2)).In conclusion,the algorithm proposed in this paper provides correct and effective clipping results for real-scene 3D models with LODs that are constructed with photogrammetric or 3D laser scanning data.展开更多
Uncertainty in 3D geological structure models has become a bottleneck that restricts the development and application of 3D geological modeling.In order to solve this problem during periods of accuracy assessment,error...Uncertainty in 3D geological structure models has become a bottleneck that restricts the development and application of 3D geological modeling.In order to solve this problem during periods of accuracy assessment,error detection and dynamic correction in 3D geological structure models,we have reviewed the current situation and development trends in 3D geological modeling.The main context of uncertainty in 3D geological structure models is discussed.Major research issues and a general framework system of uncertainty in 3D geological structure models are proposed.We have described in detail the integration of development practices of 3D geological modeling systems,as well as the implementation process for uncertainty evaluation in 3D geological structure models.This study has laid the basis to build theoretical and methodological systems for accuracy assessment and error correction in 3D geological models and can assist in improving 3D modeling techniques under complex geological conditions.展开更多
A grain-based distinct element model featuring three-dimensional （3D） Voronoi tessellations （randompoly-crystals） is proposed for simulation of crack damage development in brittle rocks. The grainboundaries in pol...A grain-based distinct element model featuring three-dimensional （3D） Voronoi tessellations （randompoly-crystals） is proposed for simulation of crack damage development in brittle rocks. The grainboundaries in poly-crystal structure produced by Voronoi tessellations can represent flaws in intact rockand allow for numerical replication of crack damage progression through initiation and propagation ofmicro-fractures along grain boundaries. The Voronoi modelling scheme has been used widely in the pastfor brittle fracture simulation of rock materials. However the difficulty of generating 3D Voronoi modelshas limited its application to two-dimensional （2D） codes. The proposed approach is implemented inNeper, an open-source engine for generation of 3D Voronoi grains, to generate block geometry files thatcan be read directly into 3DEC. A series of Unconfined Compressive Strength （UCS） tests are simulated in3DEC to verify the proposed methodology for 3D simulation of brittle fractures and to investigate therelationship between each micro-parameter and the model＇s macro-response. The possibility of numericalreplication of the classical U-shape strength curve for anisotropic rocks is also investigated innumerical UCS tests by using complex-shaped （elongated） grains that are cemented to one another alongtheir adjoining sides. A micro-parameter calibration procedure is established for 3D Voronoi models foraccurate replication of the mechanical behaviour of isotropic and anisotropic （containing a fabric） rocks. 2014 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.展开更多
Transparent physical models of real rocks fabricated using three-dimensional(3D)printing technology are used in photoelas-tic experiments to quantify the evolution of the internal stress and deformation fields of rock...Transparent physical models of real rocks fabricated using three-dimensional(3D)printing technology are used in photoelas-tic experiments to quantify the evolution of the internal stress and deformation fields of rocks.Therefore,they are rendered as an emerging powerful technique to quantitatively reveal the intrinsic mechanisms of rock failure.The mechanical behav-ior of natural rocks exhibits a significant size effect;however,limited research has been conducted on whether transparent physical models observe similar size effects.In this study,to make the transparent printed models accurately demonstrate the mechanical behavior of natural rocks and reveal the internal mechanism of the size effect in rock mechanical behavior,the size effect in 3D printed models of fractured and porous rocks under uniaxial compressive loading was investigated.Transparent cylindrical models with different sizes that contained different fractured and porous structures were printed using the fracture and porous characteristics extracted from natural coal and sandstone.The variation in uniaxial compres-sive strength and elastic modulus of fractured and porous models for increasing model sizes were obtained through uniaxial compression experiments.Finally,the influence of internal discontinuous structural features,such as fractures and pores,on the size effect pertaining to the mechanical behavior of the model was analyzed and elaborated by comparing it with the mechanical properties of the continuous homogeneous model without fractures and pores.The findings provided support and reference to analyze the size effect of rock mechanical behavior and the effect of the internal discontinuous structure using 3D printed transparent models.展开更多
An automatic generation method of geological cross-sections in dredging engineering based on 3D geological solid models is presented.The 3D geological models are built applying the non-uniform rational B-splines(NURBS...An automatic generation method of geological cross-sections in dredging engineering based on 3D geological solid models is presented.The 3D geological models are built applying the non-uniform rational B-splines(NURBS) technique,and a 2D profile can be calculated and generated automatically through Boolean operation to meet the demands of dredging projects.Moreover,an automatic marking method for geological attributes is put forward based on database technology,and the geological attributes include the profile name,scale,horizontal and vertical relative coordinates,geological lithology,and 2D standard lithology legend.At the same time,the automatic marking method can also provide an interactive mode for geological engineers to edit and modify the profile in the modeling system.Practical engineering applications show that the automatic generation method is a simple,flexible,fast and precise visual graphics rendering process that can create 2D standard profiles automatically and efficiently.This method also provides a convenient support tool for geological engineering digital analysis.展开更多
基金funded by the Ministry of Science,Technological Development and Innovation of the Republic of Serbia(grant numbers 451-03-136/2025-03/200007 and 451-03-136/2025-03/200042).
文摘Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies.Conventional two-dimensional(2D)cell cultures cannot replicate the complexity of the in vivo tumor microenvironment(TME),limiting their utility for drug resistance research.Therefore,three-dimensional(3D)tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms.In this review,various cancer 3D models,including spheroids,organoids,scaffold-based models,and bioprinted models,are comprehensively evaluated with a focus on their application in drug resistance studies.We discuss the materials,properties,and advantages of each model,highlighting their ability to better mimic the TME and represent complex mechanisms of drug resistance such as epithelial-mesenchymal transition(EMT),drug efflux,and tumor-stroma interactions.Furthermore,we investigate the limitations of these models,including scalability,reproducibility and technical challenges,as well as their potential therapeutic impact on personalized medicine.Through a thorough comparison of model performance,we provide insights into the strengths and weaknesses of each approach and offer guidance for model selection based on specific research needs.
基金financially supported by the Scientific Research Startup Foundation of Xinjiang University(No.620312377)the National Science and Technology Major Project of China(No.2016ZX05053-013)
文摘The formation heterogeneity is considered as one of the major factors limiting the application of foam flooding.In this paper,influences of formation properties,such as permeability,permeability distribution,interlayer,sedimentary rhythm and 3D heterogeneity,on the mobility control capability and oil displacement efficiency of foam flooding,were systematically investigated using 2D homogeneous and 2D/3D heterogeneous models under 120°C and salinity of 20×10~4 mg/L.The flow resistance of foam was promoted as the permeability increased,which thus resulted in a considerable oil recovery behavior.In the scenario of the vertical heterogeneous formations,it was observed that the permeability of the high-permeable layer was crucial to foam mobility control,and the positive rhythm appeared favorable to improve the foam flooding performance.The additional oil recovery increased to about 40%.The interlayer was favorable for the increases in mobility reduction factor and oil recovery of foam flooding when the low permeability ratio was involved.For the 3D heterogeneous formations,foam could efficiently adjust the areal and vertical heterogeneity through mobility control and gravity segregation,and thus enhancing the oil recovery to 11%–14%.The results derived from this work may provide some insight for the field test designs of foam flooding.
基金Acknowledgements The authors gratefully acknowledge the financial support from the State Key Research Development Program of China （Grant No. 2016YFC0600705）, the National Natural Science Foundation of China （Grant Nos. 51674251, 51727807, 51374213）, the National Natural Science Foundation for Distinguished Young Scholars of China （Grant No. 51125017）, the Fund for Creative Research and Development Group Program of Jiangsu Province （Grant No. 2014-27）, and the Priority Academic Program Development of Jiangsu Higher Education Institutions （Grant No. PAPD2014）, and an open project sponsored by the State Key Labo- ratory for Geomechanics and Deep Underground Engineering （Grant SKLGDUE K1318） for their financial support.
文摘Soil-rock mixture （SRM） is a unique type of geomaterial characterized by a heterogeneous composition and a complicated structure. It is intractable for the continuum-based soil and rock mechanics theories to accurately characterize and predict the SRM＇s mechanical properties. This study reports a novel numerical method incorporating microfocus computed tomography and PFC3D codes to probe the deformation and failure processes of SRM. The three-dimensional （3D） PFC models that represent the SRM＇s complex structures were built. By simulating the entire failure process in PFC3D, the SRM＇s strength, elastic modulus and crack growth were obtained. The influence of rock ratios on the SRM＇s strength, deformation and failure processes, as well as its internal mesoscale mechanism, were analyzed. By comparing simulation results with experimental data, it was verified that the 3D PFC models were in good agreement with SRM＇s real structure and the SRM＇s compression process, deformation and failure patterns; its intrinsic mesomechanism can be effectively analyzed based on such 3D PFC models.
文摘Background With the rapid development of Web3D technologies, the online Web3D visualization, particularly for complex models or scenes, has been in a great demand. Owing to the major conflict between the Web3D system load and resource consumption in the processing of these huge models, the huge 3D model lightweighting methods for online Web3D visualization are reviewed in this paper. Methods By observing the geometry redundancy introduced by man-made operations in the modeling procedure, several categories of light-weighting related work that aim at reducing the amount of data and resource consumption are elaborated for Web3D visualization. Results By comparing perspectives, the characteristics of each method are summarized, and among the reviewed methods, the geometric redundancy removal that achieves the lightweight goal by detecting and removing the repeated components is an appropriate method for current online Web3D visualization. Meanwhile, the learning algorithm, still in improvement period at present, is our expected future research topic. Conclusions Various aspects should be considered in an efficient lightweight method for online Web3D visualization, such as characteristics of original data, combination or extension of existing methods, scheduling strategy, cache man-agement, and rendering mechanism. Meanwhile, innovation methods, particularly the learning algorithm, are worth exploring.
文摘In this article we present our system for scalable,robust,and fast city-scale reconstruction from Internet photo collections(IPC)obtaining geo-registered dense 3D models.The major achievements of our system are the efficient use of coarse appearance descriptors combined with strong geometric constraints to reduce the computational complexity of the image overlap search.This unique combination of recognition and geometric constraints allows our method to reduce from quadratic complexity in the number of images to almost linear complexity in the IPC size.Accordingly,our 3D-modeling framework is inherently better scalable than other state of the art methods and in fact is currently the only method to support modeling from millions of images.In addition,we propose a novel mechanism to overcome the inherent scale ambiguity of the reconstructed models by exploiting geo-tags of the Internet photo collection images and readily available StreetView panoramas for fully automatic geo-registration of the 3D model.Moreover,our system also exploits image appearance clustering to tackle the challenge of computing dense 3D models from an image collection that has significant variation in illumination between images along with a wide variety of sensors and their associated different radiometric camera parameters.Our algorithm exploits the redundancy of the data to suppress estimation noise through a novel depth map fusion.The fusion simultaneously exploits surface and free space constraints during the fusion of a large number of depth maps.Cost volume compression during the fusion achieves lower memory requirements for high-resolution models.We demonstrate our system on a variety of scenes from an Internet photo collection of Berlin containing almost three million images from which we compute dense models in less than the span of a day on a single computer.
基金National Key Research and Development Program of China(No.2023YFB3907103).
文摘Effectively managing extensive,multi-source,and multi-level real-scene 3D models for responsive retrieval scheduling and rapid visualization in the Web environment is a significant challenge in the current development of real-scene 3D applications in China.In this paper,we address this challenge by reorganizing spatial and temporal information into a 3D geospatial grid.It introduces the Global 3D Geocoding System(G_(3)DGS),leveraging neighborhood similarity and uniqueness for efficient storage,retrieval,updating,and scheduling of these models.A combination of G_(3)DGS and non-relational databases is implemented,enhancing data storage scalability and flexibility.Additionally,a model detail management scheduling strategy(TLOD)based on G_(3)DGS and an importance factor T is designed.Compared with mainstream commercial and open-source platforms,this method significantly enhances the loadable capacity of massive multi-source real-scene 3D models in the Web environment by 33%,improves browsing efficiency by 48%,and accelerates invocation speed by 40%.
文摘This paper describes a novel algorithm for fragile watermarking of 3D models. Fragile watermarking requires detection of even minute intentional changes to the 3D model along with the location of the change. This poses a challenge since inserting random amount of watermark in all the vertices of the model would generally introduce perceptible distortion. The proposed algorithm overcomes this challenge by using genetic algorithm to modify every vertex location in the model so that there is no perceptible distortion. Various experimental results are used to justify the choice of the genetic algorithm design parameters. Experimental results also indicate that the proposed algorithm can accurately detect location of any mesh modification.
文摘Auspicious patterns are an important manifestation of traditional crafts aesthetics for Chinese culture, and it not only exhibits the clever tricks of folk art, showing more personality and characteristics of Chinese culture in the humanities and arts aesthetic concerns. It shows the traditional aesthetics, based on the harmonious and success, constructed by intelligence and humbleness, shaped by symmetry and balance. This thesis contains two topics: they are the 2D image materialization and the 3D model flattening. First is analyzing the image of the auspicious pattern, and transformed the 2D image into a solid model. The second is through the mathematical operation skills of the geometric model, the existing auspicious 3D model of the triangular mesh is scaled, appropriately rotated and divided to form a flattening model of different visual effects. Finally, these models by means of other modeling software were combined into a new 3D model, then through the 3D printer to quickly print out part of the unique personalized products, to promote the natural beauty of traditional Chinese culture.
基金Supported by National Nature Science Foundation of China(61379106,61379082,61227802)Shandong Provincial Natural Science Foundation(ZR2013FM036,ZR2015FM011,ZR2015FM022)
文摘In 3D models retrieval, feature description and retrieval of non-rigid model face more complex problems due to the isometry transformation of itself. We introduce the hierarchical combination matching into the feature comparison, and build a map between the divided regions of two models, and then achieve accurate feature matching based on patch-by-patch, which successfully introduces the spatial information into feature matching. Verified by experiment, the 3D model retrieval method proposed in this paper based on hierarchical combination matching can make sure more accurate feature matching, so as to enhance the precision of retrieval.
基金supported by the Natural Science Foundation of Guangdong Province(No.2021B1515120053)Guangdong Basic and Applied Basic Research Foundation(Grant No.2024A1515140166).
文摘Background:Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity.Current preclinical models,however,are inadequate for predicting individual patient responses towards different drugs.This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations.Methods:Tumor and adjacent tissues from female breast cancer patients were collected during surgery.Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models.The obtained patient-derived conditional reprogramming breast cancer(CRBC)cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres to form 3D culture models.Comparisons between 2D and 3D models were made using immunohistochemistry(tumor markers),MTS assays(cell viability),flow cytometry(apoptosis),transwell assays(migration),and Western blotting(protein expression).Drug sensitivity tests were conducted to evaluate patient-specific responses to anti-cancer agents.Results:2D and 3D culture models were successfully established using samples from eight patients.The 3D models retained histological and marker characteristics of the original tumors.Compared to 2D cultures,3D models exhibited increased apoptosis,enhanced drug resistance,elevated stem cell marker expression,and greater migration ability—features more reflective of in vivo tumor behavior.Conclusion:Patient-derived 3D CRBC models effectively mimic the in vivo tumor microenvironment and demonstrate stronger resistance to anti-cancer drugs than 2D models.These hydrogel-based models offer a cost-effective and clinically relevant platform for drug screening and personalized breast cancer treatment.
基金financial support from the National Key R&D Program of China (No. 2021YFC3000600)National Natural Science Foundation of China (No. 41872206)National Nonprofit Fundamental Research Grant of China, Institute of Geology, China, Earthquake Administration (No. IGCEA2010)
文摘The three-dimensional(3D)geometry of a fault is a critical control on earthquake nucleation,dynamic rupture,stress triggering,and related seismic hazards.Therefore,a 3D model of an active fault can significantly improve our understanding of seismogenesis and our ability to evaluate seismic hazards.Utilising the SKUA GoCAD software,we constructed detailed seismic fault models for the 2021 M_(S)6.4 Yangbi earthquake in Yunnan,China,using two sets of relocated earthquake catalogs and focal mechanism solutions following a convenient 3D fault modeling workflow.Our analysis revealed a NW-striking main fault with a high-angle SW dip,accompanied by two branch faults.Interpretation of one dataset revealed a single NNW-striking branch fault SW of the main fault,whereas the other dataset indicated four steep NNE-striking segments with a left-echelon pattern.Additionally,a third ENE-striking short fault was identified NE of the main fault.In combination with the spatial distribution of pre-existing faults,our 3D fault models indicate that the Yangbi earthquake reactivated pre-existing NW-and NE-striking fault directions rather than the surface-exposed Weixi-Qiaohou-Weishan Fault zone.The occurrence of the Yangbi earthquake demonstrates that the reactivation of pre-existing faults away from active fault zones,through either cascade or conjugate rupture modes,can cause unexpected moderate-large earthquakes and severe disasters,necessitating attention in regions like southeast Xizang,which have complex fault systems.
基金supported by the National Natural Science Foundation of China(Nos.52074246,52275390,52375394)the National Defense Basic Scientific Research Program of China(No.JCKY2020408B002)the Key R&D Program of Shanxi Province(No.202102050201011).
文摘Accurate retrieval of casting 3D models is crucial for process reuse.Current methods primarily focus on shape similarity,neglecting process design features,which compromises reusability.In this study,a novel deep learning retrieval method for process reuse was proposed,which integrates process design features into the retrieval of casting 3D models.This method leverages the comparative language-image pretraining(CLIP)model to extract shape features from the three views and sectional views of the casting model and combines them with process design features such as modulus,main wall thickness,symmetry,and length-to-height ratio to enhance process reusability.A database of 230 production casting models was established for model validation.Results indicate that incorporating process design features improves model accuracy by 6.09%,reaching 97.82%,and increases process similarity by 30.25%.The reusability of the process was further verified using the casting simulation software EasyCast.The results show that the process retrieved after integrating process design features produces the least shrinkage in the target model,demonstrating this method’s superior ability for process reuse.This approach does not require a large dataset for training and optimization,making it highly applicable to casting process design and related manufacturing processes.
基金supported,in part,by grants from University of Ferrara,Fondo di Ateneo per la Ricerca(FAR 2023 and FAR 2024)to EM and FMFondo per l’Incentivazione alla Ricerca Dipartimentale(FIRD)grant to EM 2023+1 种基金Ministero dell’Universitàe Ricerca(MUR)PRIN 2017,project code C8RYSS to FMFoundation Cariverona and Foundation Caritro,Bando Ricerca e Sviluppo,2020 code number 50457 to ADA and LT.
文摘The increasing incidence of bone diseases has driven research towards Bone Tissue Engineering(BTE),an innovative discipline that uses biomaterials to develop three-dimensional(3D)scafolds capable of mimicking the natural environment of bone tissue.Traditional approaches relying on two-dimensional(2D)models have exhibited signifcant limitations in simulating cellular interactions and the complexity of the bone microenvironment.In response to these challenges,3D models such as organoids and cellular spheroids have emerged as efective tools for studying bone regeneration.Adult mesenchymal stem cells have proven crucial in this context,as they can diferentiate into osteoblasts and contribute to bone tissue repair.Furthermore,the integration of composite biomaterials has shown substantial potential in enhancing bone healing.Advanced technologies like microfuidics ofer additional opportunities to create controlled environments for cell culture,facilitating more detailed studies on bone regeneration.These advancements represent a fundamental step forward in the treatment of bone pathologies and the promotion of skeletal health.In this review,we report on the evolution of in vitro culture models applied to the study of bone healing/regrowth,starting from 2 to 3D cultures and microfuids.The diferent methodologies of in vitro model generation,cells and biomaterials are presented and discussed.
基金financially supported by the National Key Research and Development Program of China (2022YFB3706802)。
文摘Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical simulation plays a significant role in quantitatively evaluating current processes and making targeted improvements,but its limitations lie in the inability to dynamically reflect the formation outcomes of castings under varying process conditions,making real-time adjustments to gating and riser designs challenging.In this study,an automated design model for gating and riser systems based on integrated parametric 3D modeling-simulation framework is proposed,which enhances the flexibility and usability of evaluating the casting process by simulation.Firstly,geometric feature extraction technology is employed to obtain the geometric information of the target casting.Based on this information,an automated design framework for gating and riser systems is established,incorporating multiple structural parameters for real-time process control.Subsequently,the simulation results for various structural parameters are analyzed,and the influence of these parameters on casting formation is thoroughly investigated.Finally,the optimal design scheme is generated and validated through experimental verification.Simulation analysis and experimental results show that using a larger gate neck(24 mm in side length) and external risers promotes a more uniform temperature distribution and a more stable flow state,effectively eliminating shrinkage cavities and enhancing process yield by 15%.
基金the Chinese Academy of Sciences Pioneer Hundred Talents Program and the Second Tibetan Plateau Scientific Expedition and Research Program(Grant No.2019QZKK0708)supported by a MEXT(Ministry of Education,Culture,Sports,Science and Technology)KAKENHI(Grants-in-Aid for Scientific Research)grant(Grant No.21H05203)Kobe University Strategic International Collaborative Research Grant(Type B Fostering Joint Research).
文摘The intracontinental subduction of a>200-km-long section of the Tajik-Tarim lithosphere beneath the Pamir Mountains is proposed to explain nearly 30 km of shortening in the Tajik fold-thrust belt and the Pamir uplift.Seismic imaging revealed that the upper slab was scraped and that the lower slab had subducted to a depth of>150 km.These features constitute the tectonic complexity of the Pamirs,as well as the thermal subduction mechanism involved,which remains poorly understood.Hence,in this study,high-resolution three-dimensional(3D)kinematic modeling is applied to investigate the thermal structure and geometry of the subducting slab beneath the Pamirs.The modeled slab configuration reveals distinct along-strike variations,with a steeply dipping slab beneath the southern Pamirs,a more gently inclined slab beneath the northern Pamirs,and apparent upper slab termination at shallow depths beneath the Pamirs.The thermal field reveals a cold slab core after delamination,with temperatures ranging from 400℃to 800℃,enveloped by a hotter mantle reaching~1400℃.The occurrence of intermediate-depth earthquakes aligns primarily with colder slab regions,particularly near the slab tear-off below the southwestern Pamirs,indicating a strong correlation between slab temperature and seismicity.In contrast,the northern Pamirs exhibit reduced seismicity at depth,which is likely associated with thermal weakening and delamination.The central Pamirs show a significant thermal anomaly caused by a concave slab,where the coldest crust does not descend deeply,further suggesting crustal detachment or mechanical failure.The lateral asymmetry in slab temperature possibly explains the mechanism of lateral tearing and differential slab-mantle coupling.
基金supported by the National Major Science and Technology Projects of China[grant no 2016ZX05050005]the Big Science Program of the International Union of Geological Sciences for Deep-time Digital Earth.
文摘The development of unmanned aerial vehicle(UAV)oblique photogrammetric technology provides a good foundation for the rapid construction of large-scale and high-definition real-scene 3D models.However,due to the limitations of the modeling process,irrelevant feature data cannot be eliminated in the modeling stage.The built models contain irrelevant features and model distortions caused by errors.At present,most existing clipping algorithms cannot effectively clip real-scene 3D models that are organized as a whole or with levels of detail(LODs).Therefore,this paper proposes a novel algorithm for clipping real-scene 3D models from any perspective based on clipping boundary lines thatfit the surfaces of the models.The results of the clipping experiments for 3D models constructed with oblique UAV images show that this algorithm can effectively clip any part of the 3D models,that the clipping results of each level model closelyfit the corresponding clipping boundary lines,and that the accuracy of the clipping results is very high.Additionally,the time complexity of the algorithm is O(n^(2)).In conclusion,the algorithm proposed in this paper provides correct and effective clipping results for real-scene 3D models with LODs that are constructed with photogrammetric or 3D laser scanning data.
基金provided by the Talent Training Project of the National Natural Science Foundation of China (No.J0730534)the National Natural Science Foundation of China (No.40902093)+1 种基金the Morning Light Plan of the Shanghai Educational Development Foundation (No.2007CG34)the Open Foundation of the Shanghai Key Laboratory of Urbanization and Ecological Restoration (No.200803)
文摘Uncertainty in 3D geological structure models has become a bottleneck that restricts the development and application of 3D geological modeling.In order to solve this problem during periods of accuracy assessment,error detection and dynamic correction in 3D geological structure models,we have reviewed the current situation and development trends in 3D geological modeling.The main context of uncertainty in 3D geological structure models is discussed.Major research issues and a general framework system of uncertainty in 3D geological structure models are proposed.We have described in detail the integration of development practices of 3D geological modeling systems,as well as the implementation process for uncertainty evaluation in 3D geological structure models.This study has laid the basis to build theoretical and methodological systems for accuracy assessment and error correction in 3D geological models and can assist in improving 3D modeling techniques under complex geological conditions.
文摘A grain-based distinct element model featuring three-dimensional （3D） Voronoi tessellations （randompoly-crystals） is proposed for simulation of crack damage development in brittle rocks. The grainboundaries in poly-crystal structure produced by Voronoi tessellations can represent flaws in intact rockand allow for numerical replication of crack damage progression through initiation and propagation ofmicro-fractures along grain boundaries. The Voronoi modelling scheme has been used widely in the pastfor brittle fracture simulation of rock materials. However the difficulty of generating 3D Voronoi modelshas limited its application to two-dimensional （2D） codes. The proposed approach is implemented inNeper, an open-source engine for generation of 3D Voronoi grains, to generate block geometry files thatcan be read directly into 3DEC. A series of Unconfined Compressive Strength （UCS） tests are simulated in3DEC to verify the proposed methodology for 3D simulation of brittle fractures and to investigate therelationship between each micro-parameter and the model＇s macro-response. The possibility of numericalreplication of the classical U-shape strength curve for anisotropic rocks is also investigated innumerical UCS tests by using complex-shaped （elongated） grains that are cemented to one another alongtheir adjoining sides. A micro-parameter calibration procedure is established for 3D Voronoi models foraccurate replication of the mechanical behaviour of isotropic and anisotropic （containing a fabric） rocks. 2014 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.
基金the National Natural Science Foundation of China(51727807,52121003)Innovation Teams of Ten-Thousand Talents Program sponsored by the Ministry of Science and Technology of China(2016RA4067).
文摘Transparent physical models of real rocks fabricated using three-dimensional(3D)printing technology are used in photoelas-tic experiments to quantify the evolution of the internal stress and deformation fields of rocks.Therefore,they are rendered as an emerging powerful technique to quantitatively reveal the intrinsic mechanisms of rock failure.The mechanical behav-ior of natural rocks exhibits a significant size effect;however,limited research has been conducted on whether transparent physical models observe similar size effects.In this study,to make the transparent printed models accurately demonstrate the mechanical behavior of natural rocks and reveal the internal mechanism of the size effect in rock mechanical behavior,the size effect in 3D printed models of fractured and porous rocks under uniaxial compressive loading was investigated.Transparent cylindrical models with different sizes that contained different fractured and porous structures were printed using the fracture and porous characteristics extracted from natural coal and sandstone.The variation in uniaxial compres-sive strength and elastic modulus of fractured and porous models for increasing model sizes were obtained through uniaxial compression experiments.Finally,the influence of internal discontinuous structural features,such as fractures and pores,on the size effect pertaining to the mechanical behavior of the model was analyzed and elaborated by comparing it with the mechanical properties of the continuous homogeneous model without fractures and pores.The findings provided support and reference to analyze the size effect of rock mechanical behavior and the effect of the internal discontinuous structure using 3D printed transparent models.
基金Supported by the Science Fund for Creative Research Groups of National Natural Science Foundation of China(No.51021004)Tianjin Research Program of Application Foundation and Advanced Technology(No.12JCZDJC29200)National Key Technology R and D Program in the 12th Five-Year Plan of China(No.2011BAB10B06)
文摘An automatic generation method of geological cross-sections in dredging engineering based on 3D geological solid models is presented.The 3D geological models are built applying the non-uniform rational B-splines(NURBS) technique,and a 2D profile can be calculated and generated automatically through Boolean operation to meet the demands of dredging projects.Moreover,an automatic marking method for geological attributes is put forward based on database technology,and the geological attributes include the profile name,scale,horizontal and vertical relative coordinates,geological lithology,and 2D standard lithology legend.At the same time,the automatic marking method can also provide an interactive mode for geological engineers to edit and modify the profile in the modeling system.Practical engineering applications show that the automatic generation method is a simple,flexible,fast and precise visual graphics rendering process that can create 2D standard profiles automatically and efficiently.This method also provides a convenient support tool for geological engineering digital analysis.
